Seyed Mohammad Mahdi Rasa

Islamic Republic of Iran
LGSA Member

Characterization of the transcriptome, the epigenome, and the microbiome during aging: dietary restriction ameliorates inflammaging

Friedrich Schiller University Jena (FSU): Faculty of Biological Sciences
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI): Neri Research Group

First Supervisor:

Francesco Neri (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Co – Supervisor(s):

Karl Lenhard Rudolph (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Doctoral Disputation:

2021

Publications 2023:

  • Author Correction: IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration.
    Omrani* O, Krepelova* A, Rasa SMM, Sirvinskas D, Lu J, Annunziata F, Garside G, Bajwa S, Reinhardt S, Adam L, Käppel S, Ducano N, Donna D, Ori A, Oliviero S, Rudolph KL, Neri F
    Nat Commun 2023, 14(1), 6302 * equal contribution
  • IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration.
    Omrani* O, Krepelova* A, Rasa SMM, Sirvinskas D, Lu J, Annunziata F, Garside G, Bajwa S, Reinhardt S, Adam L, Käppel S, Ducano N, Donna D, Ori A, Oliviero S, Rudolph KL, Neri F
    Nat Commun 2023, 14(1), 6109 * equal contribution

Publications 2022:

  • The natural compound atraric acid suppresses androgen-regulated neo-angiogenesis of castration-resistant prostate cancer through angiopoietin 2.
    Ehsani M, Bartsch S, Rasa SMM, Dittmann J, Pungsrinont T, Neubert L, Huettner SS, Kotolloshi R, Schindler K, Ahmad A, Mosig AS, Adam L, Ori A, Neri F, Berndt A, Grimm MO, Baniahmad A
    Oncogene 2022, 41(23), 3263-77
  • Establishment and evaluation of module-based immune-associated gene signature to predict overall survival in patients of colon adenocarcinoma.
    Lu J, Annunziata F, Sirvinskas D, Omrani O, Li H, Rasa SMM, Krepelova A, Adam L, Neri F
    J Biomed Sci 2022, 29(1), 81
  • The androgen receptor-lncRNASAT1-AKT-p15 axis mediates androgen-induced cellular senescence in prostate cancer cells.
    Mirzakhani K, Kallenbach J, Rasa SMM, Ribaudo F, Ungelenk M, Ehsani M, Gong W, Gassler N, Leeder M, Grimm MO, Neri F, Baniahmad A
    Oncogene 2022, 41(7), 943-59
  • Androgen-Induced MIG6 Regulates Phosphorylation of Retinoblastoma Protein and AKT to Counteract Non-Genomic AR Signaling in Prostate Cancer Cells.
    Schomann T, Mirzakhani K, Kallenbach J, Lu J, Rasa SMM, Neri F, Baniahmad A
    Biomolecules 2022, 12(8), 1048
  • Single-cell atlas of the aging mouse colon.
    Širvinskas D, Omrani O, Lu J, Rasa M, Krepelova A, Adam L, Kaeppel S, Sommer F, Neri F
    iScience 2022, 25(5), 104202

Publications 2021:

  • Antithetic hTERT Regulation by Androgens in Prostate Cancer Cells: hTERT Inhibition Is Mediated by the ING1 and ING2 Tumor Suppressors.
    Bartsch S, Mirzakhani K, Neubert L, Stenzel A, Ehsani M, Esmaeili M, Pungsrinont T, Kacal M, Rasa SMM, Kallenbach J, Damodaran D, Ribaudo F, Grimm MO, Neri F, Baniahmad A
    Cancers (Basel) 2021, 13(16), 4025
  • Establishment of a fluorescent reporter of RNA-polymerase II activity to identify dormant cells
    Freter R, Falletta P, Omrani O, Rasa M, Herbert K, Annunziata F, Minetti A, Krepelova A, Adam L, Käppel S, Rüdiger T, Wang ZQ, Goding** CR, Neri** F
    Nat Commun 2021, 12(1), 3318 ** co-corresponding authors
  • Characterization of an in vitro 3D intestinal organoid model by using massive RNAseq-based transcriptome profiling.
    Lu J, Krepelova A, Rasa SMM, Annunziata F, Husak O, Adam L, Nunna S, Neri F
    Sci Rep 2021, 11(1), 16668
  • A Novel Splice Variant of the Inhibitor of Growth 3 Lacks the Plant Homeodomain and Regulates Epithelial-Mesenchymal Transition in Prostate Cancer Cells.
    Melekhova A, Leeder M, Pungsrinont T, Schmäche T, Kallenbach J, Ehsani M, Mirzakhani K, Rasa SMM, Neri F, Baniahmad A
    Biomolecules 2021, 11(8)
  • Characterization of the transcriptome, the epigenome, and the microbiome during aging : dietary restriction ameliorates inflammaging
    Rasa SMM
    Dissertation 2021, Jena, Germany
  • HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration.
    Tapias* A, Lázaro* D, Yin* BK, Rasa SMM, Krepelova A, Kelmer Sacramento E, Grigaravicius P, Koch P, Kirkpatrick J, Ori A, Neri F, Wang ZQ
    Elife 2021, 10, e61531 * equal contribution
  • DNA methylation modulates allograft survival and acute rejection after renal transplantation by regulating the mTOR pathway
    Zhu C, Xiang W, Li B, Wang Y, Feng S, Wang C, Chen Y, Xie W, Qu L, Huang H, Annunziata F, Nunna S, Krepelova A, Rasa SMM, Neri F, Chen J, Jiang H
    Am J Transplant 2021, 21(2), 567-81

Publications 2019:

  • Aging Triggers H3K27 Trimethylation Hoarding in the Chromatin of Nothobranchius furzeri Skeletal Muscle.
    Cencioni* C, Heid* J, Krepelova A, Rasa SMM, Kuenne C, Guenther S, Baumgart M, Cellerino A, Neri F, Spallotta** F, Gaetano** C
    Cells 2019, 8(10) * equal contribution, ** co-senior authors
  • Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation.
    Chen Z, Amro EM, Becker F, Hölzer M, Rasa SMM, Njeru SN, Han B, Di Sanzo S, Chen Y, Tang D, Tao S, Haenold R, Groth M, Romanov VS, Kirkpatrick JM, Kraus JM, Kestler HA, Marz M, Ori A, Neri F, Morita** Y, Rudolph** KL
    J Exp Med 2019, 216(1), 152-75 ** co-corresponding authors