Simone Di Sanzo
Italy
LGSA Member
Mapping sites of carboxymethyllysine modification on proteins reveals its consequences for proteostasis and cell proliferation
Friedrich Schiller University Jena (FSU): Faculty of Biological Sciences
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI): Ori Research Group
First Supervisor:
Alessandro Ori (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))Co – Supervisor(s):
Karl Lenhard Rudolph (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))Doctoral Disputation:
2021Publications 2022:
- Glycation Alters the Fatty Acid Binding Capacity of Human Serum Albumin.
Henning C, Stübner C, Arabi SH, Reichenwallner J, Hinderberger D, Fiedler R, Girndt M, Di Sanzo S, Ori A, Glomb MA
J Agric Food Chem 2022, 70(9), 3033-46 - Mapping sites of carboxymethyllysine modification on proteins reveals its consequences for proteostasis and cell proliferation
Di Sanzo S
Dissertation 2021, Jena, Germany - Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation.
Di Sanzo* S, Spengler* K, Leheis A, Kirkpatrick JM, Rändler TL, Baldensperger T, Dau T, Henning C, Parca L, Marx C, Wang ZQ, Glomb MA, Ori** A, Heller** R
Nat Commun 2021, 12(1), 6743 * equal contribution, ** co-senior authors - Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality.
Schüler SC, Kirkpatrick* JM, Schmidt* M, Santinha D, Koch P, Di Sanzo S, Cirri E, Hemberg M, Ori** A, von Maltzahn** J
Cell Rep 2021, 35(10), 109223 * equal contribution, ** co-senior authors - Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation.
Kelmer Sacramento* E, Kirkpatrick* JM, Mazzetto* M, Baumgart M, Bartolome A, Di Sanzo S, Caterino C, Sanguanini M, Papaevgeniou N, Lefaki M, Childs D, Bagnoli S, Terzibasi Tozzini E, Di Fraia D, Romanov N, Sudmant PH, Huber W, Chondrogianni N, Vendruscolo M, Cellerino** A, Ori** A
Mol Syst Biol 2020, 16(6), e9596 * equal contribution, ** co-corresponding authors - Quantitation of Reactive Acyl-CoA Species Mediated Protein Acylation by HPLC-MS/MS.
Baldensperger T, Simone DS, Ori A, Glomb MA
Anal Chem 2019, 91(19), 12336-43 - Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation.
Chen Z, Amro EM, Becker F, Hölzer M, Rasa SMM, Njeru SN, Han B, Di Sanzo S, Chen Y, Tang D, Tao S, Haenold R, Groth M, Romanov VS, Kirkpatrick JM, Kraus JM, Kestler HA, Marz M, Ori A, Neri F, Morita** Y, Rudolph** KL
J Exp Med 2019, 216(1), 152-75 ** co-corresponding authors - Increased Expression of Immature Mannose-Containing Glycoproteins and Sialic Acid in Aged Mouse Brains.
Simon F, Bork K, Gnanapragassam VS, Baldensperger T, Glomb MA, Di Sanzo S, Ori A, Horstkorte R
Int J Mol Sci 2019, 20(24)
Publications 2021:
Publications 2020:
Publications 2019:
Scientific CV
July 2016 - December 2016 | Research assistant - HiWi student in CF Proteomics Leibniz Institute on Aging - FLI, Beutenbergstraße 11, 07745 Jena |
March 2012 - July 2013 | Technical researcher in mass spectrometry-MALDI-TOF University of Milano-Bicocca, Via Cadore 48, Monza Milan |
January 2009 - January 2010 | Laboratory Technician University of Milano, Ospedale Maggiore Policlinico Fondazione IRCCS Milan |
Education: | |
2010 - 2013 | Master’s Degree of Science in Medical Biotechnologies at University of Milano-Bicocca |
2007 – 2010 | Bachelor Degree of Science in Biomedical Laboratory Methods at University of Milan |