Simone Di Sanzo

LGSA Member

Mapping sites of carboxymethyllysine modification on proteins reveals its consequences for proteostasis and cell proliferation

Friedrich Schiller University Jena (FSU): Faculty of Biological Sciences
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI): Ori Research Group

First Supervisor:

Alessandro Ori (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Co – Supervisor(s):

Karl Lenhard Rudolph (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Doctoral Disputation:


Publications 2022:

  • Glycation Alters the Fatty Acid Binding Capacity of Human Serum Albumin.
    Henning C, Stübner C, Arabi SH, Reichenwallner J, Hinderberger D, Fiedler R, Girndt M, Di Sanzo S, Ori A, Glomb MA
    J Agric Food Chem 2022, 70(9), 3033-46
  • Publications 2021:

    • Mapping sites of carboxymethyllysine modification on proteins reveals its consequences for proteostasis and cell proliferation
      Di Sanzo S
      Dissertation 2021, Jena, Germany
    • Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation.
      Di Sanzo* S, Spengler* K, Leheis A, Kirkpatrick JM, Rändler TL, Baldensperger T, Dau T, Henning C, Parca L, Marx C, Wang ZQ, Glomb MA, Ori** A, Heller** R
      Nat Commun 2021, 12(1), 6743 * equal contribution, ** co-senior authors
    • Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality.
      Schüler SC, Kirkpatrick* JM, Schmidt* M, Santinha D, Koch P, Di Sanzo S, Cirri E, Hemberg M, Ori** A, von Maltzahn** J
      Cell Rep 2021, 35(10), 109223 * equal contribution, ** co-senior authors

    Publications 2020:

    • Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation.
      Kelmer Sacramento* E, Kirkpatrick* JM, Mazzetto* M, Baumgart M, Bartolome A, Di Sanzo S, Caterino C, Sanguanini M, Papaevgeniou N, Lefaki M, Childs D, Bagnoli S, Terzibasi Tozzini E, Di Fraia D, Romanov N, Sudmant PH, Huber W, Chondrogianni N, Vendruscolo M, Cellerino** A, Ori** A
      Mol Syst Biol 2020, 16(6), e9596 * equal contribution, ** co-corresponding authors

    Publications 2019:

    • Quantitation of Reactive Acyl-CoA Species Mediated Protein Acylation by HPLC-MS/MS.
      Baldensperger T, Simone DS, Ori A, Glomb MA
      Anal Chem 2019, 91(19), 12336-43
    • Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation.
      Chen Z, Amro EM, Becker F, Hölzer M, Rasa SMM, Njeru SN, Han B, Di Sanzo S, Chen Y, Tang D, Tao S, Haenold R, Groth M, Romanov VS, Kirkpatrick JM, Kraus JM, Kestler HA, Marz M, Ori A, Neri F, Morita** Y, Rudolph** KL
      J Exp Med 2019, 216(1), 152-75 ** co-corresponding authors
    • Increased Expression of Immature Mannose-Containing Glycoproteins and Sialic Acid in Aged Mouse Brains.
      Simon F, Bork K, Gnanapragassam VS, Baldensperger T, Glomb MA, Di Sanzo S, Ori A, Horstkorte R
      Int J Mol Sci 2019, 20(24)

Scientific CV

July 2016 - December 2016       Research assistant - HiWi student in CF Proteomics
Leibniz Institute on Aging - FLI, Beutenbergstraße 11, 07745 Jena
March 2012 - July 2013       Technical researcher in mass spectrometry-MALDI-TOF
University of Milano-Bicocca, Via Cadore 48, Monza Milan
January 2009 - January 2010       Laboratory Technician
University of Milano, Ospedale Maggiore Policlinico Fondazione IRCCS Milan
2010 - 2013       Master’s Degree of Science in Medical Biotechnologies at University of Milano-Bicocca
2007 – 2010       Bachelor Degree of Science in Biomedical Laboratory Methods at University of Milan