Fabiana Troisi

Italy
LGSA Member

Sex differences in lipid mediator biosynthesis with consequences for the inflammatory process and its resolution

Friedrich Schiller University Jena (FSU) - Institute of Pharmacy

First Supervisor:

Oliver Werz (Friedrich Schiller University Jena (FSU))

Doctoral Disputation:

2020

Publications 2019:

  • Leukotriene-mediated sex dimorphism in murine asthma-like features during allergen sensitization.
    Rossi A, Roviezzo F, Sorrentino R, Riemma MA, Cerqua I, Bilancia R, Spaziano G, Troisi F, Pace S, Pinto A, D'Agostino B, Werz O, Cirino G
    Pharmacol Res 2019, 139, 182-90
  • Publications 2018:

    • Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation.
      Cheung SY, Werner M, Esposito L, Troisi F, Cantone V, Liening S, König S, Gerstmeier J, Koeberle A, Bilancia R, Rizza R, Rossi A, Roviezzo F, Temml V, Schuster D, Stuppner H, Schubert-Zsilavecz M, Werz O, Hanke T, Pace S
      Eur J Med Chem 2018, 156, 815-30
    • Docosahexaenoic acid in the treatment of rheumatoid arthritis: A double-blind, placebo-controlled, randomized cross-over study with microalgae vs. sunflower oil.
      Dawczynski C, Dittrich M, Neumann T, Goetze K, Welzel A, Oelzner P, Völker S, Schaible AM, Troisi F, Thomas L, Pace S, Koeberle A, Werz O, Schlattmann P, Lorkowski S, Jahreis G
      Clin Nutr 2018, 37(2), 494-504
    • Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase.
      Pein H, Ville A, Pace S, Temml V, Garscha U, Raasch M, Alsabil K, Viault G, Dinh CP, Guilet D, Troisi F, Neukirch K, König S, Bilancia R, Waltenberger B, Stuppner H, Wallert M, Lorkowski S, Weinigel C, Rummler S, Birringer M, Roviezzo F, Sautebin L, Helesbeux JJ, Séraphin D, Mosig AS, Schuster D, Rossi A, Richomme P, Werz O, Koeberle A
      Nat Commun 2018, 9(1), 3834

    Publications 2017:

    • Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males.
      Pace S, Pergola C, Dehm F, Rossi A, Gerstmeier J, Troisi F, Pein H, Schaible AM, Weinigel C, Rummler S, Northoff H, Laufer S, Maier TJ, Rådmark O, Samuelsson B, Koeberle A, Sautebin L, Werz O
      J Clin Invest 2017, 127(8), 3167-76
    • Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation.
      Pace S, Rossi A, Krauth V, Dehm F, Troisi F, Bilancia R, Weinigel C, Rummler S, Werz O, Sautebin L
      Sci Rep 2017, 7(1), 3759

    Publications 2016:

    • The hallucinogenic diterpene salvinorin A inhibits leukotriene synthesis in experimental models of inflammation.
      Rossi A, Pace S, Tedesco F, Pagano E, Guerra G, Troisi F, Werner M, Roviezzo F, Zjawiony JK, Werz O, Izzo AA, Capasso R
      Pharmacol Res 2016, 106, 64-71

Scientific CV

2012 - 2014      

M.Sc. Experimental and Applied Biology, University of Pavia (Italy)

2008 - 2012       

B.Sc. Molecular and Cellular Biology, University of Pisa (Italy)

Publications:        The hallucinogenic diterpene salvinorin A inhibits leukotriene synthesis in experimental models of inflammation.
Rossi A, Pace S, Tedesco F, Pagano E, Guerra G, Troisi F, Werner M, Roviezzo F, Zjawiony JK, Werz O, Izzo AA, Capasso R
Pharmacol. Res 2016, (15)30180-8