Kanstantin Siniuk

Belarus
LGSA Member

Poly-ADP-ribose regulation in cell cycle control and cancer therapy

Friedrich Schiller University Jena (FSU): Faculty of Biological Sciences
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI): Wang Research Group

First Supervisor:

Zhao-Qi Wang (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Doctoral Disputation:

2021

Publications 2021:

  • Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing's sarcoma cells
    Marx C, Schaarschmidt MU, Kirkpatrick J, Marx-Blümel L, Halilovic M, Westermann M, Hoelzer D, Meyer FB, Geng Y, Buder K, Schadwinkel HM, Siniuk K, Becker S, Thierbach R, Beck JF, Sonnemann* J, Wang* ZQ
    Cell Biosci 2021, 11(1), 57 * equal contribution
  • Mechanistic insights into p53-regulated cytotoxicity of combined entinostat and irinotecan against colorectal cancer cells.
    Marx C, Sonnemann J, Beyer M, Maddocks ODK, Lilla S, Hauzenberger I, Piée-Staffa A, Siniuk K, Nunna S, Marx-Blümel L, Westermann M, Wagner T, Meyer FB, Thierbach R, Mullins CS, Kdimati S, Linnebacher M, Neri F, Heinzel T, Wang ZQ, Krämer OH
    MOL ONCOL 2021 (epub ahead of print)

Publications 2020:

  • NBS1 interacts with Notch signaling in neuronal homeostasis.
    Zhou ZW, Kirtay M, Schneble N, Yakoub G, Ding M, Rüdiger T, Siniuk K, Lu R, Jiang YN, Li TL, Kaether C, Barzilai A, Wang ZQ
    Nucleic Acids Res 2020, 48(19), 10924-39

Publications 2017:

  • PARPing for Balance in the Homeostasis of Poly(ADP-ribosyl)ation.
    Schuhwerk H, Atteya R, Siniuk K, Wang ZQ
    Semin Cell Dev Biol 2017, 63, 81-91
  • Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo.
    Schuhwerk H, Bruhn C, Siniuk K, Min W, Erener S, Grigaravicius P, Krüger A, Ferrari E, Zubel T, Lazaro D, Monajembashi S, Kiesow K, Kroll T, Bürkle A, Mangerich A, Hottiger M, Wang ZQ
    Nucleic Acids Res 2017, 45(19), 11174-92