Manuel Schmidt

Germany
LGSA Member

Towards prevention of loss of muscle stem cell function during aging and prevention of cancer cachexia

Friedrich Schiller University Jena (FSU): Faculty of Biological Sciences
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI): von Maltzahn Research Group

First Supervisor:

Julia von Maltzahn (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Doctoral Disputation:

2018

Publications 2020:

  • Wnt7a Counteracts Cancer Cachexia.
    Schmidt M, Poser C, von Maltzahn J
    Mol Ther Oncolytics 2020, 16, 134-46
  • Publications 2019:

    • Analyzing Satellite Cell Function During Skeletal Muscle Regeneration by Cardiotoxin Injury and Injection of Self-delivering siRNA In Vivo.
      Ahrens* HE, Henze* H, Schüler SC, Schmidt M, Hüttner SS, von Maltzahn J
      J Vis Exp 2019 * equal contribution
    • Isolation and Culture of Individual Myofibers and Their Adjacent Muscle Stem Cells from Aged and Adult Skeletal Muscle.
      Hüttner SS, Ahrens HE, Schmidt M, Henze H, Jung MJ, Schüler SC, von Maltzahn J
      Methods Mol Biol 2019, 2045, 25-36
    • Author Correction: Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.
      Schwörer S, Becker F, Feller C, Baig AH, Köber U, Henze H, Kraus JM, Xin B, Lechel A, Lipka DB, Varghese CS, Schmidt M, Rohs R, Aebersold R, Medina KL, Kestler HA, Neri F, von Maltzahn** J, Tümpel** S, Rudolph** KL
      Nature 2019, 572(7769), E11-5 ** co-corresponding authors

    Publications 2018:

    • Klotho expression is a prerequisite for proper muscle stem cell function and regeneration of skeletal muscle.
      Ahrens* HE, Huettemeister* J, Schmidt M, Kaether C, von Maltzahn J
      Skelet Muscle 2018, 8(1), 20 * equal contribution
    • Thyroid Hormone Transporters MCT8 and OATP1C1 Control Skeletal Muscle Regeneration.
      Mayerl S, Schmidt M, Doycheva D, Darras VM, Hüttner SS, Boelen A, Visser TJ, Kaether C, Heuer** H, von Maltzahn** J
      Stem Cell Reports 2018, 10(6), 1959-74 ** co-corresponding authors
    • Towards prevention of loss of muscle stem cell function during aging and prevention of cancer cachexia.
      Schmidt M
      Dissertation 2018, Jena, Germany

    Publications 2016:

    • Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice.
      Lukjanenko L, Jung MJ, Hegde N, Perruisseau-Carrier C, Migliavacca E, Rozo M, Karaz S, Jacot G, Schmidt M, Li L, Metairon S, Raymond F, Lee U, Sizzano F, Wilson DH, Dumont NA, Palini A, Fässler R, Steiner P, Descombes P, Rudnicki MA, Fan CM, von Maltzahn J, Feige JN, Bentzinger CF
      Nat Med 2016, 22(8), 897-905
    • Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.
      Schwörer S, Becker F, Feller C, Baig AH, Köber U, Henze H, Kraus JM, Xin B, Lechel A, Lipka DB, Varghese CS, Schmidt M, Rohs R, Aebersold R, Medina KL, Kestler HA, Neri F, von Maltzahn** J, Tümpel** S, Rudolph** KL
      Nature 2016, 540(7633), 428-32 ** co-corresponding authors