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Oscar Gutierrez-Gutierrez

Spain
LGSA Member

Proteostasis is essential for planarian stem cell regulation and regeneration during starvation

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI): Gonzalez-Estevez Research Group

First Supervisor:

Cristina Gonzalez-Estevez (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Co – Supervisor(s):

Karl Lenhard Rudolph (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Doctoral Disputation:

2018

Publications 2021:

  • Regeneration in starved planarians depends on TRiC/CCT subunits modulating the unfolded protein response.
    Gutiérrez-Gutiérrez* Ó, Felix* DA, Salvetti A, Amro EM, Thems A, Pietsch S, Koeberle A, Rudolph KL, González-Estévez C
    EMBO Rep 2021, 22(8), e52905 * equal contribution

    • Publications 2020:

    • Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution.
      Jordan PM, Gerstmeier J, Pace S, Bilancia R, Rao Z, Börner F, Miek L, Gutiérrez-Gutiérrez Ó, Arakandy V, Rossi A, Ialenti A, González-Estévez C, Löffler B, Tuchscherr L, Serhan CN, Werz O
      Cell Rep 2020, 33(2), 108247

    Publications 2019:

    • It is not all about regeneration: planarians striking power to stand starvation.
      Felix DA, Gutiérrez-Gutiérrez Ó, Espada L, Thems A, González-Estévez C
      Semin Cell Dev Biol 2019, 87, 169-81
    • Downregulation of mTOR Signaling Increases Stem Cell Population Telomere Length during Starvation of Immortal Planarians.
      Iglesias M, Felix DA, Gutiérrez-Gutiérrez Ó, De Miguel-Bonet MDM, Sahu S, Fernández-Varas B, Perona R, Aboobaker AA, Flores** I, González-Estévez** C
      Stem Cell Reports 2019, 13(2), 405-18 ** co-corresponding authors

    Publications 2018:

    • Proteostasis is essential for planarian stem cell regulation and regeneration during starvation.
      Gutierrez-Gutierrez O
      Dissertation 2018, Jena, Germany

    Publications 2017:

    • Planarian finds time(less) to fight infection.
      Gutiérrez-Gutiérrez Ó, Felix DA, González-Estévez C
      Virulence 2017, 8(7), 1043-8

    Publications 2016:

    • Postnatal telomere dysfunction induces cardiomyocyte cell-cycle arrest through p21 activation.
      Aix E, Gutiérrez-Gutiérrez Ó, Sánchez-Ferrer C, Aguado T, Flores I
      J Cell Biol 2016, 213(5), 571-83

Scientific CV

2012 – 2013       MSc in Molecular Biomedicine, Universidad Autónoma de Madrid (UAM), Spain.
Master thesis at the Spanish National Centre for Cardiovascular Research (CNIC), Spain.
2007 – 2012         BSc in Biotechnology, Universidad de Salamanca (USAL), Spain.

Publications:        Telomerase Is Essential for Zebrafish Heart Regeneration.
Bednarek D, González-Rosa JM, Guzmán-Martínez G, Gutiérrez-Gutiérrez Ó, Aguado T, Sánchez-Ferrer C, Marques IJ, Galardi-Castilla M, de Diego I, Gómez MJ, Cortés A, Zapata A, Jiménez-Borreguero LJ, Mercader N, Flores I.
Cell Rep. 2015 Sep 8;12(10):1691-703
        Postnatal telomere dysfunction induces cardiomyocyte cell-cycle arrest through p21 activation.
Aix E, Gutiérrez-Gutiérrez Ó, Sánchez-Ferrer C, Aguado T, Flores I.
J Cell Biol. 2016, May 30. pii: jcb.201510091