Arne Sahm

LGSA Member

Molecular pattern associazed with exeptional lomg healthspan - the mole rats (Bathyergidae)

Friedrich Schiller University Jena (FSU): Faculty of Biological Sciences
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI): Platzer Research Group

First Supervisor:

Matthias Platzer (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)), Karol Szafranski (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Doctoral Disputation:


Publications 2019:

  • Analysis of the coding sequences of clownfish reveals molecular convergence in the evolution of lifespan.
    Sahm A, Almaida-Pagán P, Bens M, Mutalipassi M, Lucas-Sánchez A, de Costa Ruiz J, Görlach M, Cellerino A
    BMC Evol Biol 2019, 19(1), 89
  • Publications 2018:

    • Higher gene expression stability during aging in long-lived giant mole-rats than in short-lived rats.
      Sahm A, Bens M, Henning Y, Vole C, Groth M, Schwab M, Hoffmann S, Platzer* M, Szafranski* K, Dammann* P
      Aging (Albany NY) 2018, 10(12), 3938-56 * equal contribution
    • Long-lived rodents reveal signatures of positive selection in genes associated with lifespan.
      Sahm A, Bens M, Szafranski K, Holtze S, Groth M, Görlach M, Calkhoven C, Müller C, Schwab M, Kraus J, Kestler HA, Cellerino A, Burda H, Hildebrandt T, Dammann P, Platzer M
      PLoS Genet 2018, 14(3), e1007272

    Publications 2017:

    • Tissue-, sex- and age-specific DNA methylation of rat glucocorticoid receptor gene promoter and insulin like growth factor 2 imprinting control region.
      Agba OB, Lausser L, Huse K, Bergmeier C, Jahn N, Groth M, Bens M, Sahm A, Gall M, Witte OW, Kestler HA, Schwab M, Platzer M
      Physiol Genomics 2017, 49(11), 690-702 APSselect for distinction in scholarship in the Physiological Genomics
    • Positive Selektion in langlebigen Nagern und kurzlebigen Fischen : eine bioinformatische Suche nach der genetischen Basis des Alterns
      Sahm A
      Dissertation 2017, Jena, Germany
    • Parallel evolution of genes controlling mitonuclear balance in short-lived annual fishes.
      Sahm A, Bens M, Platzer M, Cellerino A
      Aging Cell 2017, 16(3), 488-96
    • PosiGene: automated and easy-to-use pipeline for genome-wide detection of positively selected genes.
      Sahm A, Bens M, Platzer M, Szafranski K
      Nucleic Acids Res 2017, 45(11), e100
    • (Anti-)parallel evolution of lifespan.
      Sahm A, Cellerino A
      Aging (Albany NY) 2017, 9(10), 2018-9

    Publications 2016:

    • FRAMA: from RNA-seq data to annotated mRNA assemblies.
      Bens M, Sahm A, Groth M, Jahn N, Morhart M, Holtze S, Hildebrandt TB, Platzer M, Szafranski K
      BMC Genomics 2016, 17(1), 54
    • Low sulfide levels and a high degree of cystathionine β-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat.
      Dziegelewska M, Holtze S, Vole C, Wachter U, Menzel U, Morhart M, Groth M, Szafranski K, Sahm A, Sponholz C, Dammann P, Huse K, Hildebrandt** T, Platzer** M
      Redox Biol 2016, 8, 192-8 ** co-senior authors
    • Outgroups and Positive Selection: The Nothobranchius furzeri Case.
      Sahm A, Platzer M, Cellerino A
      Trends Genet 2016, 32(9), 523-5

    Publications 2015:

    • Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish.
      Reichwald* K, Petzold* A, Koch* P, Downie* BR, Hartmann* N, Pietsch S, Baumgart M, Chalopin D, Felder M, Bens M, Sahm A, Szafranski K, Taudien S, Groth M, Arisi I, Weise A, Bhatt SS, Sharma V, Kraus JM, Schmid F, Priebe S, Liehr T, Görlach M, Than ME, Hiller M, Kestler HA, Volff JN, Schartl M, Cellerino** A, Englert** C, Platzer** M
      Cell 2015, 163(6), 1527-38 * equal contribution, ** co-senior authors, featured in Cell Preview by Vanisha Lakhina and Coleen T. Murphy: Genome Sequencing Fishes out Longevity Genes. Cell. 2015 163(6):1312-3,Nature News by Ewen Callaway: Short-lived fish may hold clues to human age

    Publications 2014:

    • Unusual Ratio between Free Thyroxine and Free Triiodothyronine in a Long-Lived Mole-Rat Species with Bimodal Ageing.
      Henning Y, Vole C, Begall S, Bens M, Broecker-Preuss M, Sahm A, Szafranski K, Burda H, Dammann P
      PLoS One 2014, 9(11), e113698