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Bing Han

China
LGSA Member

Reverse genetic screening identifies essential ribosomal protein genes in hematopoietic stem cells that are dysregulated during aging

Friedrich Schiller University Jena (FSU): Faculty of Biological Sciences
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI): Rudolph Research Group

First Supervisor:

Karl Lenhard Rudolph (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Doctoral Disputation:

2019

Publications 2022:

  • Age-dependent effects of Igf2bp2 on gene regulation, function, and aging of hematopoietic stem cells in mice.
    Suo M, Rommelfanger MK, Chen Y, Amro EM, Han B, Chen Z, Szafranski K, Chakkarappan SR, Boehm BO, MacLean AL, Rudolph KL
    Blood 2022, 139(17), 2653-65

    • Publications 2021:

    • Correction: Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging.
      Tang D, Tao S, Chen Z, Koliesnik IO, Calmes PG, Hoerr V, Han B, Gebert N, Zörnig M, Löffler B, Morita Y, Rudolph KL
      J Exp Med 2021, 218(1)

    Publications 2019:

    • Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation.
      Chen Z, Amro EM, Becker F, Hölzer M, Rasa SMM, Njeru SN, Han B, Di Sanzo S, Chen Y, Tang D, Tao S, Haenold R, Groth M, Romanov VS, Kirkpatrick JM, Kraus JM, Kestler HA, Marz M, Ori A, Neri F, Morita** Y, Rudolph** KL
      J Exp Med 2019, 216(1), 152-75 ** co-corresponding authors
    • Reverse genetic screening identifies essential ribosomal protein genes in hematopoietic stem cells that are dysregulated during aging
      Han B
      Dissertation 2019, Jena, Germany
    • Author Correction: Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing.
      Wang J, Morita Y, Han B, Niemann S, Löffler B, Rudolph KL
      Nat Cell Biol 2019, 21(6), 791-2

    Publications 2018:

    • Senescence mirrors the extent of liver fibrosis in chronic hepatitis C virus infection.
      Wandrer F, Han B, Liebig S, Schlue J, Manns MP, Schulze-Osthoff K, Bantel H
      Aliment Pharmacol Ther 2018, 48(3), 270-80

    Publications 2016:

    • Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging.
      Tang D, Tao S, Chen Z, Koliesnik IO, Calmes PG, Hoerr V, Han B, Gebert N, Zörnig M, Löffler B, Morita** Y, Rudolph** KL
      J Exp Med 2016, 213(4), 535-53 ** co-corresponding authors
    • Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing.
      Wang J, Morita Y, Han B, Niemann S, Löffler B, Rudolph KL
      Nat Cell Biol 2016, 18(5), 480-90 recommended by "Faculty of 1000" - Prime