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Omid Omrani

Islamic Republic of Iran
LGSA Associate

Intestine specific deletion of H2AX promotes premature aging in telomerase deficient mice

Friedrich Schiller University Jena (FSU): Faculty of Biological Sciences
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI): Rudolph Research Group

First Supervisor:

Karl Lenhard Rudolph (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Doctoral Disputation:

2020

Publications 2021:

  • Deletion of H2AX aggravates telomere dysfunction induced DNA damage and atrophy of the intestinal epithelium
    Omrani O
    Dissertation 2021, Jena, Germany

    • Publications 2020:

    • Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor.
      Njeru* SN, Kraus* J, Meena* JK, Lechel A, Katz SF, Kumar M, Knippschild U, Azoitei A, Wezel F, Bolenz C, Leithäuser F, Gollowitzer A, Omrani O, Hoischen C, Koeberle A, Kestler** HA, Günes** C, Rudolph** KL
      Oncogene 2020, 39(7), 1445-65 * equal contribution, ** co-corresponding authors

    Publications 2017:

    • Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.
      Tao S, Tang D, Morita Y, Sperka T, Omrani O, Lechel A, Sakk V, Kraus J, Kestler HA, Kühl M, Rudolph KL
      EMBO J 2017, 36(19), 2920-1 Erratum for EMBO J 2015 volume 34 page 624

    Publications 2015:

    • Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.
      Tao S, Tang D, Morita Y, Sperka T, Omrani O, Lechel A, Sakk V, Kraus J, Kestler HA, Kühl** M, Rudolph** KL
      EMBO J 2015, 34(5), 624-40 ** co-corresponding authors