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Yulin Chen

China
LGSA Member

Impaired metabolic stress responses in hematopoietic stem cell aging

Friedrich Schiller University Jena (FSU): Faculty of Biological Sciences
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI): Rudolph Research Group

First Supervisor:

Karl Lenhard Rudolph (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Doctoral Disputation:

2020

Publications 2022:

  • Age-dependent effects of Igf2bp2 on gene regulation, function, and aging of hematopoietic stem cells in mice.
    Suo M, Rommelfanger MK, Chen Y, Amro EM, Han B, Chen Z, Szafranski K, Chakkarappan SR, Boehm BO, MacLean AL, Rudolph KL
    Blood 2022, 139(17), 2653-65

    • Publications 2020:

    • Impaired metabolic stress responses in hematopoietic stem cell aging
      Chen Y
      Dissertation 2020, Jena, Germany

    Publications 2019:

    • Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation.
      Chen Z, Amro EM, Becker F, Hölzer M, Rasa SMM, Njeru SN, Han B, Di Sanzo S, Chen Y, Tang D, Tao S, Haenold R, Groth M, Romanov VS, Kirkpatrick JM, Kraus JM, Kestler HA, Marz M, Ori A, Neri F, Morita** Y, Rudolph** KL
      J Exp Med 2019, 216(1), 152-75 ** co-corresponding authors

Scientific CV

Publications:        Gadd45a Regulates Hematopoietic Stem Cell Stress Responses in Mice.
Chen Y, Ma X, Zhang M, Wang X, Wang C, Wang H, Guo P, Yuan W, Rudolph KL, Zhan Q, Ju Z
Blood 2014, 123(6):851‐62
        Gadd45a Deletion Aggravates Hematopoietic Stem Cell Dysfunction in ATM‐deficient Mice
Chen Y, Yang R, Peng Guo, Ju Z
Protein Cell 2014, 5(1):80‐9
        Quiescence and attenuated DNA damage response promote survival of esophageal cancer stem cells
Chen Y, Li D, Wang D, Liu X, Yin N, Song Y, Lu SH, Ju Z, Zhan Q
J Cell Biochem 2012, 113(12): 3643‐52
        Hematopoietic Stem Cell Aging and Cancer
Chen Y and Ju Z
In: Adult Stem Cells in Aging, Diseases and Cancer (edited by Rudolph KL), Else Kröner-Fresenius Symposia 2012, 3, 27–35, Karger Verlag, Basel