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Sören Hüttner

Germany
LGSA Member

The role of Hippo-signaling in adult satellite cell homeostasis

Friedrich Schiller University Jena (FSU): Faculty of Biological Sciences
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI): von Maltzahn Research Group

First Supervisor:

Julia von Maltzahn (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Doctoral Disputation:

2021

Publications 2024:

  • Denervation alters the secretome of myofibers and thereby affects muscle stem cell lineage progression and functionality.
    Henze H, Hüttner SS, Koch P, Schüler SC, Groth M, von Eyss B, von Maltzahn J
    NPJ Regen Med 2024, 9(1), 10

    • Publications 2023:

    • A dysfunctional miR-1-TRPS1-MYOG axis drives ERMS by suppressing terminal myogenic differentiation.
      Hüttner SS, Henze H, Elster D, Koch P, Anderer U, von Eyss B, von Maltzahn J
      Mol Ther 2023, 31(9), 2612-32

    Publications 2021:

    • Therole of the transcriptional repressor TRPS1 in rhabdomyosarcoma and myogenesis
      Hüttner S
      Dissertation 2021, Jena, Germany
    • Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo.
      Hüttner SS, Hayn C, Ahrens HE, Schmidt M, Henze H, von Maltzahn J
      J Vis Exp 2021

    Publications 2020:

    • S1P lyase inhibition protects against sepsis by promoting disease tolerance via the S1P/S1PR3 axis.
      Weigel C, Hüttner SS, Ludwig K, Krieg N, Hofmann S, Schröder NH, Robbe L, Kluge S, Nierhaus A, Winkler MS, Rubio I, von Maltzahn J, Spiegel S, Gräler MH
      EBioMedicine 2020, 58, 102898

    Publications 2019:

    • Analyzing Satellite Cell Function During Skeletal Muscle Regeneration by Cardiotoxin Injury and Injection of Self-delivering siRNA In Vivo.
      Ahrens* HE, Henze* H, Schüler SC, Schmidt M, Hüttner SS, von Maltzahn J
      J Vis Exp 2019, e60194 * equal contribution
    • Isolation and Culture of Individual Myofibers and Their Adjacent Muscle Stem Cells from Aged and Adult Skeletal Muscle.
      Hüttner SS, Ahrens HE, Schmidt M, Henze H, Jung MJ, Schüler SC, von Maltzahn J
      Methods Mol Biol 2019, 2045, 25-36
    • Adult stem cells at work: regenerating skeletal muscle.
      Schmidt M, Schüler SC, Hüttner SS, von Eyss B, von Maltzahn J
      Cell Mol Life Sci 2019, 76(13), 2559-70

    Publications 2018:

    • Thyroid Hormone Transporters MCT8 and OATP1C1 Control Skeletal Muscle Regeneration.
      Mayerl S, Schmidt M, Doycheva D, Darras VM, Hüttner SS, Boelen A, Visser TJ, Kaether C, Heuer** H, von Maltzahn** J
      Stem Cell Reports 2018, 10(6), 1959-74 ** co-corresponding authors

Scientific CV

2012 – 2015        Master of Science: Molecular Medicine, FSU Jena
Thesis: Ligand dependent regulation of cell cycle factors by the androgen receptor in human prostate cancer cell lines.
Department: Human Genetics, Molecular Genetics
Supervision: Prof. Dr. A. Baniahmad
2009 – 2012       Bachelor of Science: Biochemistry/Molecular Biology, FSU Jena
Thesis: Funktionelle Wechselwirkung zwischen DEP-1 und NF2 in Menigeomzellen.
Department: Molecular Cell Biology
Supervision: Prof. Dr. F.-D. Böhmer
Publications:        Supraphysiological androgen levels induce cellular senescence in human prostate cancer cells through the Src-Akt pathway
Roediger J, Hessenkemper W, Bartsch S, Manvelyan M, Huettner SS, Liehr T, Esmaeili M, Foller S, Petersen I, MO and Baniahmad A
Molecular Cancer 2014, 13:214