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Zhiang Chen

China
LGSA Member

Cohesin deficiency enhances hematopoietic stem cell self-renewal in the context of aging and inflammation by imparing NF-kappaB induced differentiation

Friedrich Schiller University Jena (FSU): Faculty of Biological Sciences
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI): Rudolph Research Group

First Supervisor:

Karl Lenhard Rudolph (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Doctoral Disputation:

2018

Publications 2022:

  • Age-dependent effects of Igf2bp2 on gene regulation, function, and aging of hematopoietic stem cells in mice.
    Suo M, Rommelfanger MK, Chen Y, Amro EM, Han B, Chen Z, Szafranski K, Chakkarappan SR, Boehm BO, MacLean AL, Rudolph KL
    Blood 2022, 139(17), 2653-65

    • Publications 2021:

    • Correction: Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging.
      Tang D, Tao S, Chen Z, Koliesnik IO, Calmes PG, Hoerr V, Han B, Gebert N, Zörnig M, Löffler B, Morita Y, Rudolph KL
      J Exp Med 2021, 218(1)

    Publications 2019:

    • Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation.
      Chen Z, Amro EM, Becker F, Hölzer M, Rasa SMM, Njeru SN, Han B, Di Sanzo S, Chen Y, Tang D, Tao S, Haenold R, Groth M, Romanov VS, Kirkpatrick JM, Kraus JM, Kestler HA, Marz M, Ori A, Neri F, Morita** Y, Rudolph** KL
      J Exp Med 2019, 216(1), 152-75 ** co-corresponding authors

    Publications 2018:

    • Cohesin deficiency enhances hematopoietic stem cell self-renewal in the context of aging and inflammation by impairing NK-ƙB induced differentiation.
      Chen Z
      Dissertation 2018, Jena, Germany

    Publications 2016:

    • Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging.
      Tang D, Tao S, Chen Z, Koliesnik IO, Calmes PG, Hoerr V, Han B, Gebert N, Zörnig M, Löffler B, Morita** Y, Rudolph** KL
      J Exp Med 2016, 213(4), 535-53 ** co-corresponding authors

    Publications 2015:

    • Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways.
      Chen Z, Yi W, Morita Y, Wang H, Cong Y, Liu JP, Xiao Z, Rudolph KL, Cheng T, Ju Z
      Nat Commun 2015, 6, 6808
    • Phosphatase Wip1 controls antigen-independent B cell development in a p53-dependent manner.
      Yi* W, Hu* X, Chen* Z, Liu L, Tian Y, Chen H, Cong YS, Yang F, Zhang L, Rudolph KL, Zhang Z, Zhao Y, Ju Z
      Blood 2015, 126(5), 620-8 * equal contribution