Oleksandr Dakhovnik
Ukraine
LGSA Member
Mitochondrial dysfunction and loss of metabolic plasticity cause a reversal of metformin longevity benefits in late life
Friedrich Schiller University Jena (FSU): Faculty of Biological Sciences
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI): Ermolaeva Research Group
First Supervisor:
Maria Ermolaeva (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))Co – Supervisor(s):
Zhao-Qi Wang (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))Doctoral Disputation:
2021Publications 2021:
- Mitochondrial dysfunction and loss of metabolic plasticity cause a reversal of metformin longevity benefits in late life
Dakhovnik O
Dissertation 2021, Jena, Germany - Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans.
Espada* L, Dakhovnik* A, Chaudhari* P, Martirosyan A, Miek L, Poliezhaieva T, Schaub Y, Nair A, Döring N, Rahnis N, Werz O, Koeberle A, Kirkpatrick J, Ori A, Ermolaeva MA
Nat Metab 2020, 2(11), 1316-31 * equal contribution - Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging.
Heinze* I, Bens* M, Calzia* E, Holtze S, Dakhovnik O, Sahm A, Kirkpatrick JM, Szafranski K, Romanov N, Sama SN, Holzer K, Singer S, Ermolaeva M, Platzer** M, Hildebrandt** T, Ori** A
BMC Biol 2018, 16(1), 82 * equal contribution, ** co-senior authors - DNA-Damage-Induced Hormetic Responses
Mägdefrau AS, Ludwig K, Weigel C, Köse N, Guerra GM, Dakhovnik A, Kosan C
In: The Science of Hormesis in Health and Longevity, Chapter 13 (edited by Suresh ISR, Marios K) 2018, 149-159, Academic Press, London