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Alberto Minetti

Italy
Email: alberto.minetti@leibniz-fli.de

Polyamines support epithelial regeneration in aged intestines by regulating protein homeostasis

Friedrich Schiller University Jena (FSU): Faculty of Biological Sciences
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI): Neri Research Group

First Supervisor:

Francesco Neri (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Publications 2025:

  • Aging and diet alter the protein ubiquitylation landscape in the mouse brain.
    Marino* A, Di Fraia* D, Panfilova D, Sahu AK, Minetti A, Omrani O, Cirri E, Ori A
    Nat Commun 2025, 16(1), 5266 * equal contribution

    • Publications 2024:

    • Quantitative mapping of proteasome interactomes and substrates using ProteasomeID.
      Bartolome A, Heiby* JC, Di Fraia* D, Heinze I, Knaudt H, Spaeth E, Omrani O, Minetti A, Hofmann M, Kirkpatrick JM, Dau** T, Ori** A
      Elife 2024, 13, RP93256 * equal contribution, ** co-corresponding authors
    • NRF2 activation by cysteine as a survival mechanism for triple-negative breast cancer cells.
      Bottoni L, Minetti A, Realini G, Pio E, Giustarini D, Rossi R, Rocchio C, Franci L, Salvini L, Catona O, D'Aurizio R, Rasa M, Giurisato E, Neri F, Orlandini M, Chiariello M, Galvagni F
      Oncogene 2024, 43(22), 1701-13
    • Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis
      Minetti A, Omrani O, Brenner C, Allies G, Imada S, Rösler J, Khawaled S, Cansiz F, W.Meckelmann S, Gebert N, Heinze I, Lu J, Spengler K, Rasa M, Heller R, Yilmaz O, Tasdogan A, Neri F, Ori A
      bioRxiv 2024, https://doi.org/10.1101/2024.07.
    • Leiomodin 1 promotes myogenic differentiation by modulating Sirtuin 1
      Späth* E, C.Schüler* S, Heinze I, Dau T, Minetti A, Hofmann M, von Maltzahn** J, Ori** A
      bioRxiv 2024, https://doi.org/10.1101/2024.03. * equal contribution, ** co-corresponding authors

    Publications 2022:

    • Paneth cells drive intestinal stem cell competition and clonality in aging and calorie restriction
      Annunziata F, Rasa SMM, Krepelova A, Lu J, Minetti A, Omrani O, Nunna S, Adam L, Käppel S, Neri F
      Eur J Cell Biol 2022, 101(4), 151282

    Publications 2021:

    • Establishment of a fluorescent reporter of RNA-polymerase II activity to identify dormant cells
      Freter R, Falletta P, Omrani O, Rasa M, Herbert K, Annunziata F, Minetti A, Krepelova A, Adam L, Käppel S, Rüdiger T, Wang ZQ, Goding** CR, Neri** F
      Nat Commun 2021, 12(1), 3318 ** co-corresponding authors