Publications 2023:

• Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer.
  Akdemir KC, Le VT, Chandran S, Li Y, Verhaak RG, Beroukhim R, Campbell PJ, Chin L, Dixon JR, Futreal PA, PCAWG Structural Variation Working Group, PCAWG Consortium
  Nat Genet 2023, 55(6), 1079
  
• Author Correction: The repertoire of mutational signatures in human cancer.
  Alexandrov LB, Kim J, Haradhvala NJ, Huang MN, Tian Ng AW, Wu Y, Boot A, Covington KR, Gordenin DA, Bergstrom EN, Islam SMA, Lopez-Bigas N, Klimczak LJ, McPherson JR, Morganella S, Sabarinathan R, Wheeler DA, Mustonen V, PCAWG Mutational Signatures Working Group, Getz G, Rozen SG, Stratton MR, PCAWG Consortium
  Nature 2023, 614(7948), E41
  
• Localization and Characterization of Major Neurogenic Niches in the Brain of the Lesser-Spotted Dogfish Scyliorhinus canicula.
  Bagnoli S, Chiavacci E, Cellerino A, Terzibasi Tozzini E
  Int J Mol Sci 2023, 24(4), 3650
  
• EdU and Immunofluorescence Staining of Nothobranchius furzeri Organotypic Cultures.
  Bagnoli S, Terzibasi Tozzini E, Cellerino A
  Cold Spring Harb Protoc 2023, 2023(3), pdb.prot107790
  
• Whole-Brain Clearing and Immunofluorescence in Nothobranchius furzeri.
  Bagnoli S, Terzibasi Tozzini E, Cellerino A
  Cold Spring Harb Protoc 2023 (epub ahead of print)
  
• Immunofluorescence and Aggresome Staining of Nothobranchius furzeri Cryosections.
  Bagnoli S, Terzibasi Tozzini E, Cellerino A
  Cold Spring Harb Protoc 2023 (epub ahead of print)
  
• Vaccine Side Effects in Health Care Workers after Vaccination against SARS-CoV-2: Data from TüSeRe:exact Study.
  Bareiß A, Uzun G, Mikus M, Becker M, Althaus K, Schneiderhan-Marra N, Fürstberger A, Schwab JD, Kestler HA, Holderried M, Martus P, Schenke-Layland K, Bakchoul T
  Viruses 2023, 15(1), 65
  
• Evolution, mechanism and limits of dietary restriction induced health benefits and longevity.
  Becker F, Behrends MM, Rudolph KL
  Redox Biol 2023, 63, 102725
  
• Pomalidomide combinations are a safe and effective option after daratumumab failure.
  Brioli A, Gengenbach L, Mancuso K, Binder M, Ernst T, Heidel FH, Stauch T, Zamagni E, Hilgendorf I, Hochhaus A, Engelhardt M, von Lilienfeld-Toal M
  J Cancer Res Clin Oncol 2023, 149(9), 6569
  
• Female reproductive fluid attracts more and better sperm: implications for within-ejaculate cryptic female choice.
  Cattelan S, Devigili A, Santacà M, Gasparini C
  Biol Lett 2023, 19(6), 20230063
  
• Noninvasive Ejaculate Collection from the African Turquoise Killifish Nothobranchius furzeri.
  Cattelan S, Valenzano DR
  Cold Spring Harb Protoc 2023, 5
  
• Human NMDAR autoantibodies disrupt excitatory-inhibitory balance, leading to hippocampal network hypersynchrony.
  Ceanga M, Rahmati V, Haselmann H, Schmidl L, Hunter D, Brauer AK, Liebscher S, Kreye J, Prüss H, Groc L, Hallermann S, Dalmau J, Ori A, Heckmann M, Geis C
  Cell Rep 2023 (epub ahead of print)
  
• UPF3A is dispensable for nonsense-mediated mRNA decay in mouse pluripotent and somatic cells.
  Chen C, Shen Y, Li L, Ren Y, Wang ZQ, Li T
  Life Sci Alliance 2023, 6(6), e202201589. doi: 10.26508/lsa.20
  
• Genetic separation of chronic myeloid leukemia stem cells from normal hematopoietic stem cells at single-cell resolution.
  Chen Y, Möbius S, Riege K, Hoffmann S, Hochhaus A, Ernst* T, Rudolph* KL
  Leukemia 2023, 37(7), 1561-6 * equal contribution
  
• Distribution of Brain-Derived Neurotrophic Factor in the Brain of the Small-Spotted Catshark Scyliorhinus canicula, and Evolution of Neurotrophins in Basal Vertebrates.
  Chiavacci E, Bagnoli S, Cellerino A, Terzibasi Tozzini E
  Int J Mol Sci 2023, 24(11), 9495
  
• Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy.
  Chung HY, Wickel J, Hahn N, Mein N, Schwarzbrunn M, Koch P, Ceanga M, Haselmann H, Baade-Büttner C, von Stackelberg N, Hempel N, Schmidl L, Groth M, Andreas N, Götze J, Coldewey SM, Bauer M, Mawrin C, Dargvainiene J, Leypoldt F, Steinke S, Wang ZQ, Hust M, Geis C
  Sci Adv 2023, 9(21), eabq7806
  
• Peripheral Ischemia Imprints Epigenetic Changes in Hematopoietic Stem Cells to Propagate Inflammation and Atherosclerosis.
  Coppin E, Zhang X, Ohayon L, Johny E, Dasari A, Zheng KH, Stiekema L, Cifuentes-Pagano E, Pagano PJ, Chaparala S, Stroes ES, Dutta P
  Arterioscler Thromb Vasc Biol 2023, 43(6), 889-906
  
• Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan.
  Correia-Melo C, Kamrad S, Tengölics R, Messner CB, Trebulle P, Townsend S, Jayasree Varma S, Freiwald A, Heineike BM, Campbell K, Herrera-Dominguez L, Kaur Aulakh S, Szyrwiel L, Yu JSL, Zelezniak A, Demichev V, Mülleder M, Papp B, Alam MT, Ralser M
  Cell 2023, 186(1), 63
  
• Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing.
  Cortés-Ciriano I, Lee JJK, Xi R, Jain D, Jung YL, Yang L, Gordenin D, Klimczak LJ, Zhang CZ, Pellman DS, PCAWG Structural Variation Working Group, Park PJ, PCAWG Consortium
  Nat Genet 2023, 55(6), 1076
  
• Turquoise killifish: A natural model of age-dependent brain degeneration.
  de Bakker DEM, Valenzano DR
  Ageing Res Rev 2023 (epub ahead of print)
  
• First-Line Venetoclax Combinations in Chronic Lymphocytic Leukemia.
  Eichhorst B, Niemann CU, Kater AP, Fürstenau M, von Tresckow J, Zhang C, Robrecht S, Gregor M, Juliusson G, Thornton P, Staber PB, Tadmor T, Lindström V, da Cunha-Bang C, Schneider C, Poulsen CB, Illmer T, Schöttker B, Nösslinger T, Janssens A, Christiansen I, Baumann M, Frederiksen H, van der Klift M, Jäger U, Leys MBL, Hoogendoorn M, Lotfi K, Hebart H, Gaska T, Koene H, Enggaard L, Goede J, Regelink JC, Widmer A, Simon F, De Silva N, Fink AM, Bahlo J, Fischer K, Wendtner CM, Kreuzer KA, Ritgen M, Brüggemann M, Tausch E, Levin MD, van Oers M, Geisler C, Stilgenbauer S, Hallek M, GCLLSG the HOVON and Nordic CLL Study Groups the SAKK the Israeli CLL Association and Cancer Trials Ireland
  N Engl J Med 2023, 388(19), 1739
  
• Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia.
  Eifert T, Hsu CJ, Becker AL, Graessle S, Horne A, Bemmann F, Zhang Q, Heuser M, Vasioukhin V, Scholl S, Hochhaus A, Siegerist F, Endlich N, Bullinger L, Lane SW, Haas S, Schnoeder TM, Heidel FH
  Leukemia 2023 (epub ahead of print)
  
• Assembling highly repetitive Xanthomonas TALomes using Oxford Nanopore sequencing.
  Erkes A, Grove RP, Žarković M, Krautwurst S, Koebnik R, Morgan RD, Wilson GG, Hölzer M, Marz M, Boch J, Grau J
  BMC Genomics 2023, 24(1), 151
  
• p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer.
  Fischer M
  Int J Biol Sci 2023, 19(15), 4831
  
• Physiological media advance cell culture experiments.
  Fischer M
  Trends Biochem Sci 2023, 48(2), 103-5
  
• The landscape of human p53-regulated long non-coding RNAs reveals critical host gene co-regulation.
  Fischer M, Riege K, Hoffmann S
  MOL ONCOL 2023, 17(7), 1263-79
  
• Human gene-engineered calreticulin mutant stem cells recapitulate MPN hallmarks and identify targetable vulnerabilities.
  Foßelteder J, Pabst G, Sconocchia T, Schlacher A, Auinger L, Kashofer K, Beham-Schmid C, Trajanoski S, Waskow C, Schöll W, Sill H, Zebisch A, Wölfler A, Thomas D, Reinisch A
  Leukemia 2023, 37(4), 843-53
  
• Impact of Hypermannosylation on the Structure and Functionality of the ER and the Golgi Complex.
  Franzka P, Schüler SC, Kentache T, Storm R, Bock A, Katona I, Weis J, Buder K, Kaether C, Hübner CA
  Biomedicines 2023, 11(1), 146.doi: 10.3390/biomedicines110
  
• Autism Spectrum Disorder: A Neuro-Immunometabolic Hypothesis of the Developmental Origins.
  Frasch MG, Yoon BJ, Helbing DL, Snir G, Antonelli MC, Bauer R
  Biology (Basel) 2023, 12(7)
  
• Federated electronic data capture (fEDC): Architecture and prototype.
  Ganzinger M, Blumenstock M, Fürstberger A, Greulich L, Kestler HA, Marschollek M, Niklas C, Schneider T, Spreckelsen C, Tute E, Varghese J, Dugas M
  J Biomed Inform 2023, 138, 104280
  
• Deletion of Cd44 Inhibits Metastasis Formation of Liver Cancer in Nf2 -Mutant Mice.
  Gerardo-Ramírez M, Giam V, Becker D, Groth M, Hartmann N, Morrison H, May-Simera HL, Radsak MP, Marquardt JU, Galle PR, Herrlich P, Straub BK, Hartmann M
  Cells 2023, 12(9), 1257
  
• Comparative analysis of thyroid hormone systems in rodents with subterranean lifestyle.
  Gerhardt P, Begall S, Frädrich C, Renko K, Hildebrandt TB, Holtze S, Heinrich A, Sahm A, Meci X, Köhrle J, Rijntjes E, Henning Y
  Sci Rep 2023, 13(1), 3122
  
• Author Correction: The evolutionary history of 2,658 cancers.
  Gerstung M, Jolly C, Leshchiner I, Dentro SC, Gonzalez S, Rosebrock D, Mitchell TJ, Rubanova Y, Anur P, Yu K, Tarabichi M, Deshwar A, Wintersinger J, Kleinheinz K, Vázquez-García I, Haase K, Jerman L, Sengupta S, Macintyre G, Malikic S, Donmez N, Livitz DG, Cmero M, Demeulemeester J, Schumacher S, Fan Y, Yao X, Lee J, Schlesner M, Boutros PC, Bowtell DD, Zhu H, Getz G, Imielinski M, Beroukhim R, Sahinalp SC, Ji Y, Peifer M, Markowetz F, Mustonen V, Yuan K, Wang W, Morris QD, PCAWG Evolution and Heterogeneity Working Group, Spellman PT, Wedge DC, Van Loo P, PCAWG Consortium
  Nature 2023, 614(7948), E42
  
• Corepressor inactivation through tandem linear motif-induced polymerization
  Goradia* N, Werner* S, Mullapudi E, Greimeier S, Merkens L, Lang A, Mertens H, Węglarz A, Sander S, Chojnowski G, Wikman H, Ohlenschläger O, von Amsberg G, Pantel K, Wilmanns M
  bioRxiv 2023, 10.1101/2023.06.16.545227 * equal contribution
  
• Protecting RNA quality for spatial transcriptomics while improving immunofluorescent staining quality.
  Hahn N, Bens M, Kempfer M, Reißig C, Schmidl L, Geis C
  Front Neurosci 2023, 17, 1198154
  
• Molecular-defined clonal evolution in patients with classical myeloproliferative neoplasms.
  Hinze A, Rinke J, Crodel CC, Möbius S, Schäfer V, Heidel FH, Hochhaus A, Ernst T
  Br J Haematol 2023, 202(2), 308-17
  
• Liquid biopsy: an examination of platelet RNA obtained from head and neck squamous cell carcinoma patients for predictive molecular tumor markers.
  Huber* LT, Kraus* JM, Ezić* J, Wanli A, Groth M, Laban S, Hoffmann TK, Wollenberg B, Kestler** HA, Brunner** C
  Explor Target Antitumor Ther 2023, 4(3), 422–446 * equal contribution, ** co-corresponding authors
  
• Author Correction: Pan-cancer analysis of whole genomes.
  ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium
  Nature 2023, 614(7948), E39
  
• Membrane shapers from two distinct superfamilies cooperate in the development of neuronal morphology.
  Izadi M, Wolf D, Seemann E, Ori A, Schwintzer L, Steiniger F, Kessels MM, Qualmann B
  J Cell Biol 2023, 222(8)
  
• Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers
  Jessen M, Gertzmann D, Liss F, Zenk F, Bähner L, Schöffler V, Ade CP, von Eyss B, Gaubatz S
  bioRxiv 2023, 10.1101/2023.07.27.550917
  
• Metabolic heterogeneity and cross-feeding within isogenic yeast populations captured by DILAC.
  Kamrad S, Correia-Melo C, Szyrwiel L, Aulakh SK, Bähler J, Demichev V, Mülleder M, Ralser M
  NAT MICROBIOL 2023, 8(3), 441
  
• Crafting figures to describe cellular processes.
  Kmiecik** SW, Shi** Q, Chen** YG, Moormann** J, Hildebrandt** TM, Schade** A, Fischer** M, Kim** KQ
  Trends Biochem Sci 2023, 48(6), 491-4 ** co-corresponding authors
  
• Sperm length evolution in relation to body mass is shaped by multiple trade-offs in tetrapods
  Koçillari* L, Cattelan*/* S, Rasotto MB, Seno F, Maritan A, Pilastro A
  bioRxiv 2023, 10.1101/2023.09.12.557314 * equal contribution, * corresponding author
  
• Efficacy and safety of ruxolitinib in patients with newly-diagnosed polycythemia vera: futility analysis of the RuxoBEAT clinical trial of the GSG-MPN study group.
  Koschmieder S, Isfort S, Wolf D, Heidel FH, Hochhaus A, Schafhausen P, Griesshammer M, Wolleschak D, Platzbecker U, Döhner K, Jost PJ, Parmentier S, Schaich M, von Bubnoff N, Stegelmann F, Maurer A, Crysandt M, Gezer D, Kortmann M, Franklin J, Frank J, Hellmich M, Brümmendorf TH, German Study Group for Myeloproliferative Neoplasms (GSG-MPN)
  Ann Hematol 2023, 102(2), 349
  
• Streptomyces polyketides mediate bacteria-fungi interactions across soil environments.
  Krespach MKC, Stroe MC, Netzker T, Rosin M, Zehner LM, Komor AJ, Beilmann JM, Krüger T, Scherlach K, Kniemeyer O, Schroeckh V, Hertweck C, Brakhage AA
  Nat Microbiol 2023, 8(7), 1348-61
  
• Rapid Genotyping of Nothobranchius furzeri Embryos, Larvae, and Adult Fish via High-Resolution Melt Analysis (HRMA).
  Krug J, Richter A, Englert C
  Cold Spring Harb Protoc 2023 (epub ahead of print)
  
• Genome Structure, Life Cycle, and Taxonomy of Coronaviruses and the Evolution of SARS-CoV-2.
  Lamkiewicz K, Esquivel Gomez LR, Kühnert D, Marz M
  Curr Top Microbiol Immunol 2023, 439, 305
  
• Author Correction: Patterns of somatic structural variation in human cancer genomes.
  Li Y, Roberts ND, Wala JA, Shapira O, Schumacher SE, Kumar K, Khurana E, Waszak S, Korbel JO, Haber JE, Imielinski M, PCAWG Structural Variation Working Group, Weischenfeldt J, Beroukhim R, Campbell PJ, PCAWG Consortium
  Nature 2023, 614(7948), E38
  
• Mutant Huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure
  Lisowski P, Lickfett S, Rybak-Wolf A, Le S, Dykstra W, Mlody B, Menacho C, Roth P, Richter Y, A.M.Kulka L, Glazar P, Wu H, Meierhofer D, Legnini I, Otto M, Miller D, Neuendorf N, Hahn T, Swamy Telugu N, Böddrich A, Mayatepek E, Diecke S, Olzscha H, Kirstein J, Kühn R, Cambridge S, Rajewsky N, E.Wanker E, Priller J, J.Metzger J, Prigione A
  bioRxiv 2023, 10.1101/2023.06.03.543551
  
• Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B cell lymphomas.
  Lopez C, Schleussner N, Bernhart SH, Kleinheinz K, Sungalee S, Sczakiel HL, Kretzmer H, Toprak UH, Glaser S, Wagener R, Ammerpohl O, Bens S, Giefing M, Sanchez JCG, Apic G, Hubschmann D, Janz M, Kreuz M, Mottok A, Muller JM, Seufert J, Hoffmann S, Korbel JO, Russell RB, Schule R, Trumper L, Klapper W, Radlwimmer B, Lichter P, Kuppers R, Schlesner M, Mathas S, Siebert R
  Haematologica 2023, 108(2), 543-54
  
• Validation of myeloproliferative neoplasms associated risk factor RDW as predictor of thromboembolic complications in healthy individuals: analysis on 6849 participants of the SHIP-study.
  Manz K, Bahr J, Ittermann T, Döhner K, Koschmieder S, Brümmendorf TH, Griesshammer M, Nauck M, Völzke H, Heidel FH
  Leukemia 2023, 37(8), 1745
  
• In vivo reduction of RAD51-mediated homologous recombination triggers aging but impairs oncogenesis.
  Matos-Rodrigues G, Barroca V, Muhammad AA, Dardillac E, Allouch A, Koundrioukoff S, Lewandowski D, Despras E, Guirouilh-Barbat J, Frappart L, Kannouche P, Dupaigne P, Le Cam E, Perfettini JL, Romeo PH, Debatisse M, Jasin M, Livera G, Martini E, Lopez BS
  EMBO J 2023 (epub ahead of print)
  
• Age-Associated Changes in Endothelial Transcriptome and Epigenetic Landscapes Correlate With Elevated Risk of Cerebral Microbleeds.
  Mohan K, Gasparoni G, Salhab A, Orlich MM, Geffers R, Hoffmann S, Adams RH, Walter J, Nordheim A
  J Am Heart Assoc 2023 (epub ahead of print)
  
• A computational framework for testing hypotheses of the minimal mechanical requirements for cell aggregation using early annual killifish embryogenesis as a model.
  Montenegro-Rojas I, Yañez G, Skog E, Guerrero-Calvo O, Andaur-Lobos M, Dolfi L, Cellerino A, Cerda M, Concha ML, Bertocchi C, Rojas NO, Ravasio A, Rudge TJ
  Front Cell Dev Biol 2023, 11, 959611
  
• Dietary restriction mitigates the age-associated decline in mouse B cell receptor repertoire diversity.
  Monzó C, Gkioni L, Beyer A, Valenzano** DR, Grönke** S, Partridge** L
  Cell Rep 2023 (epub ahead of print) ** co-corresponding authors
  
• Sperm production is negatively associated with muscle and sperm telomere length in a species subjected to strong sperm competition.
  Morbiato E, Cattelan S, Pilastro A, Grapputo A
  Mol Ecol 2023 (epub ahead of print)
  
• Intrasexual cuticular hydrocarbon dimorphism in a wasp sheds light on hydrocarbon biosynthesis genes in Hymenoptera.
  Moris VC, Podsiadlowski L, Martin S, Oeyen JP, Donath A, Petersen M, Wilbrandt J, Misof B, Liedtke D, Thamm M, Scheiner R, Schmitt T, Niehuis O
  Commun Biol 2023, 6(1), 147
  
• The HLA ligandome of oropharyngeal squamous cell carcinomas reveals shared tumour-exclusive peptides for semi-personalised vaccination.
  Mühlenbruch L, Abou-Kors T, Dubbelaar ML, Bichmann L, Kohlbacher O, Bens M, Thomas J, Ezić J, Kraus JM, Kestler HA, von Witzleben A, Mytilineos J, Fürst D, Engelhardt D, Doescher J, Greve J, Schuler PJ, Theodoraki MN, Brunner C, Hoffmann TK, Rammensee HG, Walz JS, Laban S
  Br J Cancer 2023, 128(9), 1777-87
  
• Protein quality control: from molecular mechanisms to therapeutic intervention-EMBO workshop, May 21-26 2023, Srebreno, Croatia.
  Münch C, Kirstein J
  Cell Stress Chaperones 2023 (epub ahead of print)
  
• Identification of altered miRNAs and their targets in placenta accreta.
  Murrieta-Coxca JM, Barth E, Fuentes-Zacarias P, Gutiérrez-Samudio RN, Groten T, Gellhaus A, Köninger A, Marz M, Markert UR, Morales-Prieto DM
  Front Endocrinol (Lausanne) 2023, 14, 1021640
  
• Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration.
  Nguyen PD, Gooijers I, Campostrini G, Verkerk AO, Honkoop H, Bouwman M, de Bakker DEM, Koopmans T, Vink A, Lamers GEM, Shakked A, Mars J, Mulder AA, Chocron S, Bartscherer K, Tzahor E, Mummery CL, de Boer TP, Bellin M, Bakkers J
  Science 2023, 380(6646), 758-64
  
• Ruxolitinib in cytopenic myelofibrosis: Response, toxicity, drug discontinuation, and outcome.
  Palandri F, Breccia M, Mazzoni C, Auteri G, Elli EM, Trawinska MM, Polverelli N, Tiribelli M, Benevolo G, Iurlo A, Tieghi A, Heidel FH, Caocci G, Beggiato E, Binotto G, Cavazzini F, Miglino M, Bosi C, Crugnola M, Bocchia M, Martino B, Pugliese N, Biondo M, Venturi M, Scaffidi L, Isidori A, Cattaneo D, Krampera M, Pane F, Cilloni D, Semenzato G, Lemoli RM, Cuneo A, Abruzzese E, Bartoletti D, Paglia S, Vianelli N, Cavo M, Bonifacio M, Palumbo GA
  Cancer 2023, 129(11), 1704
  
• Determinants of Covid19 disease and of survival after Covid19 in MPN patients treated with ruxolitinib.
  Palandri F, Elli EM, Auteri G, Bonifacio M, Benevolo G, Heidel FH, Paglia S, Trawinska MM, Bosi C, Rossi E, Tiribelli M, Tieghi A, Iurlo A, Polverelli N, Caocci G, Binotto G, Cavazzini F, Beggiato E, Cilloni D, Tatarelli C, Mendicino F, Miglino M, Bocchia M, Crugnola M, Mazzoni C, Romagnoli AD, Rindone G, Ceglie S, D'Addio A, Santoni E, Cattaneo D, Bartoletti D, Lemoli RM, Krampera M, Cuneo A, Semenzato GC, Latagliata R, Abruzzese E, Vianelli N, Cavo M, Andriani A, De Stefano V, Palumbo GA, Breccia M
  Blood Cancer J 2023, 13(1), 65
  
• Predictors of Response to Hydroxyurea and Switch to Ruxolitinib in HU-Resistant Polycythaemia VERA Patients: A Real-World PV-NET Study.
  Palandri F, Rossi E, Auteri G, Breccia M, Paglia S, Benevolo G, Elli EM, Cavazzini F, Binotto G, Tieghi A, Tiribelli M, Heidel FH, Bonifacio M, Pugliese N, Caocci G, Crugnola M, Mendicino F, D'Addio A, Tomassetti S, Martino B, Polverelli N, Ceglie S, Mazzoni C, Mullai R, Ripamonti A, Garibaldi B, Pane F, Cuneo A, Krampera M, Semenzato G, Lemoli RM, Vianelli N, Palumbo GA, Andriani A, Cavo M, Latagliata R, De Stefano V
  Cancers (Basel) 2023, 15(14), 3706
  
• Author Correction: Genomic basis for RNA alterations in cancer.
  PCAWG Transcriptome Core Group, Calabrese C, Davidson NR, Demircioğlu D, Fonseca NA, He Y, Kahles A, Lehmann KV, Liu F, Shiraishi Y, Soulette CM, Urban L, Greger L, Li S, Liu D, Perry MD, Xiang Q, Zhang F, Zhang J, Bailey P, Erkek S, Hoadley KA, Hou Y, Huska MR, Kilpinen H, Korbel JO, Marin MG, Markowski J, Nandi T, Pan-Hammarström Q, Pedamallu CS, Siebert R, Stark SG, Su H, Tan P, Waszak SM, Yung C, Zhu S, Awadalla P, Creighton CJ, Meyerson M, Ouellette BFF, Wu K, Yang H, PCAWG Transcriptome Working Group, Brazma A, Brooks AN, Göke J, Rätsch G, Schwarz RF, Stegle O, Zhang Z, PCAWG Consortium
  Nature 2023, 614(7948), E37
  
• DNA damage response in neurodevelopment and neuromaintenance.
  Qing* X, Zhang* G, Wang ZQ
  FEBS J 2023, 290(13), 3300-10 * equal contribution
  
• Microbiome and immuno-metabolic dysregulation in patients with major depressive disorder with atypical clinical presentation.
  Refisch A, Sen ZD, Klassert TE, Busch A, Besteher B, Danyeli LV, Helbing D, Schulze-Späte U, Stallmach A, Bauer M, Panagiotou G, Jacobsen ID, Slevogt H, Opel N, Walter M
  Neuropharmacology 2023, 235, 109568
  
• Simultaneous Nbs1 and p53 inactivation in neural progenitors triggers High-Grade Gliomas (HGG).
  Reuss DE, Downing SM, Camacho CV, Wang YD, Piro RM, Herold-Mende C, Wang ZQ, Hofmann TG, Sahm F, von Deimling A, McKinnon PJ, Frappart PO
  Neuropathol Appl Neurobiol 2023 (epub ahead of print)
  
• Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes.
  Rheinbay E, Nielsen MM, Abascal F, Wala JA, Shapira O, Tiao G, Hornshøj H, Hess JM, Juul RI, Lin Z, Feuerbach L, Sabarinathan R, Madsen T, Kim J, Mularoni L, Shuai S, Lanzós A, Herrmann C, Maruvka YE, Shen C, Amin SB, Bandopadhayay P, Bertl J, Boroevich KA, Busanovich J, Carlevaro-Fita J, Chakravarty D, Chan CWY, Craft D, Dhingra P, Diamanti K, Fonseca NA, Gonzalez-Perez A, Guo Q, Hamilton MP, Haradhvala NJ, Hong C, Isaev K, Johnson TA, Juul M, Kahles A, Kahraman A, Kim Y, Komorowski J, Kumar K, Kumar S, Lee D, Lehmann KV, Li Y, Liu EM, Lochovsky L, Park K, Pich O, Roberts ND, Saksena G, Schumacher SE, Sidiropoulos N, Sieverling L, Sinnott-Armstrong N, Stewart C, Tamborero D, Tubio JMC, Umer HM, Uusküla-Reimand L, Wadelius C, Wadi L, Yao X, Zhang CZ, Zhang J, Haber JE, Hobolth A, Imielinski M, Kellis M, Lawrence MS, von Mering C, Nakagawa H, Raphael BJ, Rubin MA, Sander C, Stein LD, Stuart JM, Tsunoda T, Wheeler DA, Johnson R, Reimand J, Gerstein M, Khurana E, Campbell PJ, López-Bigas N, PCAWG Drivers and Functional Interpretation Working Group, PCAWG Structural Variation Working Group, Weischenfeldt J, Beroukhim R, Martincorena I, Pedersen JS, Getz G, PCAWG Consortium
  Nature 2023, 614(7948), E40
  
• Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition.
  Rodriguez-Martin B, Alvarez EG, Baez-Ortega A, Zamora J, Supek F, Demeulemeester J, Santamarina M, Ju YS, Temes J, Garcia-Souto D, Detering H, Li Y, Rodriguez-Castro J, Dueso-Barroso A, Bruzos AL, Dentro SC, Blanco MG, Contino G, Ardeljan D, Tojo M, Roberts ND, Zumalave S, Edwards PA, Weischenfeldt J, Puiggròs M, Chong Z, Chen K, Lee EA, Wala JA, Raine KM, Butler A, Waszak SM, Navarro FCP, Schumacher SE, Monlong J, Maura F, Bolli N, Bourque G, Gerstein M, Park PJ, Wedge DC, Beroukhim R, Torrents D, Korbel JO, Martincorena I, Fitzgerald RC, Van Loo P, Kazazian HH, Burns KH, PCAWG Structural Variation Working Group, Campbell PJ, Tubio JMC, PCAWG Consortium
  Nat Genet 2023, 55(6), 1080
  
• Gene regulatory network inference with popInfer reveals dynamic regulation of hematopoietic stem cell quiescence upon diet restriction and aging.
  Rommelfanger* MK, Behrends* M, Chen Y, Martinez J, Bens M, Xiong L, Rudolph** KL, MacLean** AL
  bioRxiv 2023, 10.1101/2023.04.18.537360 * equal contribution, ** co-corresponding authors
  
• The African killifish: A short-lived vertebrate model to study the biology of sarcopenia and longevity.
  Ruparelia AA, Salavaty A, Barlow CK, Lu Y, Sonntag C, Hersey L, Eramo MJ, Krug J, Reuter H, Schittenhelm RB, Ramialison M, Cox A, Ryan MT, Creek DJ, Englert C, Currie PD
  Aging Cell 2023 (epub ahead of print)
  
• ABRAXAS1 orchestrates BRCA1 activities to counter genome destabilizing repair pathways-lessons from breast cancer patients.
  Sachsenweger J, Jansche R, Merk T, Heitmeir B, Deniz M, Faust U, Roggia C, Tzschach A, Schroeder C, Riess A, Pospiech H, Peltoketo H, Pylkäs K, Winqvist R, Wiesmüller L
  Cell Death Dis 2023, 14(5), 328
  
• Detection of reproducible liver cancer specific ligand-receptor signaling in blood
  Safrastyan A, Wollny D
  bioRxiv 2023, 10.1101/2023.09.25.559274
  
• Antioxidants Prevent the Effects of Physical Exercise on Visual Cortical Plasticity.
  Sansevero G, Consorti A, Di Marco I, Terzibasi Tozzini E, Cellerino** A, Sale** A
  Cells 2023, 12(1), doi.org/10.3390/cells12010048 ** co-senior authors
  
• Diagnosis and treatment of MPN in real life: exploratory and retrospective chart review including 960 MPN patients diagnosed with ET or MF in Germany.
  Schmidt A, Bernhardt C, Bürkle D, Fries S, Hannig CV, Jentsch-Ullrich K, Josting A, Kreher S, Reiser M, Steinmetz HT, Tesch H, Terner S, Schulte A, Crodel CC, Palandri F, Heidel FH
  J Cancer Res Clin Oncol 2023, 149(10), 7197
  
• Adapting the pantograph limb: Differential robustness of fore- and hindlimb kinematics against genetically induced perturbation in the neural control networks and its evolutionary implications.
  Schnerwitzki D, Englert C, Schmidt M
  Zoology (Jena) 2023, 157, 126076
  
• PREDICT-juvenile-stroke: PRospective evaluation of a prediction score determining individual clinical outcome three months after ischemic stroke in young adults - a study protocol.
  Schönecker S, Hoffmann V, Albashiti F, Thasler R, Hagedorn M, Louiset ML, Kopczak A, Rösler J, Baki E, Wunderlich S, Kohlmayer F, Kuhn K, Boeker M, Tünnerhoff J, Poli S, Ziemann U, Kohlbacher O, Althaus K, Müller S, Ludolph A, Kestler HA, Mansmann U, Dieterich M, Kellert L
  BMC NEUROL 2023, 23(1), 2
  
• Dynamic DNA methylation reveals novel cis-regulatory elements in mouse hematopoiesis.
  Schönung M, Hartmann M, Krämer S, Stäble S, Hakobyan M, Kleinert E, Aurich T, Cobanoglu D, Heidel FH, Fröhling S, Milsom MD, Schlesner M, Lutsik P, Lipka DB
  Exp Hematol 2023, 117, 24-42.e7
  
• Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD.
  Seddighi S, Qi YA, Brown AL, Wilkins OG, Bereda C, Belair C, Zhang Y, Prudencio M, Keuss MJ, Khandeshi A, Pickles S, Hill SE, Hawrot J, Ramos DM, Yuan H, Roberts J, Sacramento EK, Shah SI, Nalls MA, Colon-Mercado J, Reyes JF, Ryan VH, Nelson MP, Cook C, Li Z, Screven L, Kwan JY, Shantaraman A, Ping L, Koike Y, Oskarsson BR, Staff N, Duong DM, Ahmed A, Secrier M, Ule J, Jacobson S, Rohrer J, Malaspina A, Glass JD, Ori A, Seyfried NT, Maragkakis M, Petrucelli L, Fratta P, Ward ME
  bioRxiv 2023
  
• Sequencing the Immunoglobulin Heavy-Chain Locus (IgH) in Turquoise Killifish ( Nothobranchius furzeri).
  Seidel J, Bradshaw WJ, Valenzano DR
  Cold Spring Harb Protoc 2023, 5
  
• Taxonomic Profiling of Fecal and Intestinal Microbiota in the African Turquoise Killifish Nothobranchius furzeri.
  Seidel J, Popkes M, Valenzano DR
  Cold Spring Harb Protoc 2023 (epub ahead of print) published during change of institution
  
• Corrigendum: Taxonomic Profiling of Fecal and Intestinal Microbiota in the African Turquoise Killifish Nothobranchius furzeri.
  Seidel J, Popkes M, Valenzano DR
  Cold Spring Harb Protoc 2023 (epub ahead of print) published during change of institution
  
• Magnipore: Prediction of differential single nucleotide changes in the Oxford Nanopore Technologies sequencing signal of SARS-CoV-2 samples
  Spangenberg J, Höner zu Siederdissen C, Žarković M, Triebel S, Rose R, Martínez Christophersen C, Paltzow L, M.Hegab M, Wansorra A, Srivastava A, Krumbholz** A, Marz** M
  bioRxiv 2023, https://doi.org/10.1101/2023.03. ** co-senior authors
  
• Patients receiving allogeneic haematopoietic stem-cell transplantation and clinical outcomes after early access to palliative care.
  Späth C, Neumann T, Schmidt CA, Heidel FH, Krüger WH
  Lancet Haematol 2023 (epub ahead of print)
  
• Protein structure prediction with in-cell photo-crosslinking mass spectrometry and deep learning.
  Stahl K, Graziadei A, Dau T, Brock O, Rappsilber J
  Nat Biotechnol 2023 (epub ahead of print)
  
• Clinicohematologic and molecular response of essential thrombocythemia patients treated with pegylated interferon-α: a multi-center study of the German Study Group-Myeloproliferative Neoplasms (GSG-MPN).
  Stegelmann F, Teichmann LL, Heidel FH, Crodel CC, Ernst T, Kreil S, Reiter A, Otten S, Schauer S, Körber RM, Kricheldorf K, Isfort S, Döhner H, Brümmendorf TH, Griesshammer M, Döhner K, Koschmieder S
  Leukemia 2023, 37(4), 924
  
• Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia.
  Straube* J, Eifert* T, Vu T, Janardhanan Y, Haldar R, von Eyss B, Cooper L, Bruedigam C, Ling VY, Cooper E, Patch AM, Bullinger L, Schnoeder TM, Bywater M, Heidel* FH, Lane* SW
  Leukemia 2023, 37(4), 741 * equal contribution
  
• Unsupervised domain adaptation for the detection of cardiomegaly in cross-domain chest X-ray images.
  Thiam P, Lausser L, Kloth C, Blaich D, Liebold A, Beer** M, Kestler** HA
  Front Artif Intell 2023, 6, 1056422 ** co-senior authors
  
• De novo genome assembly resolving repetitive structures enables genomic analysis of 35 European Mycoplasma bovis strains
  Triebel S, Sachse K, Weber M, Heller M, Diezel C, Hölzer M, Schnee C, Marz M
  bioRxiv 2023, https://doi.org/10.1101/2023.04.
  
• Ribosomal protein L24 modulates mammalian microRNA processing and transfer RNA fragment production
  Tzur Y, Dubnov S, Madrer N, Bar A, Nadorp B, Mishra N, Heppenstall P, Bennett Estelle R, Greenberg DS, Winek** K, Soreq** H
  bioRxiv 2023, 10.1101/2023.05.03.539194 ** co-corresponding authors, published during change of institution
  
• Lack of L-type amino acid transporter 2 in murine thyroid tissue induces autophagy.
  Venugopalan V, Rehders M, Weber J, Rodermund L, Al-Hashimi A, Bargmann T, Golchert J, Reinecke V, Homuth G, Völker U, Verrey F, Kirstein J, Heuer H, Schweizer U, Braun D, Wirth EK, Brix K
  J Mol Endocrinol 2023, 70(1)
  
• Identifying Patients with Polycythemia Vera at Risk of Thrombosis after Hydroxyurea Initiation: The Polycythemia Vera-Advanced Integrated Models (PV-AIM) Project.
  Verstovsek S, Krečak I, Heidel FH, De Stefano V, Bryan K, Zuurman MW, Zaiac M, Morelli M, Smyth A, Redondo S, Bigan E, Ruhl M, Meier C, Beffy M, Kiladjian JJ
  Biomedicines 2023, 11(7)
  
• Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precision.
  Vromman M, Anckaert J, Bortoluzzi S, Buratin A, Chen CY, Chu Q, Chuang TJ, Dehghannasiri R, Dieterich C, Dong X, Flicek P, Gaffo E, Gu W, He C, Hoffmann S, Izuogu O, Jackson MS, Jakobi T, Lai EC, Nuytens J, Salzman J, Santibanez-Koref M, Stadler P, Thas O, Vanden Eynde E, Verniers K, Wen G, Westholm J, Yang L, Ye CY, Yigit N, Yuan GH, Zhang J, Zhao F, Vandesompele J, Volders PJ
  Nat Methods 2023 (epub ahead of print)
  
• Signalling by senescent melanocytes hyperactivates hair growth.
  Wang X, Ramos R, Phan AQ, Yamaga K, Flesher JL, Jiang S, Oh JW, Jin S, Jahid S, Kuan CH, Nguyen TK, Liang HY, Shettigar NU, Hou R, Tran KH, Nguyen A, Vu KN, Phung JL, Ingal JP, Levitt KM, Cao X, Liu Y, Deng Z, Taguchi N, Scarfone VM, Wang G, Paolilli KN, Wang X, Guerrero-Juarez CF, Davis RT, Greenberg EN, Ruiz-Vega R, Vasudeva P, Murad R, Widyastuti LHP, Lee HL, McElwee KJ, Gadeau AP, Lawson DA, Andersen B, Mortazavi A, Yu Z, Nie Q, Kunisada T, Karin M, Tuckermann J, Esko JD, Ganesan AK, Li J, Plikus MV
  Nature 2023, 618(7966), 808-17
  
• A protocol for the use of cloud-based quantum computers for logical network analysis of biological systems.
  Weidner FM, Rossini M, Ankerhold J, Kestler HA
  STAR Protoc 2023 (epub ahead of print)
  
• Leveraging quantum computing for dynamic analyses of logical networks in systems biology.
  Weidner FM, Schwab JD, Wölk S, Rupprecht F, Ikonomi N, Werle SD, Hoffmann S, Kühl M, Kestler HA
  Patterns (N Y) 2023, 4(3), 100705
  
• Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia
  Weinberger T, Messerer D, Joppich M, Fischer M, Garcia C, Kumaraswami K, Wimmler V, Ablinger S, Räuber S, Fang J, Liu L, Han Liu W, Winterhalter J, Lichti J, Tomas L, Esfandyari D, Percin G, Martin Salamanca S, Hidalgo A, Waskow C, Engelhardt S, Todica A, Zimmer R, Pridans C, Gomez-Perdiguero E, Schulz C
  bioRxiv 2023, 10.1101/2023.05.08.539799
  
• Light and prey influence the abundances of two rhodopsins in the dinoflagellate Oxyrrhis marina.
  Westermann M, Hoischen C, Wöhlbrand L, Rabus R, Rhiel E
  Protoplasma 2023, 260(2), 529-44
  
• Author Correction: Butler enables rapid cloud-based analysis of thousands of human genomes.
  Yakneen S, Waszak SM, PCAWG Technical Working Group, Gertz M, Korbel JO, PCAWG Consortium
  Nat Biotechnol 2023, 41(4), 577
  
• High-throughput morphometric and transcriptomic profiling uncovers composition of naïve and sensory-deprived cortical cholinergic VIP/CHAT neurons.
  Yayon N, Amsalem O, Zorbaz T, Yakov O, Dubnov S, Winek K, Dudai A, Adam G, Schmidtner AK, Tessier-Lavigne M, Renier N, Habib N, Segev I, London M, Soreq H
  EMBO J 2023, 42(1), e110565
  
• Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers.
  Yuan Y, Ju YS, Kim Y, Li J, Wang Y, Yoon CJ, Yang Y, Martincorena I, Creighton CJ, Weinstein JN, Xu Y, Han L, Kim HL, Nakagawa H, Park K, Campbell PJ, Liang H, PCAWG Consortium
  Nat Genet 2023, 55(6), 1078
  
• Author Correction: The landscape of viral associations in human cancers.
  Zapatka M, Borozan I, Brewer DS, Iskar M, Grundhoff A, Alawi M, Desai N, Sültmann H, Moch H, PCAWG Pathogens, Cooper CS, Eils R, Ferretti V, Lichter P, PCAWG Consortium
  Nat Genet 2023, 55(6), 1077
  
• Hepeliviruses in two waterbodies in Berlin, Germany.
  Zell R, Groth M, Selinka L, Selinka HC
  Arch Virol 2023, 168(1), 9
  
• Epidermal Growth Factor Receptor in Hepatic Endothelial Cells Suppresses MCP-1-Dependent Monocyte Recruitment in Diabetes.
  Zhang X, Ohayon-Steckel L, Coppin E, Johny E, Dasari A, Florentin J, Vasamsetti S, Dutta P
  J Immunol 2023, 210(9), 1363-71
  
• Antiseptic efficacy of two mouth rinses in the oral cavity to identify a suitable rinsing solution in radiation- or chemotherapy induced mucositis.
  Zwicker P, Freitag M, Heidel FH, Kocher T, Kramer A
  BMC Oral Health 2023, 23(1), 176
  

Publications 2022:

• Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing.
  Ahmad M, Krüger BT, Kroll T, Vettorazzi S, Dorn AK, Mengele F, Lee S, Nandi S, Yilmaz D, Stolz M, Tangudu NK, Vázquez DC, Pachmayr J, Cirstea IC, Spasic MV, Ploubidou A, Ignatius A, Tuckermann J
  Bone Res 2022, 10(1), 33
  
• Membrane lipids and maximum lifespan in clownfish.
  Almaida-Pagan PF, Lucas-Sanchez A, Martinez-Nicolas A, Terzibasi E, de Lama MAR, Cellerino A, Mendiola P, de Costa J
  Fish Physiol Biochem 2022, 48(1), 53-65
  
• Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT.
  Ayala Mariscal SM, Pigazzini ML, Richter Y, Özel M, Grothaus IL, Protze J, Ziege K, Kulke M, ElBediwi M, Vermaas JV, Colombi Ciacchi L, Köppen S, Liu F, Kirstein J
  Nat Commun 2022, 13(1), 4692
  
• Long-Term Brain Organotypic Cultures of the Turquoise Killifish Nothobranchius furzeri
  Bagnoli S, Brogi L, Fronte B, Bibbiani C, Terzibasi Tozzini E, Cellerino A
  Cold Spring Harb Protoc 2022, 2022(12), 624-9
  
• Quantification of noradrenergic-, dopaminergic-, and tectal-neurons during aging in the short-lived killifish Nothobranchius furzeri.
  Bagnoli S, Fronte B, Bibbiani C, Terzibasi Tozzini E, Cellerino A
  Aging Cell 2022, 21(9), e13689
  
• Breakthrough infections in MPN-COVID vaccinated patients.
  Barbui T, Carobbio A, Ghirardi A, Iurlo A, De Stefano V, Sobas MA, Rumi E, Elli EM, Lunghi F, Gasior Kabat M, Cuevas B, Guglielmelli P, Bonifacio M, Marchetti M, Alvarez-Larran A, Fox L, Bellini M, Daffini R, Benevolo G, Carreno-Tarragona G, Patriarca A, Al-Ali HK, Andrade-Campos MMM, Palandri F, Harrison C, Foncillas MA, Osorio S, Koschmieder S, Magro Mazo E, Kiladjian JJ, Bolaños Calderón E, Heidel FH, Quiroz Cervantes K, Griesshammer M, Garcia-Gutierrez V, Sanchez AM, Hernandez-Boluda JC, Lopez Abadia E, Carli G, Sagues Serrano M, Kusec R, Xicoy Cirici B, Guenova M, Navas Elorza B, Angona A, Cichocka E, Kulikowska de Nałęcz A, Cattaneo D, Bucelli C, Betti S, Borsani O, Cavalca F, Carbonell S, Curto-Garcia N, Benajiba L, Rambaldi A, Vannucchi AM
  Blood Cancer J 2022, 12(11), 154
  
• A Theoretical Approach to Ordinal Classification: Feature Space-Based Definition and Classifier-Independent Detection of Ordinal Class Structures
  Bellmann P, Lausser L, Kestler HA, Schwenker F
  APPL SCI-BASEL 2022, 12(4), 1815;
  
• Machine Learning-based Pain Intensity Estimation: Where Pattern Recognition meets Chaos Theory–An Example based on the BioVid Heat Pain Database.
  Bellmann P, Thiam P, Kestler HA, Schwenker F
  IEEE ACCESS 2022, 10, 102770-7
  
• Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish.
  Bradshaw WJ, Poeschla M, Placzek A, Kean S, Valenzano DR
  Elife 2022, 11 published during change of institution
  
• Impaired formation of neutrophil extracellular traps (NETs) in patients with myelodysplastic syndrome.
  Brings C, Fröbel J, Cadeddu RP, Germing U, Haas R, Gattermann N
  BLOOD ADV 2022, 6(1), 129-37
  
• Disruption of amphetamine sensitization by alteration of dendritic thin spines in the nucleus accumbens core.
  Cai WT, Kim WY, Kwak MJ, Rim H, Lee SE, Riecken LB, Morrison H, Kim JH
  J Neurochem 2022, 161(3), 266-80
  
• A Primeval Mechanism of Tolerance to Desiccation Based on Glycolic Acid Saves Neurons in Mammals from Ischemia by Reducing Intracellular Calcium-Mediated Excitotoxicity.
  Chovsepian A, Berchtold D, Winek K, Mamrak U, Ramírez Álvarez I, Dening Y, Golubczyk D, Weitbrecht L, Dames C, Aillery M, Fernandez-Sanz C, Gajewski Z, Dieterich M, Janowski M, Falkai P, Walczak P, Plesnila N, Meisel A, Pan-Montojo F
  Adv Sci (Weinh) 2022, 9(4), e2103265
  
• Novel biochemical, structural, and systems insights into inflammatory signaling revealed by contextual interaction proteomics.
  Ciuffa R, Uliana F, Mannion J, Mehnert M, Tenev T, Marulli C, Satanowski A, Keller LML, Rodilla Ramírez PN, Ori A, Gstaiger M, Meier P, Aebersold R
  Proc Natl Acad Sci U S A 2022, 119(40), e2117175119
  
• Partial Reduction in BRCA1 Gene Dose Modulates DNA Replication Stress Level and Thereby Contributes to Sensitivity or Resistance.
  Classen S, Rahlf E, Jungwirth J, Albers N, Hebestreit LP, Zielinski A, Poole L, Groth M, Koch P, Liehr T, Kankel S, Cordes N, Petersen C, Rothkamm K, Pospiech** H, Borgmann** K
  Int J Mol Sci 2022, 23(21) ** co-corresponding authors
  
• p53-mediated AKT and mTOR inhibition requires RFX7 and DDIT4 and depends on nutrient abundance.
  Coronel* L, Häckes* D, Schwab* K, Riege K, Hoffmann** S, Fischer** M
  Oncogene 2022, 41(7), 1063-9 * equal contribution, ** co-corresponding authors
  
• Cytoreductive treatment in real life: a chart review analysis on 1440 patients with polycythemia vera.
  Crodel CC, Jentsch-Ullrich K, Reiser M, Jacobasch L, Sauer A, Tesch H, Ulshöfer T, Wunschel R, Palandri F, Heidel FH
  J Cancer Res Clin Oncol 2022, 148(10), 2693-705
  
• A proteomic survival predictor for COVID-19 patients in intensive care.
  Demichev V, Tober-Lau P, Nazarenko T, Lemke O, Kaur Aulakh S, Whitwell HJ, Röhl A, Freiwald A, Mittermaier M, Szyrwiel L, Ludwig D, Correia-Melo C, Lippert LJ, Helbig ET, Stubbemann P, Olk N, Thibeault C, Grüning NM, Blyuss O, Vernardis S, White M, Messner CB, Joannidis M, Sonnweber T, Klein SJ, Pizzini A, Wohlfarter Y, Sahanic S, Hilbe R, Schaefer B, Wagner S, Machleidt F, Garcia C, Ruwwe-Glösenkamp C, Lingscheid T, Bosquillon de Jarcy L, Stegemann MS, Pfeiffer M, Jürgens L, Denker S, Zickler D, Spies C, Edel A, Müller NB, Enghard P, Zelezniak A, Bellmann-Weiler R, Weiss G, Campbell A, Hayward C, Porteous DJ, Marioni RE, Uhrig A, Zoller H, Löffler-Ragg J, Keller MA, Tancevski I, Timms JF, Zaikin A, Hippenstiel S, Ramharter M, Müller-Redetzky H, Witzenrath M, Suttorp N, Lilley K, Mülleder M, Sander LE, PA-COVID-19 Study group, Kurth F, Ralser M
  PLOS Digit Health 2022, 1(1), e0000007
  
• Planning preclinical confirmatory multicenter trials to strengthen translation from basic to clinical research – a multi-stakeholder workshop report
  Drude NI, Martinez-Gamboa L, Danziger M, Collazo A, Kniffert S, Wiebach J, Nilsonne G, Konietschke F, Piper SK, Pawel S, Micheloud C, Held L, Frommlet F, Segelcke D, Pogatzki-Zahn EM, Voelkl B, Friede T, Brunner E, Dempfle A, Haller B, Jung MJ, Riecken LB, Kuhn HG, Tenbusch M, Serna Higuita LM, Remarque EJ, Grüninger-Egli SL, Manske K, Kobold S, Rivalan M, Wedekind L, Wilcke JC, Boulesteix AL, Meinhardt MW, Spanagel R, Hettmer S, von Lüttichau I, Regina C, Dirnagl U, Toelch U
  Translational Medicine Communications 2022, 7(24), https://doi.org/10.1186/s41231-0
  
• Preface to Current Topics in Cellular Aging
  Englert C
  In: Current Topics in Cellular Aging, Selected articles published by MDPI, Cells 2022, MDPI - Multidisciplinary Digital
  
• Career pathways, part 8.
  Ermolaeva M, Boyman L
  Nat Metab 2022, 4(4), 407-9
  
• Histone demethylase KDM4C is a functional dependency in JAK2-mutated neoplasms.
  Ernst P, Schnöder TM, Huber N, Perner F, Jayavelu AK, Eifert T, Hsu CJ, Tubío-Santamaría N, Crodel CC, Ungelenk M, Hübner CA, Clement JH, Hochhaus A, Heidel FH
  Leukemia 2022, 36(7), 1843-9
  
• A deep neural network provides an ultraprecise multi-tissue transcriptomic clock for the short-lived fish Nothobranchius furzeri and identifies predicitive genes translatable to human aging
  Ferrari E, Reichwald K, Koch P, Groth M, Baumgart M, Cellerino A
  bioRxiv 2022
  
• Synthesizing genome regulation data with vote-counting.
  Fischer M, Hoffmann S
  Trends Genet 2022, 38(12), 1208-16
  
• Coordinating gene expression during the cell cycle.
  Fischer M, Schade AE, Branigan TB, Müller GA, DeCaprio JA
  Trends Biochem Sci 2022, 47(12), 1009-22
  
• Is there a role for statistics in artificial intelligence?
  Friedrich S, Antes G, Behr S, Binder H, Brannath W, Dumpert F, Ickstadt K, Kestler HA, Lederer J, Leitgöb H, Pauly M, Steland A, Wilhelm A, Friede  T
  ADV DATA ANAL CLASSI 2022, 10.1007/s11634-021-00455-6
  
• Comparative study of ten thogotovirus isolates and their distinct in vivo characteristics.
  Fuchs J, Lamkiewicz K, Kolesnikova L, Hölzer M, Marz M, Kochs G
  J Virol 2022, 96(5), e0155621
  
• Prediction of Antibiotic Susceptibility Profiles of Vibrio cholerae Isolates From Whole Genome Illumina and Nanopore Sequencing Data: CholerAegon.
  Fuesslin* V, Krautwurst* S, Srivastava A, Winter D, Liedigk B, Thye T, Herrera-León S, Wohl S, May J, Fobil JN, Eibach D, Marz** M, Schuldt** K
  Front Microbiol 2022, 13, 909692 * equal contribution, ** co-senior authors
  
• Osteocytes Serve as a Reservoir for Intracellular Persisting Staphylococcus aureus Due to the Lack of Defense Mechanisms.
  Garcia-Moreno M, Jordan PM, Günther K, Dau T, Fritzsch C, Vermes M, Schoppa A, Ignatius A, Wildemann B, Werz O, Löffler B, Tuchscherr L
  Front Microbiol 2022, 13, 937466
  
• CD44 Contributes to the Regulation of MDR1 Protein and Doxorubicin Chemoresistance in Osteosarcoma.
  Gerardo-Ramírez M, Keggenhoff FL, Giam V, Becker D, Groth M, Hartmann N, Straub BK, Morrison H, Galle PR, Marquardt JU, Herrlich P, Hartmann M
  Int J Mol Sci 2022, 23(15)
  
• Recurrent Upper Gastrointestinal Bleeding from Isolated Gastric Varices as Primary Symptom of Myelofibrosis: A Case Report on Combining Interventional and Pharmacologic Treatment Options.
  Giszas B, Weber M, Heidel FH, Reuken PA
  Dig Dis 2022, 40(4), 530-4
  
• Immediate predation risk alters the relationship between potential and realised selection on male traits in the Trinidad guppy Poecilia reticulata.
  Glavaschi A, Cattelan S, Devigili A, Pilastro A
  Proc Biol Sci 2022, 289(1982), 20220641
  
• Comparative transcriptomics identifies candidate genes involved in the evolutionary transition from dehiscent to indehiscent fruits in Lepidium (Brassicaceae).
  Gramzow L, Klupsch K, Fernández-Pozo N, Hölzer M, Marz M, Rensing SA, Theißen G
  BMC Plant Biol 2022, 22(1), 340
  
• Tight association of autophagy and cell cycle in leukemia cells.
  Gschwind* A, Marx* C, Just MD, Severin P, Behring H, Marx-Blümel L, Becker S, Rothenburger L, Förster M, Beck JF, Sonnemann J
  Cell Mol Biol Lett 2022, 27(1), 32 * equal contribution
  
• Interaction Empowerment in Mobile Health: Concepts, Challenges, and Perspectives.
  Hamberger M, Ikonomi N, Schwab JD, Werle SD, Fürstberger A, Kestler AM, Holderried M, Kaisers UX, Steger F, Kestler HA
  JMIR MHEALTH UHEALTH 2022, 10(4), e32696
  
• A Phase Ib Dose-finding Study of Panobinostat and Ruxolitinib in Myelofibrosis.
  Harrison C, Heidel FH, Vannucchi AM, Kiladjian JJ, Hayat A, Passamonti F, Conneally E, Kindler T, Martino B, Lipka DB, Stefanelli T, Roussou P, Germano D, Ewan J, Ribrag V
  Hemasphere 2022, 6(8), e757
  
• Organelle dysfunction and its contribution to metabolic impairments in aging and age-related diseases
  Heiby JC, Ori A
  Current Opinion in Systems Biology 2022, 30, 10041
  
• Integrated genomic surveillance enables tracing of person-to-person SARS-CoV-2 transmission chains during community transmission and reveals extensive onward transmission of travel-imported infections, Germany, June to July 2021.
  Houwaart T, Belhaj S, Tawalbeh E, Nagels D, Fröhlich Y, Finzer P, Ciruela P, Sabrià A, Herrero M, Andrés C, Antón A, Benmoumene A, Asskali D, Haidar H, von Dahlen J, Nicolai J, Stiller M, Blum J, Lange C, Adelmann C, Schroer B, Osmers U, Grice C, Kirfel PP, Jomaa H, Strelow D, Hülse L, Pigulla M, Kreuzer P, Tyshaieva A, Weber J, Wienemann T, Kohns Vasconcelos M, Hoffmann K, Lübke N, Hauka S, Andree M, Scholz CJ, Jazmati N, Göbels K, Zotz R, Pfeffer K, Timm J, Ehlkes L, Walker A, Dilthey AT, German COVID-19 OMICS Initiative (DeCOI), German COVID-19 OMICs Initiative (DeCOI)
  Euro Surveill 2022, 27(43), 2101089
  
• Women in the European Virus Bioinformatics Center.
  Hufsky F, Abecasis A, Agudelo-Romero P, Bletsa M, Brown K, Claus C, Deinhardt-Emmer S, Deng L, Friedel CC, Gismondi MI, Kostaki EG, Kühnert D, Kulkarni-Kale U, Metzner KJ, Meyer IM, Miozzi L, Nishimura L, Paraskevopoulou S, Pérez-Cataluña A, Rahlff J, Thomson E, Tumescheit C, van der Hoek L, Van Espen L, Vandamme AM, Zaheri M, Zuckerman N, Marz M
  Viruses 2022, 14(7)
  
• The International Virus Bioinformatics Meeting 2022.
  Hufsky F, Beslic D, Boeckaerts D, Duchene S, González-Tortuero E, Gruber AJ, Guo J, Jansen D, Juma J, Kongkitimanon K, Luque A, Ritsch M, Lencioni Lovate G, Nishimura L, Pas C, Domingo E, Hodcroft E, Lemey P, Sullivan MB, Weber F, González-Candelas F, Krautwurst S, Pérez-Cataluña A, Randazzo W, Sánchez G, Marz M
  Viruses 2022, 14(5)
  
• LINC00892 Is an lncRNA Induced by T Cell Activation and Expressed by Follicular Lymphoma-Resident T Helper Cells.
  Iaccarino I, Mourtada F, Reinke S, Patil P, Doose G, Monaco G, Hoffmann S, Siebert R, Klapper W
  Noncoding RNA 2022, 8(3)
  
• Discrete Logic Modeling of Cell Signaling Pathways
  Ikonomi N, Werle SD, Schwab JD, Kestler HA
  In: TGF-Beta Signaling, Methods in Molecular Biology (edited by Zi Z, Liu X) 2022, 2488(chap. 12), 159-181, Humana Press Inc., Toto
  
• Discrete Logic Modeling of Cell Signaling Pathways
  Ikonomi N, Werle SD, Schwab JD, Kestler HA
  In: TGF-Beta Signaling (edited by Zi Z, Liu X), Methods in Molecular Biology 2022, 2488, 159-181, Humana Press Inc., Toto
  
• Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity.
  Izgi H, Han D, Isildak U, Huang S, Kocabiyik E, Khaitovich** P, Somel** M, Dönertaş** HM
  Elife 2022, 11, e68048 ** co-corresponding authors
  
• Enhancing mHealth data collection applications with sensing capabilities.
  Karthan M, Martin R, Holl F, Swoboda W, Kestler HA, Pryss R, Schobel J
  Front Public Health 2022, 10, 926234
  
• Collecting Data from Senior Citizens Using Serious Games
  Karthan M, Romahn P, Pryss R, Kestler H, Schobel J
  In: Advances in Informatics, Management and Technology in Healthcare (edited by John M, Parisis G, Emmanouil Z, Arie H, Mowafa SH, Marianna D, Joseph L, Martha C), Studies in Health Technology and Informatics 2022, 295, 234 - 237, IOS Press Ebooks, Ams
  
• Lessons from a ten-year-long journey: building a student-driven computational biology society across Turkey.
  Kaya Y, Karakulak T, Can Saylan C, Gür ER, Tatlıdil E, Güleşen S, Betül Dinçaslan F, Dönertaş HM
  F1000Res 2022, 11
  
• Chaperoning the nuclear envelope.
  Kirstein J
  Nat Cell Biol 2022, 24(11), 1563
  
• Protein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration.
  Kluever V, Russo B, Mandad S, Kumar NH, Alevra M, Ori A, Rizzoli SO, Urlaub H, Schneider A, Fornasiero EF
  Sci Adv 2022, 8(20), eabn4437
  
• Functional Genomic Screening in Human Pluripotent Stem Cells Reveals New Roadblocks in Early Pancreatic Endoderm Formation.
  Krüger J, Breunig M, Pasquini LP, Morawe M, Groß A, Arnold F, Russell R, Seufferlein T, Azoitei N, Kestler HA, Julier C, Heller S, Hohwieler M, Kleger A
  Cells 2022, 11(3)
  
• RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling.
  Kuhn LB, Valentin S, Stojanovic K, Strobl DC, Babushku T, Wang Y, Rambold U, Scheffler L, Grath S, John-Robbert D, Blum H, Feuchtinger A, Blutke A, Weih F, Kitamura D, Rad R, Strobl LJ, Zimber-Strobl U
  Front Immunol 2022, 13, 913275
  
• CLN3 is required for the clearance of glycerophosphodiesters from lysosomes.
  Laqtom NN, Dong W, Medoh UN, Cangelosi AL, Dharamdasani V, Chan SH, Kunchok T, Lewis CA, Heinze I, Tang R, Grimm C, Dang Do AN, Porter FD, Ori A, Sabatini DM, Abu-Remaileh M
  Nature 2022, 609(7929), 1005-11
  
• High-yield production of coenzyme F420 in Escherichia coli by fluorescence-based screening of multi-dimensional gene expression space.
  Last D, Hasan M, Rothenburger L, Braga D, Lackner G
  Metab Eng 2022, 73, 158-67
  
• Efficient cross-validation traversals in feature subset selection.
  Lausser L, Szekely R, Schmid F, Maucher M, Kestler HA
  Sci Rep 2022, 12(1), 21485
  
• CHD5 inhibits metastasis of neuroblastoma.
  Laut AK, Dorneburg C, Fürstberger A, Barth TFE, Kestler HA, Debatin KM, Beltinger C
  Oncogene 2022, 41(5), 622-33
  
• Acetylation-Specific Interference by Anti-Histone H3K9ac Intrabody Results in Precise Modulation of Gene Expression.
  Lisi S, Trovato M, Vitaloni O, Fantini M, Chirichella M, Tognini P, Cornuti S, Costa M, Groth M, Cattaneo A
  Int J Mol Sci 2022, 23(16), 8892
  
• New lessons on TDP-43 from old N. furzeri killifish.
  Louka A, Bagnoli S, Rupert J, Esapa B, Tartaglia GG, Cellerino A, Pastore A, Terzibasi Tozzini E
  Aging Cell 2022, 21(1), e13517
  
• ADP-ribosyltransferases, an update on function and nomenclature.
  Lüscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, Cohen M, Corda D, Dantzer F, Daugherty MD, Dawson TM, Dawson VL, Deindl S, Fehr AR, Feijs KLH, Filippov DV, Gagné JP, Grimaldi G, Guettler S, Hoch NC, Hottiger MO, Korn P, Kraus WL, Ladurner A, Lehtiö L, Leung AKL, Lord CJ, Mangerich A, Matic I, Matthews J, Moldovan GL, Moss J, Natoli G, Nielsen ML, Niepel M, Nolte F, Pascal J, Paschal BM, Pawłowski K, Poirier GG, Smith S, Timinszky G, Wang ZQ, Yélamos J, Yu X, Zaja R, Ziegler M
  FEBS J 2022, 289(23), 7399-410
  
• Role of CD44 in metastasis formation of spontaneous osteosarcoma of Nf2-deficient mice
  Ma J
  Dissertation 2022, Jena, Germany
  
• Hanging the coat on a collar: Same function but different localization and mechanism for COPII.
  Malis Y, Hirschberg K, Kaether C
  Bioessays 2022, 44(10), e2200064
  
• Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease.
  Marengo L, Armbrust F, Schoenherr C, Storck SE, Schmitt U, Zampar S, Wirths O, Altmeppen H, Glatzel M, Kaether C, Weggen S, Becker-Pauly C, Pietrzik CU
  Cell Mol Life Sci 2022, 79(3), 168
  
• Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress.
  Marx C, Sonnemann J, Maddocks ODK, Marx-Blümel L, Beyer M, Hoelzer D, Thierbach R, Maletzki C, Linnebacher M, Heinzel T, Krämer OH
  Cancer Metab 2022, 10(1), 10
  
• Telomerase deficiency reflects age-associated changes in CD4+ T cells.
  Matthe DM, Thoma OM, Sperka T, Neurath MF, Waldner MJ
  Immun Ageing 2022, 19(1), 16
  
• Meeting Report: Aging Research and Drug Discovery
  Meron E, Thaysen M, Angeli S, Antebi A, Barzilai N, Baur JA, Bekker-Jensen S, Birkisdottir M, Bischof E, Bruening J, Brunet A, Buchwalter A, Cabreiro F, Cai S, Chen BH, Ermolaeva M, Ewald Collin Y, Ferrucci L, Florian MC, Fortney K, Freund A, Georgievskaya A, Gladyshev VN, Glass D, Golato T, Gorbunova V, Hoejimakers J, Houtkooper RH, Jager S, Jaksch F, Janssens G, Borch Jensen M, Kaeberlein M, Karsenty G, de Keizer P, Kennedy B, Kirkland JL, Kjaer M, Kroemer G, Lee KF, Lemaitre JM, Liaskos D, Longo VD, Lu YX, MacArthur MR, Maier AB, Manakanatas C, Mitchell SJ, Moskalev A, Niedernhofer L, Ozerov I, Partridge L, Passegué E, Petr MA, Peyer J, Radenkovic D, Rando TA, Rattan S, Riedel CG, Rudolph L, Ai R, Serrano M, Schumacher B, Sinclair DA, Smith R, Suh Y, Taub P, Trapp A, Trendelenburg AU, Valenzano DR, Verburgh K, Verdin E, Vijg J, Westendorp RGJ, Zonari A, Bakula D, Zhavoronkov A, Scheibye-Knudsen M
  Aging (Albany NY) 2022, 14(2), 530–543
  
• Correction to: The androgen receptor-lncRNASAT1-AKT-p15 axis mediates androgen-induced cellular senescence in prostate cancer cells.
  Mirzakhani K, Kallenbach J, Rasa SMM, Ribaudo F, Ungelenk M, Ehsani M, Gong W, Gassler N, Leeder M, Grimm MO, Neri F, Baniahmad A
  Oncogene 2022, 41(7), 1071-7
  
• Context sensitive neural networks for the classification of DNA, RNA and protein sequences
  Mock F
  Dissertation 2022, Jena, Germany
  
• Taxonomic classification of DNA sequences beyond sequence similarity using deep neural networks.
  Mock F, Kretschmer F, Kriese A, Böcker S, Marz M
  Proc Natl Acad Sci U S A 2022, 119(35), e2122636119
  
• Sendungsregister
  Mohnheim F, Weinzierl I, Hoppe B, Bösger J
  2022, URL https://github.com/mohnbroet
  
• Small Extracellular Vesicles from Peripheral Blood of Aged Mice Pass the Blood-Brain Barrier and Induce Glial Cell Activation.
  Morales-Prieto DM, Murrieta-Coxca JM, Stojiljkovic M, Diezel C, Streicher PE, Henao-Restrepo JA, Röstel F, Lindner J, Witte OW, Weis S, Schmeer C, Marz M
  Cells 2022, 11(4)
  
• Enhanced C/EBPβ function promotes hypertrophic versus hyperplastic fat tissue growth and prevents steatosis in response to high-fat diet feeding.
  Müller* C, Zidek* LM, Eichwald S, Kortman G, Koster MH, Calkhoven CF
  Elife 2022, 11, e62625. * equal contribution
  
• CANTATA-prediction of missing links in Boolean networks using genetic programming.
  Müssel C, Ikonomi N, Werle SD, Weidner FM, Maucher M, Schwab** JD, Kestler** HA
  Bioinformatics 2022, 38(21), 4893 ** co-senior authors
  
• Carbon fixation rates in groundwater similar to those in oligotrophic marine systems
  Overholt WA, Trumbore S, Xu X, Bornemann TLV, Probst AJ, Krüger M, Herrmann M, Thamdrup B, Bristow LA, Taubert M, Schwab VF, Hölzer M, Marz M, Küsel K
  NAT GEOSCI 2022, 15, 561–567
  
• Peripheral blasts are associated with responses to ruxolitinib and outcomes in patients with chronic-phase myelofibrosis.
  Palandri F, Bartoletti D, Iurlo A, Bonifacio M, Abruzzese E, Caocci G, Elli EM, Auteri G, Tiribelli M, Polverelli N, Miglino M, Heidel FH, Tieghi A, Benevolo G, Beggiato E, Fava C, Cavazzini F, Pugliese N, Binotto G, Bosi C, Martino B, Crugnola M, Ottaviani E, Micucci G, Trawinska MM, Cuneo A, Bocchia M, Krampera M, Pane F, Lemoli RM, Cilloni D, Vianelli N, Cavo M, Palumbo GA, Breccia M
  Cancer 2022, 128(13), 2449-54
  
• Real-world clinical outcomes of patients with myelofibrosis treated with ruxolitinib: a medical record review.
  Passamonti F, Heidel FH, Parikh RC, Ajmera M, Tang D, Nadal JA, Davis KL, Abraham P
  Future Oncol 2022, 18(18), 2217
  
• YBX1 mediates translation of oncogenic transcripts to control cell competition in AML.
  Perner F, Schnoeder TM, Xiong Y, Jayavelu AK, Mashamba N, Santamaria NT, Huber N, Todorova K, Hatton C, Perner B, Eifert T, Murphy C, Hartmann M, Hoell JI, Schröder N, Brandt S, Hochhaus A, Mertens PR, Mann M, Armstrong SA, Mandinova A, Heidel FH
  Leukemia 2022, 36(2), 426-37
  
• A gene dosage-dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH-medulloblastoma.
  Petroni M, Fabretti F, Giulio SD, Robilant VND, Monica VL, Moretti M, Belardinilli F, Bufalieri F, Anna C, Paci P, Corsi A, Smaele ED, Coni S, Canettieri G, Marcotullio LD, Wang ZQ, Giannini G
  Neuropathol Appl Neurobiol 2022, 48(6), e12837
  
• Resilience integrates concepts in aging research.
  Promislow D, Anderson RM, Scheffer M, Crespi B, DeGregori J, Harris K, Horowitz BN, Levine ME, Riolo MA, Schneider DS, Spencer SL, Valenzano DR, Hochberg ME
  iScience 2022, 25(5), 104199 published during change of institution
  
• The genomic and transcriptional landscape of primary central nervous system lymphoma.
  Radke J, Ishaque N, Koll R, Gu Z, Schumann E, Sieverling L, Uhrig S, Hübschmann D, Toprak UH, López C, Hostench XP, Borgoni S, Juraeva D, Pritsch F, Paramasivam N, Balasubramanian GP, Schlesner M, Sahay S, Weniger M, Pehl D, Radbruch H, Osterloh A, Korfel A, Misch M, Onken J, Faust K, Vajkoczy P, Moskopp D, Wang Y, Jödicke A, Trümper L, Anagnostopoulos I, Lenze D, Küppers R, Hummel M, Schmitt CA, Wiestler OD, Wolf S, Unterberg A, Eils R, Herold-Mende C, Brors B, ICGC MMML-Seq Consortium, Siebert R, Wiemann S, Heppner FL
  Nat Commun 2022, 13(1), 2558
  
• The sources of sex differences in aging in annual fishes.
  Reichard M, Blažek R, Žák J, Cellerino A, Polačik M
  J Anim Ecol 2022, 91(3), 540-50
  
• Aging Activates the Immune System and Alters the Regenerative Capacity in the Zebrafish Heart.
  Reuter H, Perner B, Wahl F, Rohde L, Koch P, Groth M, Buder K, Englert C
  Cells 2022, 11(3), 345. doi: 10.3390/cells11030345.
  
• Rhodopsins build up the birefringent bodies of the dinoflagellate Oxyrrhis marina.
  Rhiel E, Hoischen C, Westermann M
  Protoplasma 2022, 259(4), 1047-60
  
• Molecular Sexing of Nothobranchius furzeri Embryos and Larvae.
  Richter A, Krug J, Englert C
  Cold Spring Harb Protoc 2022, 2022(12), doi: 10.1101/pdb.prot107782
  
• Functional profiling of long intergenic non-coding RNAs in fission yeast.
  Rodriguez-Lopez M, Anver S, Cotobal C, Kamrad S, Malecki M, Correia-Melo C, Hoti M, Townsend S, Marguerat S, Pong SK, Wu MY, Montemayor L, Howell M, Ralser M, Bähler J
  Elife 2022, 11
  
• Correction: Functional profiling of long intergenic non-coding RNAs in fission yeast.
  Rodriguez-Lopez M, Anver S, Cotobal C, Kamrad S, Malecki M, Correia-Melo C, Hoti M, Townsend S, Marguerat S, Pong SK, Wu MY, Montemayor L, Howell M, Ralser M, Bähler J
  Elife 2022, 11
  
• Network analysis of hepatocellular carcinoma liquid biopsies augmented by single-cell sequencing data.
  Safrastyan A, Wollny D
  Front Genet 2022, 13, 921195
  
• Pollutants corrupt resilience pathways of aging in the nematode C. elegans.
  Scharf A, Limke A, Guehrs KH, von Mikecz A
  iScience 2022, 25(9), 105027
  
• Restoring Age-Related Cognitive Decline through Environmental Enrichment: A Transcriptomic Approach.
  Schmidt S, Haase M, Best L, Groth M, Lindner J, Witte OW, Kaleta C, Frahm C
  Cells 2022, 11(23), 3864
  
• Association of Telomere Length With Risk of Disease and Mortality.
  Schneider CV, Schneider KM, Teumer A, Rudolph KL, Hartmann D, Rader DJ, Strnad P
  JAMA INTERN MED 2022, 182(3), 291-300
  
• Significance of men's health in long-term survivors of allogeneic stem cell transplantation.
  Schneidewind L, Neumann T, Peters N, Kranz J, Probst KA, Heidel FH, Hakenberg OW, Krüger W
  Bone Marrow Transplant 2022, 57(6), 998
  
• PLCG1 is required for AML1-ETO leukemia stem cell self-renewal.
  Schnoeder TM, Schwarzer A, Jayavelu AK, Hsu CJ, Kirkpatrick J, Döhner K, Perner F, Eifert T, Huber N, Arreba-Tutusaus P, Dolnik A, Assi SA, Nafria M, Jiang L, Dai YT, Chen Z, Chen SJ, Kellaway SG, Ptasinska A, Ng ES, Stanley EG, Elefanty AG, Buschbeck M, Bierhoff H, Brodt S, Matziolis G, Fischer KD, Hochhaus A, Chen CW, Heidenreich O, Mann M, Lane SW, Bullinger L, Ori A, Eyss Bv, Bonifer C, Heidel F
  Blood 2022, 139(7), 1080-97
  
• A comparative study of pre-alpha islands in the entorhinal cortex from selected primates and in lissencephaly.
  Schön M, Nosanova A, Jacob C, Kraus JM, Kestler HA, Mayer B, Feldengut S, Amunts K, Del Tredici K, Boeckers TM, Braak H
  J Comp Neurol 2022, 530(4), 683-704
  
• The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response.
  Schuhwerk H, Kleemann J, Gupta P, van Roey R, Armstark I, Kreileder M, Feldker N, Ramesh V, Hajjaj Y, Fuchs K, Mahapatro M, Hribersek M, Volante M, Groenewoud A, Engel FB, Ceppi P, Eckstein M, Hartmann A, Müller F, Kroll T, Stemmler MP, Brabletz S, Brabletz T
  Cell Rep 2022, 41(11), 111819
  
• Disrupting PTPRJ transmembrane-mediated oligomerization counteracts oncogenic receptor tyrosine kinase FLT3 ITD.
  Schwarz M, Rizzo S, Paz WE, Kresinsky A, Thévenin D, Müller JP
  Front Oncol 2022, 12, 1017947
  
• Weighted average ensemble-based semantic segmentation in biological electron microscopy images.
  Shaga Devan K, Kestler HA, Read C, Walther P
  Histochem Cell Biol 2022, 158(5), 447–462
  
• A genome-wide CRISPR activation screen reveals Hexokinase 1 as a critical factor in promoting resistance to multi-kinase inhibitors in hepatocellular carcinoma cells.
  Sofer S, Lamkiewicz K, Armoza Eilat S, Partouche S, Marz M, Moskovits N, Stemmer SM, Shlomai A, Sklan EH
  FASEB J 2022, 36(3), e22191
  
• The chromatin remodeling protein ATRX positively regulates IRF3-dependent type I interferon production and interferon-induced gene expression.
  Stilp AC, Scherer M, König P, Fürstberger A, Kestler HA, Stamminger T
  PLoS Pathog 2022, 18(8), e1010748
  
• Sex chromosome differentiation via changes in the Y chromosome repeat landscape in African annual killifishes Nothobranchius furzeri and N. kadleci.
  Štundlová J, Hospodářská M, Lukšíková K, Voleníková A, Pavlica T, Altmanová M, Richter A, Reichard M, Dalíková M, Pelikánová Š, Marta A, Simanovsky SA, Hiřman M, Jankásek M, Dvořák T, Bohlen J, Ráb P, Englert C, Nguyen P, Sember A
  Chromosome Res 2022, 30(4), 309-33
  
• The Mating Pattern of Captive Naked Mole-Rats Is Best Described by a Monogamy Model
  Szafranski* K, Wetzel* M, Holtze S, Büntjen I, Lieckfeldt D, Ludwig A, Huse K, Platzer M, Hildebrandt T
  FRONT ECOL EVOL 2022, 10, 855688 * equal contribution
  
• PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling.
  Thürmer M, Gollowitzer A, Pein H, Neukirch K, Gelmez E, Waltl L, Wielsch N, Winkler R, Löser K, Grander J, Hotze M, Harder S, Döding A, Meßner M, Troisi F, Ardelt M, Schlüter H, Pachmayr J, Gutiérrez-Gutiérrez Ó, Rudolph KL, Thedieck K, Schulze-Späte U, González-Estévez C, Kosan C, Svatoš A, Kwiatkowski M, Koeberle A
  Nat Commun 2022, 13(1), 2982
  
• Comparative Panel Sequencing of DNA Variants in cf-, ev- and tumorDNA for Pancreatic Ductal Adenocarcinoma Patients.
  Waldenmaier M, Schulte L, Schönfelder J, Fürstberger A, Kraus JM, Daiss N, Seibold T, Morawe M, Ettrich TJ, Kestler HA, Kahlert C, Seufferlein T, Eiseler T
  Cancers (Basel) 2022, 14(4)
  
• Characterization of SARS-CoV-2 infection clusters based on integrated genomic surveillance, outbreak analysis and contact tracing in an urban setting.
  Walker A, Houwaart T, Finzer P, Ehlkes L, Tyshaieva A, Damagnez M, Strelow D, Duplessis A, Nicolai J, Wienemann T, Tamayo T, Kohns Vasconcelos M, Hülse L, Hoffmann K, Lübke N, Hauka S, Andree M, Däumer MP, Thielen A, Kolbe-Busch S, Göbels K, Zotz R, Pfeffer K, Timm J, Dilthey AT, German COVID-19 OMICS Initiative (DeCOI)
  Clin Infect Dis 2022, 74(6), 1039-46
  
• The Central Domain of MCPH1 Controls Development of the Cerebral Cortex and Gonads in Mice.
  Wang Y, Zong W, Sun W, Chen C, Wang** ZQ, Li** T
  Cells 2022, 11(17) ** co-corresponding authors
  
• Response to the letter to the editor: On the feasibility of dynamical analysis of network models of biochemical regulation.
  Weidner FM, Schwab JD, Werle SD, Ikonomi N, Lausser L, Kestler HA
  Bioinformatics 2022, 38(14), 3676
  
• Identification of dynamic driver sets controlling phenotypical landscapes.
  Werle SD, Ikonomi N, Schwab JD, Kraus JM, Weidner FM, Rudolph KL, Pfister AS, Schuler R, Kühl M, Kestler HA
  Comput Struct Biotechnol J 2022, 20, 1603-17
  
• Backbone and side chain resonance assignment of the intrinsically disordered human DBNDD1 protein.
  Wiedemann C, Obika KB, Liebscher S, Jirschitzka J, Ohlenschläger O, Bordusa F
  Biomol NMR Assign 2022, 16(2), 237-46
  
• Love your Data! (Poster)
  Willbrandt J
  2022, URL https://zenodo.org/record/71
  
• Biological underpinnings of sex differences in neurological disorders.
  Winek K, Tzur Y, Soreq H
  Int Rev Neurobiol 2022, 164, 27
  
• Brain–body communication in stroke - Mens sana in corpore sano
  Winek** K, Cuervo Zanatta** D, Zille** M
  NEUROFORUM 2022, 28(1), 31–39 ** co-corresponding authors
  
• De novo identification of maximally deregulated subnetworks based on multi-omics data with DeRegNet.
  Winkler S, Winkler I, Figaschewski M, Tiede T, Nordheim A, Kohlbacher O
  BMC Bioinformatics 2022, 23(1), 139
  
• Inorganic sulfur fixation via a new homocysteine synthase allows yeast cells to cooperatively compensate for methionine auxotrophy.
  Yu JSL, Heineike BM, Hartl J, Aulakh SK, Correia-Melo C, Lehmann A, Lemke O, Agostini F, Lee CT, Demichev V, Messner CB, Mülleder M, Ralser M
  PLoS Biol 2022, 20(12), e3001912
  
• Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance.
  Yu* JSL, Correia-Melo* C, Zorrilla F, Herrera-Dominguez L, Wu MY, Hartl J, Campbell K, Blasche S, Kreidl M, Egger AS, Messner CB, Demichev V, Freiwald A, Mülleder M, Howell M, Berman J, Patil KR, Alam* MT, Ralser* M
  NAT MICROBIOL 2022, 7(4), 542–555 * equal contribution
  
• The Role of Non-Coding RNAs in the Human Placenta.
  Žarković* M, Hufsky* F, Markert** UR, Marz** M
  Cells 2022, 11(9), 1588 * equal contribution, ** co-senior authors
  
• Picorna-Like Viruses of the Havel River, Germany.
  Zell R, Groth M, Selinka L, Selinka HC
  Front Microbiol 2022, 13, 865287
  

Publications 2021:

• BCL3 couples cancer stem cell enrichment with pancreatic cancer molecular subtypes.
  Ai J, Wörmann SM, Görgülü K, Vallespinos M, Zagorac S, Alcala S, Wu N, Kabacaoglu D, Berninger A, Navarro D, Kaya-Aksoy E, Ruess DA, Ciecielski KJ, Kowalska M, Demir EI, Ceyhan GO, Heid I, Braren R, Riemann M, Schreiner S, Hofmann S, Kutschke M, Jastroch M, Slotta-Huspenina J, Muckenhuber A, Schlitter AM, Schmid RM, Steiger K, Diakopoulos KN, Lesina M, Sainz B, Algül H
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• Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications.
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• Predicting disease progression in behavioral variant frontotemporal dementia.
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  Alzheimers Dement (Amst) 2021, 13(1), e12262
  
• RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve Cellular Homeostasis in Pancreatic Cancer.
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• Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration.
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• Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
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• J-domain proteins interaction with neurodegenerative disease-related proteins.
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• Aging is associated with a degeneration of noradrenergic-, but not dopaminergic-neurons, in the short-lived killifish Nothobranchius furzeri
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• Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging.
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• Life expectancy, family constellation and stress in giant mole-rats ( Fukomys mechowii).
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• Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis.
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• Corona Health-A Study- and Sensor-Based Mobile App Platform Exploring Aspects of the COVID-19 Pandemic.
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• Introducing Bidirectional Ordinal Classifier Cascades Based on a Pain Intensity Recognition Scenario.
  Bellmann P, Lausser L, Kestler HA, Schwenker F
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• Experimental Analysis of Bidirectional Pairwise Ordinal Classifier Cascades
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• Impact of comorbidities and body mass index on the outcome of polycythemia vera patients.
  Benevolo G, Elli EM, Bartoletti D, Latagliata R, Tiribelli M, Heidel FH, Cavazzini F, Bonifacio M, Crugnola M, Binotto G, D'Addio A, Tieghi A, Bergamaschi M, Caocci G, Polverelli N, Bossi E, Auteri G, Carmosino I, Catani L, Cuneo A, Krampera M, Lanza F, Lemoli RM, Vianelli N, Breccia M, Palumbo GA, Cavo M, Palandri F
  Hematol Oncol 2021, 39(3), 409-18
  
• A Prospective Feasibility Trial to Challenge Patient-Derived Pancreatic Cancer Organoids in Predicting Treatment Response.
  Beutel AK, Schütte L, Scheible J, Roger E, Müller M, Perkhofer L, Kestler AMTU, Kraus JM, Kestler HA, Barth TFE, Lemke J, Kornmann M, Ettrich TJ, Gout J, Seufferlein T, Kleger A
  Cancers (Basel) 2021, 13(11)
  
• Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study.
  Boer JM, Valsecchi MG, Hormann FM, Antić Ž, Zaliova M, Schwab C, Cazzaniga G, Arfeuille C, Cavé H, Attarbaschi A, Strehl S, Escherich G, Imamura T, Ohki K, Grüber TA, Sutton R, Pastorczak A, Lammens T, Lambert F, Li CK, Carrillo de Santa Pau E, Hoffmann S, Möricke A, Harrison CJ, Den Boer ML, De Lorenzo P, Stam RW, Bergmann AK, Pieters R
  Leukemia 2021, 35(10), 2978-82
  
• Surprisingly long survival of premature conclusions about naked mole-rat biology.
  Braude S, Holtze S, Begall S, Brenmoehl J, Burda H, Dammann P, Del Marmol D, Gorshkova E, Henning Y, Hoeflich A, Höhn A, Jung T, Hamo D, Sahm A, Shebzukhov Y, Šumbera R, Miwa S, Vyssokikh MY, von Zglinicki T, Averina O, Hildebrandt TB
  Biol Rev Camb Philos Soc 2021, 96(2), 376-93
  
• β-Glucans as Dietary Supplement to Improve Locomotion and Mitochondrial Respiration in a Model of Duchenne Muscular Dystrophy.
  Brogi L, Marchese M, Cellerino A, Licitra R, Naef V, Mero S, Bibbiani C, Fronte B
  Nutrients 2021, 13(5)
  
• Epigenetic Modifications Associated with Maternal Anxiety during Pregnancy and Children's Behavioral Measures.
  Cao-Lei L, van den Heuvel MI, Huse K, Platzer M, Elgbeili G, Braeken MAKA, Otte RA, Witte OW, Schwab M, Van den Bergh BRH
  Cells 2021, 10(9)
  
• A marine Chlamydomonas sp. emerging as an algal model.
  Carrasco Flores D, Fricke M, Wesp V, Desirò D, Kniewasser A, Hölzer M, Marz M, Mittag M
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• Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK.
  Chang LS, Oblinger JL, Smith AE, Ferrer M, Angus SP, Hawley E, Petrilli AM, Beauchamp RL, Riecken LB, Erdin S, Poi M, Huang J, Bessler WK, Zhang X, Guha R, Thomas C, Burns SS, Gilbert TSK, Jiang L, Li X, Lu Q, Yuan J, He Y, Dixon SAH, Masters A, Jones DR, Yates CW, Haggarty SJ, La Rosa S, Welling DB, Stemmer-Rachamimov AO, Plotkin SR, Gusella JF, Guinney J, Morrison H, Ramesh V, Fernandez-Valle C, Johnson GL, Blakeley JO, Clapp DW, Synodos for NF2 Consortium
  PLoS One 2021, 16(7), e0252048
  
• Granulocyte colony-stimulating factor acts on lymphoid-biased, short-term hematopoietic stem cells.
  Chen Y, Rudolph KL
  Haematologica 2021, 106(6), 1516-8
  
• Nbs1-mediated DNA damage repair pathway regulates haematopoietic stem cell development and embryonic haematopoiesis.
  Chen Y, Sun J, Ju Z, Wang ZQ, Li T
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• Hepatectomy-Induced Alterations in Hepatic Perfusion and Function - Toward Multi-Scale Computational Modeling for a Better Prediction of Post-hepatectomy Liver Function.
  Christ B, Collatz M, Dahmen U, Herrmann KH, Höpfl S, König M, Lambers L, Marz M, Meyer D, Radde N, Reichenbach JR, Ricken T, Tautenhahn HM
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• EpiDope: A Deep Neural Network for linear B-cell epitope prediction.
  Collatz M, Mock F, Barth E, Hölzer M, Sachse K, Marz M
  Bioinformatics 2021, 37(4), 448-55
  
• Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7.
  Coppin* E, Sundarasetty* BS, Rahmig S, Blume J, Verheyden NA, Bahlmann F, Ravens S, Schubert U, Schmid J, Ludwig S, Geissler K, Guntinas-Lichius O, von Kaisenberg C, Groten T, Platz A, Naumann R, Ludwig B, Prinz I, Waskow** C, Krueger** A
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• Transcription factor RFX7 governs a tumor suppressor network in response to p53 and stress.
  Coronel L, Riege K, Schwab K, Förste S, Häckes D, Semerau L, Bernhart SH, Siebert R, Hoffmann** S, Fischer** M
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• Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).
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• Ancestral transoceanic colonization and recent population reduction in a nonannual killifish from the Seychelles archipelago.
  Cui R, Tyers AM, Malubhoy ZJ, Wisotsky S, Valdesalici S, Henriette E, Kosakovsky Pond SL, Valenzano DR
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• Merlin cooperates with neurofibromin and Spred1 to suppress the Ras-Erk pathway.
  Cui** Y, Ma L, Schacke S, Yin JC, Hsueh YP, Jin H, Morrison** H
  Hum Mol Genet 2021, 29(23), 3793-806 ** co-corresponding authors
  
• Highlights from the 16th International Society for Computational Biology Student Council Symposium 2020.
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• Iron Oxide Nanoparticles Carrying 5-Fluorouracil in Combination with Magnetic Hyperthermia Induce Thrombogenic Collagen Fibers, Cellular Stress, and Immune Responses in Heterotopic Human Colon Cancer in Mice.
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• A time-resolved proteomic and prognostic map of COVID-19.
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• Molekularbiologische Beschreibung des Alterungsprozesses
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• Common genetic associations between age-related diseases.
  Dönertaş HM, Fabian DK, Valenzuela MF, Partridge L, Thornton JM
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• Anti-Proliferative and Apoptotic Effect of Gemini Curcumin in p53-Wild Type and p53-Mutant Colorectal Cancer Cell Lines.
  Ebrahimi M, Babaei E, Neri F, Ali Hosseinpour Feizi M
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• Transposable Element Landscape in Drosophila Populations Selected for Longevity.
  Fabian DK, Dönertaş HM, Fuentealba M, Partridge L, Thornton JM
  Genome Biol Evol 2021, 13(4)
  
• Functional conservation in genes and pathways linking ageing and immunity.
  Fabian DK, Fuentealba M, Dönertaş HM, Partridge L, Thornton JM
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• Modulation of FLT3-ITD Localization and Targeting of Distinct Downstream Signaling Pathways as Potential Strategies to Overcome FLT3-Inhibitor Resistance.
  Fleischmann M, Fischer M, Schnetzke U, Fortner C, Kirkpatrick J, Heidel FH, Hochhaus A, Scholl S
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• Altered Glycosylation in the Aging Heart.
  Franzka P, Krüger L, Schurig MK, Olecka M, Hoffmann S, Blanchard V, Hübner CA
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• Virus Bioinformatics
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• The Hematopoietic Bone Marrow Niche Ecosystem.
  Fröbel J, Landspersky T, Percin G, Schreck C, Rahmig S, Ori A, Nowak D, Essers M, Waskow C, Oostendorp RAJ
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• Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice.
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• Novel amyloid-beta pathology C. elegans model reveals distinct neurons as seeds of pathogenicity.
  Gallrein C, Iburg M, Michelberger T, Koçak A, Puchkov D, Liu F, Ayala Mariscal SM, Nayak T, Kaminski Schierle GS, Kirstein J
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• Identifying Cell-Type-Specific Metabolic Signatures Using Transcriptome and Proteome Analyses.
  Gebert N, Rahman S, Lewis CA, Ori** A, Cheng** CW
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• Kidney Dysfunction Is Associated with Thrombosis and Disease Severity in Myeloproliferative Neoplasms: Implications from the German Study Group for MPN Bioregistry.
  Gecht J, Tsoukakis I, Kricheldorf K, Stegelmann F, Klausmann M, Griesshammer M, Schulz H, Hollburg W, Göthert JR, Sockel K, Heidel FH, Gattermann N, Maintz C, Al-Ali HK, Platzbecker U, Hansen R, Hänel M, Parmentier S, Bommer M, Pahl HL, Lang F, Kirschner M, Isfort S, Brümmendorf TH, Döhner K, Koschmieder S
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• ITN-VIROINF: Understanding (Harmful) Virus-Host Interactions by Linking Virology and Bioinformatics.
  Goettsch W, Beerenwinkel** N, Deng** L, Dölken** L, Dutilh** BE, Erhard** F, Kaderali** L, von Kleist** M, Marquet R, Matthijnssens** J, McCallin S, McMahon** D, Rattei T, Van Rij** RP, Robertson** DL, Schwemmle** M, Stern-Ginossar N, Marz** M
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• Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer.
  Gout J, Perkhofer L, Morawe M, Arnold F, Ihle M, Biber S, Lange S, Roger E, Kraus JM, Stifter K, Hahn SA, Zamperone A, Engleitner T, Müller M, Walter K, Rodriguez-Aznar E, Sainz B, Hermann PC, Hessmann E, Müller S, Azoitei N, Lechel A, Liebau S, Wagner M, Simeone DM, Kestler HA, Seufferlein T, Wiesmüller L, Rad R, Frappart PO, Kleger A
  Gut 2021, 70(4), 743-60
  
• MLL1 is required for maintenance of intestinal stem cells.
  Goveas N, Waskow C, Arndt K, Heuberger J, Zhang Q, Alexopoulou D, Dahl A, Birchmeier W, Anastassiadis K, Stewart AF, Kranz A
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• Epigenetic State Changes Underlie Metabolic Switch in Mouse Post-Infarction Border Zone Cardiomyocytes.
  Günthel M, van Duijvenboden K, de Bakker DEM, Hooijkaas IB, Bakkers J, Barnett P, Christoffels VM
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• Power and Weakness of Repetition - Evaluating the Phylogenetic Signal From Repeatomes in the Family Rosaceae With Two Case Studies From Genera Prone to Polyploidy and Hybridization ( Rosa and Fragaria).
  Herklotz V, Kovařík A, Wissemann V, Lunerová J, Vozárová R, Buschmann S, Olbricht K, Groth M, Ritz CM
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• High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
  Heuberger J, Grinat J, Kosel F, Liu L, Kunz S, Vidal RO, Keil M, Haybaeck J, Robine S, Louvard D, Regenbrecht C, Sporbert A, Sauer S, von Eyss B, Sigal M, Birchmeier W
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• Alternative Animal Models of Aging Research
  Holtze S, Gorshkova E, Braude S, Cellerino A, Dammann P, Hildebrandt TB, Hoeflich A, Hoffmann S, Koch P, Terzibasi Tozzini E, Skulachev M, Skulachev VP, Sahm A
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• PoSeiDon: a Nextflow pipeline for the detection of evolutionary recombination events and positive selection.
  Hölzer M, Marz M
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• The Role of MacroH2A Histone Variants in Cancer.
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• Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas.
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• Vesicle-bound regulatory RNAs are associated with tissue aging
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• Direct RNA Sequencing for Complete Viral Genomes
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• Post-Translational Modification of MRE11: Its Implication in DDR and Diseases.
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• Amyloid precursor protein elevates fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load.
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• Significance of BK Polyomavirus in Long-Term Survivors after Adult Allogeneic Stem Cell Transplantation.
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• Comprehensive Characterization of Multitissue Expression Landscape, Co-Expression Networks and Positive Selection in Pikeperch.
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• An Expanded Polyproline Domain Maintains Mutant Huntingtin Soluble in vivo and During Aging.
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  Völkel* G, Fürstberger* A, Schwab* JD, Werle* SD, Ikonomi* N, Gscheidmeier T, Kraus JM, Groß A, Holderried M, Balig J, Jobst F, Kuhn P, Kuhn KA, Kohlbacher O, Kaisers UX, Seufferlein* T, Kestler* HA
  J Med Internet Res 2021, 23(6), e27348 * equal contribution
  
• Metadata Correction: Patient Empowerment During the COVID-19 Pandemic by Ensuring Safe and Fast Communication of Test Results: Implementation and Performance of a Tracking System.
  Völkel* G, Fürstberger* A, Schwab* JD, Werle* SD, Ikonomi* N, Gscheidmeier T, Kraus JM, Groß A, Holderried M, Balig J, Jobst F, Kuhn P, Kuhn KA, Kohlbacher O, Kaisers UX, Seufferlein* T, Kestler* HA
  J Med Internet Res 2021, 23(6), e31253 * equal contribution
  
• Analysis, identification and visualization of subgroups in genomics.
  Völkel* G, Laban* S, Fürstberger* A, Kühlwein SD, Ikonomi N, Hoffman TK, Brunner C, Neuberg DS, Gaidzik V, Döhner H, Kraus** JM, Kestler** HA
  Brief Bioinform 2021, 22(3) * equal contribution, ** co-senior authors
  
• Erratum to: Analysis, identification and visualization of subgroups in genomics.
  Völkel* G, Laban* S, Fürstberger* A, Kühlwein* SD, Ikonomi* N, Hoffmann TK, Brunner C, Neuberg DS, Gaidzik V, Döhner H, Kraus** JM, Kestler** HA
  Brief Bioinform 2021, 22(6) * equal contribution, ** co-corresponding authors
  
• Chapter Nine - Regulation of muscle stem cell function
  von Maltzahn J
  In: Vitamins and Hormones, Hormones and Stem Cells (edited by Gerald Litwack) 2021, 16, 295-311, Elsevier, Amsterdam
  
• Prospective longitudinal study of immune checkpoint molecule (ICM) expression in immune cell subsets during curative conventional therapy of head and neck squamous cell carcinoma (HNSCC).
  von Witzleben* A, Fehn* A, Grages A, Ezić J, Jeske SS, Puntigam LK, Brunner C, Kraus JM, Kestler HA, Doescher J, Brand M, Theodoraki MN, Ottensmeier CH, Hoffmann TK, Schuler PJ, Laban S
  Int J Cancer 2021, 148(8), 2023-35 * equal contribution
  
• Swarm Learning for decentralized and confidential clinical machine learning.
  Warnat-Herresthal S, Schultze H, Shastry KL, Manamohan S, Mukherjee S, Garg V, Sarveswara R, Händler K, Pickkers P, Aziz NA, Ktena S, Tran F, Bitzer M, Ossowski S, Casadei N, Herr C, Petersheim D, Behrends U, Kern F, Fehlmann T, Schommers P, Lehmann C, Augustin M, Rybniker J, Altmüller J, Mishra N, Bernardes JP, Krämer B, Bonaguro L, Schulte-Schrepping J, De Domenico E, Siever C, Kraut M, Desai M, Monnet B, Saridaki M, Siegel CM, Drews A, Nuesch-Germano M, Theis H, Heyckendorf J, Schreiber S, Kim-Hellmuth S, COVID-19 Aachen Study (COVAS), Nattermann J, Skowasch D, Kurth I, Keller A, Bals R, Nürnberg P, Rieß O, Rosenstiel P, Netea MG, Theis F, Mukherjee S, Backes M, Aschenbrenner AC, Ulas T, Deutsche COVID-19 Omics Initiative (DeCOI), Breteler MMB, Giamarellos-Bourboulis EJ, Kox M, Becker M, Cheran S, Woodacre MS, Goh EL, Schultze JL
  Nature 2021, 594(7862), 265-70
  
• Capturing dynamic relevance in Boolean networks using graph theoretical measures.
  Weidner* FM, Schwab* JD, Werle* SD, Ikonomi* N, Lausser L, Kestler HA
  Bioinformatics 2021 (epub ahead of print) * equal contribution
  
• CD4+ T cells promote delayed B cell responses in the ischemic brain after experimental stroke.
  Weitbrecht L, Berchtold D, Zhang T, Jagdmann S, Dames C, Winek K, Meisel C, Meisel A
  Brain Behav Immun 2021, 91, 601-14
  
• SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
  Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D, Deutsche COVID-19 OMICS Initiative (DeCOI), Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE
  Cell 2021, 184(26), 6243-6261.e27
  
• Unraveling the Molecular Tumor-Promoting Regulation of Cofilin-1 in Pancreatic Cancer.
  Werle* SD, Schwab* JD, Tatura* M, Kirchhoff S, Szekely R, Diels R, Ikonomi N, Sipos B, Sperveslage J, Gress TM, Buchholz** M, Kestler** HA
  Cancers (Basel) 2021, 13(4) * equal contribution, ** co-senior authors
  
• Backbone and nearly complete side-chain chemical shift assignments reveal the human uncharacterized protein CXorf51A as intrinsically disordered.
  Wiedemann C, Obika KB, Liebscher S, Jirschitzka J, Ohlenschlãger O, Bordusa F
  Biomol NMR Assign 2021, 15(2), 441-8
  
• Backbone and nearly complete side-chain chemical shift assignments of the human death-associated protein 1 (DAP1).
  Wiedemann C, Voigt J, Jirschitzka J, Häfner S, Ohlenschläger O, Bordusa F
  Biomol NMR Assign 2021, 15(1), 91-7
  
• Regulators of cholinergic signaling in disorders of the central nervous system.
  Winek K, Soreq H, Meisel A
  J Neurochem 2021, 158(6), 1425-38
  
• p63 and p53: Collaborative Partners or Dueling Rivals?
  Woodstock DL, Sammons MA, Fischer M
  Front Cell Dev Biol 2021, 9, 701986
  
• Shorter Leukocyte Telomere Length Is Associated with Worse Survival of Patients with Bladder Cancer and Renal Cell Carcinoma.
  Zheng X, Wezel F, Azoitei A, Meessen S, Wang W, Najjar G, Wang X, Kraus JM, Kestler HA, John A, Zengerling F, Bolenz C, Günes C
  Cancers (Basel) 2021, 13(15)
  

Publications 2020:

• Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer.
  Akdemir KC, Le VT, Chandran S, Li Y, Verhaak RG, Beroukhim R, Campbell PJ, Chin L, Dixon JR, Futreal PA, PCAWG Structural Variation Working Group, PCAWG Consortium
  Nat Genet 2020, 52(3), 294-305
  
• The repertoire of mutational signatures in human cancer.
  Alexandrov LB, Kim J, Haradhvala NJ, Huang MN, Tian Ng AW, Wu Y, Boot A, Covington KR, Gordenin DA, Bergstrom EN, Islam SMA, Lopez-Bigas N, Klimczak LJ, McPherson JR, Morganella S, Sabarinathan R, Wheeler DA, Mustonen V, PCAWG Mutational Signatures Working Group, Getz G, Rozen SG, Stratton MR, PCAWG Consortium
  Nature 2020, 578(7793), 94-101
  
• Protein Kinase D1, Reduced in Human Pancreatic Tumors, Increases Secretion of Small Extracellular Vesicles From Cancer Cells That Promote Metastasis to Lung in Mice.
  Armacki M, Polaschek S, Waldenmaier M, Morawe M, Ruhland C, Schmid R, Lechel A, Tharehalli U, Steup C, Bektas Y, Li H, Kraus JM, Kestler HA, Kruger S, Ormanns S, Walther P, Eiseler T, Seufferlein T
  Gastroenterology 2020, 159(3), 1019-1035.e22
  
• Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations.
  Austin RJ, Straube J, Bruedigam C, Pali G, Jacquelin S, Vu T, Green J, Gräsel J, Lansink L, Cooper L, Lee SJ, Chen NT, Lee CW, Haque A, Heidel FH, D'Andrea R, Hill GR, Mullally A, Milsom MD, Bywater M, Lane SW
  Leukemia 2020, 34(4), 1075-89
  
• Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19.
  Bernardes JP, Mishra N, Tran F, Bahmer T, Best L, Blase JI, Bordoni D, Franzenburg J, Geisen U, Josephs-Spaulding J, Köhler P, Künstner A, Rosati E, Aschenbrenner AC, Bacher P, Baran N, Boysen T, Brandt B, Bruse N, Dörr J, Dräger A, Elke G, Ellinghaus D, Fischer J, Forster M, Franke A, Franzenburg S, Frey N, Friedrichs A, Fuß J, Glück A, Hamm J, Hinrichsen F, Hoeppner MP, Imm S, Junker R, Kaiser S, Kan YH, Knoll R, Lange C, Laue G, Lier C, Lindner M, Marinos G, Markewitz R, Nattermann J, Noth R, Pickkers P, Rabe KF, Renz A, Röcken C, Rupp J, Schaffarzyk A, Scheffold A, Schulte-Schrepping J, Schunk D, Skowasch D, Ulas T, Wandinger KP, Wittig M, Zimmermann J, Busch H, Hoyer BF, Kaleta C, Heyckendorf J, Kox M, Rybniker J, Schreiber S, Schultze JL, Rosenstiel P, HCA Lung Biological Network, Deutsche COVID-19 Omics Initiative (DeCOI)
  Immunity 2020, 53(6), 1296-1314.e9
  
• Extreme genomic volatility characterizes the evolution of the immunoglobulin heavy chain locus in cyprinodontiform fishes.
  Bradshaw WJ, Valenzano DR
  Proc Biol Sci 2020, 287(1927), 20200489
  
• Spatially resolved analysis of FFPE tissue proteomes by quantitative mass spectrometry.
  Buczak K, Kirkpatrick JM, Truckenmueller F, Santinha D, Ferreira L, Roessler S, Singer S, Beck** M, Ori** A
  Nat Protoc 2020, 15(9), 2956-79 ** co-corresponding authors
  
• Pan-cancer analysis of whole genomes.
  Campbell PJ, Getz G, Korbel Jea, ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium
  Nature 2020, 578(7793), 82-93
  
• Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing.
  Cortés-Ciriano I, Lee JJK, Xi R, Jain D, Jung YL, Yang L, Gordenin D, Klimczak LJ, Zhang CZ, Pellman DS, PCAWG Structural Variation Working Group, Park PJ, PCAWG Consortium
  Nat Genet 2020, 52(3), 331
  
• Nothobranchius furzeri (African Turquoise Killifish).
  Cui R, Willemsen D, Valenzano DR
  Trends Genet 2020, 36(7), 540-1
  
• Optimization of blocking conditions for fluorescent Western blot.
  Cui Y
  Anal Biochem 2020, 593, 113598
  
• Structure of an RNA aptamer in complex with the fluorophore tetramethylrhodamine.
  Duchardt-Ferner E, Juen M, Bourgeois B, Madl T, Kreutz C, Ohlenschläger O, Wöhnert J
  Nucleic Acids Res 2020, 48(2), 949-61
  
• Structural insights into the main S-layer unit of Deinococcus radiodurans reveal a massive protein complex with porin-like features.
  Farci D, Aksoyoglu MA, Farci SF, Bafna JA, Bodrenko I, Ceccarelli M, Kirkpatrick J, Winterhalter M, Kereïche S, Piano D
  J Biol Chem 2020, 295(13), 4224-36
  
• An exploratory investigation of brain collateral circulation plasticity after cerebral ischemia in two experimental C57BL/6 mouse models.
  Foddis* M, Winek* K, Bentele K, Mueller S, Blumenau S, Reichhart N N, Crespo-Garcia S, Harnett D, Ivanov A, Meisel A, Joussen A, Strauss O, Beule D, Dirnagl U, Sassi C
  J Cereb Blood Flow Metab 2020, 40(2), 276-87 * equal contribution
  
• The evolutionary history of 2,658 cancers.
  Gerstung M, Jolly C, Leshchiner I, Dentro SC, Gonzalez S, Rosebrock D, Mitchell TJ, Rubanova Y, Anur P, Yu K, Tarabichi M, Deshwar A, Wintersinger J, Kleinheinz K, Vázquez-García I, Haase K, Jerman L, Sengupta S, Macintyre G, Malikic S, Donmez N, Livitz DG, Cmero M, Demeulemeester J, Schumacher S, Fan Y, Yao X, Lee J, Schlesner M, Boutros PC, Bowtell DD, Zhu H, Getz G, Imielinski M, Beroukhim R, Sahinalp SC, Ji Y, Peifer M, Markowetz F, Mustonen V, Yuan K, Wang W, Morris QD, PCAWG Evolution and Heterogeneity Working Group, Spellman PT, Wedge DC, Van Loo P, PCAWG Consortium
  Nature 2020, 578(7793), 122-8
  
• MLL1 is required for maintenance of intestinal stem cells and the expression of the cell adhesion molecule JAML
  Goveas N, Waskow C, Arndt K, Heuberger J, Zhang Q, Alexopoulou D, Dahl A, Birchmeier W, Anastassiadis K, Stewart AF, Kranz A
  bioRxiv 2020, https://doi.org/10.1101/2020.11.
  
• miR-182-5p is an evolutionarily conserved Tbx5 effector that impacts cardiac development and electrical activity in zebrafish.
  Guzzolino E, Pellegrino M, Ahuja N, Garrity D, D'Aurizio R, Groth M, Baumgart M, Hatcher CJ, Mercatanti A, Evangelista M, Ippolito C, Tognoni E, Fukuda R, Lionetti V, Pellegrini M, Cremisi F, Pitto L
  Cell Mol Life Sci 2020, 77(16), 3215-29
  
• Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
  Haenig C, Atias N, Taylor AK, Mazza A, Schaefer MH, Russ J, Riechers SP, Jain S, Coughlin M, Fontaine JF, Freibaum BD, Brusendorf L, Zenkner M, Porras P, Stroedicke M, Schnoegl S, Arnsburg K, Boeddrich A, Pigazzini L, Heutink P, Taylor JP, Kirstein J, Andrade-Navarro MA, Sharan R, Wanker EE
  Cell Rep 2020, 32(7), 108050
  
• The noncanonical small heat shock protein HSP-17 from Caenorhabditis elegans is a selective protein aggregase.
  Iburg M, Puchkov D, Rosas-Brugada IU, Bergemann L, Rieprecht U, Kirstein J
  J Biol Chem 2020, 295(10), 3064
  
• Awakening the HSC: Dynamic Modeling of HSC Maintenance Unravels Regulation of the TP53 Pathway and Quiescence.
  Ikonomi N, Kühlwein SD, Schwab JD, Kestler HA
  Front Physiol 2020, 11, 848
  
• Temporal changes in the gene expression heterogeneity during brain development and aging.
  Işıldak U, Somel M, Thornton JM, Dönertaş HM
  Sci Rep 2020, 10(1), 4080
  
• Impact of Key Nicotinic AChR Subunits on Post-Stroke Pneumococcal Pneumonia.
  Jagdmann S, Dames C, Berchtold D, Winek K, Weitbrecht L, Meisel A, Meisel C
  Vaccines (Basel) 2020, 8(2)
  
• Local and transient inhibition of p21 expression ameliorates age-related delayed wound healing.
  Jiang D, de Vries JC, Muschhammer J, Schatz S, Ye H, Hein T, Fidan M, Romanov VS, Rinkevich Y, Scharffetter-Kochanek K
  Wound Repair Regen 2020, 28(1), 49-60
  
• Pyruvate kinase variant of fission yeast tunes carbon metabolism, cell regulation, growth and stress resistance.
  Kamrad S, Grossbach J, Rodríguez-López M, Mülleder M, Townsend S, Cappelletti V, Stojanovski G, Correia-Melo C, Picotti P, Beyer A, Ralser M, Bähler J
  Mol Syst Biol 2020, 16(4), e9270
  
• Pyphe, a python toolbox for assessing microbial growth and cell viability in high-throughput colony screens.
  Kamrad S, Rodríguez-López M, Cotobal C, Correia-Melo C, Ralser M, Bähler J
  Elife 2020, 9
  
• Cohesin controls intestinal stem cell identity by maintaining association of Escargot with target promoters.
  Khaminets A, Ronnen-Oron T, Baldauf M, Meier E, Jasper H
  Elife 2020, 9, e48160
  
• Bashing irreproducibility with shournal
  Kirchner T, Riege K, Hoffmann S
  bioRxiv 2020, https://doi.org/10.1101/2020.08.
  
• 1 H, 13 C, and 15 N backbone assignments of the C-terminal region of the human retinoic acid-induced protein 2.
  Lang A, Goradia N, Wikman H, Werner S, Wilmanns M, Ohlenschläger O
  Biomol NMR Assign 2020, 14(2), 271-5
  
• Detecting Ordinal Subcascades
  Lausser* L, Schäfer* LM, Kühlwein SD, Kestler AMR, Kestler HA
  Neural Process Lett 2020, 52, 2583–2605 * equal contribution
  
• Chained correlations for feature selection
  Lausser* L, Szekely* R, Kestler HA
  Adv Data Anal Classif 2020, 14, 871–884 * equal contribution
  
• Patterns of somatic structural variation in human cancer genomes.
  Li Y, Roberts ND, Wala JA, Shapira O, Schumacher SE, Kumar K, Khurana E, Waszak S, Korbel JO, Haber JE, Imielinski M, PCAWG Structural Variation Working Group, Weischenfeldt J, Beroukhim R, Campbell PJ, PCAWG Consortium
  Nature 2020, 578(7793), 112-21
  
• The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
  Liu H, Ding J, Köhnlein K, Urban N, Ori A, Villavicencio-Lorini P, Walentek P, Klotz LO, Hollemann T, Pfirrmann T
  Autophagy 2020, 16(9), 1618-34
  
• Asymmetrical canina meiosis is accompanied by the expansion of a pericentromeric satellite in non-recombining univalent chromosomes.
  Lunerová J, Herklotz V, Laudien M, Vozárová R, Groth M, Kovařík A, Ritz CM
  Ann Bot (Lond) 2020, 125(7), 1025-38
  
• Virus Bioinformatics
  Marz M, Ibrahim B, Hufsky F, Robertson DL (eds)
  2020, pages 330. MDPI - Multidiscipli
  
• ARDD 2020: from aging mechanisms to interventions.
  Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M
  Aging (Albany NY) 2020, 12(24), 24484-503
  
• Ontogenetic Pattern Changes of Nucleobindin-2/Nesfatin-1 in the Brain and Intestinal Bulb of the Short Lived African Turquoise Killifish.
  Montesano* A, Felice* ED, Leggieri A, Palladino A, Lucini C, Scocco P, Girolamo Pd, Baumgart** M, D'Angelo** L
  J Clin Med 2020, 9(1) * equal contribution, ** co-corresponding authors
  
• Peripheral Cytokine Levels Differ by HPV Status and Change Treatment-Dependently in Patients with Head and Neck Squamous Cell Carcinoma.
  Mytilineos D, Ezić J, von Witzleben A, Mytilineos J, Lotfi R, Fürst D, Tsamadou C, Theodoraki MN, Oster A, Völkel G, Kestler HA, Brunner C, Schuler PJ, Doescher J, Hoffmann TK, Laban S
  Int J Mol Sci 2020, 21(17)
  
• Growth inhibitory role of the p53 activator SCH 529074 in non‑small cell lung cancer cells expressing mutant p53.
  Nenkov M, Ma Y, Haase D, Zhou Z, Li Y, Petersen I, Lu G, Chen Y
  Oncol Rep 2020, 43(2), 2073-82
  
• Genomic basis for RNA alterations in cancer.
  PCAWG Transcriptome Core Group, Calabrese C, Davidson NR, Demircioğlu D, Fonseca NA, He Y, Kahles A, Lehmann KV, Liu F, Shiraishi Y, Soulette CM, Urban L, Greger L, Li S, Liu D, Perry MD, Xiang Q, Zhang F, Zhang J, Bailey P, Erkek S, Hoadley KA, Hou Y, Huska MR, Kilpinen H, Korbel JO, Marin MG, Markowski J, Nandi T, Pan-Hammarström Q, Pedamallu CS, Siebert R, Stark SG, Su H, Tan P, Waszak SM, Yung C, Zhu S, Awadalla P, Creighton CJ, Meyerson M, Ouellette BFF, Wu K, Yang H, PCAWG Transcriptome Working Group, Brazma A, Brooks AN, Göke J, Rätsch G, Schwarz RF, Stegle O, Zhang Z, PCAWG Consortium
  Nature 2020, 578(7793), 129-36
  
• Characterization of Amyloid Structures in Aging C. Elegans Using Fluorescence Lifetime Imaging.
  Pigazzini ML, Gallrein C, Iburg M, Kaminski Schierle G, Kirstein J
  J Vis Exp 2020
  
• In Vivo Quantification of Protein Turnover in Aging C. Elegans using Photoconvertible Dendra2.
  Pigazzini ML, Kirstein J
  J Vis Exp 2020
  
• Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13.
  Pitrez PR, Estronca L, Monteiro LM, Colell G, Vazão H, Santinha D, Harhouri K, Thornton D, Navarro C, Egesipe AL, Carvalho T, Dos Santos RL, Lévy N, Smith JC, de Magalhães JP, Ori A, Bernardo A, De Sandre-Giovannoli A, Nissan X, Rosell A, Ferreira L
  Nat Commun 2020, 11(1), 4110
  
• The turquoise killifish: a genetically tractable model for the study of aging.
  Poeschla M, Valenzano DR
  J Exp Biol 2020, 223(Pt Suppl 1)
  
• Microbiota-host interactions shape ageing dynamics.
  Popkes M, Valenzano DR
  Philos Trans R Soc Lond B Biol Sci 2020, 375(1808), 20190596
  
• Analyses of non-coding somatic drivers in 2,658 cancer whole genomes.
  Rheinbay E, Nielsen MM, Abascal F, Wala JA, Shapira O, Tiao G, Hornshøj H, Hess JM, Juul RI, Lin Z, Feuerbach L, Sabarinathan R, Madsen T, Kim J, Mularoni L, Shuai S, Lanzós A, Herrmann C, Maruvka YE, Shen C, Amin SB, Bandopadhayay P, Bertl J, Boroevich KA, Busanovich J, Carlevaro-Fita J, Chakravarty D, Chan CWY, Craft D, Dhingra P, Diamanti K, Fonseca NA, Gonzalez-Perez A, Guo Q, Hamilton MP, Haradhvala NJ, Hong C, Isaev K, Johnson TA, Juul M, Kahles A, Kahraman A, Kim Y, Komorowski J, Kumar K, Kumar S, Lee D, Lehmann KV, Li Y, Liu EM, Lochovsky L, Park K, Pich O, Roberts ND, Saksena G, Schumacher SE, Sidiropoulos N, Sieverling L, Sinnott-Armstrong N, Stewart C, Tamborero D, Tubio JMC, Umer HM, Uusküla-Reimand L, Wadelius C, Wadi L, Yao X, Zhang CZ, Zhang J, Haber JE, Hobolth A, Imielinski M, Kellis M, Lawrence MS, von Mering C, Nakagawa H, Raphael BJ, Rubin MA, Sander C, Stein LD, Stuart JM, Tsunoda T, Wheeler DA, Johnson R, Reimand J, Gerstein M, Khurana E, Campbell PJ, López-Bigas N, PCAWG Drivers and Functional Interpretation Working Group, PCAWG Structural Variation Working Group, Weischenfeldt J, Beroukhim R, Martincorena I, Pedersen JS, Getz G, PCAWG Consortium
  Nature 2020, 578(7793), 102-11
  
• Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition.
  Rodriguez-Martin B, Alvarez EG, Baez-Ortega A, Zamora J, Supek F, Demeulemeester J, Santamarina M, Ju YS, Temes J, Garcia-Souto D, Detering H, Li Y, Rodriguez-Castro J, Dueso-Barroso A, Bruzos AL, Dentro SC, Blanco MG, Contino G, Ardeljan D, Tojo M, Roberts ND, Zumalave S, Edwards PA, Weischenfeldt J, Puiggròs M, Chong Z, Chen K, Lee EA, Wala JA, Raine KM, Butler A, Waszak SM, Navarro FCP, Schumacher SE, Monlong J, Maura F, Bolli N, Bourque G, Gerstein M, Park PJ, Wedge DC, Beroukhim R, Torrents D, Korbel JO, Martincorena I, Fitzgerald RC, Van Loo P, Kazazian HH, Burns KH, PCAWG Structural Variation Working Group, Campbell PJ, Tubio JMC, PCAWG Consortium
  Nat Genet 2020, 52(3), 306-19
  
• A virtual "Werkstatt" for digitization in the sciences
  Samuel S, Shadaydeh M, Böcker S, Brügmann B, Bucher SF, Deckert V, Denzler J, Dittrich P, Eggeling F, Güllmar D, Guntinas-Lichius O, König-Ries B, Löffler F, Maicher L, Marz M, Migliavacca M, Reichenbach JR, Reichstein M, Römermann C, Wittig A
  Res Ideas Outcomes 2020, 6, e54106
  
• Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading.
  Sandhof CA, Hoppe SO, Druffel-Augustin S, Gallrein C, Kirstein J, Voisine C, Nussbaum-Krammer C
  Autophagy 2020, 16(5), 878
  
• Stem Cell Aging: The Upcoming Era of Proteins and Metabolites.
  Schüler* SC, Gebert* N, Ori A
  Mech Ageing Dev 2020, 190, 111288 * equal contribution
  
• The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival.
  Schulz A, Sekine Y, Oyeyemi MJ, Abrams AJ, Basavaraju M, Han SM, Groth M, Morrison H, Strittmatter SM, Hammarlund M
  J Cell Biol 2020, 219(2), doi: 10.1083/jcb.201807127
  
• Apoptosis of hematopoietic progenitor-derived adipose tissue-resident macrophages contributes to insulin resistance after myocardial infarction.
  Vasamsetti SB, Coppin E, Zhang X, Florentin J, Koul S, Götberg M, Clugston AS, Thoma F, Sembrat J, Bullock GC, Kostka D, St Croix CM, Chattopadhyay A, Rojas M, Mulukutla SR, Dutta P
  Sci Transl Med 2020, 12(553), eaaw0638
  
• Intra-species differences in population size shape life history and genome evolution.
  Willemsen D, Cui R, Reichard M, Valenzano DR
  Elife 2020, 9
  
• Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade.
  Winek* K, Lobentanzer* S, Nadorp B, Dubnov S, Dames C, Jagdmann S, Moshitzky G, Hotter B, Meisel C, Greenberg DS, Shifman S, Klein J, Shenhar-Tsarfaty S, Meisel A, Soreq H
  Proc Natl Acad Sci U S A 2020, 117(51), 32606-16 * equal contribution
  
• Identification of Ppar γ -modulated miRNA hubs that target the fibrotic tumor microenvironment.
  Winkler I, Bitter C, Winkler S, Weichenhan D, Thavamani A, Hengstler JG, Borkham-Kamphorst E, Kohlbacher O, Plass C, Geffers R, Weiskirchen R, Nordheim A
  Proc Natl Acad Sci U S A 2020, 117(1), 454-63
  
• Butler enables rapid cloud-based analysis of thousands of human genomes.
  Yakneen S, Waszak SM, PCAWG Technical Working Group, Gertz M, Korbel JO, PCAWG Consortium
  Nat Biotechnol 2020, 38(3), 288–292
  
• Comprehensive molecular characterization of mitochondrial genomes in human cancers.
  Yuan Y, Ju YS, Kim Y, Li J, Wang Y, Yoon CJ, Yang Y, Martincorena I, Creighton CJ, Weinstein JN, Xu Y, Han L, Kim HL, Nakagawa H, Park K, Campbell PJ, Liang H, PCAWG Consortium
  Nat Genet 2020, 52(3), 342-52
  
• The landscape of viral associations in human cancers.
  Zapatka M, Borozan I, Brewer DS, Iskar M, Grundhoff A, Alawi M, Desai N, Sültmann H, Moch H, PCAWG Pathogens, Cooper CS, Eils R, Ferretti V, Lichter P, PCAWG Consortium
  Nat Genet 2020, 52(3), 320-30
  
• Displacement of the Gent/1999 human-like swine H1N2 influenza A virus lineage by novel H1N2 reassortants in Germany.
  Zell R, Groth M, Krumbholz A, Lange J, Philipps A, Dürrwald R
  Arch Virol 2020, 165(1), 55-67
  

Publications 2019:

• Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart.
  Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling JE, Dodzian J, Lagerborg KA, Vargas NE, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano** DR, Kurian** L
  EMBO Rep 2019, 20(4) ** co-corresponding authors
  
• Microbiome evolution during host aging.
  Aleman FDD, Valenzano DR
  PLoS Pathog 2019, 15(7), e1007727
  
• Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.
  Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF
  EMBO J 2019, 38(5), e100492
  
• Mitohormetic effects of rotenone drastically depend on age.
  Baumgart* M, Ugolini* M, Groth M, Platzer M, Cellerino A
  bioRxiv 2019, https://doi.org/10.1101/528547 * equal contribution
  
• BRCA1 mislocalization leads to aberrant DNA damage response in heterozygous ABRAXAS1 mutation carrier cells.
  Bose M, Sachsenweger J, Laurila N, Parplys AC, Willmann J, Jungwirth J, Groth M, Rapakko K, Nieminen P, Friedl TWP, Heiserich L, Meyer F, Tuppurainen H, Peltoketo H, Nevanlinna H, Pylkäs K, Borgmann K, Wiesmüller L, Winqvist** R, Pospiech** H
  Hum Mol Genet 2019, 28(24), 4148-60 ** co-corresponding authors
  
• Self-Establishing Communities: A Yeast Model to Study the Physiological Impact of Metabolic Cooperation in Eukaryotic Cells.
  Campbell K, Correia-Melo C, Ralser M
  Methods Mol Biol 2019, 2049, 263-82
  
• Resting cells rely on the DNA helicase component MCM2 to build cilia.
  Casar Tena T, Maerz LD, Szafranski K, Groth M, Blätte TJ, Donow C, Matysik S, Walther P, Jeggo PA, Burkhalter MD, Philipp M
  Nucleic Acids Res 2019, 47(1), 134-51
  
• Re-thinking the Etiological Framework of Neurodegeneration.
  Castillo X, Castro-Obregón S, Gutiérrez-Becker B, Gutiérrez-Ospina G, Karalis N, Khalil AA, Lopez-Noguerola JS, Rodríguez LL, Martínez-Martínez E, Perez-Cruz C, Pérez-Velázquez J, Piña AL, Rubio K, García HPS, Syeda T, Vanoye-Carlo A, Villringer A, Winek K, Zille M
  FRONT NEUROSCI-SWITZ 2019, 13, 728
  
• Early-life Pb exposure as a potential risk factor for Alzheimer's disease: are there hazards for the Mexican population?
  Chin-Chan M, Cobos-Puc L, Alvarado-Cruz I, Bayar M, Ermolaeva M
  J Biol Inorg Chem 2019, 24(8), 1285-303
  
• Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V.
  Claes F, Rudyak S, Laird AS, Louros N, Beerten J, Debulpaep M, Michiels E, van der Kant R, Van Durme J, De Baets G, Houben B, Ramakers M, Yuan K, Gwee SSL, Hernandez S, Broersen K, Oliveberg M, Moahamed B, Kirstein J, Robberecht W, Rousseau F, Schymkowitz J
  Protein Eng Des Sel 2019, 32(10), 443
  
• Rapamycin improves healthspan but not inflammaging in nfκb1-/- mice.
  Correia-Melo* C, Birch* J, Fielder E, Rahmatika D, Taylor J, Chapman J, Lagnado A, Carroll BM, Miwa S, Richardson G, Jurk D, Oakley F, Mann J, Mann DA, Korolchuk VI, Passos JF
  Aging Cell 2019, 18(1), e12882 * equal contribution
  
• Relaxed Selection Limits Lifespan by Increasing Mutation Load.
  Cui R, Medeiros T, Willemsen D, Iasi LNM, Collier GE, Graef M, Reichard M, Valenzano DR
  Cell 2019, 178(2), 385-399.e20
  
• Construction of cloning-friendly mini-genes for mammalian expression of full-length human NF1 isoforms.
  Cui Y, Morrison H
  Hum Mutat 2019, 40(2), 187-92
  
• Comment on 'Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age'.
  Dammann* P, Scherag* A, Zak N, Szafranski K, Holtze S, Begall S, Burda H, Kestler HA, Hildebrandt T, Platzer M
  Elife 2019, 8 * corresponding author
  
• Cell cycle dynamics during diapause entry and exit in an annual killifish revealed by FUCCI technology.
  Dolfi L, Ripa R, Antebi A, Valenzano DR, Cellerino A
  Evodevo 2019, 10, 29
  
• Identifying Potential Ageing-Modulating Drugs In Silico.
  Dönertaş* HM, Fuentealba* M, Partridge L, Thornton JM
  Trends Endocrinol Metab 2019, 30(2), 118 * equal contribution
  
• Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer.
  Drucker E, Holzer K, Pusch S, Winkler J, Calvisi DF, Eiteneuer E, Herpel E, Goeppert B, Roessler S, Ori A, Schirmacher P, Breuhahn K, Singer S
  Cell Commun Signal 2019, 17(1), 159
  
• Crosstalk Between Chaperone-Mediated Protein Disaggregation and Proteolytic Pathways in Aging and Disease.
  Feleciano DR, Juenemann K, Iburg M, Brás IC, Holmberg CI, Kirstein J
  Front Aging Neurosci 2019, 11, 9
  
• Global importance of RNA secondary structures in protein coding sequences.
  Fricke M, Gerst R, Ibrahim B, Niepmann M, Marz M
  Bioinformatics 2019, 35(4), 579-83
  
• Using the drug-protein interactome to identify anti-ageing compounds for humans.
  Fuentealba M, Dönertaş HM, Williams R, Labbadia J, Thornton JM, Partridge L
  PLoS Comput Biol 2019, 15(1), e1006639
  
• Profiling of gallbladder carcinoma reveals distinct miRNA profiles and activation of STAT1 by the tumor suppressive miRNA-145-5p.
  Goeppert B, Truckenmueller F, Ori A, Fritz V, Albrecht T, Fraas A, Scherer D, Silos RG, Sticht C, Gretz N, Mehrabi A, Bewerunge-Hudler M, Pusch S, Bermejo JL, Dietrich P, Schirmacher P, Renner M, Roessler S
  Sci Rep 2019, 9(1), 4796
  
• Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines.
  Guo T, Luna A, Rajapakse VN, Koh CC, Wu Z, Liu W, Sun Y, Gao H, Menden MP, Xu C, Calzone L, Martignetti L, Auwerx C, Buljan M, Banaei-Esfahani A, Ori A, Iskar M, Gillet L, Bi R, Zhang J, Zhang H, Yu C, Zhong Q, Varma S, Schmitt U, Qiu P, Zhang Q, Zhu Y, Wild PJ, Garnett MJ, Bork P, Beck M, Liu K, Saez-Rodriguez J, Elloumi F, Reinhold WC, Sander C, Pommier Y, Aebersold R
  iScience 2019, 21, 664-80
  
• Nucleoporin Nup155 is part of the p53 network in liver cancer.
  Holzer K, Ori A, Cooke A, Dauch D, Drucker E, Riemenschneider P, Andres-Pons A, DiGuilio AL, Mackmull MT, Baßler J, Roessler S, Breuhahn K, Zender L, Glavy JS, Dombrowski F, Hurt E, Schirmacher P, Beck M, Singer S
  Nat Commun 2019, 10(1), 2147
  
• Function, evolution, and structure of J-domain proteins.
  Kampinga HH, Andreasson C, Barducci A, Cheetham ME, Cyr D, Emanuelsson C, Genevaux P, Gestwicki JE, Goloubinoff P, Huerta-Cepas J, Kirstein J, Liberek K, Mayer MP, Nagata K, Nillegoda NB, Pulido P, Ramos C, De Los Rios P, Rospert S, Rosenzweig R, Sahi C, Taipale M, Tomiczek B, Ushioda R, Young JC, Zimmermann R, Zylicz A, Zylicz M, Craig EA, Marszalek J
  Cell Stress Chaperones 2019, 24(1), 7
  
• The widespread increase in inter-individual variability of gene expression in the human brain with age.
  Kedlian* VR, Donertas* HM, Thornton JM
  Aging (Albany NY) 2019, 11(8), 2253 * equal contribution
  
• Inverse resource allocation between vision and olfaction across the genus Drosophila.
  Keesey IW, Grabe V, Gruber L, Koerte S, Obiero GF, Bolton G, Khallaf MA, Kunert G, Lavista-Llanos S, Valenzano DR, Rybak J, Barrett BA, Knaden M, Hansson BS
  Nat Commun 2019, 10(1), 1162
  
• Transduction and transfection of difficult-to-transfect cells: Systematic attempts for the transfection of protozoa Leishmania.
  Keller AA, Scheiding B, Breitling R, Licht A, Hemmerich P, Lorkowski S, Reissmann S
  J Cell Biochem 2019, 120(1), 14-27
  
• ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans.
  Kreis P, Gallrein C, Rojas-Puente E, Mack TGA, Kroon C, Dinkel V, Willmes C, Murk K, Tom-Dieck S, Schuman EM, Kirstein** J, Eickholt** BJ
  Nat Commun 2019, 10(1), 486 ** co-corresponding authors
  
• Macaca arctoides gammaherpesvirus 1 (strain herpesvirus Macaca arctoides): virus sequence, phylogeny and characterisation of virus-transformed macaque and rabbit cell lines.
  Krumbholz A, Roempke J, Liehr T, Groth M, Meerbach A, Schacke M, Maschkowitz G, Fickenscher H, Klapper W, Sauerbrei A, Wutzler P, Zell R
  Med Microbiol Immunol 2019, 208(1), 109-29
  
• Comparison of protein quantification in a complex background by DIA and TMT workflows with fixed instrument time.
  Muntel* J, Kirkpatrick* J, Bruderer R, Huang T, Vitek O, Ori** A, Reiter** L
  J Proteome Res 2019, 18(3), 1340-51 * equal contribution, ** co-senior authors
  
• Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism.
  Olin-Sandoval V, Yu JSL, Miller-Fleming L, Alam MT, Kamrad S, Correia-Melo C, Haas R, Segal J, Peña Navarro DA, Herrera-Dominguez L, Méndez-Lucio O, Vowinckel J, Mülleder M, Ralser M
  Nature 2019, 572(7768), 249-53
  
• Metastatic-niche labelling reveals parenchymal cells with stem features.
  Ombrato L, Nolan E, Kurelac I, Mavousian A, Bridgeman VL, Heinze I, Chakravarty P, Horswell S, Gonzalez-Gualda E, Matacchione G, Weston A, Kirkpatrick J, Husain E, Speirs V, Collinson L, Ori A, Lee JH, Malanchi I
  Nature 2019, 572(7771), 603-8
  
• Disentangling Genetic and Environmental Effects on the Proteotypes of Individuals.
  Romanov N, Kuhn M, Aebersold R, Ori A, Beck M, Bork P
  Cell 2019, 177(5), 1308-18
  
• RB, p130 and p107 differentially repress G1/S and G2/M genes after p53 activation.
  Schade AE, Fischer M, DeCaprio JA
  Nucleic Acids Res 2019, 47(21), 11197-208
  
• Global network of computational biology communities: ISCB's Regional Student Groups breaking barriers.
  Shome S, Parra RG, Fatima N, Monzon AM, Cuypers B, Moosa Y, Coimbra NDR, Assis J, Giner-Delgado C, Dönertaş HM, Cuesta-Astroz Y, Saarunya G, Allali I, Gupta S, Srivastava A, Kalsan M, Valdivia C, J Olguin-Orellana G, Papadimitriou S, Parisi D, Kristensen NP, Rib L, Guebila MB, Bauer E, Zaffaroni G, Bekkar A, Ashano E, Paladin L, Necci M, Moreyra NN, Rydén M, Villalobos-Solís J, Papadopoulos N, Rafael C, Karakulak T, Kaya Y, Gladbach Y, Dhanda SK, Šoštarić N, Alex A, DeBlasio D, Rahman F
  F1000Res 2019, 8
  
• Molecular footprint of Medawar's mutation accumulation process in mammalian aging.
  Turan ZG, Parvizi P, Dönertaş HM, Tung J, Khaitovich P, Somel M
  Aging Cell 2019, 18(4), e12965
  
• An encoding of genome content for machine learning.
  Viehweger A, Krautwurst S, Parks DH, Koenig B, Marz M
  bioRxiv 2019, https://doi.org/10.1101/524280
  
• Direct RNA nanopore sequencing of full-length coronavirus genomes provides novel insights into structural variants and enables modification analysis.
  Viehweger* A, Krautwurst* S, Lamkiewicz K, Madhugiri R, Ziebuhr J, Hölzer M, Marz M
  Genome Res 2019, 29(9), 1545-54 * equal contribution
  

Publications 2018:

• Whither systems medicine?
  Apweiler R, Beissbarth T, Berthold MR, Blüthgen N, Burmeister Y, Dammann O, Deutsch A, Feuerhake F, Franke A, Hasenauer J, Hoffmann S, Höfer T, Jansen PL, Kaderali L, Klingmüller U, Koch I, Kohlbacher O, Kuepfer L, Lammert F, Maier D, Pfeifer N, Radde N, Rehm M, Roeder I, Saez-Rodriguez J, Sax U, Schmeck B, Schuppert A, Seilheimer B, Theis FJ, Vera J, Wolkenhauer O
  Exp Mol Med 2018, 50(3), e453
  
• Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly.
  Aramillo Irizar P, Schäuble S, Esser D, Groth M, Frahm C, Priebe S, Baumgart M, Hartmann N, Marthandan S, Menzel U, Müller J, Schmidt S, Ast V, Caliebe A, König R, Krawczak M, Ristow M, Schuster S, Cellerino A, Diekmann S, Englert C, Hemmerich P, Sühnel J, Guthke R, Witte OW, Platzer M, Ruppin E, Kaleta C
  Nat Commun 2018, 9(1), 327
  
• SETD1A protects HSCs from activation-induced functional decline in vivo.
  Arndt K, Kranz A, Fohgrub J, Jolly A, Bledau AS, Di Virgilio M, Lesche M, Dahl A, Höfer T, Stewart AF, Waskow C
  Blood 2018, 131(12), 1311-24
  
• mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's Disease.
  Ast A, Buntru A, Schindler F, Hasenkopf R, Schulz A, Brusendorf L, Klockmeier K, Grelle G, McMahon B, Niederlechner H, Jansen I, Diez L, Edel J, Boeddrich A, Franklin SA, Baldo B, Schnoegl S, Kunz S, Purfürst B, Gaertner A, Kampinga HH, Morton AJ, Petersén Å, Kirstein J, Bates GP, Wanker EE
  Mol Cell 2018, 71(5), 675
  
• Kidney regeneration in fish.
  Bates T, Naumann U, Hoppe B, Englert C
  Int J Dev Biol 2018, 62(6-7-8), 419-29
  
• Analysis of lncRNA-Protein Interactions by RNA-Protein Pull-Down Assays and RNA Immunoprecipitation (RIP).
  Bierhoff H
  Methods Mol Biol 2018, 1686, 241-50
  
• Spatial tissue proteomics quantifies inter- and intra-tumor heterogeneity in hepatocellular carcinoma.
  Buczak* K, Ori* A, Kirkpatrick JM, Holzer K, Dauch D, Roessler S, Endris V, Lasitschka F, Parca L, Schmidt A, Zender L, Schirmacher P, Krijgsveld J, Singer** S, Beck** M
  Mol Cell Proteomics 2018, 17(4), 810-25 * equal contribution, ** co-corresponding authors
  
• Computational pan-genomics: status, promises and challenges.
  Computational PGC, Marschall T, Marz M, Abeel T, Dijkstra L, Dutilh BE, Ghaffaari A, Kersey P, Kloosterman WP, Mäkinen V, Novak AM, Paten B, Porubsky D, Rivals E, Alkan C, Baaijens JA, De Bakker PIW, Boeva V, Bonnal RJP, Chiaromonte F, Chikhi R, Ciccarelli FD, Cijvat R, Datema E, Van Duijn CM, Eichler EE, Ernst C, Eskin E, Garrison E, El-Kebir M, Klau GW, Korbel JO, Lameijer EW, Langmead B, Martin M, Medvedev P, Mu JC, Neerincx P, Ouwens K, Peterlongo P, Pisanti N, Rahmann S, Raphael B, Reinert K, de Ridder D, de Ridder J, Schlesner M, Schulz-Trieglaff O, Sanders AD, Sheikhizadeh S, Shneider C, Smit S, Valenzuela D, Wang J, Wessels L, Zhang Y, Guryev V, Vandin F, Ye K, Schönhuth A
  Brief Bioinform 2018, 19(1), 118-35
  
• Sequential use of milk and bovine serum albumin for streptavidin-probed western blot.
  Cui Y, Ma L
  Biotechniques 2018, 65(3), 125-6
  
• X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
  Dahms SO, Hardes K, Steinmetzer T, Than ME
  Biochemistry 2018, 57(6), 925-34
  
• Immunomodulatory treatment with systemic GM-CSF augments pulmonary immune responses and improves neurological outcome after experimental stroke.
  Dames C, Winek K, Beckers Y, Engel O, Meisel A, Meisel C
  J Neuroimmunol 2018, 321, 144-9
  
• Telomeric epigenetic response mediated by Gadd45a regulates stem cell aging and lifespan.
  Diao D, Wang H, Li T, Shi Z, Jin X, Sperka T, Zhu X, Zhang M, Yang F, Cong Y, Shen L, Zhan Q, Yan J, Song Z, Ju Z
  EMBO Rep 2018, 19(10), e45494
  
• A Protocol for Laboratory Housing of Turquoise Killifish (Nothobranchius furzeri).
  Dodzian J, Kean S, Seidel J, Valenzano DR
  J Vis Exp 2018
  
• Gene expression-based drug repurposing to target aging.
  Dönertaş HM, Fuentealba Valenzuela M, Partridge L, Thornton JM
  Aging Cell 2018, 17(5), e12819
  
• DIEGO: Detection of Differential Alternative Splicing using Aitchison's Geometry.
  Doose G, Bernhart SH, Wagener R, Hoffmann S
  Bioinformatics 2018, 34(6), 1066-8
  
• Cellular and epigenetic drivers of stem cell ageing.
  Ermolaeva** M, Neri** F, Ori** A, Rudolph** KL
  Nat Rev Mol Cell Biol 2018, 19(9), 594-610 ** co-corresponding authors
  
• On the S-layer of Thermus thermophilus and the assembling of its main protein SlpA.
  Farci D, Farci SF, Esposito F, Tramontano E, Kirkpatrick J, Piano D
  Biochim Biophys Acta 2018, 1860(8), 1554-62
  
• 2016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis.
  Fisher MJ, Belzberg AJ, de Blank P, De Raedt T, Elefteriou F, Ferner RE, Giovannini M, Harris GJ, Kalamarides M, Karajannis MA, Kim A, Lázaro C, Le LQ, Li W, Listernick R, Martin S, Morrison H, Pasmant E, Ratner N, Schorry E, Ullrich NJ, Viskochil D, Weiss B, Widemann BC, Zhu Y, Bakker A, Serra E
  Am J Med Genet A 2018, 176(5), 1258-69
  
• Integrative analysis of differentially expressed genes and miRNAs predicts complex T3-mediated protective circuits in a rat model of cardiac ischemia reperfusion.
  Forini F, Nicolini G, Kusmic C, D'Aurizio R, Rizzo M, Baumgart M, Groth M, Doccini S, Iervasi G, Pitto L
  Sci Rep 2018, 8(1), 13870
  
• The eukaryotic linear motif resource - 2018 update.
  Gouw M, Michael S, Sámano-Sánchez H, Kumar M, Zeke A, Lang B, Bely B, Chemes LB, Davey NE, Deng Z, Diella F, Gürth CM, Huber AK, Kleinsorg S, Schlegel LS, Palopoli N, Roey KV, Altenberg B, Reményi A, Dinkel H, Gibson TJ
  Nucleic Acids Res 2018, 46(D1), D428-34
  
• Effects of allelic variations in the human Myxovirus resistance protein A on its antiviral activity.
  Graf L, Dick A, Sendker F, Barth E, Marz M, Daumke O, Kochs G
  J Biol Chem 2018, 293(9), 3056-72
  
• Molecular mechanisms of photoadaptation of photosystem I supercomplex of in an evolutionary cyanobacterial/algal intermediate.
  Haniewicz P, Abram M, Nosek L, Kirkpatrick J, El-Mohsnawy E, Janna Olmos JD, Kouril R, Kargul JM
  Plant Physiol 2018, 176(2), 1433-51
  
• Influence of Scribble polarity complex on hematopoiesis and leukemia - a matter of where, when and how.
  Heidel FH, Ellis S
  Oncotarget 2018, 9(78), 34642-3
  
• Managing myeloproliferative neoplasms evidence based on the ELN treatment recommendations 2018.
  Heidel FH, Gale RP, Hochhaus A
  Leukemia 2018, 32(5), 1055-6
  
• Conformational µ-conotoxin PIIIA isomers revisited: The impact of cysteine pairing on disulfide bond assignment and structure elucidation.
  Heimer P, Tietze AA, Bäuml CA, Resemann A, Mayer FJ, Suckau D, Ohlenschläger O, Tietze D, Imhof D
  Anal Chem 2018, 90(5), 3321-7
  
• Retinal S-opsin dominance in Ansell's mole-rats (Fukomys anselli) is a consequence of naturally low serum thyroxine.
  Henning Y, Mladěnková N, Burda H, Szafranski* K, Begall* S
  Sci Rep 2018, 8(1), 4337 * equal contribution
  
• The fate of ribosomal RNA genes in spontaneous polyploid dogrose hybrids (Rosa L. sect. Caninae (DC.) Ser.) exhibiting non-symmetrical meiosis.
  Herklotz V, Kovařík A, Lunerová J, Lippitsch S, Groth M, Ritz CM
  Plant J 2018, 94(1), 77-90
  
• sAPPβ and sAPPα increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Ca2+ homeostasis and CREB1-signaling
  Hesse R, von Einem B, Wagner F, Bott P, Schwanzar D, Jackson RJ, Föhr KJ, Lausser L, Kroker KS, Proepper C, Walther P, Kestler HA, Spires-Jones TL, Boeckers T, Rosenbrock H, von Arnim CAF
  Exp Neurol 2018, 304, 1-13
  
• Multiple roots of fruiting body formation in Amoebozoa.
  Hillmann F, Forbes G, Novohradská S, Ferling I, Riege K, Groth M, Westermann M, Marz M, Spaller T, Winckler T, Schaap P, Glöckner G
  Genome Biol Evol 2018, 10(2), 591-606
  
• Multimodal Light Microscopy Approaches to Reveal Structural and Functional Properties of Promyelocytic Leukemia Nuclear Bodies.
  Hoischen C, Monajembashi S, Weisshart K, Hemmerich P
  Front Oncol 2018, 8, 125
  
• CENP-C/H/I/K/M/T/W/N/L and hMis12 but not CENP-S/X participate in complex formation in the nucleoplasm of living human interphase cells outside centromeres.
  Hoischen* C, Yavas* S, Wohland T, Diekmann S
  PLoS One 2018, 13(3), e0192572 * equal contribution
  
• The microenvironment of naked mole-rat burrows in East Africa
  Holtze S, Braude S, Lemma A, Koch R, Morhart M, Szafranski K, Platzer M, Alemayehu F, Goeritz F, Hildebrandt TB
  Afr J Ecol 2018, 56(2), 279-89
  
• Virologists-Heroes need weapons.
  Hufsky F, Ibrahim B, Beer M, Deng L, Mercier PL, McMahon DP, Palmarini M, Thiel V, Marz M
  PLoS Pathog 2018, 14(2), e1006771
  
• 3D Network exploration and visualisation for lifespan data.
  Hühne* R, Kessler* V, Fürstberger* A, Kühlwein S, Platzer M, Sühnel J, Lausser L, Kestler HA
  BMC Bioinformatics 2018, 19(1), 390 * equal contribution
  
• Bioinformatics Meets Virology: The European Virus Bioinformatics Center's Second Annual Meeting.
  Ibrahim B, Arkhipova K, Andeweg AC, Posada-Céspedes S, Enault F, Gruber A, Koonin EV, Kupczok A, Lemey P, McHardy AC, McMahon DP, Pickett BE, Robertson DL, Scheuermann RH, Zhernakova A, Zwart MP, Schönhuth A, Dutilh BE, Marz M
  Viruses 2018, 10(5, 256; https://doi.org/10.33
  
• Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies.
  Juenemann K, Jansen AHP, van Riel L, Merkx R, Mulder MPC, An H, Statsyuk A, Kirstein J, Ovaa H, Reits EA
  Sci Rep 2018, 8(1), 1405
  
• Synthesis and biochemical evaluation of two novel N-hydroxyalkylated cyclosporin A analogs.
  Kahlert V, Prell E, Ohlenschläger O, Melesina J, Schumann M, Lücke C, Fischer G, Malešević M
  Org Biomol Chem 2018, 16(23), 4338-49
  
• Big data and precision medicine: challenges and strategies with healthcare data
  Kraus JM, Lausser L, Kuhn P, Jobst F, Bock M, Halanke C, Hummel M, Heuschmann P, Kestler HA
  Int J Data Sci Anal 2018
  
• Mutational impact of culturing human pluripotent and adult stem cells.
  Kuijk E, Jager M, van der Roest B, Locati M, Van Hoeck A, Korzelius J, Janssen R, Besselink N, Boymans S, van Boxtel R, Cuppen E
  bioRxiv 2018, http://dx.doi.org/10.1101/430165
  
• Identification of biological mechanisms by semantic classifier systems.
  Lausser L, Schmid F, Siegle L, Hühne R, Buchholz M, Kestler HA
  bioRxiv 2018, https://doi.org/10.1101/335737
  
• The Influence of Multi-class Feature Selection on the Prediction of Diagnostic Phenotypes
  Lausser L, Szekely R, Schirra LR, Kestler HA
  Neural Process Lett 2018, 48(2), 863–880
  
• Deletion of Menin in craniofacial osteogenic cells in mice elicits development of mandibular ossifying fibroma.
  Lee S, Liu P, Teinturier R, Jakob J, Tschaffon M, Tasdogan A, Wittig R, Hoeller S, Baumhoer D, Frappart L, Vettorazzi S, Bertolino P, Zhang C, Tuckermann J
  Oncogene 2018, 37(5), 616-26
  
• Heat Shock Factor 1 Epigenetically Stimulates Glutaminase-1-Dependent mTOR Activation to Promote Colorectal Carcinogenesis.
  Li J, Song P, Jiang T, Dai D, Wang H, Sun J, Zhu L, Xu W, Feng L, Shin VY, Morrison H, Wang X, Jin H
  Mol Ther 2018, 26(7), 1828-39
  
• Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair.
  Lopez-Baez JC, Simpson DJ, LLeras Forero L, Zeng Z, Brunsdon H, Salzano A, Brombin A, Wyatt C, Rybski W, Huitema LFA, Dale RM, Kawakami K, Englert C, Chandra T, Schulte-Merker S, Hastie ND, Patton EE
  Elife 2018, 7, e30657
  
• Cystatin A suppresses tumor cell growth through inhibiting epithelial to mesenchymal transition in human lung cancer.
  Ma Y, Chen Y, Li Y, Grün K, Berndt A, Zhou Z, Petersen I
  Oncotarget 2018, 9(18), 14084-98
  
• Structural and functional conservation of cis-acting RNA elements in coronavirus 5'-terminal genome regions.
  Madhugiri R, Karl N, Petersen D, Lamkiewicz K, Fricke M, Wend U, Scheuer R, Marz M, Ziebuhr J
  Virology 2018, 517, 44-55
  
• Internal tandem duplication mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation.
  Marhäll A, Heidel F, Fischer T, Rönnstrand L
  Ann Hematol 2018, 97(5), 773-80
  
• The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing's sarcoma cell line.
  Marx C, Marx-Blümel L, Lindig N, Thierbach R, Hoelzer D, Becker S, Wittig S, Lehmann R, Slevogt H, Heinzel T, Wang ZQ, Beck JF, Sonnemann J
  Invest New Drugs 2018, 36(3), 396-406
  
• Reduced expression of C/EBPβ-LIP extends health- and lifespan in mice.
  Müller* C, Zidek* LM, Ackermann T, de Jong T, Liu P, Kliche V, Zaini MA, Kortman G, Harkema L, Verbeek DS, Tuckermann JP, von Maltzahn J, de Bruin A, Guryev V, Wang ZQ, Calkhoven CF
  Elife 2018, 7, e34985 * equal contribution
  
• Dispersion/reaggregation in early development of annual killifishes: Phylogenetic distribution and evolutionary significance of a unique feature.
  Naumann B, Englert C
  Dev Biol 2018, 442(1), 69-79
  
• Exploratory Investigation of Intestinal Function and Bacterial Translocation After Focal Cerebral Ischemia in the Mouse.
  Oyama* N, Winek* K, Bäcker-Koduah P, Zhang T, Dames C, Werich M, Kershaw O, Meisel C, Meisel A, Dirnagl U
  Front Neurol 2018, 9, 937 * equal contribution, * corresponding author
  
• Efficacy and safety of ruxolitinib in intermediate-1 IPSS risk myelofibrosis patients: Results from an independent study.
  Palandri F, Tiribelli M, Benevolo G, Tieghi A, Cavazzini F, Breccia M, Bergamaschi M, Sgherza N, Polverelli N, Crugnola M, Isidori A, Binotto G, Heidel FH, Buccisano F, Martino B, Latagliata R, Spinsanti M, Kallenberg L, Palumbo GA, Abruzzese E, Scaffidi L, Cuneo A, Cavo M, Vianelli N, Bonifacio M
  Hematol Oncol 2018, 36(1), 285-90
  
• Quantifying compartment-associated variations of protein abundance in proteomics data.
  Parca L, Beck M, Bork P, Ori A
  Mol Syst Biol 2018, 14(7), e8131
  
• Dysregulation of chemokine receptor expression and function in leukocytes from ALS patients.
  Perner C, Perner F, Stubendorff B, Förster M, Witte OW, Heidel FH, Prell T, Grosskreutz J
  J Neuroinflammation 2018, 15(1), 99
  
• The Pseudogenes of Barley.
  Prade VM, Gundlach H, Twardziok S, Chapman B, Tan C, Langridge P, Schulman AH, Stein N, Waugh R, Zhang G, Platzer M, Li C, Spannagl M, Mayer KFX
  Plant J 2018, 93(3), 502-14
  
• Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms.
  Prestipino A, Emhardt AJ, Aumann K, O'Sullivan D, Gorantla SP, Duquesne S, Melchinger W, Braun L, Vuckovic S, Boerries M, Busch H, Halbach S, Pennisi S, Poggio T, Apostolova P, Veratti P, Hettich M, Niedermann G, Bartholomä M, Shoumariyeh K, Jutzi JS, Wehrle J, Dierks C, Becker H, Schmitt-Graeff A, Follo M, Pfeifer D, Rohr J, Fuchs S, Ehl S, Hartl FA, Minguet S, Miething C, Heidel FH, Kröger N, Triviai I, Brummer T, Finke J, Illert AL, Ruggiero E, Bonini C, Duyster J, Pahl HL, Lane SW, Hill GR, Blazar BR, von Bubnoff N, Pearce EL, Zeiser R
  SCI TRANSL MED 2018, 10(429)
  
• Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity.
  Prigent J, Jarossay A, Planchais C, Eden C, Dufloo J, Kök A, Lorin V, Vratskikh O, Couderc T, Bruel T, Schwartz O, Seaman MS, Ohlenschläger** O, Dimitrov** JD, Mouquet** H
  Cell Rep 2018, 23(9), 2568-81 ** co-corresponding authors
  
• RBFOX2 and alternative splicing in B-cell lymphoma.
  Quentmeier H, Pommerenke C, Bernhart SH, Dirks WG, Hauer V, Hoffmann S, Nagel S, Siebert R, Uphoff CC, Zaborski M, Drexler HG, ICGC MMML-Seq Consortium
  Blood Cancer J 2018, 8(8), 77
  
• Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis.
  Ravichandran M, Priebe S, Grigolon G, Rozanov L, Groth M, Laube B, Guthke R, Platzer M, Zarse K, Ristow M
  Cell Metab 2018, 27(4), 914-25
  
• Haplotypes composed of minor frequency single nucleotide polymorphism of tnf gene protect from progression into sepsis: A study using the new sepsis classification.
  Retsas T, Huse K, Lazaridis LD, Karampela N, Bauer M, Platzer M, Kolonia V, Papageorgiou E, Giamarellos-Bourboulis EJ, Dimopoulos G
  Int J Infect Dis 2018, 67, 102-6
  
• Neuropathies in the setting of Neurofibromatosis tumor syndromes: Complexities and opportunities.
  Schulz A, Grafe P, Hagel C, Bäumer P, Morrison H, Mautner VF, Farschtschi S
  Exp Neurol 2018, 299(Pt B), 334-44
  
• Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex.
  Scior A, Buntru A, Arnsburg K, Ast A, Iburg M, Juenemann K, Pigazzini ML, Mlody B, Puchkov D, Priller J, Wanker EE, Prigione A, Kirstein J
  EMBO J 2018, 37(2), 282
  
• The role of the gut microbiome during host ageing.
  Seidel J, Valenzano DR
  F1000Res 2018, 7
  
• Aspergillus fumigatus conidial metalloprotease Mep1p cleaves host complement proteins.
  Shende R, Wong SSW, Rapole S, Beau R, Ibrahim-Granet O, Monod M, Gührs KH, Pal JK, Latgé JP, Madan T, Aimanianda V, Sahu A
  J Biol Chem 2018, 293(40), 15538-55
  
• The Definition of Open Reading Frame Revisited.
  Sieber P, Platzer M, Schuster S
  Trends Genet 2018, 34(3), 167-70
  
• A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells.
  Siegle* L, Schwab* JD, Kühlwein* SD, Lausser L, Tümpel S, Pfister AS, Kühl** M, Kestler** HA
  PLoS One 2018, 13(3), e0195126 * equal contribution, ** co-senior authors
  
• LSD1 (KDM1A)-independent effects of the LSD1 inhibitor SP2509 in cancer cells.
  Sonnemann J, Zimmermann M, Marx C, Ebert F, Becker S, Lauterjung ML, Beck JF
  Br J Haematol 2018, 183(4), 494-7
  
• The microRNA miR-21 Is a Mediator of FGF8 Action on Cortical COUP-TFI Translation.
  Terrigno M, Bertacchi M, Pandolfini L, Baumgart M, Calvello M, Cellerino A, Studer M, Cremisi F
  Stem Cell Reports 2018, 11(3), 756-69
  
• Neurofibromatosis type 2 tumor suppressor protein is expressed in oligodendrocytes and regulates cell proliferation and process formation.
  Toledo* A, Grieger* E, Karram K, Morrison H, Baader SL
  PLoS One 2018, 13(5), e0196726 * equal contribution
  
• Induction chemoradiotherapy versus induction chemotherapy for potentially resectable stage IIIA (N2) non-small cell lung cancer: a systematic review and meta-analysis.
  Tong S, Qin Z, Wan M, Zhang L, Cui Y, Yao Y
  J Thorac Dis 2018, 10(4), 2428-36
  
• Rapidly evolving changes and gene loss associated with host switching in Corynebacterium pseudotuberculosis.
  Viana MVC, Sahm A, Góes Neto A, Figueiredo HCP, Wattam AR, Azevedo V
  PLoS One 2018, 13(11), e0207304
  
• A subset of chemosensory genes differs between two populations of a specialized leaf beetle after host plant shift.
  Wang D, Pentzold S, Kunert M, Groth M, Brandt W, Pasteels JM, Boland W, Burse A
  Ecol Evol 2018, 8(16), 8055-75
  
• NUFIP1 is a ribosome receptor for starvation-induced ribophagy.
  Wyant* GA, Abu-Remaileh* M, Frenkel EM, Laqtom NN, Dharamdasani V, Lewis CA, Chan SH, Heinze I, Ori** A, Sabatini** DM
  Science 2018, 360(6390), 751-8 * equal contribution, ** co-corresponding authors
  

Publications 2017:

• Common Fibril Structures Imply Systemically Conserved Protein Misfolding Pathways In Vivo.
  Annamalai K, Liberta F, Vielberg MT, Close W, Lilie H, Gührs KH, Schierhorn A, Koehler R, Schmidt A, Haupt C, Hegenbart U, Schönland S, Schmidt M, Groll M, Fändrich M
  Angew Chem Int Ed Engl 2017, 56(26), 7510-4
  
• Mutations in NOTCH1 PEST domain orchestrate CCL19-driven homing of chronic lymphocytic leukemia cells by modulating the tumor suppressor gene DUSP22.
  Arruga F, Gizdic B, Bologna C, Cignetto S, Buonincontri R, Serra S, Vaisitti T, Gizzi K, Vitale N, Garaffo G, Mereu E, Diop F, Neri F, Incarnato D, Coscia M, Allan J, Piva R, Oliviero S, Furman RR, Rossi D, Gaidano G, Deaglio S
  Leukemia 2017, 31(9), 1882-93 published during change of institution
  
• PD-L1 up-regulation in melanoma increases disease aggressiveness and is mediated through miR-17-5p.
  Audrito V, Serra S, Stingi A, Orso F, Gaudino F, Bologna C, Neri F, Garaffo G, Nassini R, Baroni G, Rulli E, Massi D, Oliviero S, Piva R, Taverna D, Mandalà M, Deaglio S
  Oncotarget 2017, 8(9), 15894-911 published during change of institution
  
• Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma.
  Barth TFE, Kraus JM, Lausser L, Flossbach L, Schulte L, Holzmann K, Kestler** HA, Möller** P
  Sci Rep 2017, 7(1), 5963 ** co-senior authors
  
• Construction of a map-based reference genome sequence for barley, Hordeum vulgare L.
  Beier S, Himmelbach A, Colmsee C, Zhang XQ, Barrero RA, Zhang Q, Li L, Bayer M, Bolser D, Taudien S, Groth M, Felder M, Hastie A, Šimková H, Staňková H, Vrána J, Chan S, Muñoz-Amatriaín M, Ounit R, Wanamaker S, Schmutzer T, Aliyeva-Schnorr L, Grasso S, Tanskanen J, Sampath D, Heavens D, Cao S, Chapman B, Dai F, Han Y, Li H, Li X, Lin C, McCooke JK, Tan C, Wang S, Yin S, Zhou G, Poland JA, Bellgard MI, Houben A, Doležel J, Ayling S, Lonardi S, Langridge P, Muehlbauer GJ, Kersey P, Clark MD, Caccamo M, Schulman AH, Platzer M, Close TJ, Hansson M, Zhang G, Braumann I, Li C, Waugh R, Scholz U, Stein N, Mascher M
  Sci Data 2017, 4, 170044
  
• Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly.
  Bianchi FT, Tocco C, Pallavicini G, Liu Y, Vernì F, Merigliano C, Bonaccorsi S, El-Assawy N, Priano L, Gai M, Berto GE, Chiotto AMA, Sgrò F, Caramello A, Tasca L, Ala U, Neri F, Oliviero S, Mauro A, Geley S, Gatti M, Di Cunto F
  Cell Rep 2017, 18(7), 1674-86 published during change of institution
  
• Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome.
  Binder H, Hopp L, Schweiger MR, Hoffmann S, Jühling F, Kerick M, Timmermann B, Siebert S, Grimm C, Nersisyan L, Arakelyan A, Herberg M, Buske P, Loeffler-Wirth H, Rosolowski M, Engel C, Przybilla J, Peifer M, Friedrichs N, Moeslein G, Odenthal M, Hussong M, Peters S, Holzapfel S, Nattermann J, Hueneburg R, Schmiegel W, Royer-Pokora B, Aretz S, Kloth M, Kloor M, Buettner R, Galle J, Loeffler M
  J Pathol 2017
  
• Repeated intra-specific divergence in lifespan and ageing of African annual fishes along an aridity gradient.
  Blažek R, Polačik M, Kačer P, Cellerino A, Řežucha R, Methling C, Tomášek O, Syslová K, Tozzini ET, Albrecht T, Vrtílek M, Reichard M
  Evolution Int J Org Evolution 2017, 71(2), 386-402
  
• Toxic effects of zinc ions on kinesin - Potential molecular cause of impaired intracellular transport.
  Böhm KJ
  Toxicol Lett 2017, 268, 58-62
  
• DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats.
  Brocks D, Schmidt CR, Daskalakis M, Jang HS, Shah NM, Li D, Li J, Zhang B, Hou Y, Laudato S, Lipka DB, Schott J, Bierhoff H, Assenov Y, Helf M, Ressnerova A, Islam MS, Lindroth AM, Haas S, Essers M, Imbusch CD, Brors B, Oehme I, Witt O, Lübbert M, Mallm JP, Rippe K, Will R, Weichenhan D, Stoecklin G, Gerhäuser C, Oakes CC, Wang T, Plass C
  Nat Genet 2017, 49(7), 1052-60 published during change of institution
  
• Renal regenerative potential of different extra-cellular vesicle populations derived from bone marrow mesenchymal stromal cells.
  Bruno S, Tapparo M, Collino F, Chiabotto G, Deregibus MC, Soares Lindoso R, Neri F, Kholia S, Giunti S, Wen S, Quesenberry P, Camussi G
  TISSUE ENG PART A 2017, 23(21-22), 1262-73
  
• Ordinal Prototype-Based Classifiers
  Burkovski A, Schirra LR, Schmid F, Lausser L, Kestler HA
  Data Science Series A (Online-First) 2017, 2/1(http://dx.doi.org/10.5445/KS
  
• What have we learned on aging from omics studies?
  Cellerino A, Ori A
  Semin Cell Dev Biol 2017, 70, 177-89
  
• MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.
  Chen Y, Anastassiadis K, Kranz A, Stewart AF, Arndt K, Waskow C, Yokoyama A, Jones K, Neff T, Lee Y, Ernst P
  Cancer Cell 2017, 31(6), 755-770.e6
  
• New insights into the operative network of FaEO, an enone oxidoreductase from Fragaria x ananassa Duch.
  Collu G, Farci D, Esposito F, Pintus F, Kirkpatrick J, Piano D
  Plant Mol Biol 2017, 94(1-2), 125-36
  
• HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development.
  Connell M, Chen H, Jiang J, Kuan CW, Fotovati A, Chu T, He Z, Lengyell TC, Li H, Kroll T, Li AM, Goldowitz D, Frappart L, Ploubidou A, Patel M, Pilarski LM, Simpson EM, Lange P, Allan DW, Maxwell CA
  Elife 2017, 6, e28672
  
• Depletion of mitochondria in mammalian cells through enforced mitophagy.
  Correia-Melo C, Ichim G, Tait SWG, Passos JF
  Nat Protoc 2017, 12(1), 183–194
  
• Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.
  Dahms SO, Jiao** GS, Than** ME
  ACS Chem Biol 2017, 12(5), 1211-6 ** co-corresponding authors
  
• Architecture of the yeast Elongator complex.
  Dauden MI, Kosinski J, Kolaj-Robin O, Desfosses A, Ori A, Faux C, Hoffmann NA, Onuma OF, Breunig KD, Beck M, Sachse C, Séraphin B, Glatt S, Müller CW
  EMBO Rep 2017, 18(2), 264-79
  
• Gene expression reversal toward pre-adult levels in the aging human brain and age-related loss of cellular identity.
  Dönertaş HM, İzgi H, Kamacıoğlu A, He Z, Khaitovich P, Somel M
  Sci Rep 2017, 7(1), 5894
  
• Raman and Infrared Spectroscopy Distinguishing Replicative Senescent from Proliferating Primary Human Fibroblast Cells by Detecting Spectral Differences Mainly Due to Biomolecular Alterations.
  Eberhardt K, Beleites C, Marthandan S, Matthäus C, Diekmann S, Popp J
  Anal Chem 2017, 89(5), 2937-47
  
• Raman and infrared spectroscopy differentiate senescent from proliferating cells in a human dermal fibroblast 3D skin model.
  Eberhardt K, Matthäus C, Winter D, Wiegand C, Hipler UC, Diekmann S, Popp J
  Analyst 2017, 142(23), 4405-14
  
• Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models.
  Evsyukov V, Domanskyi A, Bierhoff H, Gispert S, Mustafa R, Schlaudraff F, Liss B, Parlato R
  Dis Model Mech 2017, 10(5), 633-43
  
• A new procedure for a fast soft staining of BN-PAGEs on photosynthetic complexes.
  Farci D, Kirkpatrick J, Piano D
  Electrophoresis 2017, 38(3-4), 441-6
  
• Transcriptional profiling reveals protective mechanisms in brains of long-lived mice.
  Frahm C, Srivastava A, Schmidt S, Mueller J, Groth M, Guenther M, Ji Y, Priebe S, Platzer M, Witte OW
  Neurobiol Aging 2017, 52, 23-31
  
• Evolution and antiviral specificity of interferon-induced Mx proteins of bats against Ebola-, Influenza-, and other RNA viruses.
  Fuchs J, Hölzer M, Schilling M, Patzina C, Schoen A, Hoenen T, Zimmer G, Marz M, Weber F, Müller MA, Kochs G
  J Virol 2017, 91(15), e00361-17
  
• microRNA-122 target sites in the hepatitis C virus RNA NS5B coding region and 3' untranslated region: function in replication and influence of RNA secondary structure.
  Gerresheim GK, Dünnes N, Nieder-Röhrmann A, Shalamova LA, Fricke M, Hofacker I, Höner Zu Siederdissen C, Marz M, Niepmann M
  Cell Mol Life Sci 2017, 74(4), 747-60
  
• RSK-mediated nuclear accumulation of the cold-shock Y-box protein-1 controls proliferation of T cells and T-ALL blasts.
  Gieseler-Halbach S, Meltendorf S, Pierau M, Weinert S, Heidel FH, Fischer T, Handschuh J, Braun-Dullaeus RC, Schrappe M, Lindquist JA, Mertens PR, Thomas U, Brunner-Weinzierl MC
  Cell Death Differ 2017, 24(2), 371-83
  
• Exploring Short Linear Motifs Using the ELM Database and Tools.
  Gouw M, Sámano-Sánchez H, Van Roey K, Diella F, Gibson TJ, Dinkel H
  Curr Protoc Bioinformatics 2017, 58, 8.22.1-8.22.35
  
• Combined microRNA and mRNA microfluidic TaqMan array cards for the diagnosis of malignancy of multiple types of pancreatico-biliary tumors in fine-needle aspiration material.
  Gress* TM, Lausser* L, Schirra LR, Ortmüller L, Diels R, Kong B, Michalski CW, Hackert T, Strobel O, Giese NA, Schenk M, Lawlor RT, Scarpa A, Kestler** HA, Buchholz** M
  Oncotarget 2017, 8(64), 108223-37 * equal contribution, ** co-senior authors
  
• Manipulation of cells with laser microbeam scissors and optical tweezers: a review.
  Greulich KO
  Rep Prog Phys 2017, 80(2), 026601
  
• The RNA workbench: best practices for RNA and high-throughput sequencing bioinformatics in Galaxy.
  Grüning BA, Fallmann J, Yusuf D, Will S, Erxleben A, Eggenhofer F, Houwaart T, Batut B, Videm P, Bagnacani A, Wolfien M, Lott SC, Hoogstrate Y, Hess WR, Wolkenhauer O, Hoffmann S, Akalin A, Ohler U, Stadler PF, Backofen R
  Nucleic Acids Res 2017, 45(W1), W560–W566
  
• JAK2-V617F activates β1-integrin-mediated adhesion of granulocytes to vascular cell adhesion molecule 1 (VCAM1).
  Gupta* N, Edelmann* B, Schnoeder TM, Saalfeld FC, Wolleschak D, Kliche S, Schraven B, Heidel** FH, Fischer** T
  Leukemia 2017, 31(5), 1223-6 * equal contribution, ** co-senior authors
  
• mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance.
  Haller S, Kapuria S, Riley RR, O'Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H
  Cell Stem Cell 2017, 21(6), 806-818.e5
  
• Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice.
  Hartmann K, Illing A, Leithäuser F, Baisantry A, Quintanilla-Martinez L, Rudolph KL
  Leukemia 2017, 31(12), 2853 Erratum for Leukemia 2016 volume 30 page 749
  
• Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health.
  Heid* J, Cencioni* C, Ripa* R, Baumgart* M, Atlante S, Milano G, Scopece A, Kuenne C, Guenther S, Azzimato V, Farsetti A, Rossi G, Braun T, Pompilio G, Martelli F, Zeiher AM, Cellerino** A, Gaetano** C, Spallotta** F
  Sci Rep 2017, 7(1), 16839 * equal contribution, ** co-senior authors
  
• ADAM Metalloprotease-Released Cancer Biomarkers.
  Herrlich P, Herrlich A
  Trends Cancer 2017, 3(7), 482-90
  
• Protein phosphatase 4 regulatory subunit 2 (PPP4R2) is recurrently deleted in acute myeloid leukemia and required for efficient DNA double strand break repair.
  Herzig JK, Bullinger L, Tasdogan A, Zimmermann P, Schlegel M, Teleanu V, Weber D, Rücker FG, Paschka P, Dolnik A, Schneider E, Kuchenbauer F, Heidel FH, Buske C, Döhner H, Döhner K, Gaidzik VI
  Oncotarget 2017, 8(56), 95038-53
  
• Reduced cGMP levels in CSF of AD patients correlate with severity of dementia and current depression.
  Hesse R, Lausser L, Gummert P, Schmid F, Wahler A, Schnack C, Kroker KS, Otto M, Tumani H, Kestler** HA, Rosenbrock** H, von Arnim** CAF
  Alzheimers Res Ther 2017, 9(1), 17 ** co-corresponding authors
  
• XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia.
  Hoch NC, Hanzlikova H, Rulten SL, Tétreault M, Komulainen E, Ju L, Hornyak P, Zeng Z, Gittens W, Rey SA, Staras K, Mancini GMS, McKinnon PJ, Wang ZQ, Wagner JD, Care4Rare Canada Consortium, Yoon G, Caldecott KW
  Nature 2017, 541(7635), 87-91
  
• Trifunctional lipid probes for comprehensive studies of single lipid species in living cells.
  Höglinger D, Nadler A, Haberkant P, Kirkpatrick J, Schifferer M, Stein F, Hauke S, Porter FD, Schultz C
  Proc Natl Acad Sci U S A 2017, 114(7), 1566-71
  
• Proteomic Analysis Reveals GMP Synthetase as p53 Repression Target in Liver Cancer.
  Holzer K, Drucker E, Roessler S, Dauch D, Heinzmann F, Waldburger N, Eiteneuer EM, Herpel E, Breuhahn K, Zender L, Schirmacher P, Ori A, Singer S
  Am J Pathol 2017, 187(2), 228-35
  
• Corrigendum: Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells.
  Hölzer M, Krähling V, Amman F, Barth E, Bernhart SH, Carmelo VAO, Collatz M, Doose G, Eggenhofer F, Ewald J, Fallmann J, Feldhahn LM, Fricke M, Gebauer J, Gruber AJ, Hufsky F, Indrischek H, Kanton S, Linde J, Mostajo N, Ochsenreiter R, Riege K, Rivarola-Duarte L, Sahyoun AH, Saunders SJ, Seemann SE, Tanzer A, Vogel B, Wehner S, Wolfinger MT, Backofen R, Gorodkin J, Grosse I, Hofacker I, Hoffmann S, Kaleta C, Stadler PF, Becker S, Marz M
  Sci Rep 2017, 7, 39421 Erratum for Sci Rep 2016 volume 6 page 34589
  
• Software Dedicated to Virus Sequence Analysis "Bioinformatics Goes Viral".
  Hölzer M, Marz M
  In: Advances in Virus Research (edited by Beer M, Höper D) 2017, 99, 233-257, Academic Press, London
  
• PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells.
  Hsieh MH, Chen YT, Chen YT, Lee YH, Lu J, Chien CL, Chen HF, Ho HN, Yu CJ, Wang ZQ, Teng SC
  Nucleic Acids Res 2017, 45(18), 10492-503
  
• High-throughput single-base resolution mapping of RNA 2'-O-methylated residues.
  Incarnato D, Anselmi F, Morandi E, Neri F, Maldotti M, Rapelli S, Parlato C, Basile G, Oliviero S
  Nucleic Acids Res 2017, 45(3), 1433–1441 published during change of institution
  
• Optimization of Substrate-Analogue Furin Inhibitors.
  Ivanova T, Hardes K, Kallis S, Dahms SO, Than ME, Künzel S, Böttcher-Friebertshäuser E, Lindberg I, Jiao GS, Bartenschlager R, Steinmetzer T
  ChemMedChem 2017, 12(23), 1953-68
  
• OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.
  Jung LA, Gebhardt A, Koelmel W, Ade CP, Walz S, Kuper J, von Eyss B, Letschert S, Redel C, d'Artista L, Biankin A, Zender L, Sauer M, Wolf E, Evan G, Kisker C, Eilers M
  Oncogene 2017, 36(14), 1911-24 published during change of institution
  
• Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays.
  Kaspar M, Bohn-Wippert K, Bellstedt P, Häfner S, Görlach M, Sauerbrei A
  J Virol Methods 2017, 247, 51-7
  
• In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging.
  Kirstein J, Arnsburg K, Scior A, Szlachcic A, Guilbride DL, Morimoto RI, Bukau B, Nillegoda NB
  Aging Cell 2017, 16(6), 1414
  
• Archaeogenomic analysis of the first steps of Neolithization in Anatolia and the Aegean.
  Kılınç GM, Koptekin D, Atakuman Ç, Sümer AP, Dönertaş HM, Yaka R, Bilgin CC, Büyükkarakaya AM, Baird D, Altınışık E, Flegontov P, Götherström A, Togan İ, Somel M
  Proc Biol Sci 2017, 284(1867)
  
• Differential Effects of Vitamins A and D on the Transcriptional Landscape of Human Monocytes during Infection.
  Klassert TE, Bräuer J, Hölzer M, Stock M, Riege K, Zubiría-Barrera C, Müller MM, Rummler S, Skerka C, Marz M, Slevogt H
  Sci Rep 2017, 7, 40599
  
• Developmental stage-dependent regulation of spine formation by calcium-calmodulin-dependent protein kinase IIα and Rap1.
  Koeberle SC, Tanaka S, Kuriu T, Iwasaki H, Koeberle A, Schulz A, Helbing DL, Yamagata Y, Morrison H, Okabe S
  Sci Rep 2017, 7(1), 13409
  
• Verification and characterization of an alternative low density lipoprotein receptor-related protein 1 splice variant.
  Kolb M, Kurz S, Schäfer A, Huse K, Dietz A, Wichmann G, Birkenmeier G
  PLoS One 2017, 12(6), e0180354
  
• BAT: Bisulfite Analysis Toolkit: BAT is a toolkit to analyze DNA methylation sequencing data accurately and reproducibly. It covers standard processing and analysis steps from raw read mapping up to annotation data integration and calculation of correlati
  Kretzmer H, Otto C, Hoffmann S
  F1000Res 2017, 1490
  
• Genome Sequence of a Novel Picorna-Like RNA Virus from Feces of the Antarctic Fur Seal (Arctocephalus gazella).
  Krumbholz A, Groth M, Esefeld J, Peter HU, Zell R
  Genome Announc 2017, 5(36)
  
• The anti-tumorigenic activity of A2M-A lesson from the naked mole-rat.
  Kurz S, Thieme R, Amberg R, Groth M, Jahnke HG, Pieroh P, Horn LC, Kolb M, Huse K, Platzer M, Volke D, Dehghani F, Buzdin A, Engel K, Robitzki A, Hoffmann R, Gockel I, Birkenmeier G
  PLoS One 2017, 12(12), e0189514
  
• Hacking the stem cell niche.
  Lane SW, Heidel FH
  Blood 2017, 129(22), 2951-2
  
• Ustilago maydis effectors and their impact on virulence.
  Lanver D, Tollot M, Schweizer G, Lo Presti L, Reissmann S, Ma LS, Schuster M, Tanaka S, Liang L, Ludwig N, Kahmann R
  Nat Rev Microbiol 2017, 15(7), 409-21
  
• Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging.
  Lechler MC, Crawford ED, Groh N, Widmaier K, Jung R, Kirstein J, Trinidad JC, Burlingame AL, David DC
  Cell Rep 2017, 18(2), 454
  
• Spindle Misorientation of Cerebral and Cerebellar Progenitors Is a Mechanistic Cause of Megalencephaly.
  Li H, Kroll T, Moll J, Frappart L, Herrlich P, Heuer H, Ploubidou A
  Stem Cell Reports 2017, 9(4), 1071-80
  
• The E3 ubiquitin ligase APC/C(C)(dh1) degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis.
  Liu X, Zong W, Li T, Wang Y, Xu X, Zhou** ZW, Wang** ZQ
  EMBO J 2017, 36(24), 3666-81 ** co-corresponding authors
  
• Customized workflow development and data modularization concepts for RNA-Sequencing and metatranscriptome experiments.
  Lott SC, Wolfien M, Riege K, Bagnacani A, Wolkenhauer O, Hoffmann S, Hess WR
  J Biotechnol 2017
  
• Generalized enhanced suffix array construction in external memory.
  Louza FA, Telles GP, Hoffmann S, Ciferri CDA
  Algorithms Mol Biol 2017, 12, 26
  
• Landscape of nuclear transport receptor cargo specificity.
  Mackmull MT, Klaus B, Heinze I, Chokkalingam M, Beyer A, Russell RB, Ori** A, Beck** M
  Mol Syst Biol 2017, 13(12), 962 ** co-corresponding authors, highlighted in the “Principle of Systems Biology” - Cell Systems 6 - 2018
  
• A chromosome conformation capture ordered sequence of the barley genome.
  Mascher M, Gundlach H, Himmelbach A, Beier S, Twardziok SO, Wicker T, Radchuk V, Dockter C, Hedley PE, Russell J, Bayer M, Ramsay L, Liu H, Haberer G, Zhang XQ, Zhang Q, Barrero RA, Li L, Taudien S, Groth M, Felder M, Hastie A, Šimková H, Staňková H, Vrána J, Chan S, Muñoz-Amatriaín M, Ounit R, Wanamaker S, Bolser D, Colmsee C, Schmutzer T, Aliyeva-Schnorr L, Grasso S, Tanskanen J, Chailyan A, Sampath D, Heavens D, Clissold L, Cao S, Chapman B, Dai F, Han Y, Li H, Li X, Lin C, McCooke JK, Tan C, Wang P, Wang S, Yin S, Zhou G, Poland JA, Bellgard MI, Borisjuk L, Houben A, Doležel J, Ayling S, Lonardi S, Kersey P, Langridge P, Muehlbauer GJ, Clark MD, Caccamo M, Schulman AH, Mayer KFX, Platzer M, Close TJ, Scholz U, Hansson M, Zhang G, Braumann I, Spannagl M, Li C, Waugh R, Stein N
  Nature 2017, 544(7651), 427-33
  
• A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence.
  Meyer P, Maity P, Burkovski A, Schwab J, Müssel C, Singh K, Ferreira FF, Krug L, Maier HJ, Wlaschek M, Wirth T, Kestler** HA, Scharffetter-Kochanek** K
  PLoS Comput Biol 2017, 13(12), e1005741 ** co-corresponding authors
  
• Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity.
  Mindos T, Dun XP, North K, Doddrell RDS, Schulz A, Edwards P, Russell J, Gray B, Roberts SL, Shivane A, Mortimer G, Pirie M, Zhang N, Pan D, Morrison H, Parkinson DB
  J Cell Biol 2017, 216(2), 495-510
  
• Central nervous system involvement in acute lymphoblastic leukemia is mediated by vascular endothelial growth factor.
  Münch V, Trentin L, Herzig J, Demir S, Seyfried F, Kraus JM, Kestler HA, Köhler R, Barth TFE, Te Kronnie G, Debatin KM, Meyer LH
  Blood 2017, 130(5), 643-54
  
• Intragenic DNA methylation prevents spurious transcription initiation.
  Neri F, Rapelli S, Krepelova A, Incarnato D, Parlato C, Basile G, Maldotti M, Anselmi F, Oliviero S
  Nature 2017, 543(7643), 72-7
  
• Rejuvenating Strategies for Stem Cell-Based Therapies in Aging.
  Neves J, Sousa-Victor P, Jasper H
  Cell Stem Cell 2017, 20(2), 161-75
  
• Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
  Pein* H, Koeberle* SC, Voelkel M, Schneider F, Rossi A, Thürmer M, Loeser K, Sautebin L, Morrison H, Werz O, Koeberle A
  FASEB J 2017, 31(10), 4566-77 * equal contribution
  
• The DNA Methyltransferase 1 (DNMT1) Controls the Shape and Dynamics of Migrating POA-Derived Interneurons Fated for the Murine Cerebral Cortex.
  Pensold D, Symmank J, Hahn A, Lingner T, Salinas-Riester G, Downie BR, Ludewig F, Rotzsch A, Haag N, Andreas N, Schubert K, Hübner CA, Pieler T, Zimmer G
  Cereb Cortex 2017, 27, 5696-714
  
• N-Heterocyclic (4-Phenylpiperazin-1-yl)methanones Derived from Phenoxazine and Phenothiazine as Highly Potent Inhibitors of Tubulin Polymerization.
  Prinz H, Ridder AK, Vogel K, Böhm KJ, Ivanov I, Ghasemi J, Aghaee E, Müller K:
  J Med Chem 2017, 60(2), 749-66
  
• Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.
  Ranjan S, Goihl A, Kohli S, Gadi I, Pierau M, Shahzad K, Gupta D, Bock F, Wang H, Shaikh H, Kähne T, Reinhold D, Bank U, Zenclussen AC, Niemz J, Schnöder TM, Brunner-Weinzierl M, Fischer T, Kalinski T, Schraven B, Luft T, Huehn J, Naumann M, Heidel FH, Isermann B
  Nat Commun 2017, 8(1), 311
  
• Mitochondrial BAX Determines the Predisposition to Apoptosis in Human AML.
  Reichenbach F, Wiedenmann C, Schalk E, Becker D, Funk K, Scholz-Kreisel P, Todt F, Wolleschak D, Döhner K, Marquardt** JU, Heidel** F, Edlich** F
  Clin Cancer Res 2017, 23(16), 4805-16 ** co-corresponding authors
  
• Alternative splicing of SMPD1 coding for acid sphingomyelinase in major depression.
  Rhein C, Reichel M, Kramer M, Rotter A, Lenz B, Mühle C, Gulbins E, Kornhuber J
  J Affect Disord 2017, 209, 10-5
  
• Central immune tolerance depends on crosstalk between the classical and alternative NF-κB pathways in medullary thymic epithelial cells.
  Riemann M, Andreas N, Fedoseeva M, Meier E, Weih D, Freytag H, Schmidt-Ullrich R, Klein U, Wang ZQ, Weih F
  J Autoimmun 2017, 81, 56-67
  
• MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging.
  Ripa R, Dolfi L, Terrigno M, Pandolfini L, Savino A, Arcucci V, Groth M, Terzibasi Tozzini E, Baumgart M, Cellerino A
  BMC Biol 2017, 15(1), 9
  
• Pomalidomide in myeloproliferative neoplasm-associated myelofibrosis.
  Schlenk RF, Stegelmann F, Reiter A, Jost E, Gattermann N, Hebart H, Waller C, Hochhaus A, Platzbecker U, Schafhausen P, Blau IW, Verbeek W, Heidel FH, Werner M, Kreipe H, Teleanu V, Benner A, Döhner H, Grießhammer M, Döhner K
  Leukemia 2017, 31(4), 889-95
  
• Macrophage's little helper: vitamin A directs alternatively activated monocyte-derived macrophages to tissue-resident macrophages.
  Schlüter D, Heidel FH
  Cell Mol Immunol 2017, 14(10), 805-8
  
• The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase.
  Schneble N, Müller J, Kliche S, Bauer R, Wetzker R, Böhmer FD, Wang ZQ, Müller JP
  Glia 2017, 65(2), 416-28
  
• Phosphoinositide 3-kinase γ ties chemoattractant- and adrenergic control of microglial motility.
  Schneble N, Schmidt C, Bauer R, Müller JP, Monajembashi S, Wetzker R
  Mol Cell Neurosci 2017, 78, 1-8
  
• Cell autonomous expression of CXCL-10 in JAK2V617F-mutated MPN.
  Schnöder TM, Eberhardt J, Koehler M, Bierhoff HB, Weinert S, Pandey AD, Nimmagadda SC, Wolleschak D, Jöhrens K, Fischer T, Heidel FH
  J Cancer Res Clin Oncol 2017, 143(5), 807-20
  
• Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells.
  Schreck C, Istvánffy R, Ziegenhain C, Sippenauer T, Ruf F, Henkel L, Gärtner F, Vieth B, Florian MC, Mende N, Taubenberger A, Prendergast Á, Wagner A, Pagel C, Grziwok S, Götze KS, Guck J, Dean DC, Massberg S, Essers M, Waskow C, Geiger H, Schiemann M, Peschel C, Enard W, Oostendorp RAJ
  J Exp Med 2017, 214(1), 165-81
  
• ViSiBooL - visualization and simulation of Boolean networks with temporal constraints.
  Schwab J, Burkovski A, Siegle L, Müssel** C, Kestler** HA
  Bioinformatics 2017, 33(4), 601-4 ** co-senior authors
  
• Stability of Signaling Pathways during Aging-A Boolean Network Approach.
  Schwab JD, Siegle L, Kühlwein SD, Kühl M, Kestler HA
  Biology (Basel) 2017, 6(4)
  
• An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.
  Scott RA, Scott LJ, Mägi R, Marullo L, Gaulton KJ, Kaakinen M, Pervjakova N, Pers TH, Johnson AD, Eicher JD, Jackson AU, Ferreira T, Lee Y, Ma C, Steinthorsdottir V, Thorleifsson G, Qi L, Van Zuydam NR, Mahajan A, Chen H, Almgren P, Voight BF, Grallert H, Müller-Nurasyid M, Ried JS, Rayner WN, Robertson N, Karssen LC, van Leeuwen EM, Willems SM, Fuchsberger C, Kwan P, Teslovich TM, Chanda P, Li M, Lu Y, Dina C, Thuillier D, Yengo L, Jiang L, Sparso T, Kestler HA, Chheda H, Eisele L, Gustafsson S, Frånberg M, Strawbridge RJ, Benediktsson R, Hreidarsson AB, Kong A, Sigurðsson G, Kerrison ND, Luan J, Liang L, Meitinger T, Roden M, Thorand B, Esko T, Mihailov E, Fox C, Liu CT, Rybin D, Isomaa B, Lyssenko V, Tuomi T, Couper DJ, Pankow JS, Grarup N, Have CT, Jørgensen ME, Jørgensen T, Linneberg A, Cornelis MC, van Dam RM, Hunter DJ, Kraft P, Sun Q, Edkins S, Owen KR, Perry JR, Wood AR, Zeggini E, Tajes-Fernandes J, Abecasis GR, Bonnycastle LL, Chines PS, Stringham HM, Koistinen HA, Kinnunen L, Sennblad B, Mühleisen TW, Nöthen MM, Pechlivanis S, Baldassarre D, Gertow K, Humphries SE, Tremoli E, Klopp N, Meyer J, Steinbach G, Wennauer R, Eriksson JG, Mӓnnistö S, Peltonen L, Tikkanen E, Charpentier G, Eury E, Lobbens S, Gigante B, Leander K, McLeod O, Bottinger EP, Gottesman O, Ruderfer D, Blüher M, Kovacs P, Tonjes A, Maruthur NM, Scapoli C, Erbel R, Jöckel KH, Moebus S, de Faire U, Hamsten A, Stumvoll M, Deloukas P, Donnelly PJ, Frayling TM, Hattersley AT, Ripatti S, Salomaa V, Pedersen NL, Boehm BO, Bergman RN, Collins FS, Mohlke KL, Tuomilehto J, Hansen T, Pedersen O, Barroso I, Lannfelt L, Ingelsson E, Lind L, Lindgren CM, Cauchi S, Froguel P, Loos RJ, Balkau B, Boeing H, Franks PW, Gurrea AB, Palli D, van der Schouw YT, Altshuler D, Groop LC, Langenberg C, Wareham NJ, Sijbrands E, van Duijn CM, Florez JC, Meigs JB, Boerwinkle E, Gieger C, Strauch K, Metspalu A, Morris AD, Palmer CN, Hu FB, Thorsteinsdottir U, Stefansson K, Dupuis J, Morris AP, Boehnke M, McCarthy MI, Prokopenko I, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
  Diabetes 2017, 66(11), 2888-902
  
• Regulation of life span by the gut microbiota in the short-lived African turquoise killifish.
  Smith P, Willemsen D, Popkes M, Metge F, Gandiwa E, Reichard M, Valenzano DR
  Elife 2017, 6
  
• TRE5-A retrotransposition profiling reveals putative RNA polymerase III transcription complex binding sites on the Dictyostelium extrachromosomal rDNA element.
  Spaller T, Groth M, Glöckner G, Winckler T
  PLoS One 2017, 12(4), e0175729
  
• Candidate Brocadiales dominates C, N and S cycling in anoxic groundwater of a pristine limestone-fracture aquifer.
  Starke R, Müller M, Gaspar M, Marz M, Küsel K, Totsche KU, von Bergen M, Jehmlich N
  J PROTEOMICS 2017, 152, 153-60
  
• Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development.
  Stopp S, Gründl M, Fackler M, Malkmus J, Leone M, Naumann R, Frantz S, Wolf E, von Eyss B, Engel FB, Gaubatz S
  Proc Natl Acad Sci U S A 2017, 114(30), 8029-34 published during change of institution
  
• Switch-like behavior enables Wnt11 concentration specific response during dorso-ventral axis formation in Xenopus laevis.
  Sträng JE, Schuler R, Kühl** M, Kestler** HA
  J Theor Biol 2017, 429, 82-94 ** co-senior authors
  
• Cdc45-induced loading of human RPA onto single-stranded DNA.
  Szambowska A, Tessmer I, Prus P, Schlott B, Pospiech H, Grosse F
  Nucleic Acids Res 2017, 45(6), 3217-30
  
• Lysine Acetylation and Deacetylation in Brain Development and Neuropathies.
  Tapias A, Wang ZQ
  Genomics Proteomics Bioinformatics 2017, 15(1), 19-36
  
• Variation and Functional Impact of Neanderthal Ancestry in Western Asia.
  Taskent RO, Alioglu ND, Fer E, Melike Donertas H, Somel M, Gokcumen O
  Genome Biol Evol 2017, 9(12), 3516
  
• Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis.
  Tassone B, Saoncella S, Neri F, Ala U, Brusa D, Magnuson MA, Provero P, Oliviero S, Riganti C, Calautti E
  Cell Death Differ 2017, 24(4), 731-46 published during change of institution
  
• RHEB1 insufficiency in aged male mice is associated with stress-induced seizures.
  Tian Q, Gromov P, Clement JH, Wang Y, Riemann M, Weih F, Sun XX, Dai MS, Fedorov LM
  Geroscience 2017, 39(5-6), 557-70
  
• Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation.
  Tsitsipatis D, Jayavelu AK, Müller JP, Bauer R, Schmidt-Arras D, Mahboobi S, Schnöder TM, Heidel F, Böhmer FD
  Oncotarget 2017, 8(16), 26613-24
  
• Keeping it complicated: Mitochondrial genome plasticity across diplonemids.
  Valach M, Moreira S, Hoffmann S, Stadler PF, Burger G
  Sci Rep 2017, 7(1), 14166
  
• Non-canonical aging model systems and why we need them.
  Valenzano DR, Aboobaker A, Seluanov A, Gorbunova V
  EMBO J 2017, 36(8), 959-63
  
• The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels.
  Valkova C, Liebmann L, Krämer A, Hübner CA, Kaether C
  Sci Rep 2017, 7, 41248
  
• NMR spectroscopic studies of a TAT-derived model peptide in imidazolium-based ILs: influence on chemical shifts and the cis/trans equilibrium state.
  Wiedemann C, Ohlenschläger O, Mrestani-Klaus C, Bordusa F
  Phys Chem Chem Phys 2017, 19(35), 24115-25
  
• Synthesis and Evaluation of Amyloid β Derived and Amyloid β Independent Enhancers of the Peroxidase-like Activity of Heme.
  Wißbrock A, Kühl T, Silbermann K, Becker AJ, Ohlenschläger** O, Imhof** D
  J Med Chem 2017, 60(1), 373-85 ** co-corresponding authors
  
• A Stably Protonated Adenine Nucleotide with a Highly Shifted pKa Value Stabilizes the Tertiary Structure of a GTP-Binding RNA Aptamer.
  Wolter AC, Weickhmann AK, Nasiri AH, Hantke K, Ohlenschläger O, Wunderlich CH, Kreutz C, Duchardt-Ferner E, Wöhnert J
  Angew Chem Int Ed Engl 2017, 56(1), 401-4
  
• Nucleosome Positioning Assay
  Zhao Z, Bierhoff H
  Bio-protocol 2017, 7(10), e2285
  

Publications 2016:

• Differential sensitivity of lipegfilgrastim and pegfilgrastim to neutrophil elastase correlates with differences in clinical pharmacokinetic profile.
  Abdolzade-Bavil A, von Kerczek A, Cooksey BA, Kaufman T, Krasney PA, Pukac L, Görlach M, Lammerich A, Scheckermann C, Allgaier H, Shen WD, Liu PM
  J Clin Pharmacol 2016, 56(2), 186-94
  
• Polymorphism of Amyloid Fibrils In Vivo.
  Annamalai K, Gührs KH, Koehler R, Schmidt M, Michel H, Loos C, Gaffney PM, Sigurdson CJ, Hegenbart U, Schönland S, Fändrich M
  Angew Chem Int Ed Engl 2016, 55(15), 4822-5
  
• Impact of FLT3-ITD location on sensitivity to TKI-therapy in vitro and in vivo.
  Arreba-Tutusaus P, Mack TS, Bullinger L, Schnöder TM, Polanetzki A, Weinert S, Ballaschk A, Wang Z, Deshpande AJ, Armstrong SA, Döhner K, Fischer T, Heidel FH
  Leukemia 2016, 30(5), 1220-5
  
• Multiplex sequencing of bacterial artificial chromosomes for assembling complex plant genomes.
  Beier S, Himmelbach A, Schmutzer T, Felder M, Taudien S, Mayer KFX, Platzer M, Stein N, Scholz U, Mascher M
  Plant Biotechnol J 2016, 14(7), 1511-22
  
• Changes of bivalent chromatin coincide with increased expression of developmental genes in cancer.
  Bernhart SH, Kretzmer H, Holdt LM, Jühling F, Ammerpohl O, Bergmann AK, Northoff BH, Doose G, Siebert R, Stadler PF, Hoffmann S
  Sci Rep 2016, 6, 37393
  
• Blood stem cells: from beginning to end.
  Bigas A, Waskow C
  Development 2016, 143(19), 3429-33
  
• From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology.
  Cellerino A, Valenzano DR, Reichard M
  Biol Rev Camb Philos Soc 2016, 91(2), 511-33
  
• Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing.
  Chandel NS, Jasper H, Ho TT, Passegué E
  Nat Cell Biol 2016, 18(8), 823-32
  
• Powering senescence: The ugly side of mitochondria.
  Correia-Melo C, Birch J, Passos JF
  Cell Cycle 2016, 15(19), 2541
  
• Mitochondria are required for pro-ageing features of the senescent phenotype.
  Correia-Melo C, Marques FDM, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SWG, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF
  EMBO J 2016, 35(7), 724
  
• Demystifying the role of mitochondria in senescence.
  Correia-Melo C, Passos JF
  Mol Cell Oncol 2016, 3(4), e1162896
  
• Discovering miRNA regulatory networks in Holt-Oram Syndrome using a Zebrafish model
  D'Aurizio R, Russo F, Chiavacci E, Baumgart M, Groth M, D'Onofrio M, Arisi I, Rainaldi G, Pitto L, Pellegrini M
  Front. Bioeng. Biotechnol. 2016, 4, Article 60
  
• Boolean modeling identifies greatwall/MASTL as an important regulator in the AURKA network of neuroblastoma.
  Dahlhaus M, Burkovski A, Hertwig F, Mussel C, Volland R, Fischer M, Debatin KM, Kestler** HA, Beltinger** C
  Cancer Lett 2016, 371(1), 79-89 ** co-corresponding authors
  
• The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.
  Dahms SO, Creemers JWM, Schaub Y, Bourenkov GP, Zögg T, Brandstetter H, Than ME
  Sci Rep 2016, 6, 34303.doi:10.1038/srep303
  
• Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
  Dahms* SO, Arciniega* M, Steinmetzer T, Huber** R, Than** ME
  Proc Natl Acad Sci U S A 2016, 113(40), 11196-201 * equal contribution, ** co-corresponding authors
  
• The role of hypothalamic NF-κB signaling in the response of the HPT-axis to acute inflammation in female mice.
  de Vries EM, Nagel S, Haenold R, Sundaram SM, Pfrieger FW, Fliers E, Heuer H, Boelen A
  Endocrinology 2016, 157(7), 2947-56
  
• Analysis of cultivable microbiota and diet intake pattern of the long-lived naked mole-rat.
  Debebe T, Holtze S, Morhart M, Hildebrandt TB, Rodewald S, Huse K, Platzer M, Wyohannes D, Yirga S, Lemma A, Thieme R, König B, Birkenmeier G
  Gut Pathog 2016, 8, 25
  
• Ethyl Pyruvate: An Anti-Microbial Agent that Selectively Targets Pathobionts and Biofilms.
  Debebe T, Krüger M, Huse K, Kacza J, Mühlberg K, König B, Birkenmeier G
  PLoS One 2016, 11(9), e0162919
  
• Sexual Dimorphism: How Female Cells Win the Race.
  Deng H, Jasper H
  Curr Biol 2016, 26(5), R212-5
  
• Characterising Complex Enzyme Reaction Data.
  Dönertaş* HM, Martínez Cuesta* S, Rahman SA, Thornton JM
  PLoS One 2016, 11(2), e0147952 * equal contribution
  
• Reply to Hart et al.: MINCR and MYC: More than expression correlation.
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• Wnt/β-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers.
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• Characteristics and treatment of polycythemia vera patients in clinical practice: a multicenter chart review on 1476 individuals in Germany.
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• A homolog of Blade-On-Petiole 1 and 2 (BOP1/2) controls internode length and homeotic changes of the barley inflorescence.
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• metilene: fast and sensitive calling of differentially methylated regions from bisulfite sequencing data.
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• PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways.
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• Analysis of an echovirus 18 outbreak in Thuringia, Germany: insights into the molecular epidemiology and evolution of several enterovirus species B members.
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• Gastrointestinal stem cells in health and disease: from flies to humans.
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• Intestinal IRE1 Is Required for Increased Triglyceride Metabolism and Longer Lifespan under Dietary Restriction.
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• Olfactory phenotypic expression unveils human aging.
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  Tepper S, Jeschke J, Böttcher K, Schmidt A, Davari K, Müller P, Kremmer E, Hemmerich P, Pfeil I, Jungnickel B
  Oncotarget 2016, 7(11), 13197-208
  
• Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6.
  Uras IZ, Walter GJ, Scheicher R, Bellutti F, Prchal-Murphy M, Tigan AS, Valent P, Heidel FH, Kubicek S, Scholl C, Fröhling S, Sexl V
  Blood 2016, 127(23), 2890-902
  
• Stress promotes Arabidopsis - Piriformospora indica interaction.
  Vahabi K, Dorcheh SK, Monajembashi S, Westermann M, Reichelt M, Falkenberg D, Hemmerich P, Sherameti I, Oelmüller R
  Plant Signal Behav 2016, 11(5), e1136763
  
• NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions.
  Vlantis K, Wullaert A, Polykratis A, Kondylis V, Dannappel M, Schwarzer R, Welz P, Corona T, Walczak H, Weih F, Klein U, Kelliher M, Pasparakis M
  Immunity 2016, 44(3), 553-67
  
• TraqBio - Flexible Progress Tracking for Core Unit Projects.
  Völkel G, Wiese S, Holzmann K, Kraus JM, Schneider F, Görlach M, Kestler HA
  PLoS One 2016, 11(9), e0162857
  
• Characterization of SKAP/Kinastrin isoforms - The N-terminus defines tissue specificity and Pontin binding.
  Vranesic AC, Reiche J, Hoischen C, Wohlmann A, Bratsch J, Friedrich K, Günes B, Cappallo-Obermann H, Kirchhoff C, Diekmann S, Günes C, Huber O
  Hum Mol Genet 2016, 25(13), 2838-52
  
• SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling.
  Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Wu Y, Rudolph KL, Liu G, Li T, Ju Z
  Cell Stem Cell 2016, 18(4), 495-507
  
• A Set of Efficient nD NMR Protocols for Resonance Assignments of Intrinsically Disordered Proteins.
  Wiedemann C, Bellstedt P, Häfner S, Herbst C, Bordusa F, Görlach M, Ohlenschläger O, Ramachandran R
  Chemphyschem 2016, 17(13), 1961-8
  
• Analysis of Large and Complex Data
  Wilhelm AFX, Kestler HA (eds)
  Book series: Studies in Classification, Data Analysis, and Knowledge Organization 2016, Springer International Publishin
  
• The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke.
  Winek K, Dirnagl U, Meisel A
  Neurotherapeutics 2016, 13(4), 762-74
  
• Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke.
  Winek K, Engel O, Koduah P, Heimesaat MM, Fischer A, Bereswill S, Dames C, Kershaw O, Gruber AD, Curato C, Oyama N, Meisel C, Meisel A, Dirnagl U
  Stroke 2016, 47(5), 1354-63
  
• Gut microbiota impact on stroke outcome: Fad or fact?
  Winek K, Meisel A, Dirnagl U
  J Cereb Blood Flow Metab 2016, 36(5), 891-8
  
• Cellular apoptosis susceptibility (CAS) is linked to integrin β1 and required for tumor cell migration and invasion in hepatocellular carcinoma (HCC).
  Winkler J, Roessler S, Sticht C, DiGuilio AL, Drucker E, Holzer K, Eiteneuer E, Herpel E, Breuhahn K, Gretz N, Schirmacher P, Ori A, Singer S
  Oncotarget 2016, 7(16), 22883-92
  
• Finding approximate gene clusters with Gecko 3.
  Winter S, Jahn K, Wehner S, Kuchenbecker L, Marz M, Stoye J, Böcker S
  Nucleic Acids Res 2016, 44(20), 9600-10
  
• Chronic myelogenous leukemia evolving after treatment of multiple myeloma.
  Wolleschak D, Heidel FH
  Blood 2016, 128(1), 146
  
• Attenuated LKB1-SIK1 signaling promotes epithelial-mesenchymal transition and radioresistance of non-small cell lung cancer cells.
  Yao YH, Cui Y, Qiu XN, Zhang LZ, Zhang W, Li H, Yu JM
  Chin J Cancer 2016, 35(1), 50
  
• Inhibition of cargo export at ER-exit sites and the trans-Golgi network by the secretion inhibitor FLI-06.
  Yonemura Y, Li X, Müller K, Krämer A, Atigbire P, Mentrup T, Feuerhake T, Kroll T, Shomron O, Nohl R, Arndt HD, Hoischen C, Hemmerich P, Hirschberg K, Kaether C
  J Cell Sci 2016, 129(20), 3868-77
  
• Age-Dependent Changes of Monocarboxylate Transporter 8 Availability in the Postnatal Murine Retina
  Yoshiyuki H, Szafranski K
  Front Cell Neurosci 2016, http://dx.doi.org/10.3389/fncel.
  
• lncRNA-Induced Nucleosome Repositioning Reinforces Transcriptional Repression of rRNA Genes upon Hypotonic Stress.
  Zhao Z, Dammert MA, Grummt I, Bierhoff H
  Cell Rep 2016, 14(8), 1876-82
  
• Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning.
  Zhao Z, Dammert MA, Hoppe S, Bierhoff H, Grummt I
  Nucleic Acids Res 2016, 44(17), 8144-52
  

Publications 2015:

• Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer.
  Adams* PD, Jasper* H, Rudolph* KL
  Cell Stem Cell 2015, 16(6), 601-12 ** co-corresponding authors
  
• Amyloid domains in the cell nucleus controlled by nucleoskeletal protein lamin B1 reveal a new pathway of mercury neurotoxicity.
  Arnhold F, Gührs KH, von Mikecz A
  PeerJ 2015, 3, e754
  
• Stem Cells and Aging: What’s Next?
  Artandi SE, Blau HM, de Haan G, Geiger H, Goodell MA, Jones L, Levine RL, Munoz-Canoves P, Rodewald HR, Wagers A, Wang ZQ, Yamashita Y
  Cell Stem Cell 2015, 16, 578-81
  
• Haemocytes control stem cell activity in the Drosophila intestine.
  Ayyaz A, Li H, Jasper H
  Nat Cell Biol 2015, 17(6), 736-48
  
• Differential Regulation of MicroRNAs in End-Stage Failing Hearts Is Associated with Left Ventricular Assist Device Unloading.
  Barsanti C, Trivella MG, D'Aurizio R, El Baroudi M, Baumgart M, Groth M, Caruso R, Verde A, Botta L, Cozzi L, Pitto L
  Biomed Res Int 2015, 2015, 592512
  
• Comparison of captive lifespan, age-associated liver neoplasias and age-dependent gene expression between two annual fish species: Nothobranchius furzeri and Nothobranchius korthause.
  Baumgart M, Di Cicco E, Rossi G, Cellerino A, Tozzini ET
  Biogerontology 2015, 16(1), 63-9
  
• DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease.
  Birch J, Anderson RK, Correia-Melo C, Jurk D, Hewitt G, Marques FM, Green NJ, Moisey E, Birrell MA, Belvisi MG, Black F, Taylor JJ, Fisher AJ, De Soyza A, Passos JF
  Am J Physiol Lung Cell Mol Physiol 2015, 309(10), L1124
  
• Elevated copper ion levels as potential cause of impaired kinesin-dependent transport processes.
  Böhm KJ
  Arch Toxicol 2015, 89(4), 565-72
  
• Aluminium-induced kinesin inactivation as potential molecular cause of impairment of neuronal transport processes.
  Böhm KJ, Shabanpour M, Kalchishkova N
  Chem Res Toxicol 2015, 28(6), 1275-81
  
• A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis.
  Buch S, Stickel F, Trépo E, Way M, Herrmann A, Nischalke HD, Brosch M, Rosendahl J, Berg T, Ridinger M, Rietschel M, McQuillin A, Frank J, Kiefer F, Schreiber S, Lieb W, Soyka M, Semmo N, Aigner E, Datz C, Schmelz R, Brückner S, Zeissig S, Stephan AM, Wodarz N, Devière J, Clumeck N, Sarrazin C, Lammert F, Gustot T, Deltenre P, Völzke H, Lerch MM, Mayerle J, Eyer F, Schafmayer C, Cichon S, Nöthen MM, Nothnagel M, Ellinghaus D, Huse K, Franke A, Zopf S, Hellerbrand C, Moreno C, Franchimont D, Morgan MY, Hampe J
  Nat Genet 2015, 47(12), 1443-8
  
• Phenotypic regulation of the sphingosine 1-phosphate receptor Miles Apart by GRK2.
  Burczyk MS, Burkhalter MD, Blätte T, Matysik S, Caron MG, Barak LS, Philipp M
  Biochemistry 2015, 54(3), 765-75
  
• Genome instability of ageing stem cells-Induction and defence mechanisms.
  Burkhalter MD, Rudolph KL, Sperka T
  Ageing Res Rev 2015, 23(Pt A), 29-36
  
• Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupying an essential rRNA-binding site.
  Calviño FR, Kharde S, Ori A, Hendricks A, Wild K, Kressler D, Bange G, Hurt E, Beck M, Sinning I
  Nat Commun 2015, 6, 6510
  
• Annual fishes of the genus Nothobranchius as an experimental model. p.93-99 in Annual Fishes
  Cellerino A
  In: Annual Fishes, Life History Strategy, Diversity and Evolution. (edited by Beiros N, García G, de Sá R) 2015, 93-99, CRC Press Taylor and Fran
  
• Editorial for "Regulatory RNAs in the nervous system".
  Cellerino A, Bally-Cuif L, Pizzorusso T
  Front Cell Neurosci 2015, 9, 38
  
• MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome.
  Chiavacci E, D'Aurizio R, Guzzolino E, Russo F, Baumgart M, Groth M, Mariani L, D'Onofrio M, Arisi I, Pellegrini M, Cellerino A, Cremisi F, Pitto L
  Sci Rep 2015, 5, 18240
  
• AKI Recovery Induced by Mesenchymal Stromal Cell-Derived Extracellular Vesicles Carrying MicroRNAs.
  Collino F, Bruno S, Incarnato D, Dettori D, Neri F, Provero P, Pomatto M, Oliviero S, Tetta C, Quesenberry PJ, Camussi G
  J Am Soc Nephrol 2015, 26(10), 2349-60
  
• Mitochondria: Are they causal players in cellular senescence?
  Correia-Melo C, Passos JF
  Biochim Biophys Acta 2015, 1847(11), 1373
  
• Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes.
  Dahms SO, Mayer MC, Roeser D, Multhaup G, Than ME
  Acta Crystallogr D Biol Crystallogr 2015, 71(Pt 3), 494-504
  
• Signal integration by Ca(2+) regulates intestinal stem-cell activity.
  Deng H, Gerencser AA, Jasper H
  Nature 2015, 528(7581), 212-7
  
• Mutants of Metal Binding Site M1 in APP E2 Show Metal Specific Differences in Binding of Heparin but Not of sorLA.
  Dienemann C, Coburger I, Mehmedbasic A, Andersen OM, Than ME
  Biochemistry 2015, 54(15), 2490-9
  
• MicroRNAs provide the first evidence of genetic link between diapause and aging in vertebrates
  Dolfi* L, Baumgart* M, Groth M, Platzer M, Cellerino A
  bioRxiv 2015, https://doi.org/10.1101/017848 * equal contribution
  
• MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells.
  Doose G, Haake A, Bernhart SH, López C, Duggimpudi S, Wojciech F, Bergmann AK, Borkhardt A, Burkhardt B, Claviez A, Dimitrova L, Haas S, Hoell JI, Hummel M, Karsch D, Klapper W, Kleo K, Kretzmer H, Kreuz M, Küppers R, Lawerenz C, Lenze D, Loeffler M, Mantovani-Löffler L, Möller P, Ott G, Richter J, Rohde M, Rosenstiel P, Rosenwald A, Schilhabel M, Schneider M, Scholz I, Stilgenbauer S, Stunnenberg HG, Szczepanowski M, Trümper L, Weniger MA, ICGC MMML-Seq Consortium, Hoffmann S, Siebert R, Iaccarino I
  Proc Natl Acad Sci U S A 2015, 112(38), E5261-70
  
• Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division.
  Dumont NA, Wang YX, von Maltzahn J, Pasut A, Bentzinger CF, Brun CE, Rudnicki MA
  Nat Med 2015, 21(12), 1455-63
  
• SPLIFF: A Single-Cell Method to Map Protein-Protein Interactions in Time and Space.
  Dünkler A, Rösler R, Kestler HA, Moreno-Andrés D, Johnsson N
  Methods Mol Biol 2015, 1346, 151-68 published during change of institution
  
• The butterfly plant arms-race escalated by gene and genome duplications.
  Edger PP, Heidel-Fischer HM, Bekaert M, Rota J, Glöckner G, Platts AE, Heckel DG, Der JP, Wafula EK, Tang M, Hofberger JA, Smithson A, Hall JC, Blanchette M, Bureau TE, Wright SI, dePamphilis CW, Schranz ME, Barker MS, Conant GC, Wahlberg N, Vogel H, Pires JC, Wheat CW
  Proc Natl Acad Sci U S A 2015, 112(27), 8362-6
  
• Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke.
  Engel O, Akyüz L, da Costa Goncalves AC, Winek K, Dames C, Thielke M, Herold S, Böttcher C, Priller J, Volk HD, Dirnagl U, Meisel C, Meisel A
  Stroke 2015, 46(11), 3232-40
  
• Quality control mechanisms in cellular and systemic DNA damage responses.
  Ermolaeva** MA, Dakhovnik A, Schumacher** B
  Ageing Res Rev 2015, 23(Pt A), 3-11 ** co-corresponding authors
  
• Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization.
  Eschbach J, von Einem B, Müller K, Bayer H, Scheffold A, Morrison BE, Rudolph KL, Thal DR, Witting A, Weydt P, Otto M, Fauler M, Liss B, McLean PJ, Spada ARL, Ludolph AC, Weishaupt JH, Danzer KM
  Ann Neurol 2015, 77(1), 15-32
  
• Telomeres and Stem Cell Aging
  Felix DA
  In: Adult Stem Cells in Aging, Diseases and Cancer (edited by Rudolph KL), Else Kröner-Fresenius Symposia 2015, 5, 69-73, Karger Verlag, Basel
  
• Stem Cells in Adult Intestine
  Feng J, Sperka T
  In: Adult Stem Cells in Aging, Diseases and Cancer (edited by Rudolph KL), Else Kröner-Fresenius Symposia 2015, 5, 18-24, Karger Verlag, Basel
  
• Engineering a Constrained Peptidic Scaffold towards Potent and Selective Furin Inhibitors.
  Fittler H, Depp A, Avrutina O, Dahms SO, Than ME, Empting M, Kolmar H
  Chembiochem 2015, 16(17), 2441-4
  
• VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice with Colitis.
  Foersch S, Sperka T, Lindner C, Taut A, Rudolph KL, Breier G, Boxberger F, Rau TT, Hartmann A, Stürzl M, Wittkopf N, Haep L, Wirtz S, Neurath MF, Waldner MJ
  Gastroenterology 2015, 149(1), 177-89
  
• Conserved RNA secondary structures and long-range interactions in hepatitis C viruses.
  Fricke M, Dünnes N, Zayas M, Bartenschlager R, Niepmann M, Marz M
  RNA 2015, 21(7), 1219-32
  
• Extended pairwise local alignment of wild card DNA/RNA sequences using dynamic programming
  Fürstenberg A, Maucher M, Kestler HA
  J Stat Comput Sim 2015, 85(1), 3-13 published during change of institution
  
• Structural basis for assembly and function of the Nup82 complex in the nuclear pore scaffold.
  Gaik M, Flemming D, von Appen A, Kastritis P, Mücke N, Fischer J, Stelter P, Ori A, Bui KH, Baßler J, Barbar E, Beck M, Hurt E
  J Cell Biol 2015, 208(3), 283-97
  
• Snai1 represses Nanog to promote embryonic stem cell differentiation.
  Galvagni F, Neri F
  Genom Data 2015, 4, 82-3
  
• Snai1 promotes ESC exit from the pluripotency by direct repression of self-renewal genes.
  Galvagni* F, Lentucci* C, Neri* F, Dettori D, De Clemente C, Orlandini M, Anselmi F, Rapelli S, Grillo M, Borghi S, Oliviero S
  Stem Cells 2015, 33(3), 742-50 * equal contribution
  
• Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
  Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, William Rayner N, Robertson N, Scott RA, Prokopenko I, Scott LJ, Green T, Sparso T, Thuillier D, Yengo L, Grallert H, Wahl S, Frånberg M, Strawbridge RJ, Kestler H, Chheda H, Eisele L, Gustafsson S, Steinthorsdottir V, Thorleifsson G, Qi L, Karssen LC, van Leeuwen EM, Willems SM, Li M, Chen H, Fuchsberger C, Kwan P, Ma C, Linderman M, Lu Y, Thomsen SK, Rundle JK, Beer NL, van de Bunt M, Chalisey A, Kang HM, Voight BF, Abecasis GR, Almgren P, Baldassarre D, Balkau B, Benediktsson R, Blüher M, Boeing H, Bonnycastle LL, Bottinger EP, Burtt NP, Carey J, Charpentier G, Chines PS, Cornelis MC, Couper DJ, Crenshaw AT, van Dam RM, Doney ASF, Dorkhan M, Edkins S, Eriksson JG, Esko T, Eury E, Fadista J, Flannick J, Fontanillas P, Fox C, Franks PW, Gertow K, Gieger C, Gigante B, Gottesman O, Grant GB, Grarup N, Groves CJ, Hassinen M, Have CT, Herder C, Holmen OL, Hreidarsson AB, Humphries SE, Hunter DJ, Jackson AU, Jonsson A, Jørgensen ME, Jørgensen T, Kao WHL, Kerrison ND, Kinnunen L, Klopp N, Kong A, Kovacs P, Kraft P, Kravic J, Langford C, Leander K, Liang L, Lichtner P, Lindgren CM, Lindholm E, Linneberg A, Liu CT, Lobbens S, Luan J, Lyssenko V, Männistö S, McLeod O, Meyer J, Mihailov E, Mirza G, Mühleisen TW, Müller-Nurasyid M, Navarro C, Nöthen MM, Oskolkov NN, Owen KR, Palli D, Pechlivanis S, Peltonen L, Perry JRB, Platou CGP, Roden M, Ruderfer D, Rybin D, van der Schouw YT, Sennblad B, Sigurðsson G, Stančáková A, Steinbach G, Storm P, Strauch K, Stringham HM, Sun Q, Thorand B, Tikkanen E, Tonjes A, Trakalo J, Tremoli E, Tuomi T, Wennauer R, Wiltshire S, Wood AR, Zeggini E, Dunham I, Birney E, Pasquali L, Ferrer J, Loos RJF, Dupuis J, Florez JC, Boerwinkle E, Pankow JS, van Duijn C, Sijbrands E, Meigs JB, Hu FB, Thorsteinsdottir U, Stefansson K, Lakka TA, Rauramaa R, Stumvoll M, Pedersen NL, Lind L, Keinanen-Kiukaanniemi SM, Korpi-Hyövälti E, Saaristo TE, Saltevo J, Kuusisto J, Laakso M, Metspalu A, Erbel R, Jöcke KH, Moebus S, Ripatti S, Salomaa V, Ingelsson E, Boehm BO, Bergman RN, Collins FS, Mohlke KL, Koistinen H, Tuomilehto J, Hveem K, Njølstad I, Deloukas P, Donnelly PJ, Frayling TM, Hattersley AT, de Faire U, Hamsten A, Illig T, Peters A, Cauchi S, Sladek R, Froguel P, Hansen T, Pedersen O, Morris AD, Palmer CNA, Kathiresan S, Melander O, Nilsson PM, Groop LC, Barroso I, Langenberg C, Wareham NJ, O'Callaghan CA, Gloyn AL, Altshuler D, Boehnke M, Teslovich TM, McCarthy MI, Morris AP, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
  Nat Genet 2015, 47(12), 1415-25
  
• Grundlagen der Durchflusszytometrie
  Gompf A
  In: Zelluläre Diagnostik und Therapie (edited by Sack U) 2015, 1-28, Walter de Gruyter GmbH, Be
  
• Predicting Variabilities in Cardiac Gene Expression with a Boolean Network Incorporating Uncertainty.
  Grieb M, Burkovski A, Sträng JE, Kraus JM, Groß A, Palm G, Kühl M, Kestler HA
  PLoS One 2015, 10(7), e0131832
  
• Novel Furin Inhibitors with Potent Anti-infectious Activity.
  Hardes K, Becker GL, Lu Y, Dahms SO, Köhler S, Beyer W, Sandvig K, Yamamoto H, Lindberg I, Walz L, von Messling V, Than ME, Garten W, Steinmetzer T
  ChemMedChem 2015, 10(7), 1218-31
  
• A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.
  Harel I, Benayoun BA, Machado B, Singh PP, Hu CK, Pech MF, Valenzano DR, Zhang E, Sharp SC, Artandi SE, Brunet A
  Cell 2015, 160(5), 1013-26
  
• Core cross-linked nanogels based on the self-assembly of double hydrophilic poly(2-oxazoline) block copolymers
  Hartlieb M, Pretzel D, Wagner M, Hoeppener S, Bellstedt P, Görlach M, Englert C, Kempe K, Schubert US
  J Mater Chem B 2015, 3, 1748-59
  
• Plasma N-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome.
  Hartmann D, von Figura G, Song Z, Harden S, Scott LC, Evans TJ, Rudolph KL, Bilsland AE, Keith WN
  Future Oncol 2015, 11(2), 193-203
  
• Evolutionarily conserved signaling pathways: acting in the shadows of acute myelogenous leukemia's genetic diversity.
  Heidel FH, Arreba-Tutusaus P, Armstrong SA, Fischer T
  Clin Cancer Res 2015, 21(2), 240-8
  
• Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response.
  Hein K, Mittler G, Cizelsky W, Kühl M, Ferrante F, Liefke R, Berger IM, Just S, Sträng JE, Kestler HA, Oswald F, Borggrefe T
  Sci Signal 2015, 8(369), ra30
  
• A simple data-adaptive probabilistic variant calling model.
  Hoffmann S, Stadler PF, Strimmer K
  Algorithms Mol Biol 2015, 10, 10
  
• High-throughput whole-genome sequencing of E14 mouse embryonic stem cells.
  Incarnato D, Neri F
  Genom Data 2015, 3, 6-7
  
• Exploring the physiology and pathology of aging in the intestine of Drosophila melanogaster.
  Jasper H
  Invertebr Reprod Dev 2015, 59(sup1), 51-8
  
• Proceedings of Reisensburg 2013 (Foreword).
  Kestler HA, Schmid M
  J Stat Comput Sim 2015, 85(1), 1-2
  
• Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments.
  Kirstein** J, Morito D, Kakihana T, Sugihara M, Minnen A, Hipp MS, Nussbaum-Krammer C, Kasturi P, Hartl** FU, Nagata** K, Morimoto** RI
  EMBO J 2015, 34(18), 2334 ** co-corresponding authors
  
• Polyketide synthesis genes associated with toxin production in two species of Gambierdiscus (Dinophyceae).
  Kohli GS, John U, Figueroa RI, Rhodes LL, Harwood DT, Groth M, Bolch CJS, Murray SA
  BMC Genomics 2015, 16, 410
  
• NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis.
  Kondylis V, Polykratis A, Ehlken H, Ochoa-Callejero L, Straub BK, Krishna-Subramanian S, Van TM, Curth HM, Heise N, Weih F, Klein U, Schirmacher P, Kelliher M, Pasparakis M
  Cancer Cell 2015, 28(5), 582-98
  
• Xlink Analyzer: software for analysis and visualization of cross-linking data in the context of three-dimensional structures.
  Kosinski J, von Appen A, Ori A, Karius K, Müller CW, Beck M
  J Struct Biol 2015, 189(3), 177-83
  
• Alternative Splicing of SMPD1 in Human Sepsis.
  Kramer M, Quickert S, Sponholz C, Menzel U, Huse K, Platzer M, Bauer M, Claus RA
  PLoS One 2015, 10(4), e0124503
  
• Exhaustive k-nearest-neighbour subspace clustering
  Krause JM, Lausser L, Kestler HA
  J Stat Comput Sim 2015, 85(1), 30–46 published during change of institution
  
• DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control.
  Kretzmer H, Bernhart SH, Wang W, Haake A, Weniger MA, Bergmann AK, Betts MJ, Carrillo-de-Santa-Pau E, Doose G, Gutwein J, Richter J, Hovestadt V, Huang B, Rico D, Jühling F, Kolarova J, Lu Q, Otto C, Wagener R, Arnolds J, Burkhardt B, Claviez A, Drexler HG, Eberth S, Eils R, Flicek P, Haas S, Humme M, Karsch D, Kerstens HHD, Klapper W, Kreuz M, Lawerenz C, Lenzek D, Loeffler M, López C, MacLeod RAF, Martens JHA, Kulis M, Martín-Subero JI, Möller P, Nage I, Picelli S, Vater I, Rohde M, Rosenstiel P, Rosolowski M, Russell RB, Schilhabel M, Schlesner M, Stadler PF, Szczepanowski M, Trümper L, Stunnenberg HG, Küppers R, Ammerpohl O, Lichter P, Siebert R, Hoffmann S, Radlwimmer B
  Nat Genet 2015, 47(11), 1316-25
  
• Survival of primary, but not of cancer cells after combined Plk1-HDAC inhibition.
  Lange L, Hemmerich P, Spänkuch B
  Oncotarget 2015, 6(28), 25801-14
  
• Defining the transcriptomic landscape of Candida glabrata by RNA-Seq.
  Linde J, Duggan S, Weber M, Horn F, Sieber P, Hellwig D, Riege K, Marz M, Martin R, Guthke R, Kurzai O
  Nucleic Acids Res 2015, 43(3), 1392-406
  
• Genomic and epigenomic co-evolution in follicular lymphomas.
  Loeffler M, Kreuz M, Haake A, Hasenclever D, Trautmann H, Arnold C, Winter K, Koch K, Klapper W, Scholtysik R, Rosolowski M, Hoffmann S, Ammerpohl O, Szczepanowski M, Herrmann D, Küppers R, Pott C, Siebert R, HaematoSys-Project
  Leukemia 2015, 29(2), 456-63
  
• Interventions to Slow Aging in Humans: Are We Ready?
  Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L
  Aging Cell 2015, 14(4), 497-510
  
• Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells.
  Lu Y, Hardes K, Dahms SO, Böttcher-Friebertshäuser E, Steinmetzer T, Than ME, Klenk HD, Garten W
  Antiviral Res 2015, 120, 89-100
  
• Histone Deacetylase Inhibitors (HDACi) Cause the Selective Depletion of Bromodomain Containing Proteins (BCPs).
  Mackmull MT, Iskar M, Parca L, Singer S, Bork P, Ori** A, Beck** M
  Mol Cell Proteomics 2015, 14(5), 1350-60 ** co-corresponding authors
  
• Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.
  Madhusudhan T, Wang H, Dong W, Ghosh S, Bock F, Thangapandi VR, Ranjan S, Wolter J, Kohli S, Shahzad K, Heidel F, Krueger M, Schwenger V, Moeller MJ, Kalinski T, Reiser J, Chavakis T, Isermann B
  Nat Commun 2015, 6, 6496
  
• Effects of ebselen and N-acetyl cysteine on replicative aging of primary human fibroblast strains.
  Marthandan S
  Immun Ageing 2015, 12, 8
  
• Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts.
  Marthandan S, Priebe S, Baumgart M, Groth M, Cellerino A, Guthke R, Hemmerich P, Diekmann S
  Biomed Res Int 2015, 2015, 731938
  
• Hormetic effect of rotenone in primary human fibroblasts.
  Marthandan S, Priebe S, Groth M, Guthke R, Platzer M, Hemmerich P, Diekmann S
  Immun Ageing 2015, 12, 11
  
• MicroRNAs as biomarker of Parkinson disease? Small but mighty.
  Marz M, Ferracin M, Klein C
  Neurology 2015, 84(7), 636-8
  
• Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.
  Matthews LC, Berry AA, Morgan DJ, Poolman TM, Bauer K, Kramer F, Spiller DG, Richardson RV, Chapman KE, Farrow SN, Norman MR, Williamson AJK, Whetton AD, Taylor SS, Tuckermann JP, White MRH, Ray DW
  Proc Natl Acad Sci U S A 2015, 112(17), 5479-84
  
• CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo.
  Mende N, Kuchen EE, Lesche M, Grinenko T, Kokkaliaris KD, Hanenberg H, Lindemann D, Dahl A, Platz A, Höfer T, Calegari F, Waskow C
  J Exp Med 2015, 212(8), 1171-83
  
• Comprehensive insights in the Mycobacterium avium subsp. paratuberculosis genome using new WGS data of sheep strain JIII-386 from Germany.
  Möbius P, Hölzer M, Felder M, Nordsiek G, Groth M, Köhler H, Reichwald K, Platzer M, Marz M
  Genome Biol Evol 2015, 7(9), 2585-601
  
• Mechanism of Functional Alterations in Hematopoietic Stem Cell Aging
  Morita Y
  In: Adult Stem Cells in Aging, Diseases and Cancer (edited by Rudolph KL), Else Kröner-Fresenius Symposia 2015, 5, 40-59, Karger Verlag, Basel
  
• Space constraints govern fate of hematopoietic stem and progenitor cells in vitro.
  Müller E, Grinenko T, Pompe T, Waskow C, Werner C
  Biomaterials 2015, 53, 709-15
  
• The function of embryonic stem cell-expressed Ras (E-Ras), a unique Ras family member, correlates with its additional motifs and its structural properties.
  Nakhaei-Rad S, Nakhaeizadeh H, Kordes C, Cirstea IC, Schmick M, Dvorsky R, Bastiaens PIH, Häussinger D, Ahmadian MR
  J Biol Chem 2015, 290(25), 15892-903
  
• Cooperative development of logical modelling standards and tools with CoLoMoTo.
  Naldi A, Monteiro PT, Müssel C, the Consortium for Logical Models and Tools, Kestler HA, Thieffry D, Xenarios I, Saez-Rodriguez J, Helikar T, Chaouiya C
  Bioinformatics 2015, 31(7), 1154-9
  
• TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway.
  Neri F, Dettori D, Incarnato D, Krepelova A, Rapelli S, Maldotti M, Parlato C, Paliogiannis P, Oliviero S
  Oncogene 2015, 34(32), 4168-76
  
• TET1 is controlled by pluripotency-associated factors in ESCs and downmodulated by PRC2 in differentiated cells and tissues.
  Neri F, Incarnato D, Krepelova A, Dettori D, Rapelli S, Maldotti M, Parlato C, Anselmi F, Galvagni F, Oliviero S
  Nucleic Acids Res 2015, 43(14), 6814-26
  
• DNA methylation and demethylation dynamics.
  Neri F, Incarnato D, Oliviero S
  Oncotarget 2015, 6(33), 34049-50
  
• Murine Embryonic Stem Cells Synthesize Retinoic Acid to Promote their Own Differentiation
  Neri* F, De Clemente* C, Orlandini M, Lentucci C, Anselmi F, Galvagni F
  J Stem Cell Res Ther 2015, 5(7), 293 * equal contribution
  
• Single-Base Resolution Analysis of 5-Formyl and 5-Carboxyl Cytosine Reveals Promoter DNA Methylation Dynamics.
  Neri* F, Incarnato* D, Krepelova A, Rapelli S, Anselmi F, Parlato C, Medana C, Dal Bello F, Oliviero S
  Cell Rep 2015, 10(5), 674–683 * equal contribution
  
• Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging.
  Neves J, Demaria M, Campisi J, Jasper H
  Dev Cell 2015, 32(1), 9-18
  
• Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation.
  Nillegoda NB, Kirstein J, Szlachcic A, Berynskyy M, Stank A, Stengel F, Arnsburg K, Gao X, Scior A, Aebersold R, Guilbride DL, Wade RC, Morimoto RI, Mayer MP, Bukau B
  Nature 2015, 524(7564), 247
  
• Stat5 gene dosage in T cells modulates CD8+ T-cell homeostasis and attenuates contact hypersensitivity response in mice.
  Nivarthi H, Prchal-Murphy M, Swoboda A, Hager M, Schlederer M, Kenner L, Tuckermann J, Sexl V, Moriggl R, Ermakova O
  Allergy 2015, 70(1), 67-79 published during change of institution
  
• Identification of ageing-associated naturally occurring peptides in human urine.
  Nkuipou-Kenfack E, Bhat A, Klein J, Jankowski V, Mullen W, Vlahou A, Dakna M, Koeck T, Schanstra JP, Zürbig P, Rudolph KL, Schumacher B, Pich A, Mischak H
  Oncotarget 2015, 6(33), 34106-17
  
• Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats
  Ori* A, Toyama* BH, Harris MS, Bock T, Iskar M, Bork P, Ingolia NT, Hetzer MW, Beck M
  Cell Syst 2015, 1(3), 224–237 * equal contribution, published during change of institution
  
• High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation.
  Parplys AC, Seelbach JI, Becker S, Behr M, Jend C, Mansour WY, Joosse S, Stuerzbecher HW, Pospiech H, Petersen C, Dikomey E, Borgmann K
  Cell Cycle 2015, 14(19), 3190-202
  
• Distinct Intracellular Domain Substrate Modifications Selectively Regulate Ectodomain Cleavage of NRG1 or CD44
  Parra* LM, Hartmann* M, Schubach S, Li Y, Herrlich P, Herrlich A
  Mol Cell Biol 2015, 35(19), 3381-95 * equal contribution
  
• Deficiency of the protein-tyrosine phosphatase DEP-1/PTPRJ promotes matrix metalloproteinase-9 expression in meningioma cells.
  Petermann A, Stampnik Y, Cui Y, Morrison H, Pachow D, Kliese N, Mawrin C, Böhmer FD
  J Neurooncol 2015, 122(3), 451-9
  
• Characterization and quantification of proteins secreted by single human embryos prior to implantation.
  Poli* M, Ori* A, Child T, Jaroudi S, Spath K, Beck M, Wells D
  EMBO Mol Med 2015, 7(11), 1465-79 * equal contribution, published during change of institution
  
• Glandular ß-glucosidases in juvenile Chrysomelina leaf beetles support the evolution of a host-plant-dependent chemical defense.
  Rahfeld P, Haeger W, Kirsch R, Pauls G, Becker T, Schulze E, Wielsch N, Wang D, Groth M, Brandt W, Boland W, Burse A
  Insect Biochem Mol Biol 2015, 58, 28-38
  
• Turquoise killifish.
  Reichard M, Cellerino A, Valenzano DR
  Curr Biol 2015, 25(17), R741-2
  
• The deubiquitinating enzyme CYLD regulates the differentiation and maturation of thymic medullary epithelial cells.
  Reissig S, Hövelmeyer N, Tang Y, Weih D, Nikolaev A, Riemann M, Weih F, Waisman A
  Immunol Cell Biol 2015, 93(6), 558-66
  
• Blocking stroke-induced immunodeficiency increases CNS antigen-specific autoreactivity but does not worsen functional outcome after experimental stroke.
  Römer C, Engel O, Winek K, Hochmeister S, Zhang T, Royl G, Klehmet J, Dirnagl U, Meisel C, Meisel A
  J Neurosci 2015, 35(20), 7777-94
  
• The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection.
  Roquis D, Lepesant JMJ, Picard MAL, Freitag M, Parrinello H, Groth M, Emans R, Cosseau C, Grunau C
  PLoS Negl Trop Dis 2015, 9(8), e0003853
  
• Adult Stem Cells in Aging, Diseases and Cancer
  Rudolph KL (ed)
  Book series: Else Kröner-Fresenius Symposia 2015, 5, Karger Verlag, Basel, Switzerlan
  
• Loss of ATM accelerates pancreatic cancer formation and epithelial-mesenchymal transition.
  Russell R, Perkhofer L, Liebau S, Lin Q, Lechel A, Feld FM, Hessmann E, Gaedcke J, Güthle M, Zenke M, Hartmann D, von Figura G, Weissinger SE, Rudolph KL, Möller P, Lennerz JK, Seufferlein T, Wagner M, Kleger A
  Nat Commun 2015, 6, 7677
  
• Towards a comprehensive picture of alloacceptor tRNA remolding in metazoan mitochondrial genomes.
  Sahyoun AH, Hölzer M, Jühling F, Höner zu Siederdissen C, Al-Arab M, Tout K, Marz M, Middendorf M, Stadler PF, Bernt M
  Nucleic Acids Res 2015, 43(16), 8044-56
  
• Central Venous Catheter-Related Bloodstream Infections in Obese Hematologic Patients.
  Schalk E, Färber J, Fischer T, Heidel FH
  Infect Control Hosp Epidemiol 2015, 36(8), 995-6
  
• Prediction of central venous catheter-related bloodstream infections (CRBSIs) in patients with haematologic malignancies using a modified Infection Probability Score (mIPS).
  Schalk E, Hanus L, Färber J, Fischer T, Heidel FH
  Ann Hematol 2015, 94(9), 1451-6
  
• On the validity of time-dependent AUC estimators.
  Schmid M, Kestler HA, Potapov S
  Brief Bioinform 2015, 16(1), 153-68 published during change of institution
  
• Epo-induced erythroid maturation is dependent on Plcγ1 signaling.
  Schnöder TM, Arreba-Tutusaus P, Griehl I, Bullinger L, Buschbeck M, Lane SW, Döhner K, Plass C, Lipka DB, Heidel FH, Fischer T
  Cell Death Differ 2015, 22(6), 974-85
  
• Mast cell promotion of T cell-driven antigen-induced arthritis despite being dispensable for antibody-induced arthritis in which T cells are bypassed.
  Schubert N, Dudeck J, Liu P, Karutz A, Speier S, Maurer M, Tuckermann J, Dudeck A
  Arthritis Rheumatol 2015, 67(4), 903-13 published during change of institution
  
• High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation.
  Sokka M, Rilla K, Miinalainen I, Pospiech H, Syväoja JE
  Nucleic Acids Res 2015, 43(10), 4975-89
  
• It's a bit over, is that ok? The subtle surplus from tandem alternative splicing.
  Szafranski K, Kramer M
  RNA BIOL 2015, 12(2), 115-22
  
• Sestrins in Aging and Metabolism
  Tang D, Tao S
  In: Adult Stem Cells in Aging, Diseases and Cancer (edited by Rudolph KL), Else Kröner-Fresenius Symposia 2015, 5, 60-65, Karger Verlag, Basel
  
• Internalization of near-infrared fluorescently labeled activatable cell-penetrating peptide and of proteins into human fibrosarcoma cell line HT-1080.
  Tansi F, Kallweit E, Kaether C, Kappe K, Schumann C, Hilger I, Reissmann S
  J Cell Biochem 2015, 116(7), 1222-31
  
• Left-right asymmetry in the light of TOR: An update on what we know so far.
  Tena TC, Burkhalter** MD, Philipp** M
  Biol Cell 2015, 107(9), 306-18 ** co-corresponding authors
  
• A Branch-and-Bound Approach for Tautomer Enumeration
  Thalheim T, Wagner B, Kühne R, Middendorf M, Schüürmann G
  Mol Inform 2015, 34, 263–75
  
• Analysis of Alpha-2 Macroglobulin from the Long-Lived and Cancer-Resistant Naked Mole-Rat and Human Plasma.
  Thieme R, Kurz S, Kolb M, Debebe T, Holtze S, Morhart M, Huse K, Szafranski K, Platzer M, Hildebrandt TB, Birkenmeier G
  PLoS One 2015, 10(6), e0130470
  
• The African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan.
  Valenzano DR, Benayoun BA, Singh PP, Zhang E, Etter PD, Hu CK, Clément-Ziza M, Willemsen D, Cui R, Harel I, Machado BE, Yee MC, Sharp SC, Bustamante CD, Beyer A, Johnson EA, Brunet A
  Cell 2015, 163(6), 1539-54
  
• A pooled analysis of overall survival in COMFORT-I and COMFORT-II, 2 randomized phase III trials of ruxolitinib for the treatment of myelofibrosis.
  Vannucchi AM, Kantarjian HM, Kiladjian JJ, Gotlib J, Cervantes F, Mesa RA, Sarlis NJ, Peng W, Sandor V, Gopalakrishna P, Hmissi A, Stalbovskaya V, Gupta V, Harrison C, Verstovsek S, COMFORT Investigators
  Haematologica 2015, 100(9), 1139-45
  
• Sputnik: Ad hoc distributed computation.
  Völkel G, Lausser L, Schmid F, Kraus JM, Kestler HA
  Bioinformatics 2015, 31(8), 1298-301
  
• In situ structural analysis of the human nuclear pore complex.
  von Appen A, Kosinski J, Sparks L, Ori A, DiGuilio AL, Vollmer B, Mackmull MT, Banterle N, Parca L, Kastritis P, Buczak K, Mosalaganti S, Hagen W, Andres-Pons A, Lemke EA, Bork P, Antonin W, Glavy JS, Bui KH, Beck M
  Nature 2015, 526(7571), 140-3 published during change of institution
  
• A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer.
  von Eyss B, Jaenicke LA, Kortlever RM, Royla N, Wiese KE, Letschert S, McDuffus LA, Sauer M, Rosenwald A, Evan GI, Kempa S, Eilers M
  Cancer Cell 2015, 28(6), 743-57
  
• The PCBP1 gene encoding poly(rC) binding protein I is recurrently mutated in Burkitt lymphoma.
  Wagener R, Aukema SM, Schlesner M, Haake A, Burkhardt B, Claviez A, Drexler HG, Hummel M, Kreuz M, Loeffler M, Rosolowski M, López C, Möller P, Richter J, Rohde M, Betts MJ, Russell RB, Bernhart SH, Hoffmann S, Rosenstiel P, Schilhabel M, Szczepanowski M, Trümper L, Klapper W, Siebert R, ICGC MMML-Seq-Project, "Molecular Mechanisms in Malignant Lymphomas" Network Project of the Deutsche Krebshilfe
  Genes Chromosomes Cancer 2015, 54(9), 555-64
  
• Sumoylation of HDAC2 promotes NF-κB-dependent gene expression.
  Wagner T, Kiweler N, Wolff K, Knauer SK, Brandl A, Hemmerich P, Dannenberg JH, Heinzel T, Schneider G, Krämer OH
  Oncotarget 2015, 6(9), 7123-35
  
• PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress.
  Wang L, Ryoo HD, Qi Y, Jasper H
  PLoS Genet 2015, 11(5), e1005220
  
• Structure and regulatory role of the C-terminal winged helix domain of the archaeal minichromosome maintenance complex.
  Wiedemann C, Szambowska A, Häfner S, Ohlenschläger O, Gührs KH, Görlach M
  Nucleic Acids Res 2015, 43(5), 2958-67
  
• Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells.
  Wiese* KE, Haikala* HM, von Eyss* B, Wolf E, Esnault C, Rosenwald A, Treisman R, Klefström J, Eilers M
  EMBO J 2015, 34(11), 1554-71 * equal contribution
  
• Generation of Aorta Transcript Atlases of Wild-Type and Apolipoprotein E-null Mice by Laser Capture Microdissection-Based mRNA Expression Microarrays.
  Yin C, Mohanta S, Ma Z, Weber C, Hu D, Weih F, Habenicht A
  Methods Mol Biol 2015, 1339, 297-308
  
• Inhibition of Wild-type p53-induced phosphatase 1 promotes liver regeneration in mice by direct activation of mTOR.
  Zhang L, Liu L, He Z, Li G, Liu J, Song Z, Jin H, Rudolph KL, Yang H, Mao Y, Zhang L, Zhang H, Xiao Z, Ju Z
  Hepatology 2015, 61(6), 2030-41
  
• Merlin's wizardry guides cohesive migration.
  Zoch A, Morrison H
  Nat Cell Biol 2015, 17(3), 212-3
  

Publications 2014:

• A sequence-ready physical map of barley anchored genetically by two million single-nucleotide polymorphisms.
  Ariyadasa R, Mascher M, Nussbaumer T, Schulte D, Frenkel Z, Poursarebani N, Zhou R, Steuernagel B, Gundlach H, Taudien S, Felder M, Platzer M, Himmelbach A, Schmutzer T, Hedley P, Muehlbauer G, Scholz U, Korol A, Mayer K, Waugh R, Langridge P, Graner A, Stein N
  Plant Physiol 2014, 164(1), 412-23
  
• Interrelation between protein synthesis, proteostasis and life span.
  Arnsburg K, Kirstein-Miles J
  Curr Genomics 2014, 15(1), 66
  
• HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization.
  Azoitei N, Diepold K, Brunner C, Rouhi A, Genze F, Becher A, Kestler H, van Lint J, Chiosis G, Koren J, Fröhling S, Scholl C, Seufferlein T
  Cancer Res 2014, 74(23), 7125-36 published during change of institution
  
• Transcriptomic immune response of the cotton stainer Dysdercus fasciatus to experimental elimination of vitamin-supplementing intestinal symbionts.
  Bauer E, Salem H, Marz M, Vogel H, Kaltenpoth M
  PLoS One 2014, 9(12), e114865
  
• RNA-seq of the aging brain in the short-lived fish N. furzeri - conserved pathways and novel genes associated with neurogenesis.
  Baumgart* M, Groth* M, Priebe* S, Savino A, Testa G, Dix A, Ripa R, Spallotta F, Gaetano C, Ori M, Terzibasi Tozzini E, Guthke R, Platzer M, Cellerino A
  Aging Cell 2014, 13(6), 965-74 * equal contribution
  
• Explorative Analysis of Heterogeneous, Unstructured, and Uncertain Data: A Computer Science Perspective on Biodiversity Research
  Beckstein C, Böcker S, Bogdan M, Bücker HM.Bruelheide H, Denzler J, Dittrich P, Grosse I, Hinneburg A, König-Ries B, Löffler F, Marz M, Müller-Hannemann M, Winter M, Zimmermann W
  In: Proceedings of 3rd International Conference on Data Management Technologies and Applications (DATA-2014) 2014, 251-257, Science and Technology
  
• Impact of genomic damage and ageing on stem cell function.
  Behrens A, van Deursen JM, Rudolph* KL, Schumacher B
  Nat Cell Biol 2014, 16(3), 201-7 * corresponding author, based on the Else Kröner-Fresenius-Symposium in Molecular Medicine
  
• Analysis of disorder in tricalcium silicate by 29Si NMR spectroscopy and additional methods
  Bellmann F, Leppert J, Görlach M, Krbetschek M, Damidot D, Ludwig HM
  Cement Concrete Res 2014, 57, 105-16
  
• Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength.
  Bentzinger* CF, von Maltzahn* J, Dumont NA, Stark DA, Wang YX, Nhan K, Frenette J, Cornelison DDW, Rudnicki MA
  J Cell Biol 2014, 205(1), 97-111 * equal contribution, published during change of institution
  
• Slit/Robo signaling regulates cell fate decisions in the intestinal stem cell lineage of Drosophila.
  Biteau B, Jasper H
  Cell Rep 2014, 7(6), 1867-75
  
• Chlamydia psittaci inclusion membrane protein IncB associates with host protein Snapin.
  Böcker S, Heurich A, Franke C, Monajembashi S, Sachse K, Saluz HP, Hänel F
  Int J Med Microbiol 2014, 304(5-6), 542-53
  
• Kinesin-dependent motility generation as target mechanism of cadmium intoxication.
  Böhm KJ
  Toxicol Lett 2014, 224(3), 356-61
  
• Novel Insights into Structure and Function of Factor XIIIa-Inhibitor Tridegin.
  Böhm M, Bäuml CA, Hardes K, Steinmetzer T, Roeser D, Schaub Y, Than ME, Biswas A, Imhof D
  J Med Chem 2014, 57(24), 10355-65
  
• The Wilms' tumor suppressor WT1 enhances CD95L expression and promotes activation-induced cell death in leukemic T cells.
  Bourkoula K, Englert C, Giaisi M, Koehler R, Krammer PH, Li-Weber M
  Int J Cancer 2014, 134(2), 291-300
  
• A 'telomere-associated secretory phenotype' cooperates with BCR-ABL to drive malignant proliferation of leukemic cells.
  Braig M, Pällmann N, Preukschas M, Steinemann D, Hofmann W, Gompf A, Streichert T, Braunschweig T, Copland M, Rudolph KL, Bokemeyer C, Koschmieder S, Schuppert A, Balabanov S, Brümmendorf TH
  Leukemia 2014, 28(10), 2028-39
  
• Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.
  Bruedigam C, Bagger FO, Heidel FH, Paine Kuhn C, Guignes S, Song A, Austin R, Vu T, Lee E, Riyat S, Moore AS, Lock RB, Bullinger L, Hill GR, Armstrong SA, Williams DA, Lane SW
  Cell Stem Cell 2014, 15(6), 775-90
  
• Lin28a - boost your energy for youthful regeneration.
  Burkhalter MD, Morita Y, Rudolph KL
  EMBO J 2014, 33(1), 5–6
  
• Control of metabolic adaptation to fasting by dILP6-induced insulin signaling in Drosophila oenocytes.
  Chatterjee D, Katewa SD, Qi Y, Jackson SA, Kapahi P, Jasper H
  Proc Natl Acad Sci U S A 2014, 111(50), 17959-64
  
• Gadd45a Regulates Hematopoietic Stem Cell Stress Responses in Mice.
  Chen Y, Ma X, Zhang M, Wang X, Wang C, Wang H, Guo P, Yuan W, Rudolph KL, Zhan Q, Ju Z
  Blood 2014, 123(6), 851-62
  
• Gender identity rather than sexual orientation impacts on facial preferences.
  Ciocca G, Limoncin E, Cellerino A, Fisher AD, Gravina GL, Carosa E, Mollaioli D, Valenzano DR, Mennucci A, Bandini E, Di Stasi SM, Maggi M, Lenzi A, Jannini EA
  J Sex Med 2014, 11(10), 2500-7
  
• Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?
  Correia-Melo C, Hewitt G, Passos JF
  Longev Healthspan 2014, 3(1), 1
  
• Kit regulates HSC engraftment across the human-mouse species barrier.
  Cosgun KN, Rahmig S, Mende N, Reinke S, Hauber I, Schäfer C, Petzold A, Weisbach H, Heidkamp G, Purbojo A, Cesnjevar R, Platz A, Bornhäuser M, Schmitz M, Dudziak D, Hauber J, Kirberg J, Waskow C
  Cell Stem Cell 2014, 15(2), 227-38
  
• Nerve growth factor in the adult brain of a teleostean model for aging research: Nothobranchius furzeri.
  D'Angelo L, Castaldo L, Cellerino A, de Girolamo P, Lucini C
  Ann Anat 2014, 196(4), 183-91
  
• Brain derived neurotrophic factor: mRNA expression and protein distribution in the brain of the teleost Nothobranchius furzeri.
  D'Angelo L, de Girolamo P, Lucini C, Terzibasi ET, Baumgart M, Castaldo L, Cellerino A
  J Comp Neurol 2014, 522(5), 1004-30
  
• X-ray structures of human furin in complex with competitive inhibitors.
  Dahms SO, Hardes K, Becker GL, Steinmetzer T, Brandstetter H, Than ME
  ACS Chem Biol 2014, 9(5), 1113-18
  
• FACS-FRET: Reply to comments on "Biomolecular dynamics and binding studies in the living cell".
  Diekmann S, Hoischen C
  Phys Life Rev 2014, 11(1), 38
  
• Biomolecular dynamics and binding studies in the living cell.
  Diekmann S, Hoischen C
  Phys Life Rev 2014, 11(1), 1-30
  
• Transition to annual life history coincides with reduction in cell cycle speed during early cleavage in three independent clades of annual killifish.
  Dolfi L, Ripa R, Cellerino A
  Evodevo 2014, 5, 32
  
• Expression of the lymphoid enhancer factor 1 is required for normal hematopoietic stem and progenitor cell function.
  Edmaier KE, Stahnke K, Vegi N, Mulaw M, Ihme S, Scheffold A, Rudolph KL, Buske C
  Leukemia 2014, 28(1), 227-30 published during change of institution
  
• The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells.
  Eguether T, Ermolaeva MA, Zhao Y, Bonnet MC, Jain A, Pasparakis M, Courtois G, Tassin AM
  Nat Commun 2014, 5, 4585
  
• Systemic DNA damage responses: organismal adaptations to genome instability.
  Ermolaeva MA, Schumacher B
  Trends Genet 2014, 30(3), 95-102
  
• Insights from the worm: the C. elegans model for innate immunity.
  Ermolaeva MA, Schumacher B
  Semin Immunol 2014, 26(4), 303-9
  
• Functional Mutation Analysis Provides Evidence for a Role of REEP1 in Lipid Droplet Biology.
  Falk J, Rohde M, Bekhite MM, Sophie Neugebauer, Hemmerich P, Kiehntopf M, Deufel T, Hübner CA, Beetz C
  Hum Mutat 2014, 35(4), 497-504
  
• Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2α and ETS1.
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• Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis.
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• Brain derived neurotrophic factor in the retina of the teleost N. furzeri.
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• The Genome of the Foraminiferan Reticulomyxa filosa.
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• Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cells.
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• The genome of an influenza virus from a pilot whale: Relation to influenza viruses of gulls and marine mammals.
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• Transkriptom-Sequenzierung in der Alternsforschung
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• PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan.
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• A multi-split mapping algorithm for circular RNA, splicing, trans-splicing and fusion detection.
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• AgeFactDB – The JenAge Ageing Factor Database – Towards data integration in ageing research
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• Telomerase exerts physiological and tumor promoting functions by stimulating ribosomal biogenesis
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• High-throughput single nucleotide variant discovery in E14 mouse embryonic stem cells provides a new reference genome assembly.
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• Genome-wide profiling of mouse RNA secondary structures reveals key features of the mammalian transcriptome.
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• Functional crosstalk between Ras and Rho pathways: p120RasGAP competitively inhibits the RhoGAP activity of Deleted in Liver Cancer (DLC) tumor suppressors by masking its catalytic arginine finger.
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• Mitochondrial proteostasis in the control of aging and longevity.
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• Myc and max genome-wide binding sites analysis links the Myc regulatory network with the polycomb and the core pluripotency networks in mouse embryonic stem cells.
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• The origin of the European avian-like swine influenza viruses.
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• Enhanced Telomere Rejuvenation in Pluripotent Cells Reprogrammed via Nuclear Transfer Relative to Induced Pluripotent Stem Cells.
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• Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features.
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• Challenges in RNA virus bioinformatics.
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• Novel Zinc-binding Site in the E2 Domain Regulates Amyloid Precursor-like Protein 1 (APLP1) Oligomerization.
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• Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice.
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• Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures.
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• DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage.
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• Substantial telomere shortening in the substantia nigra of telomerase-deficient mice does not increase susceptibility to MPTP-induced dopamine depletion.
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• Häm und seine Abbauprodukte
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• The use of targeted proteomics to determine the stoichiometry of large macromolecular assemblies.
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• Lacking alignments? The next-generation sequencing mapper segemehl revisited.
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• Association of condensin with chromosomes depends on DNA binding by its HEAT-repeat subunits.
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• Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.
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• Inhibition of JAK-STAT signaling stimulates adult satellite cell function.
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• The Ca2+ sensor protein swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons.
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• Graph-distance distribution of the Boltzmann ensemble of RNA secondary structures.
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• Independently recruited oxidases from the glucose-methanol-choline oxidoreductase family enabled chemical defences in leaf beetle larvae (subtribe Chrysomelina) to evolve.
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• The Comet-Fish technique, a tool for detection of specific DNA damage and repair
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• A first glimpse at the genome of the Baikalian amphipod Eulimnogammarus verrucosus.
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• Novel mechanism of JNK pathway activation by adenoviral E1A.
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  Oncotarget 2014, 5(8), 2176-86 * equal contribution
  
• Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans.
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• Evidence for the existence of two new members of the family Chlamydiaceae and proposal of Chlamydia avium sp. nov. and Chlamydia gallinacea sp. nov.
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• Vitamin supplementation by gut symbionts ensures metabolic homeostasis in an insect host.
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• Miz1 deficiency in the mammary gland causes a lactation defect by attenuated Stat5 expression and phosphorylation.
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• Germ and hematology: underlying disease influences diversity of germ spectra and antibiotic therapy.
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• Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum.
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• Exon 11 skipping of SCN10A coding for voltage-gated sodium channels in dorsal root ganglia.
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• Gene expansion shapes genome architecture in the human pathogen Lichtheimia corymbifera: an evolutionary genomics analysis in the ancient terrestrial mucorales (Mucoromycotina).
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• Epithelial regeneration and cancer: news from the Src front.
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• Integrin αvβ3 and thyroid hormones promote expansion of progenitors in embryonic neocortex.
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• Physiological state co-regulates thousands of mammalian mRNA splicing events at tandem splice sites and alternative exons.
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• DNA binding properties of human Cdc45 suggest a function as molecular wedge for DNA unwinding.
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• RelB-induced expression of Cot, a MAP3K, rescues RANKL-induced osteoclastogenesis in alymphoplasia mice by promoting NF-κB2 processing by IKKα
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• Narrowing down the distal border of the copy number variable beta-defensin gene cluster on human 8p23.
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• Regulation of microRNA expression in the neuronal stem cell niches during aging of the short-lived annual fish Nothobranchius furzeri.
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• Comparative analysis of mitochondrial genomes from closely related Rhynchosporium species reveals extensive intron invasion.
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• Aging stem cells: transcriptome meets epigenome meets methylome.
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• Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles.
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• Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres.
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• Promoting longevity by maintaining metabolic and proliferative homeostasis.
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• Integration of UPRER and oxidative stress signaling in the control of intestinal stem cell proliferation.
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• A coimmunization vaccine of Aβ42 ameliorates cognitive deficits without brain inflammation in an Alzheimer's disease model.
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• The fidelity of the ligation step determines how ends are resolved during nonhomologous end joining.
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• Detection of very long antisense transcripts by whole transcriptome RNA-Seq analysis of Listeria monocytogenes by semiconductor sequencing technology.
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• CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies.
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• Prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer.
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• A rare cause of lower back pain.
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  Wolleschak D, Mack TS, Perner F, Frey S, Schnöder TM, Wagner MC, Höding C, Pils MC, Parkner A, Kliche S, Schraven B, Hebel K, Brunner-Weinzierl M, Ranjan S, Isermann B, Lipka DB, Fischer T, Heidel FH
  Haematologica 2014, 99(6), e90-3
  
• Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutants.
  Wolters S, Ermolaeva MA, Bickel JS, Fingerhut JM, Khanikar J, Chan RC, Schumacher B
  Genetics 2014, 196(4), 985-99
  
• Quantitative Dissection and Modeling of the NF-κB p100-p105 Module Reveals Interdependent Precursor Proteolysis.
  Yılmaz ZB, Kofahl B, Beaudette P, Baum K, Ipenberg I, Weih F, Wolf J, Dittmar G, Scheidereit C
  Cell Rep 2014, 9(5), 1756-69
  
• Exonuclease 1 is essential for maintaining genomic stability and the proliferative capacity of neural but not hematopoietic stem cells.
  Zhang J, Yang R, Zhou D, Rudolph KL, Meng A, Ju Z
  Stem Cell Res 2014, 12(1), 250-9
  
• Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1.
  Zhang SC, Gremer L, Heise H, Janning P, Shymanets A, Cirstea IC, Krause E, Nürnberg B, Ahmadian MR
  PLoS One 2014, 9(7), e102425
  
• 8p23 beta-defensin copy number determination by single-locus pseudogene-based paralog ratio tests risk bias due to low-frequency sequence variations.
  Zhang X, Müller S, Möller M, Huse K, Taudien S, Book M, Stuber F, Platzer M, Groth M
  BMC Genomics 2014, 15(1), 64
  

Publications 2013:

• The African coelacanth genome provides insights into tetrapod evolution.
  Amemiya CT, Alföldi J, Lee AP, Fan S, Philippe H, Maccallum I, Braasch I, Manousaki T, Schneider I, Rohner N, Organ C, Chalopin D, Smith JJ, Robinson M, Dorrington RA, Gerdol M, Aken B, Biscotti MA, Barucca M, Baurain D, Berlin AM, Blatch GL, Buonocore F, Burmester T, Campbell MS, Canapa A, Cannon JP, Christoffels A, De Moro G, Edkins AL, Fan L, Fausto AM, Feiner N, Forconi M, Gamieldien J, Gnerre S, Gnirke A, Goldstone JV, Haerty W, Hahn ME, Hesse U, Hoffmann S, Johnson J, Karchner SI, Kuraku S, Lara M, Levin JZ, Litman GW, Mauceli E, Miyake T, Mueller MG, Nelson DR, Nitsche A, Olmo E, Ota T, Pallavicini A, Panji S, Picone B, Ponting CP, Prohaska SJ, Przybylski D, Saha NR, Ravi V, Ribeiro FJ, Sauka-Spengler T, Scapigliati G, Searle SMJ, Sharpe T, Simakov O, Stadler PF, Stegeman JJ, Sumiyama K, Tabbaa D, Tafer H, Turner-Maier J, van Heusden P, White S, Williams L, Yandell M, Brinkmann H, Volff JN, Tabin CJ, Shubin N, Schartl M, Jaffe DB, Postlethwait JH, Venkatesh B, Di Palma F, Lander ES, Meyer A, Lindblad-Toh K
  Nature 2013, 496(7445), 311-6
  
• CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells.
  Arndt K, Grinenko T, Mende N, Reichert D, Portz M, Ripich T, Carmeliet P, Corbeil D, Waskow C
  Proc Natl Acad Sci U S A 2013, 110(14), 5582-7
  
• Intestinal inflammation and stem cell homeostasis in aging Drosophila melanogaster.
  Ayyaz A, Jasper H
  Front Cell Infect Microbiol 2013, 3, 98
  
• Strong population genetic structuring in an annual fish, Nothobranchius furzeri, suggests multiple savannah refugia in southern Mozambique.
  Bartáková V, Reichard M, Janko K, Polačik M, Blažek R, Reichwald K, Cellerino A, Bryja J
  BMC Evol Biol 2013, 13(1), 196
  
• Molecular determinants of glucocorticoid actions in inflammatory joint diseases.
  Baschant U, Culemann S, Tuckermann J
  Mol Cell Endocrinol 2013, 380(1-2), 108-18
  
• The emerging biology of muscle stem cells: implications for cell-based therapies.
  Bentzinger CF, Wang YX, von Maltzahn J, Rudnicki MA
  Bioessays 2013, 35(3), 231-41
  
• Fibronectin regulates Wnt7a signaling and satellite cell expansion.
  Bentzinger CF, Wang YX, von Maltzahn J, Soleimani VD, Yin H, Rudnicki MA
  Cell Stem Cell 2013, 12(1), 75-87
  
• The positional identity of mouse ES cell-generated neurons is affected by BMP signaling.
  Bertacchi M, Pandolfini L, Murenu E, Viegi A, Capsoni S, Cellerino A, Messina A, Casarosa S, Cremisi F
  Cell Mol Life Sci 2013, 70(6), 1095-111
  
• Quantitative proteomic profiling of tumor cell response to telomere dysfunction using isotope-coded protein labeling (ICPL) reveals interaction network of candidate senescence markers.
  Biniossek ML, Lechel A, Rudolph KL, Martens UM, Zimmermann S
  J Proteomics 2013, 91, 515-35 published during change of institution
  
• Integrated structural analysis of the human nuclear pore complex scaffold.
  Bui KH, von Appen A, DiGuilio AL, Ori A, Sparks L, Mackmull MT, Bock T, Hagen W, Andrés-Pons A, Glavy JS, Beck M
  Cell 2013, 155(6), 1233-43
  
• LMX1B is essential for the maintenance of differentiated podocytes in adult kidneys.
  Burghardt T, Kastner J, Suleiman H, Rivera-Milla E, Stepanova N, Lottaz C, Kubitza M, Böger CA, Schmidt S, Gorski M, de Vries U, Schmidt H, Hertting I, Kopp J, Rascle A, Moser M, Heid IM, Warth R, Spang R, Wegener J, Mierke CT, Englert C, Witzgall R
  J Am Soc Nephrol 2013, 24(11), 1830-48
  
• Grk5l Controls Heart Development by Limiting mTOR Signaling during Symmetry Breaking.
  Burkhalter MD, Fralish GB, Premont RT, Caron MG, Philipp M
  Cell Rep 2013, 4(4), 625-32
  
• Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and cardio-facio-cutaneous syndromes.
  Cirstea IC, Gremer L, Dvorsky R, Zhang SC, Piekorz RP, Zenker M, Ahmadian MR
  Hum Mol Genet 2013, 22(2), 262-70
  
• Robust multiparametric assessment of cellular senescence.
  Correia-Melo C, Jurk D, Passos JF
  Methods Mol Biol 2013, 965, 409
  
• Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways.
  Dang M, Armbruster N, Miller MA, Cermeno E, Hartmann M, Bell GW, Root DE, Lauffenburger DA, Lodish HF, Herrlich A
  Proc Natl Acad Sci U S A 2013, 110(24), 9776-81 Editors' Choice
  
• Mapping the RNA-Seq trash bin: unusual transcripts in prokaryotic transcriptome sequencing data.
  Doose G, Alexis M, Kirsch R, Findeiß S, Langenberger D, Machné R, Mörl M, Hoffmann S, Stadler PF
  RNA Biol 2013, 10(7), 1204-10
  
• Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.
  Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KHA, Copenhaver GP, Deluca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LET, Karpen G, Kops GJPL, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O'Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K, Cleveland DW
  Chromosome Res 2013, 21(2), 101-6
  
• Novel CIC point mutations and an exon-spanning, homozygous deletion identified in oligodendroglial tumors by a comprehensive genomic approach including transcriptome sequencing.
  Eisenreich S, Abou-El-Ardat K, Szafranski K, Campos Valenzuela JA, Rump A, Nigro JM, Bjerkvig R, Gerlach EM, Hackmann K, Schröck E, Krex D, Kaderali L, Schackert G, Platzer M, Klink B
  PLoS One 2013, 8(9), e76623
  
• The innate immune system as mediator of systemic DNA damage responses.
  Ermolaeva M, Schumacher B
  Commun Integr Biol 2013, 6(6), e26926
  
• DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance.
  Ermolaeva MA, Segref A, Dakhovnik A, Ou HL, Schneider JI, Utermöhlen O, Hoppe T, Schumacher B
  Nature 2013, 501(7467), 416-20
  
• FOSL1 controls the assembly of endothelial cells into capillary tubes by direct repression of αv and β3 integrin transcription.
  Evellin S, Galvagni F, Zippo A, Neri F, Orlandini M, Incarnato D, Dettori D, Neubauer S, Kessler H, Wagner EF, Oliviero S
  Mol Cell Biol 2013, 33(6), 1198-209
  
• Are aging biomarkers clinically relevant in oncogeriatrics?
  Falandry C, Gilson E, Rudolph KL
  Crit Rev Oncol Hematol 2013, 85(3), 257-65 published during change of institution
  
• Characterization of a novel picornavirus isolate from a diseased European eel (Anguilla anguilla).
  Fichtner D, Philipps A, Groth M, Schmidt-Posthaus H, Granzow H, Dauber M, Platzer M, Bergmann SM, Schrudde D, Sauerbrei A, Zell R
  J Virol 2013, 87(19), 10895-99
  
• In silico approaches and the role of ontologies in aging research.
  Fuellen G, Boerries M, Busch H, de Grey A, Hahn U, Hiller T, Hoeflich A, Jansen L, Janssens GE, Kaleta C, Meinema AC, Schäuble S, Simm A, Schofield PN, Smith B, Sühnel J, Vera J, Wagner W, Wönne EC, Wuttke D
  Rejuvenation Res 2013, 16(6), 540-6
  
• Haplotypes of IL-12Rβ1 impact on the clinical phenotype of hidradenitis suppurativa.
  Giatrakos S, Huse K, Kanni T, Tzanetakou V, Kramer M, Grech I, Papadavid E, Katoulis A, Stavrianeas N, Nothnagel M, Platzer M, Bauer M, Giamarellos-Bourboulis EJ
  Cytokine 2013, 62(2), 297-301
  
• The mitochondrial genome of Arctica islandica; Phylogeny and variation.
  Glöckner G, Heinze I, Platzer M, Held C, Abele D
  PLoS One 2013, 8(12), e82857
  
• Absence of replicative senescence in cultured cells from the short-lived killifish Nothobranchius furzeri.
  Graf* M, Hartmann* N, Reichwald K, Englert C
  Exp Gerontol 2013, 48(1), 17-28 * equal contribution
  
• What is a particle? A lesson from the photon
  Greulich KO
  In: The Nature of Light: What are Photons? V 2013, 8832, 431-7, SPIE Press, Bellingham, W
  
• The role of telomeres in stem cells and cancer.
  Günes C, Rudolph KL
  Cell 2013, 152(3), 390-3
  
• Role of NF-κB in Neurodegenerative Diseases
  Haenold R, Kretz A, Weih F
  In: Forum on Immunopathological Diseases and Therapeutics (edited by Benjamin B, Zouhair Atassi M) 2013, 4(2), 161-79, Begell House, Inc., Redd
  
• Ein kurzlebiger Fisch als Modell für die Alternsforschung
  Hartmann N, Reichwald K, Platzer M, Englert C
  Biol Unserer Zeit 2013, 43, 87-95
  
• The holocentric species Luzula elegans shows interplay between centromere and large-scale genome organization.
  Heckmann S, Macas J, Kumke K, Fuchs J, Schubert V, Ma L, Novák P, Neumann P, Taudien S, Platzer M, Houben A
  Plant J 2013, 73(4), 555-65
  
• The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML.
  Heidel FH, Bullinger L, Arreba-Tutusaus P, Wang Z, Gaebel J, Hirt C, Niederwieser D, Lane SW, Döhner K, Vasioukhin V, Fischer T, Armstrong SA
  J Exp Med 2013, 210(1), 15-22
  
• Defining the subcellular interface of nanoparticles by live-cell imaging.
  Hemmerich PH, von Mikecz AH
  PLoS One 2013, 8(4), e62018
  
• The responsibility of the scientist. What can history teach us about how scientists should handle research that has the potential to create harm?
  Herrlich P
  EMBO Rep 2013, 14(9), 759-64
  
• The pathophysiological consequences of thyroid hormone transporter deficiencies: Insights from mouse models.
  Heuer H, Visser TJ
  Bba-Gen Subjects 2013, 1830(7), 3974-8
  
• Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks.
  Holdt LM, Hoffmann S, Sass K, Langenberger D, Scholz M, Krohn K, Finstermeier K, Stahringer A, Wilfert W, Beutner F, Gielen S, Schuler G, Gäbel G, Bergert H, Bechmann I, Stadler PF, Thiery J, Teupser D
  PLoS Genet 2013, 9(7), e1003588
  
• The duck genome and transcriptome provide insight into an avian influenza virus reservoir species.
  Huang Y, Li Y, Burt DW, Chen H, Zhang Y, Qian W, Kim H, Gan S, Zhao Y, Li J, Yi K, Feng H, Zhu P, Li B, Liu Q, Fairley S, Magor KE, Du Z, Hu X, Goodman L, Tafer H, Vignal A, Lee T, Kim KW, Sheng Z, An Y, Searle S, Herrero J, Groenen MAM, Crooijmans RPMA, Faraut T, Cai Q, Webster RG, Aldridge JR, Warren WC, Bartschat S, Kehr S, Marz M, Stadler PF, Smith J, Kraus RHS, Zhao Y, Ren L, Fei J, Morisson M, Kaiser P, Griffin DK, Rao M, Pitel F, Wang J, Li N
  Nat Genet 2013, 45(7), 776-83
  
• JenAge Ageing Factor Database - AgeFactDB
  Hühne R, Thalheim T, Sühnel J
  JenAge 2013, JenAge, version 1, URL http://ag
  
• Mutation in CYP27A1 identified in family with coronary artery disease.
  Inanloorahatloo K, Zand Parsa AF, Huse K, Rasooli P, Davaran S, Platzer M, Fan JB, Amini S, Steemers F, Elahi E
  Eur J Med Genet 2013, 56(12), 655-60
  
• MREdictor: a two-step dynamic interaction model that accounts for mRNA accessibility and Pumilio binding accurately predicts microRNA targets.
  Incarnato D, Neri F, Diamanti D, Oliviero S
  Nucleic Acids Res 2013, 41(18), 8421-33
  
• GABAB receptor antibodies in paraneoplastic cerebellar ataxia.
  Jarius S, Steinmeyer F, Knobel A, Streitberger K, Hotter B, Horn S, Heuer H, Schreiber SJ, Wilhelm T, Trefzer U, Wildemann B, Ruprecht K
  J Neuroimmunol 2013, 256(1-2), 94-6
  
• Sirtuins: Longevity focuses on NAD+.
  Jasper H
  Nat Chem Biol 2013, 9(11), 666-7
  
• Misregulation of an adaptive metabolic response contributes to the age-related disruption of lipid homeostasis in Drosophila.
  Karpac J, Biteau B, Jasper H
  Cell Rep 2013, 4(6), 1250-61
  
• Aging: seeking mitonuclear balance.
  Karpac J, Jasper H
  Cell 2013, 154(2), 271-3
  
• Relationships between Cargo, Cell Penetrating Peptides and Cell Type for Uptake of Non-Covalent Complexes into Live Cells.
  Keller AA, Mussbach F, Breitling R, Hemmerich P, Schaefer B, Lorkowski S, Reissmann S
  Pharmaceuticals 2013, 6(2), 184-203
  
• Ribosome-associated chaperones act as proteostasis sentinels.
  Kirstein-Miles J, Morimoto RI
  Cell Cycle 2013, 12(15), 2335
  
• The nascent polypeptide-associated complex is a key regulator of proteostasis.
  Kirstein-Miles J, Scior A, Deuerling E, Morimoto RI
  EMBO J 2013, 32(10), 1451
  
• Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding.
  Koeberle A, Shindou H, Koeberle SC, Laufer SA, Shimizu T, Werz O
  Proc Natl Acad Sci U S A 2013, 110(7), 2546-51
  
• Alternative 5' Untranslated Regions Are Involved in Expression Regulation of Human Heme Oxygenase-1.
  Kramer M, Sponholz C, Slaba M, Wissuwa B, Claus RA, Menzel U, Huse K, Platzer M, Bauer M
  PLoS One 2013, 8(10), e77224
  
• CEBP factors regulate telomerase reverse transcriptase promoter activity in whey acidic protein-T mice during mammary carcinogenesis.
  Kumar M, Witt B, Knippschild U, Koch S, Meena JK, Heinlein C, Weise JM, Krepulat F, Kuchenbauer F, Iben S, Rudolph KL, Deppert W, Günes C
  Int J Cancer 2013, 132(9), 2032-43 published during change of institution
  
• Reassortants of the pandemic (H1N1) 2009 virus and establishment of a novel porcine H1N2 influenza virus, lineage in Germany.
  Lange J, Groth M, Schlegel M, Krumbholz A, Wieczorek K, Ulrich R, Köppen S, Schulz K, Appl D, Selbitz HJ, Sauerbrei A, Platzer M, Zell R, Dürrwald R
  Vet Microbiol 2013, 167(3-4), 345-56
  
• Dicer-processed small RNAs: rules and exceptions.
  Langenberger D, Çakir MV, Hoffmann S, Stadler PF
  J Exp Zool B Mol Dev Evol 2013, 320(1), 35-46
  
• The correlation of genome size and DNA methylation rate in metazoans.
  Lechner M, Marz M, Ihling C, Sinz A, Stadler PF, Krauss V
  Theor Biosci 2013, 132(1), 47-60
  
• Characterization of a new class of androgen receptor antagonists with potential therapeutic application in advanced prostate cancer.
  Li H, Hassona MD, Lack NA, Axerio-Cilies P, Leblanc E, Kanaan N, Frewin K, Singh K, Adomat H, Böhm KJ, Prinz H, Guns ET, Rennie PS, Cherkasov A
  Mol Cancer Ther 2013, 12(11), 2425-35
  
• Dpp signaling determines regional stem cell identity in the regenerating adult Drosophila gastrointestinal tract.
  Li H, Qi Y, Jasper H
  Cell Rep 2013, 4(1), 10-8
  
• Identification of purple sea urchin telomerase RNA using a next-generation sequencing based approach.
  Li* Y, Podlevsky* JD, Marz* M, Qi X, Hoffmann S, Stadler PF, Chen JJL
  RNA 2013, 19(6), 852-60 * equal contribution
  
• BSTA: a targeted approach combines bulked segregant analysis with next- generation sequencing and de novo transcriptome assembly for SNP discovery in sunflower.
  Livaja M, Wang Y, Wieckhorst S, Haseneyer G, Seidel M, Hahn V, Knapp SJ, Taudien S, Schön CC, Bauer E
  BMC Genomics 2013, 14, 628
  
• Genomics-based high-resolution mapping of the BaMMV/BaYMV resistance gene rym11 in barley (Hordeum vulgare L.).
  Lüpken T, Stein N, Perovic D, Habekuß A, Krämer I, Hähnel U, Steuernagel B, Scholz U, Zhou R, Ariyadasa R, Taudien S, Platzer M, Martis M, Mayer K, Friedt W, Ordon F
  Theor Appl Genet 2013, 126(5), 1201-12
  
• An investigation of the effects of the antioxidants, ebselen or N-acetyl cysteine on human peripheral blood mononuclear cells and T cells.
  Marthandan S, Hyland P, Pawelec G, Barnett Y
  Immun Ageing 2013, 10(1), 7
  
• RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model.
  Mills JR, Malina A, Lee T, Di Paola D, Larsson O, Miething C, Grosse F, Tang H, Zannis-Hadjopoulos M, Lowe SW, Pelletier J
  Blood 2013, 121(17), 3402-12
  
• Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera.
  Mullally A, Bruedigam C, Poveromo L, Heidel FH, Purdon A, Vu T, Austin R, Heckl D, Breyfogle LJ, Kuhn CP, Kalaitzidis D, Armstrong SA, Williams DA, Hill GR, Ebert BL, Lane SW
  Blood 2013, 121(18), 3692-702
  
• Distribution, functional impact, and origin mechanisms of copy number variation in the barley genome.
  Muñoz-Amatriaín M, Eichten SR, Wicker T, Richmond TA, Mascher M, Steuernagel B, Scholz U, Ariyadasa R, Spannagl M, Nussbaumer T, Mayer KF, Taudien S, Platzer M, Jeddeloh JA, Springer NM, Muehlbauer GJ, Stein N
  Genome Biol 2013, 14(6), R58
  
• Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells.
  Neri F, Incarnato D, Krepelova A, Rapelli S, Pagnani A, Zecchina R, Parlato C, Oliviero S
  Genome Biol 2013, 14(8), R91
  
• Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs.
  Neri* F, Krepelova* A, Incarnato D, Maldotti M, Parlato C, Galvagni F, Matarese F, Stunnenberg HG, Oliviero S
  Cell 2013, 155(1), 121-34 * equal contribution
  
• Heterozygous mutations in PALB2 cause DNA replication and damage response defects.
  Nikkilä J, Parplys AC, Pylkäs K, Bose M, Huo Y, Borgmann K, Rapakko K, Nieminen P, Xia B, Pospiech* H, Winqvist* R
  Nat Commun 2013, 4, 2578 * equal contribution
  
• Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines.
  Ori A, Banterle N, Iskar M, Andrés-Pons A, Escher C, Bui KH, Sparks L, Solis-Mezarino V, Rinner O, Bork P, Lemke EA, Beck M
  Mol Syst Biol 2013, 9, 648
  
• Swimming behavior of the monotrichous bacterium Pseudomonas fluorescens SBW25.
  Ping L, Birkenbeil J, Monajembashi S
  FEMS Microbiol Ecol 2013, 86(1), 36-44
  
• Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments.
  Prewitz MC, Seib FP, von Bonin M, Friedrichs J, Stißel A, Niehage C, Müller K, Anastassiadis K, Waskow C, Hoflack B, Bornhäuser M, Werner C
  Nat Methods 2013, 10(8), 788-94
  
• Extension of Life Span by Impaired Glucose Metabolism in Caenorhabditis elegans Is Accompanied by Structural Rearrangements of the Transcriptomic Network.
  Priebe S, Menzel U, Zarse K, Groth M, Platzer M, Ristow M, Guthke R
  PLoS One 2013, 8(10), e77776
  
• α-Synuclein Oligomers Impair Neuronal Microtubule-Kinesin Interplay.
  Prots I, Veber V, Brey S, Campioni S, Buder K, Riek R, Böhm KJ, Winner B
  J Biol Chem 2013, 288(30), 21742-54
  
• The common ancestral core of vertebrate and fungal telomerase RNAs.
  Qi X, Li Y, Honda S, Hoffmann S, Marz M, Mosig A, Podlevsky JD, Stadler PF, Selker EU, Chen JJL
  Nucleic Acids Res 2013, 41(1), 450-62
  
• Why soft UV-A damages DNA: An optical micromanipulation study
  Rapp A, Greulich KO
  In: Optical Trapping and Optical Micromanipulation X (edited by Dholakia K, Spalding GC), Proceedings of SPIEE 2013, 8810, 511-7, SPIE Press, Bellingham, W
  
• Pan genome of the phytoplankton Emiliania underpins its global distribution.
  Read BA, Kegel J, Klute MJ, Kuo A, Lefebvre SC, Maumus F, Mayer C, Miller J, Monier A, Salamov A, Young J, Aguilar M, Claverie JM, Frickenhaus S, Gonzalez K, Herman EK, Lin YC, Napier J, Ogata H, Sarno AF, Shmutz J, Schroeder D, de Vargas C, Verret F, von Dassow P, Valentin K, Van de Peer Y, Wheeler G, Emiliania huxleyi Annotation Consortium, Dacks JB, Delwiche CF, Dyhrman ST, Glöckner G, John U, Richards T, Worden AZ, Zhang X, Grigoriev IV
  Nature 2013, 499(7457), 209-13
  
• Identification of prolyl oligopeptidase as a cyclosporine-sensitive protease by screening of mouse liver extracts.
  Rentzsch A, Kahlert V, Jahreis G, Schlott B, Schutkowski M, Malešević M, Fischer G
  Biol Chem 2013, 394(8), 1057-67
  
• Histone acetyltransferase cofactor trrap maintains self-renewal and restricts differentiation of embryonic stem cells.
  Sawan C, Hernandez-Vargas H, Murr R, Lopez F, Vaissière T, Ghantous AY, Cuenin C, Imbert J, Wang ZQ, Ren B, Herceg Z
  Stem Cells 2013, 31(5), 979-91
  
• Conserved gene regulatory function of the carboxy-terminal domain of dictyostelid C-module-binding factor.
  Schmith A, Groth M, Ratka J, Gatz S, Spaller T, Siol O, Glöckner G, Winckler T
  Eukaryot Cell 2013, 12(3), 460-8
  
• Structural RNA alignment by multi-objective optimization.
  Schnattinger T, Schöning U, Kestler HA
  Bioinformatics 2013, 29(13), 1607-13
  
• PPARβ/δ governs Wnt signaling and bone turnover.
  Scholtysek C, Katzenbeisser J, Fu H, Uderhardt S, Ipseiz N, Stoll C, Zaiss MM, Stock M, Donhauser L, Böhm C, Kleyer A, Hess A, Engelke K, David JP, Djouad F, Tuckermann JP, Desvergne B, Schett G, Krönke G
  Nat Med 2013, 19(5), 608-13
  
• Ciliated sensory hair cell formation and function require the F-BAR protein syndapin I and the WH2 domain-based actin nucleator Cobl.
  Schüler S, Hauptmann J, Perner B, Kessels** MM, Englert** C, Qualmann** B
  J Cell Sci 2013, 126(Pt 1), 196-208 ** co-corresponding authors
  
• Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors.
  Schwitalla S, Ziegler PK, Horst D, Becker V, Kerle I, Begus-Nahrmann Y, Lechel A, Rudolph KL, Langer R, Slotta-Huspenina J, Bader FG, Prazeres da Costa O, Neurath MF, Meining A, Kirchner T, Greten FR
  Cancer Cell 2013, 23(1), 93-106 published during change of institution
  
• Inflammatory monocytes and Fcγ receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice.
  Seeling M, Hillenhoff U, David JP, Schett G, Tuckermann J, Lux A, Nimmerjahn F
  Proc Natl Acad Sci U S A 2013, 110(26), 10729-34 published during change of institution
  
• Putative Sugar Transporters of the Mustard Leaf Beetle Phaedon cochleariae: Their Phylogeny and Role for Nutrient Supply in Larval Defensive Glands.
  Stock M, Gretscher RR, Groth M, Eiserloh S, Boland W, Burse A
  PLoS One 2013, 8(12), e84461
  
• Rule-based modeling and simulations of the inner kinetochore structure.
  Tschernyschkow S, Herda S, Gruenert G, Döring V, Görlich D, Hofmeister A, Hoischen C, Dittrich P, Diekmann S, Ibrahim B
  Prog Biophys Mol Biol 2013, 113(1), 33-45
  
• Monocarboxylate transporter 8 modulates the viability and invasive capacity of human placental cells and fetoplacental growth in mice.
  Vasilopoulou E, Loubière LS, Heuer H, Trajkovic-Arsic M, Darras VM, Visser TJ, Lash GE, Whitley GS, McCabe CJ, Franklyn JA, Kilby MD, Chan SY
  PLoS One 2013, 8(6), e65402
  
• Systematic analysis and evolution of 5S ribosomal DNA in metazoans.
  Vierna J, Wehner S, Höner zu Siederdissen C, Martínez-Lage A, Marz M
  Heredity 2013, 111(5), 410-21
  
• Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locus.
  von Kampen O, Buch S, Nothnagel M, Azocar L, Molina H, Brosch M, Erhart W, von Schönfels W, Egberts J, Seeger M, Arlt A, Balschun T, Franke A, Lerch MM, Mayerle J, Kratzer W, Boehm BO, Huse K, Schniewind B, Tiemann K, Jiang ZY, Han TQ, Mittal B, Srivastava A, Fenger M, Jørgensen T, Schirin-Sokhan R, Tönjes A, Wittenburg H, Stumvoll M, Kalthoff H, Lammert F, Tepel J, Puschel K, Becker T, Schreiber S, Platzer M, Völzke H, Krawczak M, Miquel JF, Schafmayer C, Hampe J
  Hepatology 2013, 57(6), 2407-17
  
• Pax7 is critical for the normal function of satellite cells in adult skeletal muscle.
  von Maltzahn J, Jones AE, Parks RJ, Rudnicki MA
  Proc Natl Acad Sci U S A 2013, 110(41), 16474-9
  
• A truncated Wnt7a retains full biological activity in skeletal muscle.
  von Maltzahn J, Zinoviev R, Chang NC, Bentzinger CF, Rudnicki MA
  Nat Commun 2013, 4, 2869 research results from former institution
  
• Nilotinib shows prolonged intracellular accumulation upon pulse-exposure: a novel mechanism for induction of apoptosis in CML cells.
  Wagner MC, Dziadosz M, Melo JV, Heidel F, Fischer T, Lipka DB
  Leukemia 2013, 27(7), 1567-70
  
• The role of MIZ-1 in MYC-dependent tumorigenesis.
  Wiese KE, Walz S, von Eyss B, Wolf E, Athineos D, Sansom O, Eilers M
  Cold Spring Harb Perspect Med 2013, 3(12), a014290
  
• Miz1 is required to maintain autophagic flux.
  Wolf E, Gebhardt A, Kawauchi D, Walz S, von Eyss B, Wagner N, Renninger C, Krohne G, Asan E, Roussel MF, Eilers M
  Nat Commun 2013, 4, 2535
  
• Rapid induction of complete molecular remission by sequential therapy with LDAC and sorafenib in FLT3-ITD-positive patients unfit for intensive treatment: two cases and review of the literature.
  Wolleschak D, Schalk E, Krogel C, Schnoeder TM, Luehr H, Jentsch-Ullrich K, Fischer T, Heidel FH
  J Hematol Oncol 2013, 6, 39
  
• Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.
  Yamamoto* R, Morita* Y, Ooehara J, Hamanaka S, Onodera M, Rudolph KL, Ema H, Nakauchi H
  Cell 2013, 154(5), 1112-26 * equal contribution
  
• PARP-1 Controls Immunosuppressive Function of Regulatory T Cells by Destabilizing Foxp3.
  Zhang P, Maruyama T, Konkel JE, Abbatiello B, Zamarron B, Wang ZQ, Chen W
  PLoS One 2013, 8(8), e71590
  
• PARP-1 regulates expression of TGF-β receptors in T cells.
  Zhang P, Nakatsukasa H, Tu E, Kasagi S, Cui K, Ishikawa M, Konkel JE, Maruyama T, Wei G, Abbatiello B, Wang ZQ, Zhao K, Chen W
  Blood 2013, 122(13), 2224-32
  

Publications 2012:

• Comparative evaluation of the gut microbiota associated with the below- and above-ground life stages (larvae and beetles) of the forest cockchafer, Melolontha hippocastani.
  Arias-Cordero E, Ping L, Reichwald K, Delb H, Platzer M, Boland W
  PLoS One 2012, 7(12), e51557
  
• Developmental gene regulation by an ancient intercellular communication system in social amoebae.
  Asghar A, Groth M, Siol O, Gaube F, Enzensperger C, Glöckner G, Winckler T
  Protist 2012, 163(1), 25-37
  
• The multiple facets of glucocorticoid action in rheumatoid arthritis.
  Baschant U, Lane NE, Tuckermann J
  Nat Rev Rheumatol 2012, 8(11), 645-55
  
• Age-dependent regulation of tumor-related microRNAs in the brain of the annual fish Nothobranchius furzeri.
  Baumgart M, Groth M, Priebe S, Appelt J, Guthke R, Platzer M, Cellerino A
  Mech Ageing Dev 2012, 133(5), 226-33
  
• A pRNA-induced structural rearrangement triggers 6S-1 RNA release from RNA polymerase in Bacillus subtilis.
  Beckmann BM, Hoch PG, Marz M, Willkomm DK, Salas M, Hartmann RK
  EMBO J 2012, 31(7), 1727-38
  
• Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis.
  Begus-Nahrmann Y, Hartmann D, Kraus J, Eshraghi P, Scheffold A, Grieb M, Rasche V, Schirmacher P, Lee HW, Kestler HA, Lechel A, Rudolph KL
  J Clin Invest 2012, 122(6), 2283-8 published during change of institution
  
• Fungal-Induced Cell Cycle Impairment, Chromosome Instability and Apoptosis via Differential Activation of NF-κB.
  Ben-Abdallah M, Sturny-Leclère A, Avé P, Louise A, Moyrand F, Weih F, Janbon G, Mémet S
  PLoS Pathog 2012, 8(3), e1002555
  
• Precise RNAi-mediated silencing of metabolically active proteins in the defence secretions of juvenile leaf beetles.
  Bodemann RR, Rahfeld P, Stock M, Kunert M, Wielsch N, Groth M, Frick S, Boland W, Burse A
  Proc Biol Sci 2012, 279(1745), 4126-34
  
• RSK2 protects mice against TNF-induced bone loss.
  Böhm C, Derer A, Axmann R, Hillienhoff U, Zaiss MM, Luther J, Zech C, Stock M, Scholtysek C, Engelke K, Hess A, Tuckermann JP, Schett G, David JP
  J Cell Sci 2012, 125(Pt 9), 2160-71
  
• Synthesis and functional characterization of tridegin and its analogues: inhibitors and substrates of factor XIIIa.
  Böhm M, Kühl T, Hardes K, Coch R, Arkona C, Schlott B, Steinmetzer T, Imhof D
  ChemMedChem 2012, 7(2), 326-33
  
• Cell-cycle-dependent structural transitions in the human CENP-A nucleosome in vivo.
  Bui M, Dimitriadis EK, Hoischen C, An E, Quénet D, Giebe S, Nita-Lazar A, Diekmann S, Dalal Y
  Cell 2012, 150(2), 317-26
  
• Unusual combinatorial involvement of poly-A/T tracts in organizing genes and chromatin in Dictyostelium.
  Chang GS, Noegel AA, Mavrich TN, Müller R, Tomsho L, Ward E, Felder M, Jiang C, Eichinger L, Glöckner G, Schuster SC, Pugh BF
  Genome Res 2012, 22(6), 1098-106
  
• Genome dynamics explain the evolution of flowering time CCT domain gene families in the Poaceae.
  Cockram J, Thiel T, Steuernagel B, Stein N, Taudien S, Bailey PC, O'Sullivan DM
  PLoS One 2012, 7(9), e45307
  
• Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity.
  Creemers JWM, Choquet H, Stijnen P, Vatin V, Pigeyre M, Beckers S, Meulemans S, Than ME, Yengo L, Tauber M, Balkau B, Elliott P, Jarvelin MR, Van Hul W, Van Gaal L, Horber F, Pattou F, Froguel P, Meyre D
  Diabetes 2012, 61(2), 383-90
  
• Immunolocalization of S100-like protein in the brain of an emerging model organism: Nothobranchius furzeri.
  D'Angelo L, De Girolamo P, Cellerino A, Terzibasi Tozzini E, Varricchio E, Castaldo L, Lucini C
  Microsc Res Tech 2012, 75(4), 441-47
  
• Neurotrophin Trk receptors in the brain of a teleost fish, Nothobranchius furzeri.
  D'Angelo L, de Girolamo P, Cellerino A, Tozzini ET, Castaldo L, Lucini C
  Microsc Res Tech 2012, 75(1), 81-8
  
• CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin.
  Dambacher S, Deng W, Hahn M, Sadic D, Fröhlich J, Nuber A, Hoischen C, Diekmann S, Leonhardt H, Schotta G
  Nucleus 2012, 3(1), 101-10
  
• ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis.
  Dellago H, Khan A, Nussbacher M, Gstraunthaler A, Lämmermann I, Schosserer M, Mück C, Anrather D, Scheffold A, Ammerer G, Jansen-Dürr P, Rudolph KL, Voglauer-Grillari R, Grillari J
  Aging (Albany NY) 2012, 4(4), 290-304 published during change of institution
  
• Transcriptional Repression of ATF4 Gene by CCAAT/Enhancer-binding Protein β (C/EBPβ) Differentially Regulates Integrated Stress Response.
  Dey S, Savant S, Teske BF, Hatzoglou M, Calkhoven CF, Wek RC
  J Biol Chem 2012, 287(26), 21936-49
  
• Genome-wide search for novel human uORFs and N-terminal protein extensions using ribosomal footprinting.
  Fritsch C, Herrmann A, Nothnagel M, Szafranski K, Huse K, Schumann F, Schreiber S, Platzer M, Krawczak M, Hampe J, Brosch M
  Genome Res 2012, 22(11), 2208-18
  
• Systems biology and bioinformatics in aging research: a workshop report.
  Fuellen G, Dengjel J, Hoeflich A, Hoeijemakers J, Kestler HA, Kowald A, Priebe S, Rebholz-Schuhmann D, Schmeck B, Schmitz U, Stolzing A, Sühnel J, Wuttke D, Vera J
  Rejuvenation Res 2012, 15(6), 631-41
  
• A novel role of human holiday junction resolvase GEN1 in the maintenance of centrosome integrity.
  Gao M, Rendtlew Danielsen J, Wei LZ, Zhou DP, Xu Q, Li MM, Wang ZQ, Tong WM, Yang YG
  PLoS One 2012, 7(11), e49687
  
• Contribution of the C-terminal regions of promyelocytic leukemia protein (PML) isoforms II and V to PML nuclear body formation.
  Geng Y, Monajembashi S, Shao A, Cui D, He W, Chen Z, Hemmerich** P, Tang** J
  J Biol Chem 2012, 287(36), 30729-42 ** co-senior authors
  
• Autophagy researchers
  González-Estévez C
  Autophagy 2012, 8(10), 1411-14
  
• Decreased neoblast progeny and increased cell death during starvation-induced planarian degrowth.
  González-Estévez C, Felix DA, Rodríguez-Esteban G, Aboobaker AA
  Int J Dev Biol 2012, 56(1-3), 83-91
  
• SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians.
  González-Estévez C, Felix DA, Smith MD, Paps J, Morley SJ, James V, Sharp TV, Aboobaker AA
  PLoS Genet 2012, 8(3), e1002619
  
• UVA-induced DNA double-strand breaks result from the repair of clustered oxidative DNA damages.
  Greinert R, Volkmer B, Henning S, Breitbart EW, Greulich KO, Cardoso MC, Rapp A
  Nucleic Acids Res 2012, 40(20), 10263-73
  
• Single DNA Molecule Typing, Heart Beating, DNA Repair and Ageing: The Contribution of Fluorescence Techniques
  Greulich KO, Grigaravicius P, Monajembashi S
  In: Reviews in Fluorescence 2012, Volume 2010, 199-222, Springer, Heidelberg
  
• Colony-stimulating factor-1 mediates macrophage-related neural damage in a model for Charcot-Marie-Tooth disease type 1X.
  Groh J, Weis J, Zieger H, Stanley ER, Heuer H, Martini R
  Brain 2012, 135(1), 88-104
  
• Telomere dysfunction puts the brakes on oncogene-induced cancers.
  Günes C, Rudolph KL
  EMBO J 2012, 31(13), 2833-4
  
• The actin nucleator Cobl is crucial for Purkinje cell development and works in close conjunction with the F-actin binding protein Abp1.
  Haag N, Schwintzer L, Ahuja R, Koch N, Grimm J, Heuer H, Qualmann B, Kessels MM
  J Neurosci 2012, 32(49), 17842-56
  
• Trafficking and proteolytic processing of APP.
  Haass C, Kaether C, Thinakaran G, Sisodia S
  Cold Spring Harb Perspect Med 2012, 2(5), a006270
  
• Magnetic resonance imaging of the mouse visual pathway for in vivo studies of degeneration and regeneration in the CNS.
  Haenold R, Herrmann KH, Schmidt S, Reichenbach JR, Schmidt KF, Löwel S, Witte OW, Weih F, Kretz A
  Neuroimage 2012, 59(1), 363-76
  
• Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.
  Hamidi T, Algül H, Cano CE, Sandi MJ, Molejon MI, Riemann M, Calvo EL, Lomberk G, Dagorn JC, Weih F, Urrutia R, Schmid RM, Iovanna JL
  J Clin Invest 2012, 122(6), 2092-103
  
• A microinjection protocol for the generation of transgenic killifish (Species: Nothobranchius furzeri).
  Hartmann N, Englert C
  Dev Dyn 2012, 241(6), 1133-41
  
• Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia stem cells in CML.
  Heidel FH, Bullinger L, Feng Z, Wang Z, Neff TA, Stein L, Kalaitzidis D, Lane SW, Armstrong SA
  Cell Stem Cell 2012, 10(4), 412-24
  
• Possibilities and limitations for high resolution small animal MRI on a clinical whole-body 3T scanner.
  Herrmann KH, Schmidt S, Kretz A, Haenold R, Krumbein I, Metzler M, Gaser C, Witte OW, Reichenbach JR
  MAGMA 2012, 25(3), 233-44
  
• Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.
  Hewitt G, Jurk D, Marques FDM, Correia-Melo C, Hardy T, Gackowska A, Anderson R, Taschuk M, Mann J, Passos JF
  Nat Commun 2012, 3, 708
  
• Niche science: the aging stem cell.
  Jasper H, Kennedy BK
  Cell Cycle 2012, 11(16), 2959-60
  
• Neurofibromatosis 2011: a report of the Children's Tumor Foundation Annual Meeting.
  Kalamarides M, Acosta MT, Babovic-Vuksanovic D, Carpen O, Cichowski K, Gareth Evans D, Giancotti F, Oliver Hanemann C, Ingram D, Lloyd AC, Mayes DA, Messiaen L, Morrison H, North K, Packer R, Pan D, Stemmer-Rachamimov A, Upadhyaya M, Viskochil D, Wallace MR, Hunter-Schaedle K, Ratner N
  Acta Neuropathol (Berl) 2012, 123(3), 369-80
  
• Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage.
  Kapuria S, Karpac J, Biteau B, Hwangbo D, Jasper H
  PLoS Genet 2012, 8(11), e1003045
  
• Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation.
  Katz SF, Lechel A, Obenauf AC, Begus-Nahrmann Y, Kraus JM, Hoffmann EM, Duda J, Eshraghi P, Hartmann D, Liss B, Schirmacher P, Kestler HA, Speicher MR, Rudolph KL
  Gastroenterology 2012, 142(5), 1229-1239.e3 published during change of institution
  
• Functionality, growth and accelerated aging of tissue engineered living autologous vascular grafts.
  Kelm JM, Emmert MY, Zürcher A, Schmidt D, Begus Nahrmann Y, Rudolph KL, Weber B, Brokopp CE, Frauenfelder T, Leschka S, Odermatt B, Jenni R, Falk V, Zünd G, Hoerstrup SP
  Biomaterials 2012, 33(33), 8277-85 published during change of institution
  
• Schnurri regulates hemocyte function to promote tissue recovery after DNA damage.
  Kelsey EM, Luo X, Brückner K, Jasper H
  J Cell Sci 2012, 125(Pt 6), 1393-400
  
• Malfunctioning DNA Damage Response (DDR) Leads to the Degeneration of Nigro-Striatal Pathway in Mouse Brain.
  Kirshner M, Galron R, Frenkel D, Mandelbaum G, Shiloh Y, Wang ZQ, Barzilai A
  J Mol Neurosci 2012, 46(3), 554-68
  
• Increased reprogramming capacity of mouse liver progenitor cells, compared with differentiated liver cells, requires the BAF complex.
  Kleger A, Mahaddalkar PU, Katz SF, Lechel A, Joo JY, Loya K, Lin Q, Hartmann D, Liebau S, Kraus JM, Cantz T, Kestler HA, Zaehres H, Schöler H, Rudolph KL
  Gastroenterology 2012, 142(4), 907-17 published during change of institution
  
• Liver X receptors orchestrate osteoblast/osteoclast crosstalk and counteract pathologic bone loss.
  Kleyer A, Scholtysek C, Bottesch E, Hillienhof U, Beyer C, Distler JH, Tuckermann JP, Schett G, Krönke G
  J Bone Miner Res 2012, 27(12), 2442-51
  
• Guidelines for the use and interpretation of assays for monitoring autophagy.
  Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NYO, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ETW, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LAM, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RCC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SSL, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CHK, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AMK, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RSB, Clarke PGH, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CAM, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LMD, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S
  Autophagy 2012, 8(4), 445-544
  
• Guidelines for the use and interpretation of assays for monitoring autophagy.
  Klionsky DJ, Abdalla FC, other participants, González-Estévez C, other participants, Zuckerbraun B
  Autophagy 2012, 8(4), 445-544
  
• Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
  Koeberle SC, Romir J, Fischer S, Koeberle A, Schattel V, Albrecht W, Grütter C, Werz O, Rauh D, Stehle T, Laufer SA
  Nat Chem Biol 2012, 8(2), 141-3
  
• Proteomic identification of PSF and p54(nrb) as TopBP1-interacting proteins.
  Kuhnert A, Schmidt U, Monajembashi S, Franke C, Schlott B, Grosse F, Greulich KO, Saluz HP, Hänel F
  J Cell Biochem 2012, 113(5), 1744-53
  
• deepBlockAlign: a tool for aligning RNA-seq profiles of read block patterns.
  Langenberger D, Pundhir S, Ekstrøm CT, Stadler PF, Hoffmann S, Gorodkin J
  Bioinformatics 2012, 28(1), 17-24
  
• Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo.
  Lee MK, Teoh WW, Phang BH, Tong WM, Wang ZQ, Sabapathy K
  Cancer Cell 2012, 22(6), 751-64
  
• A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons.
  Li R, Yang YG, Gao Y, Wang ZQ, Tong WM
  Cell Res 2012, 22(5), 859-72
  
• Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX.
  Lowth BR, Kirstein-Miles J, Saiyed T, Brötz-Oesterhelt H, Morimoto RI, Truscott KN, Dougan DA
  J Struct Biol 2012, 179(2), 193
  
• Molecular, phylogenetic and comparative genomic analysis of the cytokinin oxidase/dehydrogenase gene family in the Poaceae.
  Mameaux S, Cockram J, Thiel T, Steuernagel B, Stein N, Taudien S, Jack P, Werner P, Gray JC, Greenland AJ, Powell W
  Plant Biotechnol J 2012, 10(1), 67-82
  
• Telomere length, telomerase activity and osteogenic differentiation are maintained in adipose-derived stromal cells from senile osteoporotic SAMP6 mice.
  Mirsaidi A, Kleinhans KN, Rimann M, Tiaden AN, Stauber M, Rudolph KL, Richards PJ
  J Tissue Eng Regen M 2012, 6(5), 378-90 published during change of institution
  
• Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development.
  Mueller KM, Themanns M, Friedbichler K, Kornfeld JW, Esterbauer H, Tuckermann JP, Moriggl R
  Mol Cell Endocrinol 2012, 361(1-2), 1-11
  
• Multi-Objective Parameter Selection for Classifiers
  Müssel C, Lausser L, Maucher M, Kestler HA
  J Stat Softw 2012, 46(5), 1–27
  
• Myc regulates the transcription of the PRC2 gene to control the expression of developmental genes in embryonic stem cells.
  Neri F, Zippo A, Krepelova A, Cherubini A, Rocchigiani M, Oliviero S
  Mol Cell Biol 2012, 32(4), 840-51
  
• Visual acuity is reduced in alpha 7 nicotinic receptor knockout mice.
  Origlia N, Valenzano DR, Moretti M, Gotti C, Domenici L
  Invest Ophthalmol Vis Sci 2012, 53(3), 1211-8
  
• Fast and sensitive mapping of bisulfite-treated sequencing data.
  Otto C, Stadler PF, Hoffmann S
  Bioinformatics 2012, 28(13), 1698-704
  
• Isolation and molecular characterization of a second serotype of the encephalomyocarditis virus.
  Philipps A, Dauber M, Groth M, Schirrmeier H, Platzer M, Krumbholz A, Wutzler P, Zell R
  Vet Microbiol 2012, 161(1-2), 49-57
  
• Coevolution of aah: a dps-like gene with the host bacterium revealed by comparative genomic analysis.
  Ping L, Platzer M, Wen G, Delaroque N
  SCI WORLD J 2012, 2012, 504905
  
• Metazoan Hsp70 machines use Hsp110 to power protein disaggregation.
  Rampelt H, Kirstein-Miles J, Nillegoda NB, Chi K, Scholz SR, Morimoto RI, Bukau B
  EMBO J 2012, 31(21), 4221
  
• The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing.
  Rashmi RN, Eckes B, Glöckner G, Groth M, Neumann S, Gloy J, Sellin L, Walz G, Schneider M, Karakesisoglou I, Eichinger L, Noegel AA
  Nucleus 2012, 3(2), 172-86
  
• Glucocorticoids Enhance Intestinal Glucose Uptake Via the Dimerized Glucocorticoid Receptor in Enterocytes.
  Reichardt SD, Föller M, Rexhepaj R, Pathare G, Minnich K, Tuckermann JP, Lang F, Reichardt HM
  Endocrinology 2012, 153(4), 1783-94
  
• Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing.
  Richter J, Schlesner M, Hoffmann S, Kreuz M, Leich E, Burkhardt B, Rosolowski M, Ammerpohl O, Wagener R, Bernhart SH, Lenze D, Szczepanowski M, Paulsen M, Lipinski S, Russell RB, Adam-Klages S, Apic G, Claviez A, Hasenclever D, Hovestadt V, Hornig N, Korbel JO, Kube D, Langenberger D, Lawerenz C, Lisfeld J, Meyer K, Picelli S, Pischimarov J, Radlwimmer B, Rausch T, Rohde M, Schilhabel M, Scholtysik R, Spang R, Trautmann H, Zenz T, Borkhardt A, Drexler HG, Möller P, MacLeod RAF, Pott C, Schreiber S, Trümper L, Loeffler M, Stadler PF, Lichter P, Eils R, Küppers R, Hummel M, Klapper W, Rosenstiel P, Rosenwald A, Brors B, Siebert R, ICGC MMML-Seq Project
  Nat Genet 2012, 44(12), 1316-20
  
• Advances in Stem Cell Aging
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• Connexin45 is expressed in vascular smooth muscle but its function remains elusive.
  Schmidt VJ, Jobs A, von Maltzahn J, Wörsdörfer P, Willecke K, de Wit C
  PLoS One 2012, 7(7), e42287
  
• Genome-wide transcriptome analysis of the plant pathogen Xanthomonas identifies sRNAs with putative virulence functions.
  Schmidtke C, Findeiss S, Sharma CM, Kuhfuss J, Hoffmann S, Vogel J, Stadler PF, Bonas U
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• Pharmacological estrogen administration causes a FSH-independent osteo-anabolic effect requiring ER alpha in osteoblasts.
  Seitz S, Keller J, Schilling AF, Jeschke A, Marshall RP, Stride BD, Wintermantel T, Beil FT, Amling M, Schütz G, Tuckermann** J, Schinke** T
  PLoS One 2012, 7(11), e50301 ** co-corresponding authors
  
• Accumulation of p100, a Precursor of NF-κB2, Enhances Osteoblastic Differentiation in Vitro and Bone Formation in Vivo in aly/aly Mice.
  Seo Y, Fukushima H, Maruyama T, Kuroishi KN, Osawa K, Nagano K, Aoki K, Weih F, Doi T, Zhang M, Ohya K, Katagiri T, Hosokawa R, Jimi E
  Mol Endocrinol 2012, 26(3), 414-22
  
• Telomere dysfunctional environment induces loss of quiescence and inherent impairments of hematopoietic stem cell function.
  Song Z, Zhang J, Ju Z, Rudolph KL
  Aging Cell 2012, 11(3), 449-55 published during change of institution
  
• DNA damage checkpoints in stem cells, ageing and cancer.
  Sperka T, Wang J, Rudolph KL
  Nat Rev Mol Cell Biol 2012, 13(9), 579-90 published during change of institution
  
• Gene polymorphisms in the heme degradation pathway and outcome of severe human sepsis.
  Sponholz C, Huse K, Kramer M, Giamarellos-Bourboulis EJ, Claus RA, Kern A, Engel C, Kuhnt E, Kiehntopf M, Routsi C, Mylona V, Tsangaris I, Heinemann SH, Reinhart K, Platzer M, Bauer M
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• Two novel germline KRAS mutations: expanding the molecular and clinical phenotype.
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• Disrupted-in-Schizophrenia 1 (DISC1) is necessary for the correct migration of cortical interneurons.
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• Kcnh1 voltage-gated potassium channels are essential for early zebrafish development.
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• Association studies of the copy-number variable ß-defensin cluster on 8p23.1 in adenocarcinoma and chronic pancreatitis.
  Taudien* S, Gäbel* G, Kuss* O, Groth M, Grützmann R, Huse K, Kluttig A, Wolf A, Nothnagel M, Rosenstiel P, Greiser KH, Werdan K, Krawczak M, Pilarsky C, Platzer M
  BMC Res Notes 2012, 5, 629 * equal contribution
  
• A physical, genetic and functional sequence assembly of the barley genome.
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  Nature 2012, 491(7426), 711-16
  
• Selective glucocorticoid receptor modulation maintains bone mineral density in mice.
  Thiele S, Ziegler N, Tsourdi E, De Bosscher K, Tuckermann JP, Hofbauer LC, Rauner M
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• VEGFR-3 is expressed on megakaryocyte precursors in the murine bone marrow and plays a regulatory role in megakaryopoiesis.
  Thiele W, Krishnan J, Rothley M, Weih D, Plaumann D, Kuch V, Quagliata L, Weich HA, Sleeman JP
  Blood 2012, 120(9), 1899-907
  
• Adult neurogenesis in the short-lived teleost Nothobranchius furzeri: localization of neurogenic niches, molecular characterization and effects of aging.
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  Aging Cell 2012, 11(2), 241-51 evaluated by "Faculty of 1000"
  
• The role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems.
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• Telomere shortening is associated with reduced duodenal HCOFormula secretory but normal gastric acid secretory capacity in aging mice.
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• Following protein-glycosaminoglycan polysaccharide interactions with differential scanning fluorimetry.
  Uniewicz KA, Ori A, Rudd TR, Guerrini M, Wilkinson MC, Fernig DG, Yates EA
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• Segregation of replicative DNA polymerases during S phase: DNA polymerase ε, but not DNA polymerases α/δ, are associated with lamins throughout S phase in human cells.
  Vaara M, Itkonen H, Hillukkala T, Liu Z, Nasheuer HP, Schaarschmidt D, Pospiech H, Syväoja JE
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• Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation.
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• The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation.
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• Wnt7a-Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle.
  von Maltzahn J, Bentzinger CF, Rudnicki MA
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• Wnt signaling in myogenesis.
  von Maltzahn J, Chang NC, Bentzinger CF, Rudnicki MA
  Trends Cell Biol 2012, 22(11), 602-9
  
• Wnt7a treatment ameliorates muscular dystrophy.
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• A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage.
  Wang J, Sun Q, Morita Y, Jiang H, Gross A, Lechel A, Hildner K, Guachalla LM, Gompf A, Hartmann D, Schambach A, Wuestefeld T, Dauch D, Schrezenmeier H, Hofmann WK, Nakauchi H, Ju Z, Kestler HA, Zender L, Rudolph KL
  Cell 2012, 148(5), 1001-14 published during change of institution
  
• Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease.
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  Neurology 2012, 78(8), 569-77 published during change of institution
  
• A cell autonomous role for the glucocorticoid receptor in skeletal muscle atrophy induced by systemic glucocorticoid exposure.
  Watson ML, Baehr LM, Reichardt HM, Tuckermann JP, Bodine SC, Furlow JD
  Am J Physiol Endocrinol Metab 2012, 302(10), E1210-20
  
• Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia.
  Weber M, Lambeck S, Ding N, Henken S, Kohl M, Deigner HP, Enot DP, Igwe EI, Frappart L, Kiehntopf M, Claus RA, Kamradt T, Weih D, Vodovotz Y, Briles DE, Ogunniyi AD, Paton JC, Maus UA, Bauer M
  FASEB J 2012, 26(6), 2424-36
  
• CD44 Promotes Intoxication by the Clostridial Iota-Family Toxins.
  Wigelsworth DJ, Ruthel G, Schnell L, Herrlich P, Blonder J, Veenstra TD, Carman RJ, Wilkins TD, Van Nhieu GT, Pauillac S, Gibert M, Sauvonnet N, Stiles BG, Popoff MR, Barth H
  PLoS One 2012, 7(12), e51356
  
• Comparative evaluation of establishing a human gut microbial community within rodent models.
  Wos-Oxley M, Bleich A, Oxley APA, Kahl S, Janus L, Smoczek A, Nahrstedt H, Pils M, Taudien S, Platzer M, Hedrich HJ, Medina E, Pieper D
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• Diversification of the structural determinants of fibroblast growth factor-heparin interactions: implications for binding specificity.
  Xu R, Ori A, Rudd TR, Uniewicz KA, Ahmed YA, Guimond SE, Skidmore MA, Siligardi G, Yates EA, Fernig DG
  J Biol Chem 2012, 287(47), 40061-73
  
• Sequencing of 21 varicella-zoster virus genomes reveals two novel genotypes and evidence of recombination.
  Zell R, Taudien S, Pfaff F, Wutzler P, Platzer M, Sauerbrei A
  J Virol 2012, 86(3), 1608-22