Publications 2025:

• Metabolic modelling reveals the aging-associated decline of host-microbiome metabolic interactions in mice.
  Best L, Dost T, Esser D, Flor S, Gamarra AM, Haase M, Kadibalban AS, Marinos G, Walker A, Zimmermann J, Simon R, Schmidt S, Taubenheim J, Künzel S, Häsler R, Franzenburg S, Groth M, Waschina S, Rosenstiel P, Sommer F, Witte OW, Schmitt-Kopplin P, Baines JF, Frahm C, Kaleta C
  Nat Microbiol 2025, 10(4), 973-91
  
• Cross-species comparison reveals that Hmga1 reduces H3K27me3 levels to promote cardiomyocyte proliferation and cardiac regeneration.
  Bouwman M, de Bakker DEM, Honkoop H, Giovou AE, Versteeg D, Boender AR, Nguyen PD, Slotboom M, Colquhoun D, Vigil-Garcia M, Kooijman L, Janssen R, Hooijkaas IB, Günthel M, Visser KJ, Klerk M, Zentilin L, Giacca M, Kaslin J, Boink GJJ, van Rooij E, Christoffels VM, Bakkers J
  Nat Cardiovasc Res 2025, 4(1), 64-82
  
• Rapid brain tumor classification from sparse epigenomic data.
  Brändl B, Steiger M, Kubelt C, Rohrandt C, Zhu Z, Evers M, Wang G, Schuldt B, Afflerbach AK, Wong D, Lum A, Halldorsson S, Djirackor L, Leske H, Magadeeva S, Smičius R, Quedenau C, Schmidt NO, Schüller U, Vik-Mo EO, Proescholdt M, Riemenschneider MJ, Zadeh G, Ammerpohl O, Yip S, Synowitz M, van Bömmel** A, Kretzmer** H, Müller** FJ
  Nat Med 2025, 31(3), 840-8 ** co-corresponding authors
  
• Nerve Growth Factor Receptor (NGFR/p75NTR) of the Small-Spotted Catshark (Scyliorhinus canicula): Evolutionary Conservation and Brain Function.
  Chiavacci E, Camera R, Costa M, Fronte B, Tozzini ET, Cellerino A
  J Comp Neurol 2025, 533(4), e70049
  
• AnchoRNA: Full virus genome alignments through conserved anchor regions
  Eulenfeld** T, Triebel S, Marz** M
  bioRxiv 2025, https://doi.org/10.1101/2025.01. ** co-corresponding authors
  
• Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation.
  Gollowitzer A, Pein H, Rao Z, Waltl L, Bereuter L, Loeser K, Meyer T, Jafari V, Witt F, Winkler R, Su F, Große S, Thürmer M, Grander J, Hotze M, Harder S, Espada L, Magnutzki A, Gstir R, Weinigel C, Rummler S, Bonn G, Pachmayr J, Ermolaeva M, Harayama T, Schlüter H, Kosan C, Heller R, Thedieck K, Schmitt M, Shimizu T, Popp J, Shindou H, Kwiatkowski M, Koeberle A
  Nat Commun 2025, 16(1), 1774
  
• How I diagnose and treat patients in the pre-fibrotic phase of primary myelofibrosis (pre-PMF) - practical approaches of a German expert panel discussion in 2024.
  Griesshammer M, Al-Ali HK, Eckardt JN, Fiegl M, Göthert J, Jentsch-Ullrich K, Koschmieder S, Kvasnicka HM, Reiter A, Schmidt B, Heidel FH
  Ann Hematol 2025 (epub ahead of print)
  
• Novel translational mouse models of metabolic dysfunction-associated steatotic liver disease comparable to human MASLD with severe obesity.
  Hupa-Breier KL, Schenk H, Campos-Murguia A, Wellhöner F, Heidrich B, Dywicki J, Hartleben B, Böker C, Mall J, Terkamp C, Wilkens L, Becker F, Rudolph KL, Manns MP, Mederacke YS, Marhenke S, Redeker H, Lieber M, Iordanidis K, Taubert R, Wedemeyer H, Noyan F, Hardtke-Wolenski M, Jaeckel E
  Mol Metab 2025 (epub ahead of print)
  
• Cell-free DNA for detection and monitoring of extramedullary AML relapse.
  Hupe HC, Wienecke CP, Bartels S, Schipper E, Leßmann J, Lasch A, Bader M, Gabdoulline R, Neugebohren M, Dammann E, Kreipe HH, Lehmann U, Bergmann AK, Di Donato N, Stadler M, Eder M, Ganser A, Heidel FH, Thol F, Heuser M
  Hemasphere 2025, 9(3), e70097
  
• Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin.
  Iqbal S, Andersson S, Nesta E, Pentinmikko N, Kumar A, Kumar Jha S, Borshagovski D, Webb A, Gebert N, Viitala EW, Ritchie A, Scharaw S, Kuuluvainen E, Larsen HL, Saarinen T, Juuti A, Ristimäki A, Jeltsch M, Ori A, Varjosalo M, Pietiläinen KH, Ollila S, Jensen KB, Oudhoff MJ, Katajisto P
  Cell Stem Cell 2025, 32(4), 613-626.e8
  
• Sparse keypoint segmentation of lung fissures: efficient geometric deep learning for abstracting volumetric images.
  Kaftan P, Heinrich MP, Hansen L, Rasche V, Kestler HA, Bigalke A
  INT J COMPUT ASS RAD 2025 (epub ahead of print)
  
• Neuronal autophagy in the control of synapse function.
  Karpova A, Hiesinger PR, Kuijpers M, Albrecht A, Kirstein J, Andres-Alonso M, Biermeier A, Eickholt BJ, Mikhaylova M, Maglione M, Montenegro-Venegas C, Sigrist SJ, Gundelfinger ED, Haucke V, Kreutz MR
  Neuron 2025, 113(7), 974-90
  
• Pathogenesis and management of high molecular risk myeloproliferative neoplasms.
  Ling VY, Heidel FH, Bywater MJ
  Haematologica 2025, 110(4), 863-76
  
• Oncogenic FLT3 internal tandem duplications (ITD) and CD45/PTPRC control osteoclast functions and bone microarchitecture.
  Lossius-Cott C, Annoh A, Bens M, Nietzsche S, Hoffmann B, Figge MT, Rauner M, Hofbauer LC, Müller JP
  JBMR Plus 2025, 9(3), ziae173
  
• Comparison of recognition of symptom burden in MPN between patient- and physician-reported assessment - an intraindividual analysis by the German Study Group for MPN (GSG-MPN).
  Manz K, Heidel FH, Koschmieder S, Schlag R, Lipke J, Stegelmann F, Griesshammer M, Klausmann M, Crodel C, Hochhaus A, Schulz H, Göthert JR, Al-Ali H, Becker H, Reiter A, Beutel G, Kricheldorf K, Brümmendorf TH, Hoffmann W, Döhner K, Isfort S, German Study Group for Myeloproliferative Neoplasms (GSG-MPN)
  Leukemia 2025, 39(4), 864-75
  
• Infection and herbicide exposure implicate c-Abl kinase in α-Synuclein Ser129 phosphorylation
  Marzieh E, Zeyang S, Alvaro QO, Gesa R, Mahdi R, David H, Saskia FE, Thomas FM
  bioRxiv 2025, https://doi.org/10.1101/2025.01.
  
• Analysis of different strains of the turquoise killifish identify transcriptomic signatures associated with heritable lifespan differences.
  Mazzetto M, Reichwald K, Koch P, Groth M, Cellerino A
  J Gerontol A Biol Sci Med Sci 2025 (epub ahead of print)
  
• Signatures of Nonlinear Aging: Molecular Stages of Life: Sudden Changes During Aging as Potential Biomarkers for an Age Classification System.
  Olecka** M, Morrison H, Hoffmann** S
  Bioessays 2025 (epub ahead of print) ** co-corresponding authors
  
• Machine Learning and Omic Data for Prediction of Health and Chronic Diseases
  Olenik M, Dönertaş HM
  In: Encyclopedia of Bioinformatics and Computational Biology (edited by Shoba R, Mario C, Asif MK) 2025, 6, 365-388, Elsevier, Amsterdam
  
• iSODA: A Comprehensive Tool for Integrative Omics Data Analysis in Single- and Multi-Omics Experiments.
  Olivier-Jimenez D, Derks RJE, Harari O, Cruchaga C, Ali M, Ori A, Di Fraia D, Cabukusta B, Henrie A, Giera M, Mohammed Y
  Anal Chem 2025 (epub ahead of print)
  
• Protecting cell cycle integrity: enhanced start-codon stringency in mitosis.
  Omrani O, Siniuk K, Fischer M
  Signal Transduct Target Ther 2025, 10(1), 34
  
• Impact of calreticulin mutations on treatment and survival outcomes in myelofibrosis during ruxolitinib therapy.
  Palandri F, Branzanti F, Morsia E, Dedola A, Benevolo G, Tiribelli M, Beggiato E, Farina M, Martino B, Caocci G, Pugliese N, Tieghi A, Crugnola M, Binotto G, Cavazzini F, Abruzzese E, Isidori A, Scalzulli E, D'Agostino D, Caserta S, Nardo A, Lemoli RM, Cilloni D, Bocchia M, Pane F, Heidel FH, Palumbo GA, Breccia M, Elli EM, Bonifacio M
  Ann Hematol 2025, 104(1), 241-51
  
• Malignant JAK-signaling: at the interface of inflammation and malignant transformation.
  Perner F, Pahl HL, Zeiser R, Heidel FH
  Leukemia 2025 (epub ahead of print)
  
• Genetic- and culture-based tools for studying Bacteroides fragilis.
  Schnizlein MK, Dubey AA, Fiebig A, Crosson S
  Microbiol Resour Announc 2025 (epub ahead of print)
  
• Anti-CD19 CAR-T cell therapy for acquired hemophilia A.
  Schultze-Florey CR, Thol FR, Aleksandrova K, Stoyanov K, Gutierrez Jauregui R, Arseniev L, Leise J, Klöß S, Heidel** FH, Tiede** A
  Leukemia 2025, 39(4), 980-2 ** co-corresponding authors
  
• A novel prognostic risk model for patients with refractory/relapsed acute myeloid leukemia receiving venetoclax plus hypomethylating agents.
  Shahswar R, Gabdoulline R, Krueger K, Wichmann M, Götze KS, Braitsch K, Meggendorfer M, Schmalbrock L, Bullinger L, Modemann F, Fiedler W, Krauter J, Kaun S, Rotermund S, Voß A, Behrens YL, Bergmann AK, Koller E, Beutel G, Thol F, Heidel F, Heuser M
  Leukemia 2025, 39(3), 614-22
  
• Author Correction: Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precision.
  Vromman M, Anckaert J, Bortoluzzi S, Buratin A, Chen CY, Chu Q, Chuang TJ, Dehghannasiri R, Dieterich C, Dong X, Flicek P, Gaffo E, Gu W, He C, Hoffmann S, Izuogu O, Jackson MS, Jakobi T, Lai EC, Nuytens J, Salzman J, Santibanez-Koref M, Stadler P, Thas O, Vanden Eynde E, Verniers K, Wen G, Westholm J, Yang L, Ye CY, Yigit N, Yuan GH, Zhang J, Zhao F, Vandesompele J, Volders PJ
  Nat Methods 2025 (epub ahead of print)
  
• Characterization of Hospital Admissions During Immune Checkpoint Inhibitor Therapy: Insights From the ICOG Study.
  Wiegmann JP, Fröhlich T, Möhn N, Duzzi L, Narten E, Aurich J, Thomas J, Grote-Levi L, Mahjoub S, Berliner D, Wirth T, Golpon H, Bollmann BA, Von Wasilewski I, Gutzmer R, Heidel FH, Skripuletz T, Beutel G, Ivanyi P, ICOG‐CCCH (Immune Cooperative Oncology Group Comprehensive Cancer Center Hannover)
  Cancer Med 2025, 14(3), e70582
  

Publications 2024:

• INHBA is enriched in HPV-negative oropharyngeal squamous cell carcinoma and promotes cancer progression.
  Abou Kors T, Hofmann L, Betzler A, Payer K, Bens M, Truong J, von Witzleben A, Thomas J, Kraus JM, Kalaajieh R, Huber D, Ezić J, Benckendorff J, Greve J, Schuler PJ, Ottensmeier CH, Kestler HA, Hoffmann TK, Theodoraki MN, Brunner C, Laban S
  Cancer Res Commun 2024, 4(2), 571-87
  
• Multi-omics analysis of overexpressed tumor-associated proteins: gene expression, immunopeptide presentation, and antibody response in oropharyngeal squamous cell carcinoma, with a focus on cancer-testis antigens.
  Abou Kors T, Meier M, Mühlenbruch L, Betzler AC, Oliveri F, Bens M, Thomas J, Kraus JM, Doescher J, von Witzleben A, Hofmann L, Ezic J, Huber D, Benckendorff J, Barth TFE, Greve J, Schuler PJ, Brunner C, Blackburn JM, Hoffmann TK, Ottensmeier C, Kestler HA, Rammensee HG, Walz JS, Laban S
  Front Immunol 2024, 15, 1408173
  
• Correction: IER3IP1-mutations cause microcephaly by selective inhibition of ER-Golgi transport.
  Anitei M, Bruno F, Valkova C, Dau T, Cirri E, Mestres I, Calegari F, Kaether C
  Cell Mol Life Sci 2024, 81(1), 465
  
• Hormesis as an adaptive response to infection.
  Bauer M, Ermolaeva M, Singer M, Wetzker R, Soares MP
  Trends Mol Med 2024, 30(7), 633-41
  
• Prospective study validating a multidimensional treatment decision score predicting the 24-month outcome in untreated patients with clinically isolated syndrome and early relapsing-remitting multiple sclerosis, the ProVal-MS study.
  Bayas A, Mansmann U, Ön BI, Hoffmann VS, Berthele A, Mühlau M, Kowarik MC, Krumbholz M, Senel M, Steuerwald V, Naumann M, Hartberger J, Kerschensteiner M, Oswald E, Ruschil C, Ziemann U, Tumani H, Vardakas I, Albashiti F, Kramer F, Soto-Rey I, Spengler H, Mayer G, Kestler HA, Kohlbacher O, Hagedorn M, Boeker M, Kuhn K, Buchka S, Kohlmayer F, Kirschke JS, Behrens L, Zimmermann H, Bender B, Sollmann N, Havla J, Hemmer B, ProVal-MS study group
  Neurol Res Pract 2024, 6(1), 15
  
• Introducing a machine learning algorithm for delirium prediction-the Supporting SURgery with GEriatric Co-Management and AI project (SURGE-Ahead).
  Benovic S, Ajlani AH, Leinert C, Fotteler M, Wolf D, Steger F, Kestler H, Dallmeier D, Denkinger M, Eschweiler GW, Thomas C, Kocar TD
  Age Ageing 2024, 53(5), afae101
  
• Metabolic modeling reveals the aging-associated decline of host-microbiome metabolic interactions in mice
  Best L, Dost T, Esser D, Flor S, Haase M, Kadibalban AS, Marinos G, Walker A, Zimmermann J, Simon R, Schmidt S, Taubenheim J, Künzel S, Häsler R, Groth M, Waschina S, W.Witte O, Schmitt-Kopplin P, F.Baines J, Frahm C, Kaleta C
  bioRxiv 2024, https://doi.org/10.1101/2024.03.
  
• [Genetics, epigenetics, and environmental factors in life expectancy-What role does nature-versus-nurture play in aging?].
  Bierhoff H
  Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2024, 67(5), 521-7
  
• RNA:DNA triplexes: a mechanism for epigenetic communication between hosts and microbes?
  Bierhoff* H, Barber* AE, Blango* MG
  mBio 2024, 15(10), e0198224 * equal contribution
  
• Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia.
  Bruedigam C, Porter AH, Song A, Vroeg In de Wei G, Stoll T, Straube J, Cooper L, Cheng G, Kahl VFS, Sobinoff AP, Ling VY, Jebaraj BMC, Janardhanan Y, Haldar R, Bray LJ, Bullinger L, Heidel FH, Kennedy GA, Hill MM, Pickett HA, Abdel-Wahab O, Hartel G, Lane SW
  Nat Cancer 2024, 5(1), 47-65
  
• Combined analysis of a serum mRNA/miRNA marker signature and CA 19-9 for timely and accurate diagnosis of recurrence after resection of pancreatic ductal adenocarcinoma: A prospective multicenter cohort study.
  Buchholz M, Lausser L, Schenk M, Earl J, Lawlor RT, Scarpa A, Sanjuanbenito A, Carrato A, Malats N, Tjaden C, Giese NA, Büchler M, Hackert T, Kestler HA, Gress TM, BioPaC consortium
  UNITED EUR GASTROENT 2024 (epub ahead of print)
  
• Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage.
  Burkhalter MD, Stiff T, Maerz LD, Casar Tena T, Wiese H, Gerhards J, Sailer SA, Vu LAT, Duong Phu M, Donow C, Alupei M, Iben S, Groth M, Wiese S, Church JA, Jeggo PA, Philipp M
  Cell Death Dis 2024, 15(9), 660
  
• Gut microbiome in atypical depression.
  Busch A, Roy S, Helbing DL, Colic L, Opel N, Besteher B, Walter M, Bauer M, Refisch A
  J Affect Disord 2024, 349, 277-85
  
• The Aging Synapse: An Integrated Proteomic And Transcriptomic Analysis
  Caterino* C, Ugolini* M, Durso W, Jevdokimenko K, Groth M, Riege K, Görlach M, Fornasiero E, Ori A, Hoffmann S, Cellerino A
  bioRxiv 2024, https://doi.org/10.1101/2024.12. * equal contribution
  
• Too old for healthy aging? Exploring age limits of longevity treatments.
  Chaudhari PS, Ermolaeva MA
  NPJ Metab Health Dis 2024, 2(1), 37
  
• Spatio-temporal variability of airborne viruses over sub-Antarctic South Georgia: Effects of sampling device and proximity of the ocean
  Das R, Malard L, Pearce DA, Rahlff J
  bioRxiv 2024, doi.org/10.1101/2024.08.23.60932
  
• Amyloid beta precursor protein contributes to brain aging and learning decline in short-lived turquoise killifish (Nothobranchius furzeri)
  E.M.de Bakker D, Mihaljević M, Gharat K, Richter Y, Bagnoli S, van Bebber F, Adam L, Shamim-Schulze F, Ohlenschläger O, Bens M, Cirri E, Antebi A, Matić I, Schneider A, Schmid B, Cellerino A, Kirstein J, Riccardo Valenzano D
  bioRxiv 2024, https://doi.org/10.1101/2024.10.
  
• Venetoclax resistance in acute lymphoblastic leukemia is characterized by increased mitochondrial activity and can be overcome by co-targeting oxidative phosphorylation.
  Enzenmüller S, Niedermayer A, Seyfried F, Muench V, Tews D, Rupp U, Tausch E, Groß A, Fischer-Posovszky P, Walther P, Stilgenbauer S, Kestler HA, Debatin KM, Meyer LH
  Cell Death Dis 2024, 15(7), 475
  
• The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4
  Feringa FM, Koppes-den Hertog SJ, Wang L, Derks RJE, Kruijff I, Erlebach L, Heijneman J, Miramontes R, Pömpner N, Blomberg N, Olivier-Jimenez D, Eva Johansen L, Cammack AJ, Giblin A, Toomey CE, Rose IVL, Yuan H, Ward M, Isaacs AM, Kampmann M, Kronenberg-Versteeg D, Lashley T, M.Thompson L, Ori A, Mohammed Y, Giera M, van der Kant R
  bioRxiv 2024, https://doi.org/10.1101/2024.07.
  
• Gene regulation by the tumor suppressor p53 - The omics era.
  Fischer M
  Bba-Rev Cancer 2024, 1879(4), 189111
  
• Genomregulation durch Tumorsuppressoren und Onkoproteine
  Fischer M
  BIOspektrum 2024, 30, 123
  
• Determinants of p53 DNA binding, gene regulation, and cell fate decisions.
  Fischer** * M, Sammons** * MA
  Cell Death Differ 2024, 31(7), 836-43 * equal contribution, ** co-corresponding authors
  
• Dominant immune tolerance in the intestinal tract imposed by RelB-dependent migratory dendritic cells regulates protective type 2 immunity.
  Geiselhöringer AL, Kolland D, Patt AJ, Hammann L, Köhler A, Kreft L, Wichmann N, Hils M, Ruedl C, Riemann M, Biedermann T, Anz D, Diefenbach A, Voehringer D, Schmidt-Weber CB, Straub T, Pasztoi M, Ohnmacht C
  Nat Commun 2024, 15(1), 9143
  
• Deciphering the regulatory pathways in skeletal muscle lineage organized by the YAP1/TAZ-TEAD transcriptional network
  Gessler L, Siudzińska A, J.Prószyński T, Sandri M, von Eyss B, Hashemolhosseini S
  bioRxiv 2024, https://doi.org/10.1101/2024.06.
  
• Cell-Type Resolved Protein Atlas of Brain Lysosomes Identifies SLC45A1-Associated Disease as a Lysosomal Disorder.
  Ghoochani A, Heiby JC, Rawat ES, Medoh UN, Di Fraia D, Dong W, Gastou M, Nyame K, Laqtom NN, Gomez-Ospina N, Ori A, Abu-Remaileh M
  bioRxiv 2024, 10.1101/2024.10.14.618295
  
• Epigenetic clock and lifespan prediction in the short-lived killifish Nothobranchius furzeri
  Giannuzzi C, Baumgart M, Neri F, Cellerino A
  bioRxiv 2024, https://doi.org/10.1101/2024.08.
  
• Master corepressor inactivation through multivalent SLiM-induced polymerization mediated by the oncogene suppressor RAI2.
  Goradia N, Werner S, Mullapudi E, Greimeier S, Bergmann L, Lang A, Mertens H, Węglarz A, Sander S, Chojnowski G, Wikman H, Ohlenschläger O, von Amsberg G, Pantel K, Wilmanns M
  Nat Commun 2024, 15(1), 5241
  
• Enhanced performance prediction of ATL model transformations
  Groner R, Bellmann P, Höppner S, Thiam P, Schwenker F, Kestler HA, Tichy M
  Perform Evaluation 2024, 164, 102413
  
• Systematic computational hunting for small RNAs derived from ncRNAs during dengue virus infection in endothelial HMEC-1 cells.
  Gutierrez-Diaz A, Hoffmann S, Gallego-Gómez JC, Bermudez-Santana CI
  Front Bioinform 2024, 4, 1293412
  
• Conceptual foundations of acetylcarnitine supplementation in neuropsychiatric long COVID syndrome: a narrative review.
  Helbing* DL, Dommaschk* EM, Danyeli LV, Liepinsh E, Refisch A, Sen ZD, Zvejniece L, Rocktäschel T, Stabenow LK, Schiöth HB, Walter M, Dambrova M, Besteher B
  Eur Arch Psychiatry Clin Neurosci 2024, 274(8), 1829-45 * equal contribution
  
• Associations between multiple neurological biomarkers and distal sensorimotor polyneuropathy: KORA F4/FF4 study.
  Herder C, Thorand B, Strom A, Rathmann W, Heier M, Koenig W, Morrison H, Ziegler D, Roden M, Peters A, Bönhof GJ, Maalmi H
  Diabetes Metab Res Rev 2024, 40(5), e3807
  
• Asynchronous and Synchronous–Asynchronous Particle Swarms
  Hotstegs CLO, Kestler HA, Kraus JM
  In: Studies in Classification, Data Analysis, and Knowledge Organization., ECDA 2022. (edited by Davino C, Palumbo F, Wilhelm AFX, Kestler HA), Recent Trends and Future Challenges in Learning from Data. 2024, 33-48, Springer, Cham
  
• Acetylation-induced proteasomal degradation of the activated glucocorticoid receptor limits hormonal signaling.
  Iyer-Bierhoff A, Wieczorek M, Peter SM, Ward D, Bens M, Vettorazzi S, Guehrs KH, Tuckermann JP, Heinzel T
  iScience 2024, 27(2), 108943
  
• Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers.
  Jessen* M, Gertzmann* D, Liss* F, Zenk F, Bähner L, Schöffler V, Schulte C, Maric HM, Ade CP, von Eyss** B, Gaubatz** S
  Oncogene 2024, 43(8), 578-93 * equal contribution, ** co-corresponding authors
  
• Immunity and bacterial recruitment in plant leaves are parallel processes whose link shapes sensitivity to temperature stress
  Jose J, Teutloff E, Naseem S, Barth E, Halitschke R, Marz M, T.Agler M
  bioRxiv 2024, https://doi.org/10.1101/2024.06.
  
• The oncogenic lncRNA MIR503HG suppresses cellular senescence counteracting supraphysiological androgen treatment in prostate cancer.
  Kallenbach J, Rasa M, Heidari Horestani M, Atri Roozbahani G, Schindler K, Baniahmad A
  J Exp Clin Cancer Res 2024, 43(1), 321
  
• RelB and C/EBPα critically regulate the development of Peyer's patch mononuclear phagocytes.
  Kanaya T, Jinnohara T, Sakakibara S, Tachibana N, Sasaki T, Kato T, Riemann M, Jin J, Shiroguchi K, Kawakami E, Ohno H
  MUCOSAL IMMUNOL 2024 (epub ahead of print)
  
• Bashing irreproducibility with shournal.
  Kirchner T, Riege K, Hoffmann S
  Sci Rep 2024, 14(1), 4872
  
• Tetrapod sperm length evolution in relation to body mass is shaped by multiple trade-offs.
  Koçillari* L, Cattelan*/* S, Rasotto MB, Seno F, Maritan A, Pilastro A
  Nat Commun 2024, 15(1), 6160 * equal contribution, * corresponding author
  
• Acetylation-dependent control of SIAH2 links JAK2V617F to mitochondrial respiration and ROS-associated apoptosis
  Krämer O, Mustafa AH, Petrosino G, Fischer M, Ricciardi L, Gül D, Christmann M, Morrison H, Wirth M
  Meta Arxiv 2024, https://doi.org/10.21203/rs.3.rs
  
• Comprehensive transcriptome analysis reveals altered mRNA splicing and post-transcriptional changes in the aged mouse brain.
  Kumar NH, Kluever V, Barth E, Krautwurst S, Furlan M, Pelizzola M, Marz M, Fornasiero EF
  Nucleic Acids Res 2024, 52(6), 2865-85
  
• HROB Is Implicated in DNA Replication.
  Kutz J, Schmietendorf H, Rahman SA, Opel F, Pospiech H
  Genes (Basel) 2024, 15(12), 1587
  
• Manipulation of radixin phosphorylation in the nucleus accumbens core modulates risky choice behavior.
  Kwak MJ, Choi SJ, Cai WT, Cho BR, Han J, Park JW, Riecken LB, Morrison H, Choi SY, Kim WY, Kim JH
  Prog Neurobiol 2024, 242, 102681
  
• Permutation-invariant linear classifiers
  Lausser L, Robin R, Hans HA
  Mach Learn 2024, 113, 7195–7221
  
• Pipeline Olympics: continuable benchmarking of computational workflows for DNA methylation sequencing data against an experimental gold-standard
  Lin YY, Breuer K, Weichenhan D, Lafrenz P, Wilk A, Chepeleva M, Mücke O, Schönung M, Petermann F, Kensche P, Weiser L, Thommen F, Giacomelli G, Nordstroem K, Gonzales-Avalos E, Merkel A, Kretzmer H, Fischer J, Krämer S, Iskar M, Wolf S, Buchhalter I, Esteller M, Lawerenz C, Twardziok S, Zapatka M, Hovestadt V, Schlesner M, Schulz M, Hoffmann S, Gerhauser C, Walter J, Hartmann M, B.Lipka D, Assenov Y, Bock C, Plass C, Toth R, Lutsik P
  bioRxiv 2024, https://doi.org/10.1101/2024.09.
  
• Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.
  Lisowski P, Lickfett S, Rybak-Wolf A, Menacho C, Le S, Pentimalli TM, Notopoulou S, Dykstra W, Oehler D, López-Calcerrada S, Mlody B, Otto M, Wu H, Richter Y, Roth P, Anand R, Kulka LAM, Meierhofer D, Glazar P, Legnini I, Telugu NS, Hahn T, Neuendorf N, Miller DC, Böddrich A, Polzin A, Mayatepek E, Diecke S, Olzscha H, Kirstein J, Ugalde C, Petrakis S, Cambridge S, Rajewsky N, Kühn R, Wanker EE, Priller J, Metzger JJ, Prigione A
  Nat Commun 2024, 15(1), 7027
  
• CRISPR/Cas9-Mediated Modification of PTP Expression.
  Lossius C, Kresinsky A, Quiet L, Müller JP
  Methods Mol Biol 2024, 2743, 43
  
• Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.
  Lyu YX, Fu Q, Wilczok D, Ying K, King A, Antebi A, Vojta A, Stolzing A, Moskalev A, Georgievskaya A, Maier AB, Olsen A, Groth A, Simon AK, Brunet A, Jamil A, Kulaga A, Bhatti A, Yaden B, Pedersen BK, Schumacher B, Djordjevic B, Kennedy B, Chen C, Huang CY, Correll CU, Murphy CT, Ewald CY, Chen D, Valenzano DR, Sołdacki D, Erritzoe D, Meyer D, Sinclair DA, Chini EN, Teeling EC, Morgen E, Verdin E, Vernet E, Pinilla E, Fang EF, Bischof E, Mercken EM, Finger F, Kuipers F, Pun FW, Gyülveszi G, Civiletto G, Zmudze G, Blander G, Pincus HA, McClure J, Kirkland JL, Peyer J, Justice JN, Vijg J, Gruhn JR, McLaughlin J, Mannick J, Passos J, Baur JA, Betts-LaCroix J, Sedivy JM, Speakman JR, Shlain J, von Maltzahn J, Andreasson KI, Moody K, Palikaras K, Fortney K, Niedernhofer LJ, Rasmussen LJ, Veenhoff LM, Melton L, Ferrucci L, Quarta M, Koval M, Marinova M, Hamalainen M, Unfried M, Ringel MS, Filipovic M, Topors M, Mitin N, Roy N, Pintar N, Barzilai N, Binetti P, Singh P, Kohlhaas P, Robbins PD, Rubin P, Fedichev PO, Kamya P, Muñoz-Canoves P, de Cabo R, Faragher RGA, Konrad R, Ripa R, Mansukhani R, Büttner S, Wickström SA, Brunemeier S, Jakimov S, Luo S, Rosenzweig-Lipson S, Tsai SY, Dimmeler S, Rando TA, Peterson TR, Woods T, Wyss-Coray T, Finkel T, Strauss T, Gladyshev VN, Longo VD, Dwaraka VB, Gorbunova V, Acosta-Rodríguez VA, Sorrentino V, Sebastiano V, Li W, Suh Y, Zhavoronkov A, Scheibye-Knudsen M, Bakula D
  Aging (Albany NY) 2024, 16(20), 12955-76
  
• Boolean network modeling and its integration with experimental read-outs: An interdisciplinary presentation using a leukemia model.
  Maier J, Schwab JD, Werle SD, Marienfeld R, Möller P, Gaisa NT, Ikonomi N, Kestler HA
  Pathologie (Heidelb) 2024, 45(Suppl 1), 26-30
  
• We need to talk-how muscle stem cells communicate.
  Majchrzak K, Hentschel E, Hönzke K, Geithe C, von Maltzahn J
  Front Cell Dev Biol 2024, 12, 1378548
  
• Identifications of Similarity Metrics for Patients With Cancer: Protocol for a Scoping Review.
  Manuilova I, Bossenz J, Weise AB, Boehm D, Strantz C, Unberath P, Reimer N, Metzger P, Pauli T, Werle SD, Schulze S, Hiemer S, Ustjanzew A, Kestler HA, Busch H, Brors B, Christoph J
  JMIR Res Protoc 2024, 13, e58705
  
• Vitamin B3 Containing Polymers for Nanodelivery.
  Mapfumo PP, Solomun JI, Becker F, Moek E, Leiske MN, Rudolph LK, Brendel JC, Traeger A
  Macromol Biosci 2024, e2400002
  
• J-domain proteins: From molecular mechanisms to diseases.
  Marszalek J, De Los Rios P, Cyr D, Mayer MP, Adupa V, Andréasson C, Blatch GL, Braun JEA, Brodsky JL, Bukau B, Chapple JP, Conz C, Dementin S, Genevaux P, Genest O, Goloubinoff P, Gestwicki J, Hammond CM, Hines JK, Ishikawa K, Joachimiak LA, Kirstein J, Liberek K, Mokranjac D, Nillegoda N, Ramos CHI, Rebeaud M, Ron D, Rospert S, Sahi C, Shalgi R, Tomiczek B, Ushioda R, Ustyantseva E, Ye Y, Zylicz M, Kampinga HH
  Cell Stress Chaperones 2024, 29(1), 21-33
  
• Data report on gene expression after hepatic portal vein ligation (PVL) in rats.
  Meyer** D, Kosacka J, von Bergen M, Christ B, Marz** M
  Front Genet 2024, 15, 1421955 ** co-corresponding authors
  
• Sex chromosome turnover in African annual killifishes of the genus Nothobranchius
  Monika H, Pablo M, Anna CV, Ahmed AR, Sergey AS, Tomáš P, Marie A, Karolína J, Jana Š, Nikolas T, Marek J, Matyáš H, Liehr T, Martin R, Eugene YK, Petr R, Englert C, Petr N, Sember A
  bioRxiv 2024, https://doi.org/10.1101/2024.03.
  
• Comprehensive Colony Health Management and Emerging Pathogens of the Annual Killifish Species Nothobranchius furzeri.
  Naumann U, Brazzell JL, Crim MJ, Hoppe B
  J Am Assoc Lab Anim Sci 2024, 63(1), 20-33
  
• Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease.
  Nyame K, Hims A, Aburous A, Laqtom NN, Dong W, Medoh UN, Heiby JC, Xiong J, Ori A, Abu-Remaileh M
  Mol Cell 2024, 84(7), 1354-1364.e9
  
• Nonlinear DNA methylation trajectories in aging male mice.
  Olecka* M, van Bömmel* A, Best L, Haase M, Foerste S, Riege K, Dost T, Flor S, Witte OW, Franzenburg S, Groth M, von Eyss B, Kaleta C, Frahm C, Hoffmann S
  Nat Commun 2024, 15(1), 3074 * equal contribution
  
• iSODA: A Comprehensive Tool for Integrative Omics Data Analysis in Single- and Multi-Omics Experiments
  Olivier-Jimenez D, J.E.Derks R, Harari O, Cruchaga C, Ali M, Ori A, Di Fraia D, Cabukusta B, Henrie A, Giera M, Mohammed Y
  bioRxiv 2024, https://doi.org/10.1101/2024.08.
  
• Rfam 15: RNA families database in 2025
  Ontiveros N, Cooke E, P.Nawrocki E, Triebel S, Marz M, Rivas E, Griffiths-Jones S, I.Petrov A, Bateman A, Sweeney B
  bioRxiv 2024, https://doi.org/10.1101/2024.09.
  
• Surface microlayer-mediated virome dissemination in the Central Arctic.
  Rahlff J, Westmeijer G, Weissenbach J, Antson A, Holmfeldt K
  Microbiome 2024, 12(1), 218
  
• Viral challenges and adaptations between Central Arctic Ocean and atmosphere
  Rahlff J, Westmeijer G, Weissenbach J, Antson A, Holmfeldt K
  bioRxiv 2024, https://doi.org/10.1101/2024.03.
  
• PAPAS promotes differentiation of mammary epithelial cells and suppresses breast carcinogenesis.
  Ren S, Bai F, Schnell V, Stanko C, Ritsch M, Schenk T, Barth E, Marz M, Wang B, Pei XH, Bierhoff H
  Cell Rep 2024, 43(1), 113644
  
• Endogenous viral elements: insights into data availability and accessibility.
  Ritsch M, Brait N, Harvey E, Marz M, Lequime S
  Virus Evol 2024, 10(1), veae099
  
• Endogenous Bornavirus-like Elements in Bats: Evolutionary Insights from the Conserved Riboviral L-Gene in Microbats and Its Antisense Transcription in Myotis daubentonii.
  Ritsch M, Eulenfeld T, Lamkiewicz K, Schoen A, Weber F, Hölzer** M, Marz** M
  Viruses 2024, 16(8), 1210 ** co-corresponding authors
  
• DNA repair deficiencies and neurodegeneration.
  Ropert B, Gallrein C, Schumacher B
  DNA Repair (Amst) 2024, 138, 103679
  
• Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases.
  Saggau C, Bacher P, Esser D, Rasa M, Meise S, Mohr N, Kohlstedt N, Hutloff A, Schacht SS, Dargvainiene J, Martini GR, Stürner KH, Schröder I, Markewitz R, Hartl J, Hastermann M, Duchow A, Schindler P, Becker M, Bautista C, Gottfreund J, Walter J, Polansky JK, Yang M, Naghavian R, Wendorff M, Schuster EM, Dahl A, Petzold A, Reinhardt S, Franke A, Wieczorek M, Henschel L, Berger D, Heine G, Holtsche M, Häußler V, Peters C, Schmidt E, Fillatreau S, Busch DH, Wandinger KP, Schober K, Martin R, Paul F, Leypoldt F, Scheffold A
  Immunity 2024, 57(10), 2416-32
  
• Hydra has mammal-like mutation rates facilitating fast adaptation despite its nonaging phenotype.
  Sahm A, Riege K, Groth M, Bens M, Kraus J, Fischer M, Kestler H, Englert C, Schaible R, Platzer M, Hoffmann S
  Genome Res 2024, 34(12), 2217-28
  
• Remodelling of the cardiac extracellular matrix proteome during chronological and pathological ageing.
  Santinha D, Vilaça A, Estronca L, Schüler SC, Bartoli C, De Sandre-Giovannoli A, Figueiredo A, Quaas M, Pompe T, Ori** A, Ferreira** L
  Mol Cell Proteomics 2024, 23(1), 100706 ** co-corresponding authors
  
• Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment.
  Schmidt D, Endres C, Hoefflin R, Andrieux G, Zwick M, Karantzelis N, Staehle HF, Vinnakota JM, Duquesne S, Mozaffari Jovein M, Pfeifer D, Becker H, Blazar BR, Zähringer A, Duyster J, Brummer T, Boerries M, Baumeister J, Shoumariyeh K, Li J, Green AR, Heidel FH, Tirosh I, Pahl HL, Leimkühler N, Köhler N, de Toledo MAS, Koschmieder S, Zeiser R
  Cancer Res 2024, 84(18), 2985-3003
  
• Tas1R3 Dependent and Independent Recognition of Sugars in the Urethra and the Role of Tuft Cells in this Process.
  Schmidt P, Perniss A, Bodenbenner-Tuerich M, Wiegand S, Briand L, Deckmann K
  Adv Biol (Weinh) 2024, e2400117
  
• Consequences of GMPPB deficiency for neuromuscular development and maintenance.
  Schurig MK, Umeh O, Henze* H, Jung* MJ, Gresing L, Blanchard V, von Maltzahn J, Hübner* CA, Franzka* P
  Front Mol Neurosci 2024, 17, 1356326 * equal contribution
  
• A First Glance on Coevolution of Boolean Networks to Simulate the Development of Interacting Systems in Molecular Biology.
  Schwab JD, Lutz M, Kestler HA
  In: Studies in Classification, Data Analysis, and Knowledge Organization., ECDA 2022. (edited by Davino C, Palumbo F, Wilhelm AFX, Kestler HA), Recent Trends and Future Challenges in Learning from Data. 2024, 129–141, Springer, Cham
  
• Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD.
  Seddighi S, Qi YA, Brown AL, Wilkins OG, Bereda C, Belair C, Zhang YJ, Prudencio M, Keuss MJ, Khandeshi A, Pickles S, Kargbo-Hill SE, Hawrot J, Ramos DM, Yuan H, Roberts J, Sacramento EK, Shah SI, Nalls MA, Colón-Mercado JM, Reyes JF, Ryan VH, Nelson MP, Cook CN, Li Z, Screven L, Kwan JY, Mehta PR, Zanovello M, Hallegger M, Shantaraman A, Ping L, Koike Y, Oskarsson B, Staff NP, Duong DM, Ahmed A, Secrier M, Ule J, Jacobson S, Reich DS, Rohrer JD, Malaspina A, Dickson DW, Glass JD, Ori A, Seyfried NT, Maragkakis M, Petrucelli L, Fratta P, Ward ME
  Sci Transl Med 2024, 16(734), eadg7162
  
• Prediction of resistance to bevacizumab plus FOLFOX in metastatic colorectal cancer-Results of the prospective multicenter PERMAD trial.
  Seufferlein T, Lausser L, Stein A, Arnold D, Prager G, Kasper-Virchow S, Niedermeier M, Müller L, Kubicka S, König A, Büchner-Steudel P, Wille K, Berger AW, Kestler AMR, Kraus JM, Werle SD, Perkhofer L, Ettrich TJ, Kestler HA
  PLoS One 2024, 19(6), e0304324
  
• Tau mediates the reshaping of the transcriptional landscape toward intermediate Alzheimer's disease stages.
  Siano G, Varisco M, Terrigno M, Wang C, Scarlatti A, Iannone V, Groth M, Galas MC, Hoozemans JJM, Cellerino A, Cattaneo A, Di Primio C
  Front Cell Dev Biol 2024, 12, 1459573
  
• Endothelial LATS2 is a suppressor of bone marrow fibrosis
  Sivaraj KK, Majev PG, Dharmalingam B, Schröder S, Banjanin B, Stehling M, Zeuschner D, Nordheim A, Schneider RK, Adams RH
  Nat Cardiovasc Res 2024, 3(8), 951-69
  
• Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity.
  Soll D, Chu CF, Sun S, Lutz V, Arunkumar M, Gachechiladze M, Schäuble S, Alissa-Alkhalaf M, Nguyen T, Khalil MA, Garcia-Ribelles I, Mueller M, Buder K, Michalke B, Panagiotou G, Ziegler-Martin K, Benz P, Schatzlmaier P, Hiller K, Stockinger H, Luu M, Schober K, Moosmann C, Schamel WW, Huber M, Zielinski CE
  Nat Immunol 2024, 25(10), 1830-44
  
• Pyjacker identifies enhancer hijacking events in acute myeloid leukemia including MNX1 activation via deletion 7q
  Sollier E, Riedel A, H.Toprak U, A.Wierzbinska J, Weichenhan D, Philipp Schmid J, Hakobyan M, Touzart A, Jahn E, Vick B, Brown-Burke F, Kelly K, Kelekci S, Pejkovska A, Goyal A, Bähr M, Breuer K, May Chen MJ, Llamazares-Prada M, Hartmann M, Schönung M, Correia N, Trumpp A, Abdullah Y, Klingmüller U, S.Mughal S, Brors B, Westermann F, Schlesner M, Vosberg S, Herold T, A.Greif P, Pfeifer D, Lübbert M, Fischer T, H.Heidel F, Gebhard C, Walter W, Haferlach T, Eisfeld AK, Mrózek K, Nicolet D, Bullinger L, Smeenk L, Erpelinck C, Mulet-Lazaro R, Delwel R, Ernst A, Scherer M, Lutsik P, Jeremias I, Döhner K, Döhner H, B.Lipka D, Plass C
  bioRxiv 2024, https://doi.org/10.1101/2024.09.
  
• Npbwr1 signaling mediates fast antidepressant action.
  Stein G, Aly JS, Lange L, Manzolillo A, Riege K, Brancato A, Hübner CA, Turecki G, Hoffmann S, Engmann O
  Mol Psychiatry 2024 (epub ahead of print)
  
• Transthyretin orchestrates vitamin B12-induced stress resilience.
  Stein G, Aly JS, Manzolillo A, Lange L, Riege K, Hussain I, Heller EA, Cubillos S, Ernst T, Hübner CA, Turecki G, Hoffmann S, Engmann O
  Biol Psychiatry 2024, 97(1), 54-63
  
• Npbwr1 signaling mediates fast antidepressant action
  Stein G, S.Aly J, Lange L, Manzolillo A, Riege K, Brancato A, A.Hübner C, Turecki G, Hoffmann S, Engmann O
  bioRxiv 2024, 10.1101/2024.02.02.578166
  
• Proteomic profiling reveals CEACAM6 function in driving gallbladder cancer aggressiveness through integrin receptor, PRKCD and AKT/ERK signaling.
  Sugiyanto RN, Metzger C, Inal A, Truckenmueller F, Gür K, Eiteneuer E, Huth T, Fraas A, Heinze I, Kirkpatrick J, Sticht C, Albrecht T, Goeppert B, Poth T, Pusch S, Mehrabi A, Schirmacher P, Ji J, Ori A, Roessler S
  Cell Death Dis 2024, 15(10), 780
  
• An artificial intelligence-assisted clinical framework to facilitate diagnostics and translational discovery in hematologic neoplasia.
  Tang M, Antić Ž, Fardzadeh P, Pietzsch S, Schröder C, Eberhardt A, van Bömmel A, Escherich G, Hofmann W, Horstmann MA, Illig T, McCrary JM, Lentes J, Metzler M, Nejdl W, Schlegelberger B, Schrappe M, Zimmermann M, Miarka-Walczyk K, Patsorczak A, Cario G, Renard BY, Stanulla M, Bergmann AK
  EBioMedicine 2024, 104, 105171
  
• Segmentation-based cardiomegaly detection based on semi-supervised estimation of cardiothoracic ratio.
  Thiam P, Kloth C, Blaich D, Liebold A, Beer M, Kestler HA
  Sci Rep 2024, 14(1), 5695
  
• Engineering extracellular vesicles to transiently permeabilize the blood-brain barrier.
  Tomatis F, Rosa S, Simões S, Barão M, Jesus C, Novo J, Barth E, Marz M, Ferreira L
  J Nanobiotechnology 2024, 22(1), 747
  
• Comprehensive survey of conserved RNA secondary structures in full-genome alignment of Hepatitis C virus.
  Triebel S, Lamkiewicz K, Ontiveros N, Sweeney B, Stadler PF, Petrov AI, Niepmann M, Marz M
  Sci Rep 2024, 14(1), 15145
  
• Ribosomal protein L24 mediates mammalian microRNA processing in an evolutionarily conserved manner.
  Tzur Y, Dubnov S, Madrer N, Bar A, Nadorp B, Mishra N, Heppenstall P, Bennett ER, Greenberg DS, Winek* K, Soreq* H
  Cell Mol Life Sci 2024, 81(1), 55 * corresponding author, Selected as Paper of The Month ELSC Jerusalem January 2024
  
• Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2.
  Tzur Y, Winek K, Madrer N, Dubnov S, Bennett ER, Greenberg DS, Hanin G, Gammal A, Tam J, Arkin IT, Paldor I, Soreq H
  Mol Metab 2024, 79, 101856
  
• Ten simple rules for implementing electronic lab notebooks (ELNs).
  Vandendorpe J, Adam B, Wilbrandt J, Lindstädt B, Förstner KU
  PLoS Comput Biol 2024, 20(6), e1012170
  
• Editorial for ADAC issue 2 of volume 18 (2024)
  Vichi M, Cerioli A, Kestler HA, Okada A, Weihs C
  ADV DATA ANAL CLASSI 2024, 18(2), 245–249
  
• Bidirectional Impact of miR-29a modulation on Memory Stability in the Adult Brain
  Viglione A, Giannuzzi C, Putignano E, Mazziotti R, Cellerino A, Pizzorusso T
  bioRxiv 2024, https://doi.org/10.1101/2024.11.
  
• Immune checkpoint expression on tumor-infiltrating lymphocytes (TIL) is dependent on HPV status in oropharyngeal carcinoma (OPSCC) - A single-cell RNA sequencing analysis.
  von Witzleben A, Grages A, Thomas J, Ezić J, Brunner C, Schuler PJ, Kraus JM, Kestler HA, Vahl JM, Doescher J, King EV, Ottensmeier CH, Hoffmann TK, Laban S
  Oral Oncol 2024, 159, 107107
  
• Maternal perceived stress and green spaces during pregnancy are associated with adult offspring gene (NR3C1 and IGF2/H19) methylation patterns in adulthood: A pilot study.
  Vos S, Van den Bergh BRH, Martens DS, Bijnens E, Shkedy Z, Kindermans H, Platzer M, Schwab M, Nawrot TS
  Psychoneuroendocrinology 2024, 167, 107088
  
• The Neurobeachin-like 2 protein (NBEAL2) controls the homeostatic level of the ribosomal protein RPS6 in mast cells.
  Wegner P, Drube J, Ziegler L, Strotmann B, Marquardt R, Küchler C, Groth M, Nieswandt B, Andreas N, Drube S
  Immunology 2024, 172(1), 61-76
  
• GatekeepR: an R shiny application for the identification of nodes with high dynamic impact in boolean networks.
  Weidner FM, Ikonomi N, Werle SD, Schwab JD, Kestler HA
  Bioinformatics 2024, 40(1), btae007
  
• SEPTIN10-mediated crosstalk between cytoskeletal networks controls mechanotransduction and oncogenic YAP/TAZ signaling.
  Weiler SME, Bissinger M, Rose F, von Bubnoff F, Lutz T, Ori A, Schirmacher P, Breuhahn K
  Cancer Lett 2024, 584, 216637
  
• Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia.
  Weinberger T, Denise M, Joppich M, Fischer M, Garcia Rodriguez C, Kumaraswami K, Wimmler V, Ablinger S, Räuber S, Fang J, Liu L, Liu WH, Winterhalter J, Lichti J, Thomas L, Esfandyari D, Percin G, Matin S, Hidalgo A, Waskow C, Engelhardt S, Todica A, Zimmer R, Pridans C, Gomez Perdiguero E, Schulz C
  Elife 2024, 12, RP89377
  
• Repopulated microglia after pharmacological depletion decrease dendritic spine density in adult mouse brain.
  Wickel J, Chung HY, Ceanga M, von Stackelberg N, Hahn N, Candemir Ö, Baade-Büttner C, Mein N, Tomasini P, Woldeyesus DM, Andreas N, Baumgarten P, Koch P, Groth M, Wang ZQ, Geis C
  Glia 2024, 72(8), 1484-500
  
• Ferritin heavy chain supports stability and function of the regulatory T cell lineage.
  Wu* Q, Carlos* AR, Braza* F, Bergman ML, Kitoko JZ, Bastos-Amador P, Cuadrado E, Martins R, Oliveira BS, Martins VC, Scicluna BP, Landry JJ, Jung FE, Ademolue TW, Peitzsch M, Almeida-Santos J, Thompson J, Cardoso S, Ventura P, Slot M, Rontogianni S, Ribeiro V, Domingues VDS, Cabral IA, Weis S, Groth M, Ameneiro C, Fidalgo M, Wang F, Demengeot J, Amsen D, Soares MP
  EMBO J 2024, 43(8), 1445-83
  
• Aggregates of nonmuscular myosin IIA in erythrocytes associate with GATA1- and GFI1B-related thrombocytopenia.
  Zaninetti C, Rivera J, Vater L, Ohlenforst S, Leinøe E, Böckelmann D, Freson K, Thiele T, Makhloufi H, Rath M, Eberl W, Wolff M, Freyer C, Wesche J, Zieger B, Felbor U, Heidel FH, Greinacher A
  J Thromb Haemost 2024, 22(4), 1179-86
  
• Immunofluorescence microscopy on the blood smear identifies patients with myeloproliferative neoplasms.
  Zaninetti C, Vater L, Kaderali L, Crodel CC, Schnöder TM, Fuhrmann J, Swensson L, Wesche J, Freyer C, Greinacher A, Heidel FH
  Leukemia 2024, 38(9), 2051-8
  
• Metagenomic Analyses of Water Samples of Two Urban Freshwaters in Berlin, Germany, Reveal New Highly Diverse Invertebrate Viruses.
  Zell R, Groth M, Selinka L, Selinka HC
  Microorganisms 2024, 12(11), 2361
  
• Diversity of Picorna-Like Viruses in the Teltow Canal, Berlin, Germany.
  Zell R, Groth M, Selinka L, Selinka HC
  Viruses 2024, 16(7), 1020
  

Publications 2023:

• Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer.
  Akdemir KC, Le VT, Chandran S, Li Y, Verhaak RG, Beroukhim R, Campbell PJ, Chin L, Dixon JR, Futreal PA, PCAWG Structural Variation Working Group, PCAWG Consortium
  Nat Genet 2023, 55(6), 1079
  
• Author Correction: The repertoire of mutational signatures in human cancer.
  Alexandrov LB, Kim J, Haradhvala NJ, Huang MN, Tian Ng AW, Wu Y, Boot A, Covington KR, Gordenin DA, Bergstrom EN, Islam SMA, Lopez-Bigas N, Klimczak LJ, McPherson JR, Morganella S, Sabarinathan R, Wheeler DA, Mustonen V, PCAWG Mutational Signatures Working Group, Getz G, Rozen SG, Stratton MR, PCAWG Consortium
  Nature 2023, 614(7948), E41
  
• Recurrent DNMT3B rearrangements are associated with unfavorable outcome in dicentric (9;20)-positive pediatric BCP-ALL.
  Antić Ž, van Bömmel A, Riege K, Lentes J, Schröder C, Alten J, Eckert C, Fuhrmann L, Steinemann D, Lenk L, Schewe DM, Zimmermann M, Schrappe M, Schlegelberger B, Cario G, Hoffmann S, Bergmann AK
  Leukemia 2023, 37(12), 2522-5
  
• Erratum: Long-Term Brain Organotypic Cultures of the Turquoise Killifish Nothobranchius furzeri.
  Bagnoli S, Brogi L, Fronte B, Bibbiani C, Tozzini ET, Cellerino A
  Cold Spring Harb Protoc 2023, 2023(8), pdb.err108392
  
• Localization and Characterization of Major Neurogenic Niches in the Brain of the Lesser-Spotted Dogfish Scyliorhinus canicula.
  Bagnoli S, Chiavacci E, Cellerino A, Terzibasi Tozzini E
  Int J Mol Sci 2023, 24(4), 3650
  
• Whole-Brain Clearing and Immunofluorescence in Nothobranchius furzeri.
  Bagnoli S, Terzibasi Tozzini E, Cellerino A
  Cold Spring Harb Protoc 2023, 2023(9), 698-704
  
• Immunofluorescence and Aggresome Staining of Nothobranchius furzeri Cryosections.
  Bagnoli S, Terzibasi Tozzini E, Cellerino A
  Cold Spring Harb Protoc 2023, 2023(9), 693-7
  
• EdU and Immunofluorescence Staining of Nothobranchius furzeri Organotypic Cultures.
  Bagnoli S, Terzibasi Tozzini E, Cellerino A
  Cold Spring Harb Protoc 2023, 2023(3), pdb.prot107790
  
• Vaccine Side Effects in Health Care Workers after Vaccination against SARS-CoV-2: Data from TüSeRe:exact Study.
  Bareiß A, Uzun G, Mikus M, Becker M, Althaus K, Schneiderhan-Marra N, Fürstberger A, Schwab JD, Kestler HA, Holderried M, Martus P, Schenke-Layland K, Bakchoul T
  Viruses 2023, 15(1), 65
  
• Evolution, mechanism and limits of dietary restriction induced health benefits and longevity.
  Becker F, Behrends MM, Rudolph KL
  Redox Biol 2023, 63, 102725
  
• Self-Assessment of Having COVID-19 With the Corona Check mHealth App.
  Beierle F, Allgaier J, Stupp C, Keil T, Schlee W, Schobel J, Vogel C, Haug F, Haug J, Holfelder M, Langguth B, Langguth J, Riens B, King R, Mulansky L, Schickler M, Stach M, Heuschmann P, Wildner M, Greger H, Reichert M, Kestler HA, Pryss R
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  Blood Cancer J 2023, 13(1), 65
  
• A Prognostic Model to Predict Ruxolitinib Discontinuation and Death in Patients with Myelofibrosis.
  Palandri F, Palumbo GA, Bonifacio M, Elli EM, Tiribelli M, Auteri G, Trawinska MM, Polverelli N, Benevolo G, Tieghi A, Cavalca F, Caocci G, Beggiato E, Binotto G, Cavazzini F, Miglino M, Bosi C, Crugnola M, Bocchia M, Martino B, Pugliese N, Venturi M, Isidori A, Cattaneo D, Krampera M, Pane F, Cilloni D, Semenzato G, Lemoli RM, Cuneo A, Abruzzese E, Branzanti F, Vianelli N, Cavo M, Heidel F, Iurlo A, Breccia M
  Cancers (Basel) 2023, 15(20), 5027
  
• Predictors of Response to Hydroxyurea and Switch to Ruxolitinib in HU-Resistant Polycythaemia VERA Patients: A Real-World PV-NET Study.
  Palandri F, Rossi E, Auteri G, Breccia M, Paglia S, Benevolo G, Elli EM, Cavazzini F, Binotto G, Tieghi A, Tiribelli M, Heidel FH, Bonifacio M, Pugliese N, Caocci G, Crugnola M, Mendicino F, D'Addio A, Tomassetti S, Martino B, Polverelli N, Ceglie S, Mazzoni C, Mullai R, Ripamonti A, Garibaldi B, Pane F, Cuneo A, Krampera M, Semenzato G, Lemoli RM, Vianelli N, Palumbo GA, Andriani A, Cavo M, Latagliata R, De Stefano V
  Cancers (Basel) 2023, 15(14), 3706
  
• Author Correction: Genomic basis for RNA alterations in cancer.
  PCAWG Transcriptome Core Group, Calabrese C, Davidson NR, Demircioğlu D, Fonseca NA, He Y, Kahles A, Lehmann KV, Liu F, Shiraishi Y, Soulette CM, Urban L, Greger L, Li S, Liu D, Perry MD, Xiang Q, Zhang F, Zhang J, Bailey P, Erkek S, Hoadley KA, Hou Y, Huska MR, Kilpinen H, Korbel JO, Marin MG, Markowski J, Nandi T, Pan-Hammarström Q, Pedamallu CS, Siebert R, Stark SG, Su H, Tan P, Waszak SM, Yung C, Zhu S, Awadalla P, Creighton CJ, Meyerson M, Ouellette BFF, Wu K, Yang H, PCAWG Transcriptome Working Group, Brazma A, Brooks AN, Göke J, Rätsch G, Schwarz RF, Stegle O, Zhang Z, PCAWG Consortium
  Nature 2023, 614(7948), E37
  
• DNA damage response in neurodevelopment and neuromaintenance.
  Qing* X, Zhang* G, Wang ZQ
  FEBS J 2023, 290(13), 3300-10 * equal contribution
  
• VIRify: An integrated detection, annotation and taxonomic classification pipeline using virus-specific protein profile hidden Markov models.
  Rangel-Pineros G, Almeida A, Beracochea M, Sakharova E, Marz M, Reyes Muñoz A, Hölzer M, Finn RD
  PLoS Comput Biol 2023, 19(8), e1011422
  
• T Cells Expressing a Modified FcγRI Exert Antibody-Dependent Cytotoxicity and Overcome the Limitations of CAR T-cell Therapy against Solid Tumors.
  Rasoulouniriana D, Santana-Magal N, Gutwillig A, Farhat-Younis L, Tal L, Amar S, Milyavsky M, Muddineni SSNA, Solomon N, Shpilt H, Dotan S, Pilpel N, Waskow C, Feinmesser M, Rider P, Carmi Y
  CANCER IMMUNOL RES 2023, 11(6), 792
  
• Microbiome and immuno-metabolic dysregulation in patients with major depressive disorder with atypical clinical presentation.
  Refisch A, Sen ZD, Klassert TE, Busch A, Besteher B, Danyeli LV, Helbing D, Schulze-Späte U, Stallmach A, Bauer M, Panagiotou G, Jacobsen ID, Slevogt H, Opel N, Walter M
  Neuropharmacology 2023, 235, 109568
  
• Simultaneous Nbs1 and p53 inactivation in neural progenitors triggers High-Grade Gliomas (HGG).
  Reuss DE, Downing SM, Camacho CV, Wang YD, Piro RM, Herold-Mende C, Wang ZQ, Hofmann TG, Sahm F, von Deimling A, McKinnon PJ, Frappart PO
  Neuropathol Appl Neurobiol 2023, 49(4), e12915
  
• Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes.
  Rheinbay E, Nielsen MM, Abascal F, Wala JA, Shapira O, Tiao G, Hornshøj H, Hess JM, Juul RI, Lin Z, Feuerbach L, Sabarinathan R, Madsen T, Kim J, Mularoni L, Shuai S, Lanzós A, Herrmann C, Maruvka YE, Shen C, Amin SB, Bandopadhayay P, Bertl J, Boroevich KA, Busanovich J, Carlevaro-Fita J, Chakravarty D, Chan CWY, Craft D, Dhingra P, Diamanti K, Fonseca NA, Gonzalez-Perez A, Guo Q, Hamilton MP, Haradhvala NJ, Hong C, Isaev K, Johnson TA, Juul M, Kahles A, Kahraman A, Kim Y, Komorowski J, Kumar K, Kumar S, Lee D, Lehmann KV, Li Y, Liu EM, Lochovsky L, Park K, Pich O, Roberts ND, Saksena G, Schumacher SE, Sidiropoulos N, Sieverling L, Sinnott-Armstrong N, Stewart C, Tamborero D, Tubio JMC, Umer HM, Uusküla-Reimand L, Wadelius C, Wadi L, Yao X, Zhang CZ, Zhang J, Haber JE, Hobolth A, Imielinski M, Kellis M, Lawrence MS, von Mering C, Nakagawa H, Raphael BJ, Rubin MA, Sander C, Stein LD, Stuart JM, Tsunoda T, Wheeler DA, Johnson R, Reimand J, Gerstein M, Khurana E, Campbell PJ, López-Bigas N, PCAWG Drivers and Functional Interpretation Working Group, PCAWG Structural Variation Working Group, Weischenfeldt J, Beroukhim R, Martincorena I, Pedersen JS, Getz G, PCAWG Consortium
  Nature 2023, 614(7948), E40
  
• Pain Recognition Differences between Female and Male Subjects: An Analysis based on the Physiological Signals of the X-ITE Pain Database
  Ricken TB, Bellmann P, Gruss S, Kestler HA, Walter S, Schwenker F
  ACM ICMI 2023, 121-30
  
• Navigating the Landscape: A Comprehensive Review of Current Virus Databases.
  Ritsch M, Cassman NA, Saghaei S, Marz M
  Viruses 2023, 15(9)
  
• Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition.
  Rodriguez-Martin B, Alvarez EG, Baez-Ortega A, Zamora J, Supek F, Demeulemeester J, Santamarina M, Ju YS, Temes J, Garcia-Souto D, Detering H, Li Y, Rodriguez-Castro J, Dueso-Barroso A, Bruzos AL, Dentro SC, Blanco MG, Contino G, Ardeljan D, Tojo M, Roberts ND, Zumalave S, Edwards PA, Weischenfeldt J, Puiggròs M, Chong Z, Chen K, Lee EA, Wala JA, Raine KM, Butler A, Waszak SM, Navarro FCP, Schumacher SE, Monlong J, Maura F, Bolli N, Bourque G, Gerstein M, Park PJ, Wedge DC, Beroukhim R, Torrents D, Korbel JO, Martincorena I, Fitzgerald RC, Van Loo P, Kazazian HH, Burns KH, PCAWG Structural Variation Working Group, Campbell PJ, Tubio JMC, PCAWG Consortium
  Nat Genet 2023, 55(6), 1080
  
• Gene regulatory network inference with popInfer reveals dynamic regulation of hematopoietic stem cell quiescence upon diet restriction and aging.
  Rommelfanger* MK, Behrends* M, Chen Y, Martinez J, Bens M, Xiong L, Rudolph** KL, MacLean** AL
  bioRxiv 2023, 10.1101/2023.04.18.537360 * equal contribution, ** co-corresponding authors
  
• Explaining variation in individual aging, its sources, and consequences: A comprehensive conceptual model of human aging.
  Rothermund K, Englert C, Gerstorf D
  Gerontology 2023, 69(12), 1437-47
  
• The African killifish: A short-lived vertebrate model to study the biology of sarcopenia and longevity.
  Ruparelia AA, Salavaty A, Barlow CK, Lu Y, Sonntag C, Hersey L, Eramo MJ, Krug J, Reuter H, Schittenhelm RB, Ramialison M, Cox A, Ryan MT, Creek DJ, Englert C, Currie PD
  Aging Cell 2023, 23(1), e13862
  
• Genomic analysis of 61 Chlamydia psittaci strains reveals extensive divergence associated with host preference.
  Sachse K, Hölzer M, Vorimore F, Barf LM, Sachse C, Laroucau K, Marz M, Lamkiewicz K
  BMC Genomics 2023, 24(1), 288
  
• ABRAXAS1 orchestrates BRCA1 activities to counter genome destabilizing repair pathways-lessons from breast cancer patients.
  Sachsenweger J, Jansche R, Merk T, Heitmeir B, Deniz M, Faust U, Roggia C, Tzschach A, Schroeder C, Riess A, Pospiech H, Peltoketo H, Pylkäs K, Winqvist R, Wiesmüller L
  Cell Death Dis 2023, 14(5), 328
  
• Detection of reproducible liver cancer specific ligand-receptor signaling in blood
  Safrastyan A, Wollny D
  bioRxiv 2023, 10.1101/2023.09.25.559274
  
• Antioxidants Prevent the Effects of Physical Exercise on Visual Cortical Plasticity.
  Sansevero G, Consorti A, Di Marco I, Terzibasi Tozzini E, Cellerino** A, Sale** A
  Cells 2023, 12(1), doi.org/10.3390/cells12010048 ** co-senior authors
  
• Streptomyces marispadix sp. nov., isolated from marine beach sediment.
  Santos JDND, Vitorino IR, Kallscheuer N, Srivastava A, Krautwurst S, Marz M, Jogler C, Lobo-da-Cunha A, Catita J, Gonçalves H, González I, Reyes F, Lage OM
  Int J Syst Evol Microbiol 2023, 73(7), doi: 10.1099/ijsem.0.005956.
  
• Abl depletion via autophagy mediates the beneficial effects of quercetin against Alzheimer pathology across species.
  Schiavi A, Cirotti C, Gerber LS, Di Lauro G, Maglioni S, Shibao PYT, Montresor S, Kirstein J, Petzsch P, Köhrer K, Schins RPF, Wahle T, Barilà D, Ventura N
  Cell Death Discov 2023, 9(1), 376
  
• Diagnosis and treatment of MPN in real life: exploratory and retrospective chart review including 960 MPN patients diagnosed with ET or MF in Germany.
  Schmidt A, Bernhardt C, Bürkle D, Fries S, Hannig CV, Jentsch-Ullrich K, Josting A, Kreher S, Reiser M, Steinmetz HT, Tesch H, Terner S, Schulte A, Crodel CC, Palandri F, Heidel FH
  J Cancer Res Clin Oncol 2023, 149(10), 7197
  
• Adapting the pantograph limb: Differential robustness of fore- and hindlimb kinematics against genetically induced perturbation in the neural control networks and its evolutionary implications.
  Schnerwitzki D, Englert C, Schmidt M
  Zoology (Jena) 2023, 157, 126076
  
• Functional comparisons of the virus sensor RIG-I from humans, the microbat Myotis daubentonii, and the megabat Rousettus aegyptiacus, and their response to SARS-CoV-2 infection.
  Schoen A, Hölzer M, Müller MA, Wallerang KB, Drosten C, Marz M, Lamp B, Weber F
  J Virol 2023, 97(10), e0020523
  
• PREDICT-juvenile-stroke: PRospective evaluation of a prediction score determining individual clinical outcome three months after ischemic stroke in young adults - a study protocol.
  Schönecker S, Hoffmann V, Albashiti F, Thasler R, Hagedorn M, Louiset ML, Kopczak A, Rösler J, Baki E, Wunderlich S, Kohlmayer F, Kuhn K, Boeker M, Tünnerhoff J, Poli S, Ziemann U, Kohlbacher O, Althaus K, Müller S, Ludolph A, Kestler HA, Mansmann U, Dieterich M, Kellert L
  BMC NEUROL 2023, 23(1), 2
  
• Dynamic DNA methylation reveals novel cis-regulatory elements in mouse hematopoiesis.
  Schönung M, Hartmann M, Krämer S, Stäble S, Hakobyan M, Kleinert E, Aurich T, Cobanoglu D, Heidel FH, Fröhling S, Milsom MD, Schlesner M, Lutsik P, Lipka DB
  Exp Hematol 2023, 117, 24-42.e7
  
• The Necessity of Interoperability to Uncover the Full Potential of Digital Health Devices.
  Schwab JD, Werle SD, Hühne R, Spohn H, Kaisers UX, Kestler HA
  JMIR Med Inform 2023, 11, e49301
  
• Sequencing the Immunoglobulin Heavy-Chain Locus (IgH) in Turquoise Killifish ( Nothobranchius furzeri).
  Seidel J, Bradshaw WJ, Valenzano DR
  Cold Spring Harb Protoc 2023, 5
  
• Taxonomic Profiling of Fecal and Intestinal Microbiota in the African Turquoise Killifish Nothobranchius furzeri.
  Seidel J, Popkes M, Valenzano DR
  Cold Spring Harb Protoc 2023, 2023(10), 755-62 published during change of institution
  
• Corrigendum: Taxonomic Profiling of Fecal and Intestinal Microbiota in the African Turquoise Killifish Nothobranchius furzeri.
  Seidel J, Popkes M, Valenzano DR
  Cold Spring Harb Protoc 2023, 2023(10), pdb.corr108388 published during change of institution
  
• Tau alters global gene expression affecting chromatin in the early stages of Alzheimer’s disease
  Siano* G, Varisco* M, Terrigno M, Wang C, Groth M, Galas MC, Hoozemans JJM, Cellerino A, Cattaneo** A, Di Primio** C
  bioRxiv 2023, 10.1101/2023.11.17.567548 * equal contribution, ** co-senior authors
  
• Magnipore: Prediction of differential single nucleotide changes in the Oxford Nanopore Technologies sequencing signal of SARS-CoV-2 samples
  Spangenberg J, Höner zu Siederdissen C, Žarković M, Triebel S, Rose R, Martínez Christophersen C, Paltzow L, M.Hegab M, Wansorra A, Srivastava A, Krumbholz** A, Marz** M
  bioRxiv 2023, https://doi.org/10.1101/2023.03. ** co-senior authors
  
• Patients receiving allogeneic haematopoietic stem-cell transplantation and clinical outcomes after early access to palliative care.
  Späth C, Neumann T, Schmidt CA, Heidel FH, Krüger WH
  Lancet Haematol 2023, 10(9), e777-84
  
• Protein structure prediction with in-cell photo-crosslinking mass spectrometry and deep learning.
  Stahl K, Graziadei A, Dau T, Brock O, Rappsilber J
  Nat Biotechnol 2023, 41(12), 1810-9
  
• Clinicohematologic and molecular response of essential thrombocythemia patients treated with pegylated interferon-α: a multi-center study of the German Study Group-Myeloproliferative Neoplasms (GSG-MPN).
  Stegelmann F, Teichmann LL, Heidel FH, Crodel CC, Ernst T, Kreil S, Reiter A, Otten S, Schauer S, Körber RM, Kricheldorf K, Isfort S, Döhner H, Brümmendorf TH, Griesshammer M, Döhner K, Koschmieder S
  Leukemia 2023, 37(4), 924
  
• Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia.
  Straube* J, Eifert* T, Vu T, Janardhanan Y, Haldar R, von Eyss B, Cooper L, Bruedigam C, Ling VY, Cooper E, Patch AM, Bullinger L, Schnoeder TM, Bywater M, Heidel* FH, Lane* SW
  Leukemia 2023, 37(4), 741 * equal contribution
  
• Unsupervised domain adaptation for the detection of cardiomegaly in cross-domain chest X-ray images.
  Thiam P, Lausser L, Kloth C, Blaich D, Liebold A, Beer** M, Kestler** HA
  Front Artif Intell 2023, 6, 1056422 ** co-senior authors
  
• Oxford nanopore technologies-a valuable tool to generate whole-genome sequencing data for in silico serotyping and the detection of genetic markers in Salmonella.
  Thomas C, Methner U, Marz M, Linde J
  Front Vet Sci 2023, 10, 1178922
  
• De novo genome assembly resolving repetitive structures enables genomic analysis of 35 European Mycoplasmopsis bovis strains.
  Triebel S, Sachse K, Weber M, Heller M, Diezel C, Hölzer M, Schnee C, Marz M
  BMC Genomics 2023, 24(1), 548
  
• NFDI4Microbiota – national research data infrastructure for microbiota research
  U.Förstner K, Becker A, Blom J, Bork P, Clavel T, Dieckmann M, Goesmann A, Götz B, Gübitz T, Hufsky F, Jünemann S, Körner ML, Marz M, Nunes Da Rocha U, Overmann J, Pühler A, Rebholz-Schuhmann D, Sczyrba A, Stoye J, Vandendorpe J, Van Rossum T, McHardy A
  Res Ideas Outcomes 2023, e110501
  
• Lack of L-type amino acid transporter 2 in murine thyroid tissue induces autophagy.
  Venugopalan V, Rehders M, Weber J, Rodermund L, Al-Hashimi A, Bargmann T, Golchert J, Reinecke V, Homuth G, Völker U, Verrey F, Kirstein J, Heuer H, Schweizer U, Braun D, Wirth EK, Brix K
  J Mol Endocrinol 2023, 70(1), e220060
  
• Identifying Patients with Polycythemia Vera at Risk of Thrombosis after Hydroxyurea Initiation: The Polycythemia Vera-Advanced Integrated Models (PV-AIM) Project.
  Verstovsek S, Krečak I, Heidel FH, De Stefano V, Bryan K, Zuurman MW, Zaiac M, Morelli M, Smyth A, Redondo S, Bigan E, Ruhl M, Meier C, Beffy M, Kiladjian JJ
  Biomedicines 2023, 11(7), 1925
  
• Editorial for ADAC issue 2 of volume 17 (2023)
  Vichi M, Cerioli A, Kestler HA, Okada A, Weihs C
  ADV DATA ANAL CLASSI 2023, 17(2), 287–290
  
• Editorial for ADAC issue 4 of volume 17 (2023)
  Vichi M, Cerioli A, Kestler HA, Okada A, Weihs C
  ADV DATA ANAL CLASSI 2023, 17(4), 823–827
  
• Editorial for ADAC issue 1 of volume 17 (2023)
  Vichi M, Cerioli A, Kestler HA, Okada A, Weihs C
  ADV DATA ANAL CLASSI 2023, 17(1), 1–4
  
• Editorial for ADAC issue 3 of volume 17 (2023)
  Vichi M, Cerioli A, Kestler HA, Okada A, Weihs C
  ADV DATA ANAL CLASSI 2023, 17(3), 545–548
  
• Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precision.
  Vromman M, Anckaert J, Bortoluzzi S, Buratin A, Chen CY, Chu Q, Chuang TJ, Dehghannasiri R, Dieterich C, Dong X, Flicek P, Gaffo E, Gu W, He C, Hoffmann S, Izuogu O, Jackson MS, Jakobi T, Lai EC, Nuytens J, Salzman J, Santibanez-Koref M, Stadler P, Thas O, Vanden Eynde E, Verniers K, Wen G, Westholm J, Yang L, Ye CY, Yigit N, Yuan GH, Zhang J, Zhao F, Vandesompele J, Volders PJ
  Nat Methods 2023, 20(8), 1159-69
  
• Signalling by senescent melanocytes hyperactivates hair growth.
  Wang X, Ramos R, Phan AQ, Yamaga K, Flesher JL, Jiang S, Oh JW, Jin S, Jahid S, Kuan CH, Nguyen TK, Liang HY, Shettigar NU, Hou R, Tran KH, Nguyen A, Vu KN, Phung JL, Ingal JP, Levitt KM, Cao X, Liu Y, Deng Z, Taguchi N, Scarfone VM, Wang G, Paolilli KN, Wang X, Guerrero-Juarez CF, Davis RT, Greenberg EN, Ruiz-Vega R, Vasudeva P, Murad R, Widyastuti LHP, Lee HL, McElwee KJ, Gadeau AP, Lawson DA, Andersen B, Mortazavi A, Yu Z, Nie Q, Kunisada T, Karin M, Tuckermann J, Esko JD, Ganesan AK, Li J, Plikus MV
  Nature 2023, 618(7966), 808-17
  
• A protocol for the use of cloud-based quantum computers for logical network analysis of biological systems.
  Weidner FM, Rossini M, Ankerhold J, Kestler HA
  STAR Protoc 2023, 4(3), 102438
  
• Leveraging quantum computing for dynamic analyses of logical networks in systems biology.
  Weidner FM, Schwab JD, Wölk S, Rupprecht F, Ikonomi N, Werle SD, Hoffmann S, Kühl M, Kestler HA
  PATTERNS 2023, 4(3), 100705
  
• A systems biology approach to define mechanisms, phenotypes, and drivers in PanNETs with a personalized perspective.
  Werle SD, Ikonomi N, Lausser L, Kestler AMTU, Weidner FM, Schwab JD, Maier J, Buchholz M, Gress TM, Kestler AMR, Kestler HA
  NPJ Syst Biol Appl 2023, 9(1), 22
  
• Light and prey influence the abundances of two rhodopsins in the dinoflagellate Oxyrrhis marina.
  Westermann M, Hoischen C, Wöhlbrand L, Rabus R, Rhiel E
  Protoplasma 2023, 260(2), 529-44
  
• Transcriptomes of aging brain, heart, muscle, and spleen from female and male African turquoise killifish.
  Xu A, Teefy BB, Lu RJ, Nozownik S, Tyers AM, Valenzano DR, Benayoun BA
  Sci Data 2023, 10(1), 695 published during change of institution
  
• Author Correction: Butler enables rapid cloud-based analysis of thousands of human genomes.
  Yakneen S, Waszak SM, PCAWG Technical Working Group, Gertz M, Korbel JO, PCAWG Consortium
  Nat Biotechnol 2023, 41(4), 577
  
• High-throughput morphometric and transcriptomic profiling uncovers composition of naïve and sensory-deprived cortical cholinergic VIP/CHAT neurons.
  Yayon N, Amsalem O, Zorbaz T, Yakov O, Dubnov S, Winek K, Dudai A, Adam G, Schmidtner AK, Tessier-Lavigne M, Renier N, Habib N, Segev I, London M, Soreq H
  EMBO J 2023, 42(1), e110565
  
• Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers.
  Yuan Y, Ju YS, Kim Y, Li J, Wang Y, Yoon CJ, Yang Y, Martincorena I, Creighton CJ, Weinstein JN, Xu Y, Han L, Kim HL, Nakagawa H, Park K, Campbell PJ, Liang H, PCAWG Consortium
  Nat Genet 2023, 55(6), 1078
  
• Author Correction: The landscape of viral associations in human cancers.
  Zapatka M, Borozan I, Brewer DS, Iskar M, Grundhoff A, Alawi M, Desai N, Sültmann H, Moch H, PCAWG Pathogens, Cooper CS, Eils R, Ferretti V, Lichter P, PCAWG Consortium
  Nat Genet 2023, 55(6), 1077
  
• Exploring the Diversity of Plant-Associated Viruses and Related Viruses in Riverine Freshwater Samples Collected in Berlin, Germany.
  Zell R, Groth M, Selinka L, Selinka HC
  Pathogens 2023, 12(12), 1458
  
• Hepeliviruses in two waterbodies in Berlin, Germany.
  Zell R, Groth M, Selinka L, Selinka HC
  Arch Virol 2023, 168(1), 9
  
• Epidermal Growth Factor Receptor in Hepatic Endothelial Cells Suppresses MCP-1-Dependent Monocyte Recruitment in Diabetes.
  Zhang X, Ohayon-Steckel L, Coppin E, Johny E, Dasari A, Florentin J, Vasamsetti S, Dutta P
  J Immunol 2023, 210(9), 1363-71
  
• Ribosomal Dysfunction Is a Common Pathomechanism in Different Forms of Trichothiodystrophy.
  Zhu G, Khalid F, Zhang D, Cao Z, Maity P, Kestler HA, Orioli D, Scharffetter-Kochanek K, Iben S
  Cells 2023, 12(14), 1877
  
• Antiseptic efficacy of two mouth rinses in the oral cavity to identify a suitable rinsing solution in radiation- or chemotherapy induced mucositis.
  Zwicker P, Freitag M, Heidel FH, Kocher T, Kramer A
  BMC Oral Health 2023, 23(1), 176
  

Publications 2022:

• Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing.
  Ahmad M, Krüger BT, Kroll T, Vettorazzi S, Dorn AK, Mengele F, Lee S, Nandi S, Yilmaz D, Stolz M, Tangudu NK, Vázquez DC, Pachmayr J, Cirstea IC, Spasic MV, Ploubidou A, Ignatius A, Tuckermann J
  Bone Res 2022, 10(1), 33
  
• Membrane lipids and maximum lifespan in clownfish.
  Almaida-Pagan PF, Lucas-Sanchez A, Martinez-Nicolas A, Terzibasi E, de Lama MAR, Cellerino A, Mendiola P, de Costa J
  Fish Physiol Biochem 2022, 48(1), 53-65
  
• Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT.
  Ayala Mariscal SM, Pigazzini ML, Richter Y, Özel M, Grothaus IL, Protze J, Ziege K, Kulke M, ElBediwi M, Vermaas JV, Colombi Ciacchi L, Köppen S, Liu F, Kirstein J
  Nat Commun 2022, 13(1), 4692
  
• Long-Term Brain Organotypic Cultures of the Turquoise Killifish Nothobranchius furzeri
  Bagnoli S, Brogi L, Fronte B, Bibbiani C, Terzibasi Tozzini E, Cellerino A
  Cold Spring Harb Protoc 2022, 2022(12), 624-9
  
• Quantification of noradrenergic-, dopaminergic-, and tectal-neurons during aging in the short-lived killifish Nothobranchius furzeri.
  Bagnoli S, Fronte B, Bibbiani C, Terzibasi Tozzini E, Cellerino A
  Aging Cell 2022, 21(9), e13689
  
• Breakthrough infections in MPN-COVID vaccinated patients.
  Barbui T, Carobbio A, Ghirardi A, Iurlo A, De Stefano V, Sobas MA, Rumi E, Elli EM, Lunghi F, Gasior Kabat M, Cuevas B, Guglielmelli P, Bonifacio M, Marchetti M, Alvarez-Larran A, Fox L, Bellini M, Daffini R, Benevolo G, Carreno-Tarragona G, Patriarca A, Al-Ali HK, Andrade-Campos MMM, Palandri F, Harrison C, Foncillas MA, Osorio S, Koschmieder S, Magro Mazo E, Kiladjian JJ, Bolaños Calderón E, Heidel FH, Quiroz Cervantes K, Griesshammer M, Garcia-Gutierrez V, Sanchez AM, Hernandez-Boluda JC, Lopez Abadia E, Carli G, Sagues Serrano M, Kusec R, Xicoy Cirici B, Guenova M, Navas Elorza B, Angona A, Cichocka E, Kulikowska de Nałęcz A, Cattaneo D, Bucelli C, Betti S, Borsani O, Cavalca F, Carbonell S, Curto-Garcia N, Benajiba L, Rambaldi A, Vannucchi AM
  Blood Cancer J 2022, 12(11), 154
  
• A Theoretical Approach to Ordinal Classification: Feature Space-Based Definition and Classifier-Independent Detection of Ordinal Class Structures
  Bellmann P, Lausser L, Kestler HA, Schwenker F
  APPL SCI-BASEL 2022, 12(4), 1815;
  
• Machine Learning-based Pain Intensity Estimation: Where Pattern Recognition meets Chaos Theory–An Example based on the BioVid Heat Pain Database.
  Bellmann P, Thiam P, Kestler HA, Schwenker F
  IEEE ACCESS 2022, 10, 102770-7
  
• Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish.
  Bradshaw WJ, Poeschla M, Placzek A, Kean S, Valenzano DR
  Elife 2022, 11, e65117 published during change of institution
  
• Impaired formation of neutrophil extracellular traps (NETs) in patients with myelodysplastic syndrome.
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• Gib mir den Virus und ich sag dir den Wirt
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  Cold Spring Harb Protoc 2022, 2022(12), doi: 10.1101/pdb.prot107782
  
• Functional profiling of long intergenic non-coding RNAs in fission yeast.
  Rodriguez-Lopez M, Anver S, Cotobal C, Kamrad S, Malecki M, Correia-Melo C, Hoti M, Townsend S, Marguerat S, Pong SK, Wu MY, Montemayor L, Howell M, Ralser M, Bähler J
  Elife 2022, 11, e76000
  
• Correction: Functional profiling of long intergenic non-coding RNAs in fission yeast.
  Rodriguez-Lopez M, Anver S, Cotobal C, Kamrad S, Malecki M, Correia-Melo C, Hoti M, Townsend S, Marguerat S, Pong SK, Wu MY, Montemayor L, Howell M, Ralser M, Bähler J
  Elife 2022, 11
  
• Pollutants corrupt resilience pathways of aging in the nematode C. elegans.
  Scharf A, Limke A, Guehrs KH, von Mikecz A
  iScience 2022, 25(9), 105027
  
• Restoring Age-Related Cognitive Decline through Environmental Enrichment: A Transcriptomic Approach.
  Schmidt S, Haase M, Best L, Groth M, Lindner J, Witte OW, Kaleta C, Frahm C
  Cells 2022, 11(23), 3864
  
• Association of Telomere Length With Risk of Disease and Mortality.
  Schneider CV, Schneider KM, Teumer A, Rudolph KL, Hartmann D, Rader DJ, Strnad P
  JAMA INTERN MED 2022, 182(3), 291-300
  
• Significance of men's health in long-term survivors of allogeneic stem cell transplantation.
  Schneidewind L, Neumann T, Peters N, Kranz J, Probst KA, Heidel FH, Hakenberg OW, Krüger W
  Bone Marrow Transplant 2022, 57(6), 998
  
• PLCG1 is required for AML1-ETO leukemia stem cell self-renewal.
  Schnoeder TM, Schwarzer A, Jayavelu AK, Hsu CJ, Kirkpatrick J, Döhner K, Perner F, Eifert T, Huber N, Arreba-Tutusaus P, Dolnik A, Assi SA, Nafria M, Jiang L, Dai YT, Chen Z, Chen SJ, Kellaway SG, Ptasinska A, Ng ES, Stanley EG, Elefanty AG, Buschbeck M, Bierhoff H, Brodt S, Matziolis G, Fischer KD, Hochhaus A, Chen CW, Heidenreich O, Mann M, Lane SW, Bullinger L, Ori A, Eyss Bv, Bonifer C, Heidel F
  Blood 2022, 139(7), 1080-97
  
• A comparative study of pre-alpha islands in the entorhinal cortex from selected primates and in lissencephaly.
  Schön M, Nosanova A, Jacob C, Kraus JM, Kestler HA, Mayer B, Feldengut S, Amunts K, Del Tredici K, Boeckers TM, Braak H
  J Comp Neurol 2022, 530(4), 683-704
  
• The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response.
  Schuhwerk H, Kleemann J, Gupta P, van Roey R, Armstark I, Kreileder M, Feldker N, Ramesh V, Hajjaj Y, Fuchs K, Mahapatro M, Hribersek M, Volante M, Groenewoud A, Engel FB, Ceppi P, Eckstein M, Hartmann A, Müller F, Kroll T, Stemmler MP, Brabletz S, Brabletz T
  Cell Rep 2022, 41(11), 111819
  
• Disrupting PTPRJ transmembrane-mediated oligomerization counteracts oncogenic receptor tyrosine kinase FLT3 ITD.
  Schwarz M, Rizzo S, Paz WE, Kresinsky A, Thévenin D, Müller JP
  Front Oncol 2022, 12, 1017947
  
• Weighted average ensemble-based semantic segmentation in biological electron microscopy images.
  Shaga Devan K, Kestler HA, Read C, Walther P
  Histochem Cell Biol 2022, 158(5), 447–462
  
• A genome-wide CRISPR activation screen reveals Hexokinase 1 as a critical factor in promoting resistance to multi-kinase inhibitors in hepatocellular carcinoma cells.
  Sofer S, Lamkiewicz K, Armoza Eilat S, Partouche S, Marz M, Moskovits N, Stemmer SM, Shlomai A, Sklan EH
  FASEB J 2022, 36(3), e22191
  
• The chromatin remodeling protein ATRX positively regulates IRF3-dependent type I interferon production and interferon-induced gene expression.
  Stilp AC, Scherer M, König P, Fürstberger A, Kestler HA, Stamminger T
  PLoS Pathog 2022, 18(8), e1010748
  
• Sex chromosome differentiation via changes in the Y chromosome repeat landscape in African annual killifishes Nothobranchius furzeri and N. kadleci.
  Štundlová J, Hospodářská M, Lukšíková K, Voleníková A, Pavlica T, Altmanová M, Richter A, Reichard M, Dalíková M, Pelikánová Š, Marta A, Simanovsky SA, Hiřman M, Jankásek M, Dvořák T, Bohlen J, Ráb P, Englert C, Nguyen P, Sember A
  Chromosome Res 2022, 30(4), 309-33
  
• The Mating Pattern of Captive Naked Mole-Rats Is Best Described by a Monogamy Model
  Szafranski* K, Wetzel* M, Holtze S, Büntjen I, Lieckfeldt D, Ludwig A, Huse K, Platzer M, Hildebrandt T
  FRONT ECOL EVOL 2022, 10, 855688 * equal contribution
  
• PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling.
  Thürmer M, Gollowitzer A, Pein H, Neukirch K, Gelmez E, Waltl L, Wielsch N, Winkler R, Löser K, Grander J, Hotze M, Harder S, Döding A, Meßner M, Troisi F, Ardelt M, Schlüter H, Pachmayr J, Gutiérrez-Gutiérrez Ó, Rudolph KL, Thedieck K, Schulze-Späte U, González-Estévez C, Kosan C, Svatoš A, Kwiatkowski M, Koeberle A
  Nat Commun 2022, 13(1), 2982
  
• Comparative Panel Sequencing of DNA Variants in cf-, ev- and tumorDNA for Pancreatic Ductal Adenocarcinoma Patients.
  Waldenmaier M, Schulte L, Schönfelder J, Fürstberger A, Kraus JM, Daiss N, Seibold T, Morawe M, Ettrich TJ, Kestler HA, Kahlert C, Seufferlein T, Eiseler T
  Cancers (Basel) 2022, 14(4), 1074
  
• Characterization of SARS-CoV-2 infection clusters based on integrated genomic surveillance, outbreak analysis and contact tracing in an urban setting.
  Walker A, Houwaart T, Finzer P, Ehlkes L, Tyshaieva A, Damagnez M, Strelow D, Duplessis A, Nicolai J, Wienemann T, Tamayo T, Kohns Vasconcelos M, Hülse L, Hoffmann K, Lübke N, Hauka S, Andree M, Däumer MP, Thielen A, Kolbe-Busch S, Göbels K, Zotz R, Pfeffer K, Timm J, Dilthey AT, German COVID-19 OMICS Initiative (DeCOI)
  Clin Infect Dis 2022, 74(6), 1039-46
  
• The Central Domain of MCPH1 Controls Development of the Cerebral Cortex and Gonads in Mice.
  Wang Y, Zong W, Sun W, Chen C, Wang** ZQ, Li** T
  Cells 2022, 11(17), 2715 ** co-corresponding authors
  
• Response to the letter to the editor: On the feasibility of dynamical analysis of network models of biochemical regulation.
  Weidner FM, Schwab JD, Werle SD, Ikonomi N, Lausser L, Kestler HA
  Bioinformatics 2022, 38(14), 3676
  
• Identification of dynamic driver sets controlling phenotypical landscapes.
  Werle SD, Ikonomi N, Schwab JD, Kraus JM, Weidner FM, Rudolph KL, Pfister AS, Schuler R, Kühl M, Kestler HA
  Comput Struct Biotechnol J 2022, 20, 1603-17
  
• Backbone and side chain resonance assignment of the intrinsically disordered human DBNDD1 protein.
  Wiedemann C, Obika KB, Liebscher S, Jirschitzka J, Ohlenschläger O, Bordusa F
  Biomol NMR Assign 2022, 16(2), 237-46
  
• Love your Data! (Poster)
  Willbrandt J
  2022, URL https://zenodo.org/record/71
  
• Biological underpinnings of sex differences in neurological disorders.
  Winek K, Tzur Y, Soreq H
  Int Rev Neurobiol 2022, 164, 27
  
• Brain–body communication in stroke - Mens sana in corpore sano
  Winek** K, Cuervo Zanatta** D, Zille** M
  NEUROFORUM 2022, 28(1), 31–39 ** co-corresponding authors
  
• De novo identification of maximally deregulated subnetworks based on multi-omics data with DeRegNet.
  Winkler S, Winkler I, Figaschewski M, Tiede T, Nordheim A, Kohlbacher O
  BMC Bioinformatics 2022, 23(1), 139
  
• Inorganic sulfur fixation via a new homocysteine synthase allows yeast cells to cooperatively compensate for methionine auxotrophy.
  Yu JSL, Heineike BM, Hartl J, Aulakh SK, Correia-Melo C, Lehmann A, Lemke O, Agostini F, Lee CT, Demichev V, Messner CB, Mülleder M, Ralser M
  PLoS Biol 2022, 20(12), e3001912
  
• Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance.
  Yu* JSL, Correia-Melo* C, Zorrilla F, Herrera-Dominguez L, Wu MY, Hartl J, Campbell K, Blasche S, Kreidl M, Egger AS, Messner CB, Demichev V, Freiwald A, Mülleder M, Howell M, Berman J, Patil KR, Alam* MT, Ralser* M
  NAT MICROBIOL 2022, 7(4), 542–555 * equal contribution
  
• The Role of Non-Coding RNAs in the Human Placenta.
  Žarković* M, Hufsky* F, Markert** UR, Marz** M
  Cells 2022, 11(9), 1588 * equal contribution, ** co-senior authors
  
• Picorna-Like Viruses of the Havel River, Germany.
  Zell R, Groth M, Selinka L, Selinka HC
  Front Microbiol 2022, 13, 865287
  

Publications 2021:

• Nicotinamide for the treatment of heart failure with preserved ejection fraction.
  Abdellatif M, Trummer-Herbst V, Koser F, Durand S, Adão R, Vasques-Nóvoa F, Freundt JK, Voglhuber J, Pricolo MR, Kasa M, Türk C, Aprahamian F, Herrero-Galán E, Hofer SJ, Pendl T, Rech L, Kargl J, Anto-Michel N, Ljubojevic-Holzer S, Schipke J, Brandenberger C, Auer M, Schreiber R, Koyani CN, Heinemann A, Zirlik A, Schmidt A, von Lewinski D, Scherr D, Rainer PP, von Maltzahn J, Mühlfeld C, Krüger M, Frank S, Madeo F, Eisenberg T, Prokesch A, Leite-Moreira AF, Lourenço AP, Alegre-Cebollada J, Kiechl S, Linke WA, Kroemer G, Sedej S
  Sci Transl Med 2021, 13(580), eabd7064
  
• BCL3 couples cancer stem cell enrichment with pancreatic cancer molecular subtypes.
  Ai J, Wörmann SM, Görgülü K, Vallespinos M, Zagorac S, Alcala S, Wu N, Kabacaoglu D, Berninger A, Navarro D, Kaya-Aksoy E, Ruess DA, Ciecielski KJ, Kowalska M, Demir EI, Ceyhan GO, Heid I, Braren R, Riemann M, Schreiner S, Hofmann S, Kutschke M, Jastroch M, Slotta-Huspenina J, Muckenhuber A, Schlitter AM, Schmid RM, Steiger K, Diakopoulos KN, Lesina M, Sainz B, Algül H
  Gastroenterology 2021, 161(1), 318-32
  
• Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications.
  Altincekic N, Korn SM, Qureshi NS, Dujardin M, Ninot-Pedrosa M, Abele R, Abi Saad MJ, Alfano C, Almeida FCL, Alshamleh I, de Amorim GC, Anderson TK, Anobom CD, Anorma C, Bains JK, Bax A, Blackledge M, Blechar J, Böckmann A, Brigandat L, Bula A, Bütikofer M, Camacho-Zarco AR, Carlomagno T, Caruso IP, Ceylan B, Chaikuad A, Chu F, Cole L, Crosby MG, de Jesus V, Dhamotharan K, Felli IC, Ferner J, Fleischmann Y, Fogeron ML, Fourkiotis NK, Fuks C, Fürtig B, Gallo A, Gande SL, Gerez JA, Ghosh D, Gomes-Neto F, Gorbatyuk O, Guseva S, Hacker C, Häfner S, Hao B, Hargittay B, Henzler-Wildman K, Hoch JC, Hohmann KF, Hutchison MT, Jaudzems K, Jović K, Kaderli J, Kalniņš G, Kaņepe I, Kirchdoerfer RN, Kirkpatrick J, Knapp S, Krishnathas R, Kutz F, Zur Lage S, Lambertz R, Lang A, Laurents D, Lecoq L, Linhard V, Löhr F, Malki A, Bessa LM, Martin RW, Matzel T, Maurin D, McNutt SW, Mebus-Antunes NC, Meier BH, Meiser N, Mompeán M, Monaca E, Montserret R, Mariño Perez L, Moser C, Muhle-Goll C, Neves-Martins TC, Ni X, Norton-Baker B, Pierattelli R, Pontoriero L, Pustovalova Y, Ohlenschläger O, Orts J, Da Poian AT, Pyper DJ, Richter C, Riek R, Rienstra CM, Robertson A, Pinheiro AS, Sabbatella R, Salvi N, Saxena K, Schulte L, Schiavina M, Schwalbe H, Silber M, Almeida MdS, Sprague-Piercy MA, Spyroulias GA, Sreeramulu S, Tants JN, Tārs K, Torres F, Töws S, Treviño MÁ, Trucks S, Tsika AC, Varga K, Wang Y, Weber ME, Weigand JE, Wiedemann C, Wirmer-Bartoschek J, Wirtz Martin MA, Zehnder J, Hengesbach M, Schlundt A
  Front Mol Biosci 2021, 8, 653148
  
• Predicting disease progression in behavioral variant frontotemporal dementia.
  Anderl-Straub S, Lausser L, Lombardi J, Uttner I, Fassbender K, Fliessbach K, Huppertz HJ, Jahn H, Kornhuber J, Obrig H, Schneider A, Semler E, Synofzik M, Danek A, Prudlo J, Kassubek J, Landwehrmeyer B, Lauer M, Volk AE, Wiltfang J, Diehl-Schmid J, Ludolph AC, Schroeter ML, Kestler HA, Otto M, FTLD consortium
  Alzheimers Dement (Amst) 2021, 13(1), e12262
  
• RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve Cellular Homeostasis in Pancreatic Cancer.
  Arnold F, Gout J, Wiese H, Weissinger SE, Roger E, Perkhofer L, Walter K, Scheible J, Prelli Bozzo C, Lechel A, Ettrich TJ, Azoitei N, Hao L, Fürstberger A, Kaminska EK, Sparrer KMJ, Rasche V, Wiese S, Kestler HA, Möller P, Seufferlein T, Frappart PO, Kleger A
  Cancer Res 2021, 81(7), 1758-74
  
• Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration.
  Arnold F, Mahaddalkar PU, Kraus JM, Zhong X, Bergmann W, Srinivasan D, Gout J, Roger E, Beutel AK, Zizer E, Tharehalli U, Daiss N, Russell R, Perkhofer L, Oellinger R, Lin Q, Azoitei N, Weiss FU, Lerch MM, Liebau S, Katz SF, Lechel A, Rad R, Seufferlein T, Kestler HA, Ott M, Sharma AD, Hermann PC, Kleger A
  Adv Sci (Weinh) 2021, 8(14), 2100626
  
• Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
  Aschenbrenner AC, Mouktaroudi M, Krämer B, Oestreich M, Antonakos N, Nuesch-Germano M, Gkizeli K, Bonaguro L, Reusch N, Baßler K, Saridaki M, Knoll R, Pecht T, Kapellos TS, Doulou S, Kröger C, Herbert M, Holsten L, Horne A, Gemünd ID, Rovina N, Agrawal S, Dahm K, van Uelft M, Drews A, Lenkeit L, Bruse N, Gerretsen J, Gierlich J, Becker M, Händler K, Kraut M, Theis H, Mengiste S, De Domenico E, Schulte-Schrepping J, Seep L, Raabe J, Hoffmeister C, ToVinh M, Keitel V, Rieke G, Talevi V, Skowasch D, Aziz NA, Pickkers P, van de Veerdonk FL, Netea MG, Schultze JL, Kox M, Breteler MMB, Nattermann J, Koutsoukou A, Giamarellos-Bourboulis EJ, Ulas T, German COVID-19 Omics Initiative (DeCOI)
  Genome Med 2021, 13(1), 7
  
• J-domain proteins interaction with neurodegenerative disease-related proteins.
  Ayala Mariscal SM, Kirstein J
  Exp Cell Res 2021, 399(2), 112491
  
• Analysis of microRNA expression reveals convergent evolution of the molecular control of diapause in annual fish
  Barth E, Baumgart M, Dolfi L, Cui R, Groth M, Ripa R, Savino A, R.Valenzano D, Marz M, Cellerino A
  Research Square 2021, https://doi.org/10.21203/rs.3.rs
  
• Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging.
  Barth E, Srivastava A, Wengerodt D, Stojiljkovic M, Axer H, Witte OW, Kretz** A, Marz** M
  Aging (Albany NY) 2021, 13(24), 25694-716
  
• Life expectancy, family constellation and stress in giant mole-rats ( Fukomys mechowii).
  Begall S, Nappe R, Hohrenk L, Schmidt TC, Burda H, Sahm A, Szafranski K, Dammann P, Henning Y
  Philos Trans R Soc Lond B Biol Sci 2021, 376(1823), 20200207
  
• Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis.
  Begus-Nahrmann Y, Hartmann D, Kraus J, Eshraghi P, Scheffold A, Grieb M, Rasche V, Schirmacher P, Lee HW, Kestler HA, Lechel A, Rudolph KL
  J Clin Invest 2021, 131(1) Corrigendum for J Clin Invest. 2012;122(6):2283–2288
  
• Corona Health-A Study- and Sensor-Based Mobile App Platform Exploring Aspects of the COVID-19 Pandemic.
  Beierle F, Schobel J, Vogel C, Allgaier J, Mulansky L, Haug F, Haug J, Schlee W, Holfelder M, Stach M, Schickler M, Baumeister H, Cohrdes C, Deckert J, Deserno L, Edler JS, Eichner FA, Greger H, Hein G, Heuschmann P, John D, Kestler HA, Krefting D, Langguth B, Meybohm P, Probst T, Reichert M, Romanos M, Störk S, Terhorst Y, Weiß M, Pryss R
  Int J Environ Res Public Health 2021, 18(14), 7395
  
• Introducing Bidirectional Ordinal Classifier Cascades Based on a Pain Intensity Recognition Scenario.
  Bellmann P, Lausser L, Kestler HA, Schwenker F
  In: ICPR International Workshops and Challenges. ICPR 2021, Pattern Recognition (edited by Del Bimbo A, Cucciara R, Sclaroff S, Farinella GM, Mei T, Bertini M, Escalante HJ, Vezzani R), Lecture Notes in Computer Science 2021, 12666, 773-787, Springer, Heidelberg
  
• Experimental Analysis of Bidirectional Pairwise Ordinal Classifier Cascades
  Bellmann P, Lausser L, Kestler HA, Schwenker F
  In: Joint IAPR International Workshops on Statistical Techniques in Pattern Recognition (SPR) and Structural and Syntactic Pattern Recognition (SSPR), Structural, Syntactic, and Statistical Pattern Recognition (edited by Torsello A, Rossi L, Pelillo M, Bi 2021, 12644, 55-64, Springer, Heidelberg
  
• Impact of comorbidities and body mass index on the outcome of polycythemia vera patients.
  Benevolo G, Elli EM, Bartoletti D, Latagliata R, Tiribelli M, Heidel FH, Cavazzini F, Bonifacio M, Crugnola M, Binotto G, D'Addio A, Tieghi A, Bergamaschi M, Caocci G, Polverelli N, Bossi E, Auteri G, Carmosino I, Catani L, Cuneo A, Krampera M, Lanza F, Lemoli RM, Vianelli N, Breccia M, Palumbo GA, Cavo M, Palandri F
  Hematol Oncol 2021, 39(3), 409-18
  
• A Prospective Feasibility Trial to Challenge Patient-Derived Pancreatic Cancer Organoids in Predicting Treatment Response.
  Beutel AK, Schütte L, Scheible J, Roger E, Müller M, Perkhofer L, Kestler AMTU, Kraus JM, Kestler HA, Barth TFE, Lemke J, Kornmann M, Ettrich TJ, Gout J, Seufferlein T, Kleger A
  Cancers (Basel) 2021, 13(11), 2539
  
• Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study.
  Boer JM, Valsecchi MG, Hormann FM, Antić Ž, Zaliova M, Schwab C, Cazzaniga G, Arfeuille C, Cavé H, Attarbaschi A, Strehl S, Escherich G, Imamura T, Ohki K, Grüber TA, Sutton R, Pastorczak A, Lammens T, Lambert F, Li CK, Carrillo de Santa Pau E, Hoffmann S, Möricke A, Harrison CJ, Den Boer ML, De Lorenzo P, Stam RW, Bergmann AK, Pieters R
  Leukemia 2021, 35(10), 2978-82
  
• Surprisingly long survival of premature conclusions about naked mole-rat biology.
  Braude S, Holtze S, Begall S, Brenmoehl J, Burda H, Dammann P, Del Marmol D, Gorshkova E, Henning Y, Hoeflich A, Höhn A, Jung T, Hamo D, Sahm A, Shebzukhov Y, Šumbera R, Miwa S, Vyssokikh MY, von Zglinicki T, Averina O, Hildebrandt TB
  Biol Rev Camb Philos Soc 2021, 96(2), 376-93
  
• β-Glucans as Dietary Supplement to Improve Locomotion and Mitochondrial Respiration in a Model of Duchenne Muscular Dystrophy.
  Brogi L, Marchese M, Cellerino A, Licitra R, Naef V, Mero S, Bibbiani C, Fronte B
  Nutrients 2021, 13(5), 1619
  
• Epigenetic Modifications Associated with Maternal Anxiety during Pregnancy and Children's Behavioral Measures.
  Cao-Lei L, van den Heuvel MI, Huse K, Platzer M, Elgbeili G, Braeken MAKA, Otte RA, Witte OW, Schwab M, Van den Bergh BRH
  Cells 2021, 10(9), 2421
  
• A marine Chlamydomonas sp. emerging as an algal model.
  Carrasco Flores D, Fricke M, Wesp V, Desirò D, Kniewasser A, Hölzer M, Marz M, Mittag M
  J Phycol 2021, 57(1), 54-69
  
• Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK.
  Chang LS, Oblinger JL, Smith AE, Ferrer M, Angus SP, Hawley E, Petrilli AM, Beauchamp RL, Riecken LB, Erdin S, Poi M, Huang J, Bessler WK, Zhang X, Guha R, Thomas C, Burns SS, Gilbert TSK, Jiang L, Li X, Lu Q, Yuan J, He Y, Dixon SAH, Masters A, Jones DR, Yates CW, Haggarty SJ, La Rosa S, Welling DB, Stemmer-Rachamimov AO, Plotkin SR, Gusella JF, Guinney J, Morrison H, Ramesh V, Fernandez-Valle C, Johnson GL, Blakeley JO, Clapp DW, Synodos for NF2 Consortium
  PLoS One 2021, 16(7), e0252048
  
• The economical lifestyle of CPR bacteria in groundwater allows little preference for environmental drivers.
  Chaudhari NM, Overholt WA, Figueroa-Gonzalez PA, Taubert M, Bornemann TLV, Probst AJ, Hölzer M, Marz M, Küsel K
  Environ Microbiome 2021, 16(1), 24
  
• Granulocyte colony-stimulating factor acts on lymphoid-biased, short-term hematopoietic stem cells.
  Chen Y, Rudolph KL
  Haematologica 2021, 106(6), 1516-8
  
• Nbs1-mediated DNA damage repair pathway regulates haematopoietic stem cell development and embryonic haematopoiesis.
  Chen Y, Sun J, Ju Z, Wang ZQ, Li T
  Cell Prolif 2021, 54(3), e12972
  
• Hepatectomy-Induced Alterations in Hepatic Perfusion and Function - Toward Multi-Scale Computational Modeling for a Better Prediction of Post-hepatectomy Liver Function.
  Christ B, Collatz M, Dahmen U, Herrmann KH, Höpfl S, König M, Lambers L, Marz M, Meyer D, Radde N, Reichenbach JR, Ricken T, Tautenhahn HM
  Front Physiol 2021, 12, 733868
  
• EpiDope: A Deep Neural Network for linear B-cell epitope prediction.
  Collatz M, Mock F, Barth E, Hölzer M, Sachse K, Marz M
  Bioinformatics 2021, 37(4), 448-55
  
• Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7.
  Coppin* E, Sundarasetty* BS, Rahmig S, Blume J, Verheyden NA, Bahlmann F, Ravens S, Schubert U, Schmid J, Ludwig S, Geissler K, Guntinas-Lichius O, von Kaisenberg C, Groten T, Platz A, Naumann R, Ludwig B, Prinz I, Waskow** C, Krueger** A
  Leukemia 2021, 35(12), 3561-7 * equal contribution, ** co-senior authors
  
• Transcription factor RFX7 governs a tumor suppressor network in response to p53 and stress.
  Coronel L, Riege K, Schwab K, Förste S, Häckes D, Semerau L, Bernhart SH, Siebert R, Hoffmann** S, Fischer** M
  Nucleic Acids Res 2021, 49(13), 7437-56 ** co-corresponding authors
  
• Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).
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  Eur J Immunol 2021, 51(12), 2708-3145
  
• Ancestral transoceanic colonization and recent population reduction in a nonannual killifish from the Seychelles archipelago.
  Cui R, Tyers AM, Malubhoy ZJ, Wisotsky S, Valdesalici S, Henriette E, Kosakovsky Pond SL, Valenzano DR
  Mol Ecol 2021, 30(14), 3610-23
  
• Merlin cooperates with neurofibromin and Spred1 to suppress the Ras-Erk pathway.
  Cui** Y, Ma L, Schacke S, Yin JC, Hsueh YP, Jin H, Morrison** H
  Hum Mol Genet 2021, 29(23), 3793-806 ** co-corresponding authors
  
• Highlights from the 16th International Society for Computational Biology Student Council Symposium 2020.
  Cuypers* WL, Dönertaş* HM, Grewal JK, Fatima N, Donnelly C, Mer AS, Krieger S, Cuypers B, Rahman F
  F1000Res 2021, 10 * equal contribution
  
• Iron Oxide Nanoparticles Carrying 5-Fluorouracil in Combination with Magnetic Hyperthermia Induce Thrombogenic Collagen Fibers, Cellular Stress, and Immune Responses in Heterotopic Human Colon Cancer in Mice.
  Dabaghi M, Rasa SMM, Cirri E, Ori A, Neri F, Quaas R, Hilger I
  Pharmaceutics 2021, 13(10), 1625
  
• A time-resolved proteomic and prognostic map of COVID-19.
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• Molekularbiologische Beschreibung des Alterungsprozesses
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• Common genetic associations between age-related diseases.
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  Nature Aging 2021, 1(4), 400
  
• Anti-Proliferative and Apoptotic Effect of Gemini Curcumin in p53-Wild Type and p53-Mutant Colorectal Cancer Cell Lines.
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• Transposable Element Landscape in Drosophila Populations Selected for Longevity.
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• Functional conservation in genes and pathways linking ageing and immunity.
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• Modulation of FLT3-ITD Localization and Targeting of Distinct Downstream Signaling Pathways as Potential Strategies to Overcome FLT3-Inhibitor Resistance.
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  Cells 2021, 10(11), 2992
  
• Altered Glycosylation in the Aging Heart.
  Franzka P, Krüger L, Schurig MK, Olecka M, Hoffmann S, Blanchard V, Hübner CA
  Front Mol Biosci 2021, 8, 673044
  
• Virus Bioinformatics
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• The Hematopoietic Bone Marrow Niche Ecosystem.
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• Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice.
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• Novel amyloid-beta pathology C. elegans model reveals distinct neurons as seeds of pathogenicity.
  Gallrein C, Iburg M, Michelberger T, Koçak A, Puchkov D, Liu F, Ayala Mariscal SM, Nayak T, Kaminski Schierle GS, Kirstein J
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• Identifying Cell-Type-Specific Metabolic Signatures Using Transcriptome and Proteome Analyses.
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• Kidney Dysfunction Is Associated with Thrombosis and Disease Severity in Myeloproliferative Neoplasms: Implications from the German Study Group for MPN Bioregistry.
  Gecht J, Tsoukakis I, Kricheldorf K, Stegelmann F, Klausmann M, Griesshammer M, Schulz H, Hollburg W, Göthert JR, Sockel K, Heidel FH, Gattermann N, Maintz C, Al-Ali HK, Platzbecker U, Hansen R, Hänel M, Parmentier S, Bommer M, Pahl HL, Lang F, Kirschner M, Isfort S, Brümmendorf TH, Döhner K, Koschmieder S
  Cancers (Basel) 2021, 13(16), 4086
  
• ITN-VIROINF: Understanding (Harmful) Virus-Host Interactions by Linking Virology and Bioinformatics.
  Goettsch W, Beerenwinkel** N, Deng** L, Dölken** L, Dutilh** BE, Erhard** F, Kaderali** L, von Kleist** M, Marquet R, Matthijnssens** J, McCallin S, McMahon** D, Rattei T, Van Rij** RP, Robertson** DL, Schwemmle** M, Stern-Ginossar N, Marz** M
  Viruses 2021, 13(5) ** co-corresponding authors
  
• Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer.
  Gout J, Perkhofer L, Morawe M, Arnold F, Ihle M, Biber S, Lange S, Roger E, Kraus JM, Stifter K, Hahn SA, Zamperone A, Engleitner T, Müller M, Walter K, Rodriguez-Aznar E, Sainz B, Hermann PC, Hessmann E, Müller S, Azoitei N, Lechel A, Liebau S, Wagner M, Simeone DM, Kestler HA, Seufferlein T, Wiesmüller L, Rad R, Frappart PO, Kleger A
  Gut 2021, 70(4), 743-60
  
• MLL1 is required for maintenance of intestinal stem cells.
  Goveas N, Waskow C, Arndt K, Heuberger J, Zhang Q, Alexopoulou D, Dahl A, Birchmeier W, Anastassiadis K, Stewart AF, Kranz A
  PLoS Genet 2021, 17(12), e1009250 published during change of institution
  
• Epigenetic State Changes Underlie Metabolic Switch in Mouse Post-Infarction Border Zone Cardiomyocytes.
  Günthel M, van Duijvenboden K, de Bakker DEM, Hooijkaas IB, Bakkers J, Barnett P, Christoffels VM
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• Power and Weakness of Repetition - Evaluating the Phylogenetic Signal From Repeatomes in the Family Rosaceae With Two Case Studies From Genera Prone to Polyploidy and Hybridization ( Rosa and Fragaria).
  Herklotz V, Kovařík A, Wissemann V, Lunerová J, Vozárová R, Buschmann S, Olbricht K, Groth M, Ritz CM
  Front Plant Sci 2021, 12, 738119
  
• High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
  Heuberger J, Grinat J, Kosel F, Liu L, Kunz S, Vidal RO, Keil M, Haybaeck J, Robine S, Louvard D, Regenbrecht C, Sporbert A, Sauer S, von Eyss B, Sigal M, Birchmeier W
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• Alternative Animal Models of Aging Research
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• PoSeiDon: a Nextflow pipeline for the detection of evolutionary recombination events and positive selection.
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• The Role of MacroH2A Histone Variants in Cancer.
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• Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas.
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• Computational strategies to combat COVID-19: useful tools to accelerate SARS-CoV-2 and coronavirus research.
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• Fetal-like reversion in the regenerating intestine is regulated by mesenchymal Asporin
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  bioRxiv 2021, https://doi.org/10.1101/2021.06.
  
• ATP/IL-33-triggered hyperactivation of mast cells results in an amplified production of pro-inflammatory cytokines and eicosanoids.
  Jordan PM, Andreas N, Groth M, Wegner P, Weber F, Jäger U, Küchler C, Werz O, Serfling E, Kamradt T, Dudeck A, Drube S
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• Publisher Correction: SIRT7: an influence factor in healthy aging and the development of age-dependent myeloid stem-cell disorders.
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• Rfam 14: expanded coverage of metagenomic, viral and microRNA families.
  Kalvari I, Nawrocki EP, Ontiveros-Palacios N, Argasinska J, Lamkiewicz K, Marz M, Griffiths-Jones S, Toffano-Nioche C, Gautheret D, Weinberg Z, Rivas E, Eddy SR, Finn RD, Bateman A, Petrov AI
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• DNA-binding properties of the MADS-domain transcription factor SEPALLATA3 and mutant variants characterized by SELEX-seq.
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• Reduced Rate of Inpatient Hospital Admissions in 18 German University Hospitals During the COVID-19 Lockdown.
  Kapsner LA, Kampf MO, Seuchter SA, Gruendner J, Gulden C, Mate S, Mang JM, Schüttler C, Deppenwiese N, Krause L, Zöller D, Balig J, Fuchs T, Fischer P, Haverkamp C, Holderried M, Mayer G, Stenzhorn H, Stolnicu A, Storck M, Storf H, Zohner J, Kohlbacher O, Strzelczyk A, Schüttler J, Acker T, Boeker M, Kaisers UX, Kestler HA, Prokosch HU
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• Vesicle-bound regulatory RNAs are associated with tissue aging
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  bioRxiv 2021, https://doi.org/10.1101/2021.05.
  
• Digitalization of adverse event management in oncology to improve treatment outcome-A prospective study protocol.
  Kestler* AMR, Kühlwei* SD, Kraus* JM, Schwab JD, Szekely R, Thiam P, Hühne R, Jahn N, Fürstberger A, Ikonomi N, Balig J, Schuler R, Kuhn P, Steger F, Seufferlein T, Kestler HA
  PLoS One 2021, 16(6), e0252493 * equal contribution
  
• Large-scale characterization of sex pheromone communication systems in Drosophila.
  Khallaf MA, Cui R, Weißflog J, Erdogmus M, Svatoš A, Dweck HKM, Valenzano DR, Hansson BS, Knaden M
  Nat Commun 2021, 12(1), 4165
  
• Human population dynamics and Yersinia pestis in ancient northeast Asia.
  Kılınç GM, Kashuba N, Koptekin D, Bergfeldt N, Dönertaş HM, Rodríguez-Varela R, Shergin D, Ivanov G, Kichigin D, Pestereva K, Volkov D, Mandryka P, Kharinskii A, Tishkin A, Ineshin E, Kovychev E, Stepanov A, Dalén L, Günther T, Kırdök E, Jakobsson M, Somel M, Krzewińska M, Storå J, Götherström A
  Sci Adv 2021, 7(2), eabc4587
  
• Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.
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  Immunity 2021, 54(11), 2650-2669.e14
  
• Direct RNA Sequencing for Complete Viral Genomes
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• Low-Input Whole-Genome Bisulfite Sequencing.
  Krepelova A, Neri F
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• Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence.
  Kumari R, Hummerich* H, Shen* X, Fischer* M, Litovchick L, Mittnacht S, DeCaprio JA, Jat PS
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• [Tumor biology of oropharyngeal carcinoma].
  Laban S, Brand M, Ezić J, Doescher J, Völkel G, Kestler HA, Brunner C, Hoffmann TK
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• The Role of the Pathogen Dose and PI3Kγ in Immunometabolic Reprogramming of Microglia for Innate Immune Memory.
  Lajqi T, Marx C, Hudalla H, Haas F, Große S, Wang ZQ, Heller R, Bauer M, Wetzker R, Bauer R
  Int J Mol Sci 2021, 22(5), 2578
  
• Systems Analysis Reveals Ageing-Related Perturbations in Retinoids and Sex Hormones in Alzheimer's and Parkinson's Diseases.
  Lam S, Hartmann N, Benfeitas R, Zhang C, Arif M, Turkez H, Uhlén M, Englert C, Knight R, Mardinoglu A
  Biomedicines 2021, 9(10), 1310
  
• Isolation, ‘omics characterization and organotypic culture of alveolar type II pulmonary epithelial cells
  Li* H, Schütte* M, Bober* M, Kroll T, Frappart L, Bou About G, Lin YC, Sorg T, Herault Y, Wierling C, Rinner O, Lange Bodo MH, Ploubidou A
  bioRxiv 2021, https://doi.org/10.1101/2021.08. * equal contribution
  
• Post-Translational Modification of MRE11: Its Implication in DDR and Diseases.
  Lu R, Zhang H, Jiang YN, Wang ZQ, Sun L, Zhou ZW
  Genes (Basel) 2021, 12(8)
  
• An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness.
  Marfil-Sánchez A, Zhang L, Alonso-Pernas P, Mirhakkak M, Mueller M, Seelbinder B, Ni Y, Santhanam R, Busch A, Beemelmanns C, Ermolaeva** M, Bauer** M, Panagiotou** G
  Gut Microbes 2021, 13(1), 1993598 ** co-corresponding authors
  
• Amyloid precursor protein elevates fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load.
  Marks D, Heinen N, Bachmann L, Meermeyer S, Werner M, Gallego L, Hemmerich P, Bader V, Winklhofer KF, Schröder E, Knauer SK, Müller T
  Acta Neuropathol Commun 2021, 9(1), 66
  
• Molecular characterization of hematopoietic stem cells after in vitro amplification on biomimetic 3D PDMS cell culture scaffolds.
  Marx-Blümel* L, Marx* C, Sonnemann J, Weise F, Hampl J, Frey J, Rothenburger L, Cirri E, Rahnis N, Koch P, Groth M, Schober A, Wang ZQ, Beck JF
  Sci Rep 2021, 11(1), 21163 * equal contribution
  
• Implementing FAIR data management within the German Network for Bioinformatics Infrastructure (de.NBI) exemplified by selected use cases.
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• PHACTR1 genetic variability is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice.
  Messerschmidt C, Foddis M, Blumenau S, Müller S, Bentele K, Holtgrewe M, Kun-Rodrigues C, Alonso I, do Carmo Macario M, Morgadinho AS, Velon AG, Santo G, Santana I, Mönkäre S, Kuuluvainen L, Schleutker J, Pöyhönen M, Myllykangas L, Senatore A, Berchtold D, Winek K, Meisel A, Pavlovic A, Kostic V, Dobricic V, Lohmann E, Hanagasi H, Guven G, Bilgic B, Bras J, Guerreiro R, Beule D, Dirnagl U, Sassi C
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• Butyrate and Metformin Affect Energy Metabolism Independently of the Metabolic Phenotype in the Tumor Therapy Model.
  Meyer FB, Marx C, Spangel SB, Thierbach R
  Biomolecules 2021, 11(12), 1831
  
• Sequence Classification with Machine Learning at the Example of Viral Host Prediction
  Mock F, Marz M
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• VIDHOP, viral host prediction with Deep Learning.
  Mock F, Viehweger A, Barth E, Marz M
  Bioinformatics 2021, 37(3), 318-25
  
• Intrasexual cuticular hydrocarbon dimorphism in a wasp sheds light on hydrocarbon biosynthesis genes in Hymenoptera
  Moris VC, Podsiadlowski L, Martin S, Oeyen JP, Donath A, Petersen M, Wilbrandt J, Misof B, Liedtke D, Thamm M, Scheiner R, Schmitt T, Niehuis O
  bioRxiv 2021, https://doi.org/10.1101/2021.11.
  
• A perceptually optimised bivariate visualisation scheme for high-dimensional fold-change data
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  ADV DATA ANAL CLASSI 2021, https://doi.org/10.1007/s11634-0 * equal contribution, ** co-corresponding authors
  
• Silicon-rhodamine isothiocyanate for fluorescent labelling.
  Nasufović V, Then P, Dröge F, Duong M, Kaether C, Dietzek B, Heintzmann R, Arndt HD
  Org Biomol Chem 2021, 19(3), 574-8
  
• QUAREP-LiMi: A community-driven initiative to establish guidelines for quality assessment and reproducibility for instruments and images in light microscopy
  Nelson G, Boehm U, Bagley S, Bajcsy P, Bischof J, Brown CM, Dauphin A, Dobbie IM, Eriksson JE, Faklaris O, Fernandez-Rodriguez J, Ferrand A, Gelman L, Gheisari A, Hartmann H, Kukat C, Laude A, Mitkovski M, Munck S, North Alison J, Rasse TM, Resch-Genger U, Schuetz LC, Seitz A, Strambio-De-Castillia C, Swedlow Jason R, Alexopoulos I, Aumayr K, Avilov S, Bakker GJ, Bammann Rodrigo R, Bassi A, Beckert H, Beer S, Belyaev Y, Bierwagen J, Birngruber KA, Bosch M, Breitlow J, Cameron LA, Chalfoun J, Chambers JJ, Chen CL, Conde-Sousa E, Corbett AD, Cordelieres FP, Nery ED, Dietzel R, Eismann F, Fazeli E, Felscher A, Fried H, Gaudreault N, Goh WI, Guilbert T, Hadleigh R, Hemmerich P, Holst GA, Itano MS, Jaffe CB, Jambor HK, Jarvis Stuart C, Keppler A, Kirchenbuechler D, Kirchner M, Kobayashi N, Krens G, Kunis S, Lacoste J, Marcello M, Martins Gabriel G, Metcalf DJ, Mitchell CA, Moore J, Mueller T, Nelson MS, Ogg S, Onami S, Palmer AL, Paul-Gilloteaux P, Pimentel Jaime A, Plantard L, Podder S, Rexhepaj E, Royon A, Saari Markku A, Schapman D, Schoonderwoert V, Schroth-Diez B, Schwartz S, Shaw M, Spitaler M, Stoeckl MT, Sudar D, Teillon J, Terjung S, Thuenauer R, Wilms CD, Wright Graham D, Nitschke R
  arXiv 2021, arXiv:2101.09153
  
• Significance of BK Polyomavirus in Long-Term Survivors after Adult Allogeneic Stem Cell Transplantation.
  Neumann T, Peters N, Kranz J, Dräger DL, Heidel FH, Krüger W, Schneidewind L
  Biology (Basel) 2021, 10(6), 553
  
• Comprehensive Characterization of Multitissue Expression Landscape, Co-Expression Networks and Positive Selection in Pikeperch.
  Nguinkal JA, Verleih M, de Los Ríos-Pérez L, Brunner RM, Sahm A, Bej S, Rebl A, Goldammer T
  Cells 2021, 10(9), 2289
  
• NADH Fluorescence Lifetime Imaging Microscopy Reveals Selective Mitochondrial Dysfunction in Neurons Overexpressing Alzheimer's Disease-Related Proteins.
  Niederschweiberer MA, Schaefer PM, Singh LN, Lausser L, Bhosale D, Hesse R, Calzia E, Kestler HA, Rueck A, Wallace DC, von Einem B, von Arnim CAF
  Front Mol Biosci 2021, 8, 671274
  
• The LIM domain protein nTRIP6 modulates the dynamics of myogenic differentiation.
  Norizadeh Abbariki T, Gonda Z, Kemler D, Urbanek P, Wagner T, Litfin M, Wang ZQ, Herrlich P, Kassel O
  Sci Rep 2021, 11(1), 12904
  
• Rates of primary production in groundwater rival those in oligotrophic marine systems
  Overholt WA, Trumbore S, Xu X, Bornemann TLV, Probst AJ, Krüger M, Herrmann M, Thamdrup B, Bristow L, Taubert M, Schwab VF, Hölzer M, Marz M, Küsel K
  bioRxiv 2021, https://doi.org/10.1101/2021.10.
  
• Ruxolitinib rechallenge in resistant or intolerant patients with myelofibrosis: Frequency, therapeutic effects, and impact on outcome.
  Palandri F, Tiribelli M, Breccia M, Bartoletti D, Elli EM, Benevolo G, Martino B, Cavazzini F, Tieghi A, Iurlo A, Abruzzese E, Pugliese N, Binotto G, Caocci G, Auteri G, Cattaneo D, Trawinska MM, Stella R, Scaffidi L, Polverelli N, Micucci G, Masselli E, Crugnola M, Bosi C, Heidel FH, Latagliata R, Pane F, Cuneo A, Krampera M, Semenzato G, Lemoli RM, Cavo M, Vianelli N, Bonifacio M, Palumbo GA
  Cancer 2021, 127(15), 2657-65
  
• Virus Bioinformatics
  Pappas N, Roux S, Hölzer M, Lamkiewicz K, Mock F, Marz M, Dutilh BE
  In: Encyclopedia of Virology, The Virus as a Concept - Fundamentals of Virology (edited by Dennis H. Bamford and Mark Zuckerman) 2021, 1, 124-132, Elsevier, Amsterdam
  
• An Expanded Polyproline Domain Maintains Mutant Huntingtin Soluble in vivo and During Aging.
  Pigazzini ML, Lawrenz M, Margineanu A, Kaminski Schierle GS, Kirstein J
  Front Mol Neurosci 2021, 14, 721749
  
• Second primary malignancy in myelofibrosis patients treated with ruxolitinib.
  Polverelli N, Elli EM, Abruzzese E, Palumbo GA, Benevolo G, Tiribelli M, Bonifacio M, Tieghi A, Caocci G, D'Adda M, Bergamaschi M, Binotto G, Heidel FH, Cavazzini F, Crugnola M, Pugliese N, Bosi C, Isidori A, Bartoletti D, Auteri G, Latagliata R, Gandolfi L, Martino B, Scaffidi L, Cattaneo D, D'Amore F, Trawinska MM, Stella R, Markovic U, Catani L, Pane F, Cuneo A, Krampera M, Semenzato G, Lemoli RM, Vianelli N, Breccia M, Russo D, Cavo M, Iurlo A, Palandri F
  Br J Haematol 2021, 193(2), 356-68
  
• The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation.
  Pras A, Houben B, Aprile FA, Seinstra R, Gallardo R, Janssen L, Hogewerf W, Gallrein C, De Vleeschouwer M, Mata-Cabana A, Koopman M, Stroo E, de Vries M, Louise Edwards S, Kirstein J, Vendruscolo M, Falsone SF, Rousseau F, Schymkowitz J, Nollen EAA
  EMBO J 2021, 40(21), e107568
  
• Correction to: The proteorhodopsins of the dinoflagellate Oxyrrhis marina: ultrastructure and localization by immunofluorescence light microscopy and immunoelectron microscopy.
  Rhiel E, Westermann M, Steiniger F, Hoischen C
  Protoplasma 2021
  
• Distinct single-component adjuvants steer human DC-mediated T-cell polarization via Toll-like receptor signaling toward a potent antiviral immune response.
  Roßmann L, Bagola K, Stephen T, Gerards AL, Walber B, Ullrich A, Schülke S, Kamp C, Spreitzer I, Hasan M, David-Watine B, Shorte SL, Bastian M, van Zandbergen G
  Proc Natl Acad Sci U S A 2021, 118(39), e2103651118
  
• DNA-methylation aging at single-cell level
  Rudolph KL
  Nature Aging 2021, 1, 1086–1087
  
• Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo.
  Rummelt C, Gorantla SP, Meggendorfer M, Charlet A, Endres C, Döhner K, Heidel FH, Fischer T, Haferlach T, Duyster J, von Bubnoff N
  Leukemia 2021, 35(7), 2017-29
  
• An analysis of methylome evolution in primates
  Sahm** A, Koch P, Horvath S, Hoffmann** S
  Mol Biol Evol 2021, 38(11), 4700-14 ** co-corresponding authors
  
• Aging drives organ-specific alterations of the inflammatory microenvironment guided by immunomodulatory mediators in mice.
  Schädel P, Troisi F, Czapka A, Gebert N, Pace S, Ori A, Werz O
  FASEB J 2021, 35(5), e21558
  
• NMR-Based Structural Characterization of a Two-Disulfide-Bonded Analogue of the FXIIIa Inhibitor Tridegin: New Insights into Structure-Activity Relationships.
  Schmitz T, Paul George AA, Nubbemeyer B, Bäuml CA, Steinmetzer T, Ohlenschläger O, Biswas A, Imhof D
  Int J Mol Sci 2021, 22(2), 880
  
• A JAK of all trades: how global phosphoproteomics reveal the Achilles heel of MPNs.
  Schnoeder TM, Perner F, Heidel FH
  Mol Cell Oncol 2021, 8(2), 1871172
  
• Supporting Medical Staff from Psycho-Oncology with Smart Mobile Devices: Insights into the Development Process and First Results.
  Schobel* J, Volz* M, Hörner K, Kuhn P, Jobst F, Schwab JD, Ikonomi N, Werle SD, Fürstberger A, Hoenig** K, Kestler** HA
  Int J Environ Res Public Health 2021, 18(10), 5092 * equal contribution, ** co-senior authors
  
• Letalität von Patienten mit COVID-19: Untersuchungen zu Ursachen und Dynamik an deutschen Univer- sitätsklinika
  Schüttler J, Mang JM, Kapsner LA, Seuchter SA, Binder H, Zöller D, Kohlbacher O, Boeker M, Zacharowski K, Rohde G, Balig J, Kampf MO, Röhrig R, Prokosch HU, MII-AG (Medizininformatik- Initiative) „COVID-19-Letalität (COV-LET-MII
  Anasth Intensivmed 2021, 62, 244–257.
  
• Reconstructing Boolean network ensembles from single-cell data for unraveling dynamics in the aging of human hematopoietic stem cells.
  Schwab JD, Ikonomi N, Werle SD, Weidner FM, Geiger H, Kestler HA
  Comput Struct Biotechnol J 2021, 19, 5321-32
  
• Perspective on mHealth Concepts to Ensure Users’ Empowerment–From Adverse Event Tracking for COVID-19 Vaccinations to Oncological Treatment
  Schwab* JD, Schobel* J, Werle* WD, Fürstberger* A, Ikonomi N, Azekely R, Thiam P, Hühne R, Jahn N, Schuler R, Kuhn P, Holderried M, Steger F, Reichert M, Kaisers UX, Kestler AMR, Seufferlein** T, Kestler** HA
  IEEE ACCESS 2021, 9, 83863-75 * equal contribution, ** co-senior authors
  
• Complete suppression of Htt fibrillization and disaggregation of Htt fibrils by a trimeric chaperone complex.
  Scior A, Arnsburg K, Iburg M, Juenemann K, Lucia Pigazzini M, Mlody B, Puchkov D, Ast A, Buntru A, Priller J, Wanker EE, Prigione A, Kirstein J
  EMBO J 2021, 40(19), e109413
  
• Improved automatic detection of herpesvirus secondary envelopment stages in electron microscopy by augmenting training data with synthetic labelled images generated by a generative adversarial network.
  Shaga Devan K, Walther P, von Einem J, Ropinski T, A Kestler H, Read C
  Cell Microbiol 2021, 23(2), e13280
  
• Biogenesis of Iron-Sulfur Clusters and Their Role in DNA Metabolism.
  Shi R, Hou W, Wang ZQ, Xu X
  Front Cell Dev Biol 2021, 9, 735678
  
• COPII collar defines the boundary between ER and ER exit site and does not coat cargo containers
  Shomron O, Nevo-Yassaf I, Aviad T, Yaffe Y, Erez Zahavi E, Dukhovny A, Perlson E, Brodsky I, Yeheskel A, Pasmanik-Chor M, Mironov A, Beznoussenko GV, Mironov AA, Sklan EH, Patterson GH, Yonemura Y, Sannai M, Kaether** C, Hirschberg** K
  J Cell Biol 2021, 220(6), e201907224 ** co-corresponding authors
  
• TRIP6 functions in brain ciliogenesis.
  Shukla S, Haenold* R, Urbánek* P, Frappart L, Monajembashi S, Grigaravicius P, Nagel S, Min WK, Tapias A, Kassel O, Heuer H, Wang ZQ, Ploubidou** A, Herrlich** P
  Nat Commun 2021, 12(1), 5887 * equal contribution, ** co-senior authors
  
• SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells.
  Singh Y, Trautwein C, Fendel R, Krickeberg N, Berezhnoy G, Bissinger R, Ossowski S, Salker MS, Casadei N, Riess O, Deutsche COVID-19 OMICS Initiate (DeCOI)
  Heliyon 2021, 7(6), e07147
  
• Author Correction: Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction.
  Sperka T, Song Z, Morita Y, Nalapareddy K, Guachalla LM, Lechel A, Begus-Nahrmann Y, Burkhalter MD, Mach M, Schlaudraff F, Liss B, Ju Z, Speicher MR, Rudolph KL
  Nat Cell Biol 2021, 23(3), 292
  
• Loss of hepatic Mboat7 leads to liver fibrosis.
  Thangapandi VR, Knittelfelder O, Brosch M, Patsenker E, Vvedenskaya O, Buch S, Hinz S, Hendricks A, Nati M, Herrmann A, Rekhade DR, Berg T, Matz-Soja M, Huse K, Klipp E, Pauling JK, Wodke JA, Miranda Ackerman J, Bonin Mv, Aigner E, Datz C, von Schönfels W, Nehring S, Zeissig S, Röcken C, Dahl A, Chavakis T, Stickel F, Shevchenko A, Schafmayer C, Hampe J, Subramanian P
  Gut 2021, 70(5), 940-50
  
• Multi-Modal Pain Intensity Assessment Based on Physiological Signals: A Deep Learning Perspective.
  Thiam P, Hihn H, Braun DA, Kestler** HA, Schwenker** F
  Front Physiol 2021, 12, 720464 ** co-senior authors
  
• Immunoproteasome Function in Normal and Malignant Hematopoiesis.
  Tubío-Santamaría N, Ebstein F, Heidel FH, Krüger E
  Cells 2021, 10(7)
  
• Transcriptional Regulation
  Tuckermann J, Herrlich P, Caratti G
  In: Encyclopedia of Molecular Pharmacology (edited by Stefan Offermanns and Walter Rosenthal) 2021, Springer International Publishin
  
• The Thyroid Hormone Transporter Mct8 Restricts Cathepsin-Mediated Thyroglobulin Processing in Male Mice through Thyroid Auto-Regulatory Mechanisms That Encompass Autophagy.
  Venugopalan V, Al-Hashimi A, Rehders M, Golchert J, Reinecke V, Homuth G, Völker U, Manirajah M, Touzani A, Weber J, Bogyo MS, Verrey F, Wirth EK, Schweizer U, Heuer H, Kirstein J, Brix K
  Int J Mol Sci 2021, 22(1), 462
  
• Editorial for ADAC issue 1 of volume 15
  Vichi M, Cerioli A, Kestler H, Okada A, Weihs C
  Adv Data Anal Classif 2021, 1(15), 1-4
  
• Patient Empowerment During the COVID-19 Pandemic by Ensuring Safe and Fast Communication of Test Results: Implementation and Performance of a Tracking System.
  Völkel* G, Fürstberger* A, Schwab* JD, Werle* SD, Ikonomi* N, Gscheidmeier T, Kraus JM, Groß A, Holderried M, Balig J, Jobst F, Kuhn P, Kuhn KA, Kohlbacher O, Kaisers UX, Seufferlein* T, Kestler* HA
  J Med Internet Res 2021, 23(6), e27348 * equal contribution
  
• Metadata Correction: Patient Empowerment During the COVID-19 Pandemic by Ensuring Safe and Fast Communication of Test Results: Implementation and Performance of a Tracking System.
  Völkel* G, Fürstberger* A, Schwab* JD, Werle* SD, Ikonomi* N, Gscheidmeier T, Kraus JM, Groß A, Holderried M, Balig J, Jobst F, Kuhn P, Kuhn KA, Kohlbacher O, Kaisers UX, Seufferlein* T, Kestler* HA
  J Med Internet Res 2021, 23(6), e31253 * equal contribution
  
• Analysis, identification and visualization of subgroups in genomics.
  Völkel* G, Laban* S, Fürstberger* A, Kühlwein SD, Ikonomi N, Hoffman TK, Brunner C, Neuberg DS, Gaidzik V, Döhner H, Kraus** JM, Kestler** HA
  Brief Bioinform 2021, 22(3) * equal contribution, ** co-senior authors
  
• Erratum to: Analysis, identification and visualization of subgroups in genomics.
  Völkel* G, Laban* S, Fürstberger* A, Kühlwein* SD, Ikonomi* N, Hoffmann TK, Brunner C, Neuberg DS, Gaidzik V, Döhner H, Kraus** JM, Kestler** HA
  Brief Bioinform 2021, 22(6) * equal contribution, ** co-corresponding authors
  
• Chapter Nine - Regulation of muscle stem cell function
  von Maltzahn J
  In: Vitamins and Hormones, Hormones and Stem Cells (edited by Gerald Litwack) 2021, 16, 295-311, Elsevier, Amsterdam
  
• Prospective longitudinal study of immune checkpoint molecule (ICM) expression in immune cell subsets during curative conventional therapy of head and neck squamous cell carcinoma (HNSCC).
  von Witzleben* A, Fehn* A, Grages A, Ezić J, Jeske SS, Puntigam LK, Brunner C, Kraus JM, Kestler HA, Doescher J, Brand M, Theodoraki MN, Ottensmeier CH, Hoffmann TK, Schuler PJ, Laban S
  Int J Cancer 2021, 148(8), 2023-35 * equal contribution
  
• Swarm Learning for decentralized and confidential clinical machine learning.
  Warnat-Herresthal S, Schultze H, Shastry KL, Manamohan S, Mukherjee S, Garg V, Sarveswara R, Händler K, Pickkers P, Aziz NA, Ktena S, Tran F, Bitzer M, Ossowski S, Casadei N, Herr C, Petersheim D, Behrends U, Kern F, Fehlmann T, Schommers P, Lehmann C, Augustin M, Rybniker J, Altmüller J, Mishra N, Bernardes JP, Krämer B, Bonaguro L, Schulte-Schrepping J, De Domenico E, Siever C, Kraut M, Desai M, Monnet B, Saridaki M, Siegel CM, Drews A, Nuesch-Germano M, Theis H, Heyckendorf J, Schreiber S, Kim-Hellmuth S, COVID-19 Aachen Study (COVAS), Nattermann J, Skowasch D, Kurth I, Keller A, Bals R, Nürnberg P, Rieß O, Rosenstiel P, Netea MG, Theis F, Mukherjee S, Backes M, Aschenbrenner AC, Ulas T, Deutsche COVID-19 Omics Initiative (DeCOI), Breteler MMB, Giamarellos-Bourboulis EJ, Kox M, Becker M, Cheran S, Woodacre MS, Goh EL, Schultze JL
  Nature 2021, 594(7862), 265-70
  
• Capturing dynamic relevance in Boolean networks using graph theoretical measures.
  Weidner* FM, Schwab* JD, Werle* SD, Ikonomi* N, Lausser L, Kestler HA
  Bioinformatics 2021 (epub ahead of print) * equal contribution
  
• CD4+ T cells promote delayed B cell responses in the ischemic brain after experimental stroke.
  Weitbrecht L, Berchtold D, Zhang T, Jagdmann S, Dames C, Winek K, Meisel C, Meisel A
  Brain Behav Immun 2021, 91, 601-14
  
• SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
  Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D, Deutsche COVID-19 OMICS Initiative (DeCOI), Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE
  Cell 2021, 184(26), 6243-6261.e27
  
• Unraveling the Molecular Tumor-Promoting Regulation of Cofilin-1 in Pancreatic Cancer.
  Werle* SD, Schwab* JD, Tatura* M, Kirchhoff S, Szekely R, Diels R, Ikonomi N, Sipos B, Sperveslage J, Gress TM, Buchholz** M, Kestler** HA
  Cancers (Basel) 2021, 13(4), 725 * equal contribution, ** co-senior authors
  
• Backbone and nearly complete side-chain chemical shift assignments reveal the human uncharacterized protein CXorf51A as intrinsically disordered.
  Wiedemann C, Obika KB, Liebscher S, Jirschitzka J, Ohlenschlãger O, Bordusa F
  Biomol NMR Assign 2021, 15(2), 441-8
  
• Backbone and nearly complete side-chain chemical shift assignments of the human death-associated protein 1 (DAP1).
  Wiedemann C, Voigt J, Jirschitzka J, Häfner S, Ohlenschläger O, Bordusa F
  Biomol NMR Assign 2021, 15(1), 91-7
  
• Regulators of cholinergic signaling in disorders of the central nervous system.
  Winek K, Soreq H, Meisel A
  J Neurochem 2021, 158(6), 1425-38
  
• p63 and p53: Collaborative Partners or Dueling Rivals?
  Woodstock DL, Sammons MA, Fischer M
  Front Cell Dev Biol 2021, 9, 701986
  
• Shorter Leukocyte Telomere Length Is Associated with Worse Survival of Patients with Bladder Cancer and Renal Cell Carcinoma.
  Zheng X, Wezel F, Azoitei A, Meessen S, Wang W, Najjar G, Wang X, Kraus JM, Kestler HA, John A, Zengerling F, Bolenz C, Günes C
  Cancers (Basel) 2021, 13(15), 3774
  

Publications 2020:

• Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer.
  Akdemir KC, Le VT, Chandran S, Li Y, Verhaak RG, Beroukhim R, Campbell PJ, Chin L, Dixon JR, Futreal PA, PCAWG Structural Variation Working Group, PCAWG Consortium
  Nat Genet 2020, 52(3), 294-305
  
• The repertoire of mutational signatures in human cancer.
  Alexandrov LB, Kim J, Haradhvala NJ, Huang MN, Tian Ng AW, Wu Y, Boot A, Covington KR, Gordenin DA, Bergstrom EN, Islam SMA, Lopez-Bigas N, Klimczak LJ, McPherson JR, Morganella S, Sabarinathan R, Wheeler DA, Mustonen V, PCAWG Mutational Signatures Working Group, Getz G, Rozen SG, Stratton MR, PCAWG Consortium
  Nature 2020, 578(7793), 94-101
  
• Protein Kinase D1, Reduced in Human Pancreatic Tumors, Increases Secretion of Small Extracellular Vesicles From Cancer Cells That Promote Metastasis to Lung in Mice.
  Armacki M, Polaschek S, Waldenmaier M, Morawe M, Ruhland C, Schmid R, Lechel A, Tharehalli U, Steup C, Bektas Y, Li H, Kraus JM, Kestler HA, Kruger S, Ormanns S, Walther P, Eiseler T, Seufferlein T
  Gastroenterology 2020, 159(3), 1019-1035.e22
  
• Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations.
  Austin RJ, Straube J, Bruedigam C, Pali G, Jacquelin S, Vu T, Green J, Gräsel J, Lansink L, Cooper L, Lee SJ, Chen NT, Lee CW, Haque A, Heidel FH, D'Andrea R, Hill GR, Mullally A, Milsom MD, Bywater M, Lane SW
  Leukemia 2020, 34(4), 1075-89
  
• Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19.
  Bernardes JP, Mishra N, Tran F, Bahmer T, Best L, Blase JI, Bordoni D, Franzenburg J, Geisen U, Josephs-Spaulding J, Köhler P, Künstner A, Rosati E, Aschenbrenner AC, Bacher P, Baran N, Boysen T, Brandt B, Bruse N, Dörr J, Dräger A, Elke G, Ellinghaus D, Fischer J, Forster M, Franke A, Franzenburg S, Frey N, Friedrichs A, Fuß J, Glück A, Hamm J, Hinrichsen F, Hoeppner MP, Imm S, Junker R, Kaiser S, Kan YH, Knoll R, Lange C, Laue G, Lier C, Lindner M, Marinos G, Markewitz R, Nattermann J, Noth R, Pickkers P, Rabe KF, Renz A, Röcken C, Rupp J, Schaffarzyk A, Scheffold A, Schulte-Schrepping J, Schunk D, Skowasch D, Ulas T, Wandinger KP, Wittig M, Zimmermann J, Busch H, Hoyer BF, Kaleta C, Heyckendorf J, Kox M, Rybniker J, Schreiber S, Schultze JL, Rosenstiel P, HCA Lung Biological Network, Deutsche COVID-19 Omics Initiative (DeCOI)
  Immunity 2020, 53(6), 1296-1314.e9
  
• Modulation of FLT3 signal transduction through cytoplasmic cysteine residues indicates the potential for redox regulation.
  Böhmer A, Barz S, Schwab K, Kolbe U, Gabel A, Kirkpatrick J, Ohlenschläger O, Görlach M, Böhmer FD
  Redox Biol 2020, 28, 101325
  
• Extreme genomic volatility characterizes the evolution of the immunoglobulin heavy chain locus in cyprinodontiform fishes.
  Bradshaw WJ, Valenzano DR
  Proc Biol Sci 2020, 287(1927), 20200489
  
• Fibrosis and Immune Cell Infiltration Are Separate Events Regulated by Cell-Specific Receptor Notch3 Expression.
  Brandt S, Ballhause TM, Bernhardt A, Becker A, Salaru D, Le-Deffge HM, Fehr A, Fu Y, Philipsen L, Djudjaj S, Müller AJ, Kramann R, Ibrahim M, Geffers R, Siebel C, Isermann B, Heidel FH, Lindquist JA, Mertens PR
  J Am Soc Nephrol 2020, 31(11), 2589-608
  
• Spatially resolved analysis of FFPE tissue proteomes by quantitative mass spectrometry.
  Buczak K, Kirkpatrick JM, Truckenmueller F, Santinha D, Ferreira L, Roessler S, Singer S, Beck** M, Ori** A
  Nat Protoc 2020, 15(9), 2956-79 ** co-corresponding authors
  
• Pan-cancer analysis of whole genomes.
  Campbell PJ, Getz G, Korbel Jea, ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium
  Nature 2020, 578(7793), 82-93
  
• Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing.
  Cortés-Ciriano I, Lee JJK, Xi R, Jain D, Jung YL, Yang L, Gordenin D, Klimczak LJ, Zhang CZ, Pellman DS, PCAWG Structural Variation Working Group, Park PJ, PCAWG Consortium
  Nat Genet 2020, 52(3), 331
  
• Nothobranchius furzeri (African Turquoise Killifish).
  Cui R, Willemsen D, Valenzano DR
  Trends Genet 2020, 36(7), 540-1
  
• Optimization of blocking conditions for fluorescent Western blot.
  Cui Y
  Anal Biochem 2020, 593, 113598
  
• Structure of an RNA aptamer in complex with the fluorophore tetramethylrhodamine.
  Duchardt-Ferner E, Juen M, Bourgeois B, Madl T, Kreutz C, Ohlenschläger O, Wöhnert J
  Nucleic Acids Res 2020, 48(2), 949-61
  
• Structural insights into the main S-layer unit of Deinococcus radiodurans reveal a massive protein complex with porin-like features.
  Farci D, Aksoyoglu MA, Farci SF, Bafna JA, Bodrenko I, Ceccarelli M, Kirkpatrick J, Winterhalter M, Kereïche S, Piano D
  J Biol Chem 2020, 295(13), 4224-36
  
• C-Fiber Loss as a Possible Cause of Neuropathic Pain in Schwannomatosis.
  Farschtschi SC, Mainka T, Glatzel M, Hannekum AL, Hauck M, Gelderblom M, Hagel C, Friedrich RE, Schuhmann MU, Schulz A, Morrison H, Kehrer-Sawatzki H, Luhmann J, Gerloff C, Bendszus M, Bäumer P, Mautner VF
  Int J Mol Sci 2020, 21(10), 3569
  
• An exploratory investigation of brain collateral circulation plasticity after cerebral ischemia in two experimental C57BL/6 mouse models.
  Foddis* M, Winek* K, Bentele K, Mueller S, Blumenau S, Reichhart N N, Crespo-Garcia S, Harnett D, Ivanov A, Meisel A, Joussen A, Strauss O, Beule D, Dirnagl U, Sassi C
  J Cereb Blood Flow Metab 2020, 40(2), 276-87 * equal contribution
  
• Ribosome Pausing at Inefficient Codons at the End of the Replicase Coding Region Is Important for Hepatitis C Virus Genome Replication.
  Gerresheim GK, Hess CS, Shalamova LA, Fricke M, Marz M, Andreev DE, Shatsky IN, Niepmann M
  Int J Mol Sci 2020, 21(18), 6955
  
• The evolutionary history of 2,658 cancers.
  Gerstung M, Jolly C, Leshchiner I, Dentro SC, Gonzalez S, Rosebrock D, Mitchell TJ, Rubanova Y, Anur P, Yu K, Tarabichi M, Deshwar A, Wintersinger J, Kleinheinz K, Vázquez-García I, Haase K, Jerman L, Sengupta S, Macintyre G, Malikic S, Donmez N, Livitz DG, Cmero M, Demeulemeester J, Schumacher S, Fan Y, Yao X, Lee J, Schlesner M, Boutros PC, Bowtell DD, Zhu H, Getz G, Imielinski M, Beroukhim R, Sahinalp SC, Ji Y, Peifer M, Markowetz F, Mustonen V, Yuan K, Wang W, Morris QD, PCAWG Evolution and Heterogeneity Working Group, Spellman PT, Wedge DC, Van Loo P, PCAWG Consortium
  Nature 2020, 578(7793), 122-8
  
• MLL1 is required for maintenance of intestinal stem cells and the expression of the cell adhesion molecule JAML
  Goveas N, Waskow C, Arndt K, Heuberger J, Zhang Q, Alexopoulou D, Dahl A, Birchmeier W, Anastassiadis K, Stewart AF, Kranz A
  bioRxiv 2020, https://doi.org/10.1101/2020.11.
  
• miR-182-5p is an evolutionarily conserved Tbx5 effector that impacts cardiac development and electrical activity in zebrafish.
  Guzzolino E, Pellegrino M, Ahuja N, Garrity D, D'Aurizio R, Groth M, Baumgart M, Hatcher CJ, Mercatanti A, Evangelista M, Ippolito C, Tognoni E, Fukuda R, Lionetti V, Pellegrini M, Cremisi F, Pitto L
  Cell Mol Life Sci 2020, 77(16), 3215-29
  
• Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
  Haenig C, Atias N, Taylor AK, Mazza A, Schaefer MH, Russ J, Riechers SP, Jain S, Coughlin M, Fontaine JF, Freibaum BD, Brusendorf L, Zenkner M, Porras P, Stroedicke M, Schnoegl S, Arnsburg K, Boeddrich A, Pigazzini L, Heutink P, Taylor JP, Kirstein J, Andrade-Navarro MA, Sharan R, Wanker EE
  Cell Rep 2020, 32(7), 108050
  
• Comparative Genome Analysis of 33 Chlamydia Strains Reveals Characteristic Features of Chlamydia Psittaci and Closely Related Species.
  Hölzer M, Barf LM, Lamkiewicz K, Vorimore F, Lataretu M, Favaroni A, Schnee C, Laroucau K, Marz M, Sachse K
  Pathogens 2020, 9(11), 899
  
• Bi-allelic HPDL Variants Cause a Neurodegenerative Disease Ranging from Neonatal Encephalopathy to Adolescent-Onset Spastic Paraplegia.
  Husain RA, Grimmel M, Wagner M, Hennings JC, Marx C, Feichtinger RG, Saadi A, Rostásy K, Radelfahr F, Bevot A, Döbler-Neumann M, Hartmann H, Colleaux L, Cordts I, Kobeleva X, Darvish H, Bakhtiari S, Kruer MC, Besse A, Ng ACH, Chiang D, Bolduc F, Tafakhori A, Mane S, Ghasemi Firouzabadi S, Huebner AK, Buchert R, Beck-Woedl S, Müller AJ, Laugwitz L, Nägele T, Wang ZQ, Strom TM, Sturm M, Meitinger T, Klockgether T, Riess O, Klopstock T, Brandl U, Hübner CA, Deschauer M, Mayr JA, Bonnen PE, Krägeloh-Mann I, Wortmann SB, Haack TB
  Am J Hum Genet 2020, 107(2), 364-73
  
• The noncanonical small heat shock protein HSP-17 from Caenorhabditis elegans is a selective protein aggregase.
  Iburg M, Puchkov D, Rosas-Brugada IU, Bergemann L, Rieprecht U, Kirstein J
  J Biol Chem 2020, 295(10), 3064
  
• Awakening the HSC: Dynamic Modeling of HSC Maintenance Unravels Regulation of the TP53 Pathway and Quiescence.
  Ikonomi N, Kühlwein SD, Schwab JD, Kestler HA
  Front Physiol 2020, 11, 848
  
• Temporal changes in the gene expression heterogeneity during brain development and aging.
  Işıldak U, Somel M, Thornton JM, Dönertaş HM
  Sci Rep 2020, 10(1), 4080
  
• Impact of Key Nicotinic AChR Subunits on Post-Stroke Pneumococcal Pneumonia.
  Jagdmann S, Dames C, Berchtold D, Winek K, Weitbrecht L, Meisel A, Meisel C
  Vaccines (Basel) 2020, 8(2), 253
  
• Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.
  Jayavelu AK, Schnöder TM, Perner F, Herzog C, Meiler A, Krishnamoorthy G, Huber N, Mohr J, Edelmann-Stephan B, Austin R, Brandt S, Palandri F, Schröder N, Isermann B, Edlich F, Sinha AU, Ungelenk M, Hübner CA, Zeiser R, Rahmig S, Waskow C, Coldham I, Ernst T, Hochhaus A, Jilg S, Jost PJ, Mullally A, Bullinger L, Mertens PR, Lane SW, Mann M, Heidel FH
  Nature 2020, 588(7836), 157-63
  
• Local and transient inhibition of p21 expression ameliorates age-related delayed wound healing.
  Jiang D, de Vries JC, Muschhammer J, Schatz S, Ye H, Hein T, Fidan M, Romanov VS, Rinkevich Y, Scharffetter-Kochanek K
  Wound Repair Regen 2020, 28(1), 49-60
  
• HIV-1 Lethality and Loss of Env Protein Expression Induced by Single Synonymous Substitutions in the Virus Genome Intronic-Splicing Silencer.
  Jordan-Paiz A, Nevot M, Lamkiewicz K, Lataretu M, Franco S, Marz M, Martinez MA
  J Virol 2020, 94(21), e01108-20
  
• SIRT7: an influence factor in healthy aging and the development of age-dependent myeloid stem-cell disorders.
  Kaiser A, Schmidt M, Huber O, Frietsch JJ, Scholl S, Heidel FH, Hochhaus A, Müller JP, Ernst T
  Leukemia 2020, 34(8), 2206-16
  
• Pyruvate kinase variant of fission yeast tunes carbon metabolism, cell regulation, growth and stress resistance.
  Kamrad S, Grossbach J, Rodríguez-López M, Mülleder M, Townsend S, Cappelletti V, Stojanovski G, Correia-Melo C, Picotti P, Beyer A, Ralser M, Bähler J
  Mol Syst Biol 2020, 16(4), e9270
  
• Pyphe, a python toolbox for assessing microbial growth and cell viability in high-throughput colony screens.
  Kamrad S, Rodríguez-López M, Cotobal C, Correia-Melo C, Ralser M, Bähler J
  Elife 2020, 9, e55160
  
• Cohesin controls intestinal stem cell identity by maintaining association of Escargot with target promoters.
  Khaminets A, Ronnen-Oron T, Baldauf M, Meier E, Jasper H
  Elife 2020, 9, e48160
  
• Bashing irreproducibility with shournal
  Kirchner T, Riege K, Hoffmann S
  bioRxiv 2020, https://doi.org/10.1101/2020.08.
  
• 1 H, 13 C, and 15 N backbone assignments of the C-terminal region of the human retinoic acid-induced protein 2.
  Lang A, Goradia N, Wikman H, Werner S, Wilmanns M, Ohlenschläger O
  Biomol NMR Assign 2020, 14(2), 271-5
  
• Detecting Ordinal Subcascades
  Lausser* L, Schäfer* LM, Kühlwein SD, Kestler AMR, Kestler HA
  Neural Process Lett 2020, 52, 2583–2605 * equal contribution
  
• Chained correlations for feature selection
  Lausser* L, Szekely* R, Kestler HA
  ADV DATA ANAL CLASSI 2020, 14, 871–884 * equal contribution
  
• Patterns of somatic structural variation in human cancer genomes.
  Li Y, Roberts ND, Wala JA, Shapira O, Schumacher SE, Kumar K, Khurana E, Waszak S, Korbel JO, Haber JE, Imielinski M, PCAWG Structural Variation Working Group, Weischenfeldt J, Beroukhim R, Campbell PJ, PCAWG Consortium
  Nature 2020, 578(7793), 112-21
  
• The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
  Liu H, Ding J, Köhnlein K, Urban N, Ori A, Villavicencio-Lorini P, Walentek P, Klotz LO, Hollemann T, Pfirrmann T
  Autophagy 2020, 16(9), 1618-34
  
• Asymmetrical canina meiosis is accompanied by the expansion of a pericentromeric satellite in non-recombining univalent chromosomes.
  Lunerová J, Herklotz V, Laudien M, Vozárová R, Groth M, Kovařík A, Ritz CM
  Ann Bot (Lond) 2020, 125(7), 1025-38
  
• Virus Bioinformatics
  Marz M, Ibrahim B, Hufsky F, Robertson DL (eds)
  2020, pages 330. MDPI - Multidiscipli
  
• ARDD 2020: from aging mechanisms to interventions.
  Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M
  Aging (Albany NY) 2020, 12(24), 24484-503
  
• Ontogenetic Pattern Changes of Nucleobindin-2/Nesfatin-1 in the Brain and Intestinal Bulb of the Short Lived African Turquoise Killifish.
  Montesano* A, Felice* ED, Leggieri A, Palladino A, Lucini C, Scocco P, Girolamo Pd, Baumgart** M, D'Angelo** L
  J Clin Med 2020, 9(1), 103 * equal contribution, ** co-corresponding authors
  
• Peripheral Cytokine Levels Differ by HPV Status and Change Treatment-Dependently in Patients with Head and Neck Squamous Cell Carcinoma.
  Mytilineos D, Ezić J, von Witzleben A, Mytilineos J, Lotfi R, Fürst D, Tsamadou C, Theodoraki MN, Oster A, Völkel G, Kestler HA, Brunner C, Schuler PJ, Doescher J, Hoffmann TK, Laban S
  Int J Mol Sci 2020, 21(17), 5990
  
• Growth inhibitory role of the p53 activator SCH 529074 in non‑small cell lung cancer cells expressing mutant p53.
  Nenkov M, Ma Y, Haase D, Zhou Z, Li Y, Petersen I, Lu G, Chen Y
  Oncol Rep 2020, 43(2), 2073-82
  
• Genomic basis for RNA alterations in cancer.
  PCAWG Transcriptome Core Group, Calabrese C, Davidson NR, Demircioğlu D, Fonseca NA, He Y, Kahles A, Lehmann KV, Liu F, Shiraishi Y, Soulette CM, Urban L, Greger L, Li S, Liu D, Perry MD, Xiang Q, Zhang F, Zhang J, Bailey P, Erkek S, Hoadley KA, Hou Y, Huska MR, Kilpinen H, Korbel JO, Marin MG, Markowski J, Nandi T, Pan-Hammarström Q, Pedamallu CS, Siebert R, Stark SG, Su H, Tan P, Waszak SM, Yung C, Zhu S, Awadalla P, Creighton CJ, Meyerson M, Ouellette BFF, Wu K, Yang H, PCAWG Transcriptome Working Group, Brazma A, Brooks AN, Göke J, Rätsch G, Schwarz RF, Stegle O, Zhang Z, PCAWG Consortium
  Nature 2020, 578(7793), 129-36
  
• Characterization of Amyloid Structures in Aging C. Elegans Using Fluorescence Lifetime Imaging.
  Pigazzini ML, Gallrein C, Iburg M, Kaminski Schierle G, Kirstein J
  J Vis Exp 2020
  
• In Vivo Quantification of Protein Turnover in Aging C. Elegans using Photoconvertible Dendra2.
  Pigazzini ML, Kirstein J
  J Vis Exp 2020
  
• Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13.
  Pitrez PR, Estronca L, Monteiro LM, Colell G, Vazão H, Santinha D, Harhouri K, Thornton D, Navarro C, Egesipe AL, Carvalho T, Dos Santos RL, Lévy N, Smith JC, de Magalhães JP, Ori A, Bernardo A, De Sandre-Giovannoli A, Nissan X, Rosell A, Ferreira L
  Nat Commun 2020, 11(1), 4110
  
• The turquoise killifish: a genetically tractable model for the study of aging.
  Poeschla M, Valenzano DR
  J Exp Biol 2020, 223(Pt Suppl 1)
  
• Microbiota-host interactions shape ageing dynamics.
  Popkes M, Valenzano DR
  Philos Trans R Soc Lond B Biol Sci 2020, 375(1808), 20190596
  
• Analyses of non-coding somatic drivers in 2,658 cancer whole genomes.
  Rheinbay E, Nielsen MM, Abascal F, Wala JA, Shapira O, Tiao G, Hornshøj H, Hess JM, Juul RI, Lin Z, Feuerbach L, Sabarinathan R, Madsen T, Kim J, Mularoni L, Shuai S, Lanzós A, Herrmann C, Maruvka YE, Shen C, Amin SB, Bandopadhayay P, Bertl J, Boroevich KA, Busanovich J, Carlevaro-Fita J, Chakravarty D, Chan CWY, Craft D, Dhingra P, Diamanti K, Fonseca NA, Gonzalez-Perez A, Guo Q, Hamilton MP, Haradhvala NJ, Hong C, Isaev K, Johnson TA, Juul M, Kahles A, Kahraman A, Kim Y, Komorowski J, Kumar K, Kumar S, Lee D, Lehmann KV, Li Y, Liu EM, Lochovsky L, Park K, Pich O, Roberts ND, Saksena G, Schumacher SE, Sidiropoulos N, Sieverling L, Sinnott-Armstrong N, Stewart C, Tamborero D, Tubio JMC, Umer HM, Uusküla-Reimand L, Wadelius C, Wadi L, Yao X, Zhang CZ, Zhang J, Haber JE, Hobolth A, Imielinski M, Kellis M, Lawrence MS, von Mering C, Nakagawa H, Raphael BJ, Rubin MA, Sander C, Stein LD, Stuart JM, Tsunoda T, Wheeler DA, Johnson R, Reimand J, Gerstein M, Khurana E, Campbell PJ, López-Bigas N, PCAWG Drivers and Functional Interpretation Working Group, PCAWG Structural Variation Working Group, Weischenfeldt J, Beroukhim R, Martincorena I, Pedersen JS, Getz G, PCAWG Consortium
  Nature 2020, 578(7793), 102-11
  
• Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition.
  Rodriguez-Martin B, Alvarez EG, Baez-Ortega A, Zamora J, Supek F, Demeulemeester J, Santamarina M, Ju YS, Temes J, Garcia-Souto D, Detering H, Li Y, Rodriguez-Castro J, Dueso-Barroso A, Bruzos AL, Dentro SC, Blanco MG, Contino G, Ardeljan D, Tojo M, Roberts ND, Zumalave S, Edwards PA, Weischenfeldt J, Puiggròs M, Chong Z, Chen K, Lee EA, Wala JA, Raine KM, Butler A, Waszak SM, Navarro FCP, Schumacher SE, Monlong J, Maura F, Bolli N, Bourque G, Gerstein M, Park PJ, Wedge DC, Beroukhim R, Torrents D, Korbel JO, Martincorena I, Fitzgerald RC, Van Loo P, Kazazian HH, Burns KH, PCAWG Structural Variation Working Group, Campbell PJ, Tubio JMC, PCAWG Consortium
  Nat Genet 2020, 52(3), 306-19
  
• A virtual "Werkstatt" for digitization in the sciences
  Samuel S, Shadaydeh M, Böcker S, Brügmann B, Bucher SF, Deckert V, Denzler J, Dittrich P, Eggeling F, Güllmar D, Guntinas-Lichius O, König-Ries B, Löffler F, Maicher L, Marz M, Migliavacca M, Reichenbach JR, Reichstein M, Römermann C, Wittig A
  Res Ideas Outcomes 2020, 6, e54106
  
• Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading.
  Sandhof CA, Hoppe SO, Druffel-Augustin S, Gallrein C, Kirstein J, Voisine C, Nussbaum-Krammer C
  Autophagy 2020, 16(5), 878
  
• Measuring Mental Effort for Creating Mobile Data Collection Applications.
  Schobel J, Probst T, Reichert M, Schlee W, Schickler M, Kestler HA, Pryss R
  Int J Environ Res Public Health 2020, 17(5), 1649
  
• Stem Cell Aging: The Upcoming Era of Proteins and Metabolites.
  Schüler* SC, Gebert* N, Ori A
  Mech Ageing Dev 2020, 190, 111288 * equal contribution
  
• The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival.
  Schulz A, Sekine Y, Oyeyemi MJ, Abrams AJ, Basavaraju M, Han SM, Groth M, Morrison H, Strittmatter SM, Hammarlund M
  J Cell Biol 2020, 219(2), doi: 10.1083/jcb.201807127
  
• Two-Stream Attention Network for Pain Recognition from Video Sequences.
  Thiam P, Kestler* HA, Schwenker* F
  Sensors (Basel) 2020, 20(3), 839 * equal contribution
  
• Der Hippo-Signalweg in der Regeneration und im Krebs
  Tollot M, Cindric Vranesic A, von Eyss B
  BIOspektrum 2020, 26, 154–157
  
• Apoptosis of hematopoietic progenitor-derived adipose tissue-resident macrophages contributes to insulin resistance after myocardial infarction.
  Vasamsetti SB, Coppin E, Zhang X, Florentin J, Koul S, Götberg M, Clugston AS, Thoma F, Sembrat J, Bullock GC, Kostka D, St Croix CM, Chattopadhyay A, Rojas M, Mulukutla SR, Dutta P
  Sci Transl Med 2020, 12(553), eaaw0638
  
• Intra-species differences in population size shape life history and genome evolution.
  Willemsen D, Cui R, Reichard M, Valenzano DR
  Elife 2020, 9, e55794
  
• Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade.
  Winek* K, Lobentanzer* S, Nadorp B, Dubnov S, Dames C, Jagdmann S, Moshitzky G, Hotter B, Meisel C, Greenberg DS, Shifman S, Klein J, Shenhar-Tsarfaty S, Meisel A, Soreq H
  Proc Natl Acad Sci U S A 2020, 117(51), 32606-16 * equal contribution
  
• Identification of Ppar γ -modulated miRNA hubs that target the fibrotic tumor microenvironment.
  Winkler I, Bitter C, Winkler S, Weichenhan D, Thavamani A, Hengstler JG, Borkham-Kamphorst E, Kohlbacher O, Plass C, Geffers R, Weiskirchen R, Nordheim A
  Proc Natl Acad Sci U S A 2020, 117(1), 454-63
  
• Butler enables rapid cloud-based analysis of thousands of human genomes.
  Yakneen S, Waszak SM, PCAWG Technical Working Group, Gertz M, Korbel JO, PCAWG Consortium
  Nat Biotechnol 2020, 38(3), 288–292
  
• Comprehensive molecular characterization of mitochondrial genomes in human cancers.
  Yuan Y, Ju YS, Kim Y, Li J, Wang Y, Yoon CJ, Yang Y, Martincorena I, Creighton CJ, Weinstein JN, Xu Y, Han L, Kim HL, Nakagawa H, Park K, Campbell PJ, Liang H, PCAWG Consortium
  Nat Genet 2020, 52(3), 342-52
  
• The landscape of viral associations in human cancers.
  Zapatka M, Borozan I, Brewer DS, Iskar M, Grundhoff A, Alawi M, Desai N, Sültmann H, Moch H, PCAWG Pathogens, Cooper CS, Eils R, Ferretti V, Lichter P, PCAWG Consortium
  Nat Genet 2020, 52(3), 320-30
  
• Displacement of the Gent/1999 human-like swine H1N2 influenza A virus lineage by novel H1N2 reassortants in Germany.
  Zell R, Groth M, Krumbholz A, Lange J, Philipps A, Dürrwald R
  Arch Virol 2020, 165(1), 55-67
  

Publications 2019:

• Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart.
  Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling JE, Dodzian J, Lagerborg KA, Vargas NE, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano** DR, Kurian** L
  EMBO Rep 2019, 20(4), e47407 ** co-corresponding authors
  
• Microbiome evolution during host aging.
  Aleman FDD, Valenzano DR
  PLoS Pathog 2019, 15(7), e1007727
  
• Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.
  Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF
  EMBO J 2019, 38(5), e100492
  
• Mitohormetic effects of rotenone drastically depend on age.
  Baumgart* M, Ugolini* M, Groth M, Platzer M, Cellerino A
  bioRxiv 2019, https://doi.org/10.1101/528547 * equal contribution
  
• BRCA1 mislocalization leads to aberrant DNA damage response in heterozygous ABRAXAS1 mutation carrier cells.
  Bose M, Sachsenweger J, Laurila N, Parplys AC, Willmann J, Jungwirth J, Groth M, Rapakko K, Nieminen P, Friedl TWP, Heiserich L, Meyer F, Tuppurainen H, Peltoketo H, Nevanlinna H, Pylkäs K, Borgmann K, Wiesmüller L, Winqvist** R, Pospiech** H
  Hum Mol Genet 2019, 28(24), 4148-60 ** co-corresponding authors
  
• Self-Establishing Communities: A Yeast Model to Study the Physiological Impact of Metabolic Cooperation in Eukaryotic Cells.
  Campbell K, Correia-Melo C, Ralser M
  Methods Mol Biol 2019, 2049, 263-82
  
• Resting cells rely on the DNA helicase component MCM2 to build cilia.
  Casar Tena T, Maerz LD, Szafranski K, Groth M, Blätte TJ, Donow C, Matysik S, Walther P, Jeggo PA, Burkhalter MD, Philipp M
  Nucleic Acids Res 2019, 47(1), 134-51
  
• Re-thinking the Etiological Framework of Neurodegeneration.
  Castillo X, Castro-Obregón S, Gutiérrez-Becker B, Gutiérrez-Ospina G, Karalis N, Khalil AA, Lopez-Noguerola JS, Rodríguez LL, Martínez-Martínez E, Perez-Cruz C, Pérez-Velázquez J, Piña AL, Rubio K, García HPS, Syeda T, Vanoye-Carlo A, Villringer A, Winek K, Zille M
  FRONT NEUROSCI-SWITZ 2019, 13, 728
  
• Early-life Pb exposure as a potential risk factor for Alzheimer's disease: are there hazards for the Mexican population?
  Chin-Chan M, Cobos-Puc L, Alvarado-Cruz I, Bayar M, Ermolaeva M
  J Biol Inorg Chem 2019, 24(8), 1285-303
  
• Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V.
  Claes F, Rudyak S, Laird AS, Louros N, Beerten J, Debulpaep M, Michiels E, van der Kant R, Van Durme J, De Baets G, Houben B, Ramakers M, Yuan K, Gwee SSL, Hernandez S, Broersen K, Oliveberg M, Moahamed B, Kirstein J, Robberecht W, Rousseau F, Schymkowitz J
  Protein Eng Des Sel 2019, 32(10), 443
  
• Rapamycin improves healthspan but not inflammaging in nfκb1-/- mice.
  Correia-Melo* C, Birch* J, Fielder E, Rahmatika D, Taylor J, Chapman J, Lagnado A, Carroll BM, Miwa S, Richardson G, Jurk D, Oakley F, Mann J, Mann DA, Korolchuk VI, Passos JF
  Aging Cell 2019, 18(1), e12882 * equal contribution
  
• Relaxed Selection Limits Lifespan by Increasing Mutation Load.
  Cui R, Medeiros T, Willemsen D, Iasi LNM, Collier GE, Graef M, Reichard M, Valenzano DR
  Cell 2019, 178(2), 385-399.e20
  
• Construction of cloning-friendly mini-genes for mammalian expression of full-length human NF1 isoforms.
  Cui Y, Morrison H
  Hum Mutat 2019, 40(2), 187-92
  
• Comment on 'Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age'.
  Dammann* P, Scherag* A, Zak N, Szafranski K, Holtze S, Begall S, Burda H, Kestler HA, Hildebrandt T, Platzer M
  Elife 2019, 8 * corresponding author
  
• Cell cycle dynamics during diapause entry and exit in an annual killifish revealed by FUCCI technology.
  Dolfi L, Ripa R, Antebi A, Valenzano DR, Cellerino A
  Evodevo 2019, 10, 29
  
• Identifying Potential Ageing-Modulating Drugs In Silico.
  Dönertaş* HM, Fuentealba* M, Partridge L, Thornton JM
  Trends Endocrinol Metab 2019, 30(2), 118 * equal contribution
  
• Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer.
  Drucker E, Holzer K, Pusch S, Winkler J, Calvisi DF, Eiteneuer E, Herpel E, Goeppert B, Roessler S, Ori A, Schirmacher P, Breuhahn K, Singer S
  Cell Commun Signal 2019, 17(1), 159
  
• A CRISPR Activation Screen Identifies Genes That Protect against Zika Virus Infection.
  Dukhovny A, Lamkiewicz K, Chen Q, Fricke M, Jabrane-Ferrat N, Marz M, Jung JU, Sklan EH
  J Virol 2019, 93(16), e00211-19
  
• Crosstalk Between Chaperone-Mediated Protein Disaggregation and Proteolytic Pathways in Aging and Disease.
  Feleciano DR, Juenemann K, Iburg M, Brás IC, Holmberg CI, Kirstein J
  Front Aging Neurosci 2019, 11, 9
  
• Global importance of RNA secondary structures in protein coding sequences.
  Fricke M, Gerst R, Ibrahim B, Niepmann M, Marz M
  Bioinformatics 2019, 35(4), 579-83
  
• Using the drug-protein interactome to identify anti-ageing compounds for humans.
  Fuentealba M, Dönertaş HM, Williams R, Labbadia J, Thornton JM, Partridge L
  PLoS Comput Biol 2019, 15(1), e1006639
  
• Cellular Gene Expression during Hepatitis C Virus Replication as Revealed by Ribosome Profiling.
  Gerresheim GK, Bathke J, Michel AM, Andreev DE, Shalamova LA, Rossbach O, Hu P, Glebe D, Fricke M, Marz M, Goesmann A, Kiniry SJ, Baranov PV, Shatsky IN, Niepmann M
  Int J Mol Sci 2019, 20(6), 1321
  
• Profiling of gallbladder carcinoma reveals distinct miRNA profiles and activation of STAT1 by the tumor suppressive miRNA-145-5p.
  Goeppert B, Truckenmueller F, Ori A, Fritz V, Albrecht T, Fraas A, Scherer D, Silos RG, Sticht C, Gretz N, Mehrabi A, Bewerunge-Hudler M, Pusch S, Bermejo JL, Dietrich P, Schirmacher P, Renner M, Roessler S
  Sci Rep 2019, 9(1), 4796
  
• Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines.
  Guo T, Luna A, Rajapakse VN, Koh CC, Wu Z, Liu W, Sun Y, Gao H, Menden MP, Xu C, Calzone L, Martignetti L, Auwerx C, Buljan M, Banaei-Esfahani A, Ori A, Iskar M, Gillet L, Bi R, Zhang J, Zhang H, Yu C, Zhong Q, Varma S, Schmitt U, Qiu P, Zhang Q, Zhu Y, Wild PJ, Garnett MJ, Bork P, Beck M, Liu K, Saez-Rodriguez J, Elloumi F, Reinhold WC, Sander C, Pommier Y, Aebersold R
  iScience 2019, 21, 664-80
  
• Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy.
  Haikala HM, Anttila JM, Marques E, Raatikainen T, Ilander M, Hakanen H, Ala-Hongisto H, Savelius M, Balboa D, Von Eyss B, Eskelinen V, Munne P, Nieminen AI, Otonkoski T, Schüler J, Laajala TD, Aittokallio T, Sihto H, Mattson J, Heikkilä P, Leidenius M, Joensuu H, Mustjoki S, Kovanen P, Eilers M, Leverson JD, Klefström J
  Nat Commun 2019, 10(1), 620
  
• Publisher Correction: Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy.
  Haikala HM, Anttila JM, Marques E, Raatikainen T, Ilander M, Hakanen H, Ala-Hongisto H, Savelius M, Balboa D, Von Eyss B, Eskelinen V, Munne P, Nieminen AI, Otonkoski T, Schüler J, Laajala TD, Aittokallio T, Sihto H, Mattson J, Heikkilä P, Leidenius M, Joensuu H, Mustjoki S, Kovanen P, Eilers M, Leverson JD, Klefström J
  Nat Commun 2019, 10(1), 932
  
• Nucleoporin Nup155 is part of the p53 network in liver cancer.
  Holzer K, Ori A, Cooke A, Dauch D, Drucker E, Riemenschneider P, Andres-Pons A, DiGuilio AL, Mackmull MT, Baßler J, Roessler S, Breuhahn K, Zender L, Glavy JS, Dombrowski F, Hurt E, Schirmacher P, Beck M, Singer S
  Nat Commun 2019, 10(1), 2147
  
• De novo transcriptome assembly: A comprehensive cross-species comparison of short-read RNA-Seq assemblers.
  Hölzer M, Marz M
  Gigascience 2019, 8(5), giz039
  
• Evaluation of Sequencing Library Preparation Protocols for Viral Metagenomic Analysis from Pristine Aquifer Groundwaters.
  Kallies R, Hölzer M, Brizola Toscan R, Nunes da Rocha U, Anders J, Marz M, Chatzinotas A
  Viruses 2019, 11(6), 484
  
• Function, evolution, and structure of J-domain proteins.
  Kampinga HH, Andreasson C, Barducci A, Cheetham ME, Cyr D, Emanuelsson C, Genevaux P, Gestwicki JE, Goloubinoff P, Huerta-Cepas J, Kirstein J, Liberek K, Mayer MP, Nagata K, Nillegoda NB, Pulido P, Ramos C, De Los Rios P, Rospert S, Rosenzweig R, Sahi C, Taipale M, Tomiczek B, Ushioda R, Young JC, Zimmermann R, Zylicz A, Zylicz M, Craig EA, Marszalek J
  Cell Stress Chaperones 2019, 24(1), 7
  
• The widespread increase in inter-individual variability of gene expression in the human brain with age.
  Kedlian* VR, Donertas* HM, Thornton JM
  Aging (Albany NY) 2019, 11(8), 2253 * equal contribution
  
• Inverse resource allocation between vision and olfaction across the genus Drosophila.
  Keesey IW, Grabe V, Gruber L, Koerte S, Obiero GF, Bolton G, Khallaf MA, Kunert G, Lavista-Llanos S, Valenzano DR, Rybak J, Barrett BA, Knaden M, Hansson BS
  Nat Commun 2019, 10(1), 1162
  
• Transduction and transfection of difficult-to-transfect cells: Systematic attempts for the transfection of protozoa Leishmania.
  Keller AA, Scheiding B, Breitling R, Licht A, Hemmerich P, Lorkowski S, Reissmann S
  J Cell Biochem 2019, 120(1), 14-27
  
• ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans.
  Kreis P, Gallrein C, Rojas-Puente E, Mack TGA, Kroon C, Dinkel V, Willmes C, Murk K, Tom-Dieck S, Schuman EM, Kirstein** J, Eickholt** BJ
  Nat Commun 2019, 10(1), 486 ** co-corresponding authors
  
• RNAi-Screening in Knochenbildenden Zellen.
  Kroll T, Ahmad M, Ploubidou A, Tuckermann J
  BIOspektrum 2019, 25, 523–526
  
• Macaca arctoides gammaherpesvirus 1 (strain herpesvirus Macaca arctoides): virus sequence, phylogeny and characterisation of virus-transformed macaque and rabbit cell lines.
  Krumbholz A, Roempke J, Liehr T, Groth M, Meerbach A, Schacke M, Maschkowitz G, Fickenscher H, Klapper W, Sauerbrei A, Wutzler P, Zell R
  Med Microbiol Immunol 2019, 208(1), 109-29
  
• Identification and Expression of Neurotrophin-6 in the Brain of Nothobranchius furzeri: One More Piece in Neurotrophin Research.
  Leggieri A, Attanasio C, Palladino A, Cellerino A, Lucini C, Paolucci M, Terzibasi Tozzini E, de Girolamo P, D'Angelo L
  J Clin Med 2019, 8(5), 595
  
• Comparison of protein quantification in a complex background by DIA and TMT workflows with fixed instrument time.
  Muntel* J, Kirkpatrick* J, Bruderer R, Huang T, Vitek O, Ori** A, Reiter** L
  J Proteome Res 2019, 18(3), 1340-51 * equal contribution, ** co-senior authors
  
• Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism.
  Olin-Sandoval V, Yu JSL, Miller-Fleming L, Alam MT, Kamrad S, Correia-Melo C, Haas R, Segal J, Peña Navarro DA, Herrera-Dominguez L, Méndez-Lucio O, Vowinckel J, Mülleder M, Ralser M
  Nature 2019, 572(7768), 249-53
  
• Author Correction: Metastatic-niche labelling reveals parenchymal cells with stem features.
  Ombrato L, Nolan E, Kurelac I, Mavousian A, Bridgeman VL, Heinze I, Chakravarty P, Horswell S, Gonzalez-Gualda E, Matacchione G, Weston A, Kirkpatrick J, Husain E, Speirs V, Collinson L, Ori A, Lee JH, Malanchi I
  Nature 2019, 575(7784), E8
  
• Metastatic-niche labelling reveals parenchymal cells with stem features.
  Ombrato L, Nolan E, Kurelac I, Mavousian A, Bridgeman VL, Heinze I, Chakravarty P, Horswell S, Gonzalez-Gualda E, Matacchione G, Weston A, Kirkpatrick J, Husain E, Speirs V, Collinson L, Ori A, Lee JH, Malanchi I
  Nature 2019, 572(7771), 603-8
  
• The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes.
  Pattschull G, Walz S, Gründl M, Schwab M, Rühl E, Baluapuri A, Cindric-Vranesic A, Kneitz S, Wolf E, Ade CP, Rosenwald A, von Eyss B, Gaubatz S
  Cell Rep 2019, 27(12), 3533-3546.e7
  
• Structure and Hierarchy of Influenza Virus Models Revealed by Reaction Network Analysis.
  Peter S, Hölzer M, Lamkiewicz K, di Fenizio PS, Al Hwaeer H, Marz M, Schuster S, Dittrich P, Ibrahim B
  Viruses 2019, 11(5), 449
  
• Disentangling Genetic and Environmental Effects on the Proteotypes of Individuals.
  Romanov N, Kuhn M, Aebersold R, Ori A, Beck M, Bork P
  Cell 2019, 177(5), 1308-18
  
• RB, p130 and p107 differentially repress G1/S and G2/M genes after p53 activation.
  Schade AE, Fischer M, DeCaprio JA
  Nucleic Acids Res 2019, 47(21), 11197-208
  
• Global network of computational biology communities: ISCB's Regional Student Groups breaking barriers.
  Shome S, Parra RG, Fatima N, Monzon AM, Cuypers B, Moosa Y, Coimbra NDR, Assis J, Giner-Delgado C, Dönertaş HM, Cuesta-Astroz Y, Saarunya G, Allali I, Gupta S, Srivastava A, Kalsan M, Valdivia C, J Olguin-Orellana G, Papadimitriou S, Parisi D, Kristensen NP, Rib L, Guebila MB, Bauer E, Zaffaroni G, Bekkar A, Ashano E, Paladin L, Necci M, Moreyra NN, Rydén M, Villalobos-Solís J, Papadopoulos N, Rafael C, Karakulak T, Kaya Y, Gladbach Y, Dhanda SK, Šoštarić N, Alex A, DeBlasio D, Rahman F
  F1000Res 2019, 8
  
• Exploring Deep Physiological Models for Nociceptive Pain Recognition.
  Thiam P, Bellmann P, Kestler HA, Schwenker F
  Sensors (Basel) 2019, 19(20), 4503
  
• Molecular footprint of Medawar's mutation accumulation process in mammalian aging.
  Turan ZG, Parvizi P, Dönertaş HM, Tung J, Khaitovich P, Somel M
  Aging Cell 2019, 18(4), e12965
  
• An encoding of genome content for machine learning.
  Viehweger A, Krautwurst S, Parks DH, Koenig B, Marz M
  bioRxiv 2019, https://doi.org/10.1101/524280
  
• Direct RNA nanopore sequencing of full-length coronavirus genomes provides novel insights into structural variants and enables modification analysis.
  Viehweger* A, Krautwurst* S, Lamkiewicz K, Madhugiri R, Ziebuhr J, Hölzer M, Marz M
  Genome Res 2019, 29(9), 1545-54 * equal contribution
  

Publications 2018:

• Whither systems medicine?
  Apweiler R, Beissbarth T, Berthold MR, Blüthgen N, Burmeister Y, Dammann O, Deutsch A, Feuerhake F, Franke A, Hasenauer J, Hoffmann S, Höfer T, Jansen PL, Kaderali L, Klingmüller U, Koch I, Kohlbacher O, Kuepfer L, Lammert F, Maier D, Pfeifer N, Radde N, Rehm M, Roeder I, Saez-Rodriguez J, Sax U, Schmeck B, Schuppert A, Seilheimer B, Theis FJ, Vera J, Wolkenhauer O
  Exp Mol Med 2018, 50(3), e453
  
• Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly.
  Aramillo Irizar P, Schäuble S, Esser D, Groth M, Frahm C, Priebe S, Baumgart M, Hartmann N, Marthandan S, Menzel U, Müller J, Schmidt S, Ast V, Caliebe A, König R, Krawczak M, Ristow M, Schuster S, Cellerino A, Diekmann S, Englert C, Hemmerich P, Sühnel J, Guthke R, Witte OW, Platzer M, Ruppin E, Kaleta C
  Nat Commun 2018, 9(1), 327
  
• SETD1A protects HSCs from activation-induced functional decline in vivo.
  Arndt K, Kranz A, Fohgrub J, Jolly A, Bledau AS, Di Virgilio M, Lesche M, Dahl A, Höfer T, Stewart AF, Waskow C
  Blood 2018, 131(12), 1311-24
  
• mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's Disease.
  Ast A, Buntru A, Schindler F, Hasenkopf R, Schulz A, Brusendorf L, Klockmeier K, Grelle G, McMahon B, Niederlechner H, Jansen I, Diez L, Edel J, Boeddrich A, Franklin SA, Baldo B, Schnoegl S, Kunz S, Purfürst B, Gaertner A, Kampinga HH, Morton AJ, Petersén Å, Kirstein J, Bates GP, Wanker EE
  Mol Cell 2018, 71(5), 675
  
• Kidney regeneration in fish.
  Bates T, Naumann U, Hoppe B, Englert C
  Int J Dev Biol 2018, 62(6-7-8), 419-29
  
• Analysis of lncRNA-Protein Interactions by RNA-Protein Pull-Down Assays and RNA Immunoprecipitation (RIP).
  Bierhoff H
  Methods Mol Biol 2018, 1686, 241-50
  
• Spatial tissue proteomics quantifies inter- and intra-tumor heterogeneity in hepatocellular carcinoma.
  Buczak* K, Ori* A, Kirkpatrick JM, Holzer K, Dauch D, Roessler S, Endris V, Lasitschka F, Parca L, Schmidt A, Zender L, Schirmacher P, Krijgsveld J, Singer** S, Beck** M
  Mol Cell Proteomics 2018, 17(4), 810-25 * equal contribution, ** co-corresponding authors
  
• Computational pan-genomics: status, promises and challenges.
  Computational PGC, Marschall T, Marz M, Abeel T, Dijkstra L, Dutilh BE, Ghaffaari A, Kersey P, Kloosterman WP, Mäkinen V, Novak AM, Paten B, Porubsky D, Rivals E, Alkan C, Baaijens JA, De Bakker PIW, Boeva V, Bonnal RJP, Chiaromonte F, Chikhi R, Ciccarelli FD, Cijvat R, Datema E, Van Duijn CM, Eichler EE, Ernst C, Eskin E, Garrison E, El-Kebir M, Klau GW, Korbel JO, Lameijer EW, Langmead B, Martin M, Medvedev P, Mu JC, Neerincx P, Ouwens K, Peterlongo P, Pisanti N, Rahmann S, Raphael B, Reinert K, de Ridder D, de Ridder J, Schlesner M, Schulz-Trieglaff O, Sanders AD, Sheikhizadeh S, Shneider C, Smit S, Valenzuela D, Wang J, Wessels L, Zhang Y, Guryev V, Vandin F, Ye K, Schönhuth A
  Brief Bioinform 2018, 19(1), 118-35
  
• Sequential use of milk and bovine serum albumin for streptavidin-probed western blot.
  Cui Y, Ma L
  Biotechniques 2018, 65(3), 125-6
  
• X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
  Dahms SO, Hardes K, Steinmetzer T, Than ME
  Biochemistry 2018, 57(6), 925-34
  
• Immunomodulatory treatment with systemic GM-CSF augments pulmonary immune responses and improves neurological outcome after experimental stroke.
  Dames C, Winek K, Beckers Y, Engel O, Meisel A, Meisel C
  J Neuroimmunol 2018, 321, 144-9
  
• Telomeric epigenetic response mediated by Gadd45a regulates stem cell aging and lifespan.
  Diao D, Wang H, Li T, Shi Z, Jin X, Sperka T, Zhu X, Zhang M, Yang F, Cong Y, Shen L, Zhan Q, Yan J, Song Z, Ju Z
  EMBO Rep 2018, 19(10), e45494
  
• A Protocol for Laboratory Housing of Turquoise Killifish (Nothobranchius furzeri).
  Dodzian J, Kean S, Seidel J, Valenzano DR
  J Vis Exp 2018
  
• Gene expression-based drug repurposing to target aging.
  Dönertaş HM, Fuentealba Valenzuela M, Partridge L, Thornton JM
  Aging Cell 2018, 17(5), e12819
  
• DIEGO: Detection of Differential Alternative Splicing using Aitchison's Geometry.
  Doose G, Bernhart SH, Wagener R, Hoffmann S
  Bioinformatics 2018, 34(6), 1066-8
  
• Cellular and epigenetic drivers of stem cell ageing.
  Ermolaeva** M, Neri** F, Ori** A, Rudolph** KL
  Nat Rev Mol Cell Biol 2018, 19(9), 594-610 ** co-corresponding authors
  
• On the S-layer of Thermus thermophilus and the assembling of its main protein SlpA.
  Farci D, Farci SF, Esposito F, Tramontano E, Kirkpatrick J, Piano D
  Biochim Biophys Acta 2018, 1860(8), 1554-62
  
• 2016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis.
  Fisher MJ, Belzberg AJ, de Blank P, De Raedt T, Elefteriou F, Ferner RE, Giovannini M, Harris GJ, Kalamarides M, Karajannis MA, Kim A, Lázaro C, Le LQ, Li W, Listernick R, Martin S, Morrison H, Pasmant E, Ratner N, Schorry E, Ullrich NJ, Viskochil D, Weiss B, Widemann BC, Zhu Y, Bakker A, Serra E
  Am J Med Genet A 2018, 176(5), 1258-69
  
• Integrative analysis of differentially expressed genes and miRNAs predicts complex T3-mediated protective circuits in a rat model of cardiac ischemia reperfusion.
  Forini F, Nicolini G, Kusmic C, D'Aurizio R, Rizzo M, Baumgart M, Groth M, Doccini S, Iervasi G, Pitto L
  Sci Rep 2018, 8(1), 13870
  
• The eukaryotic linear motif resource - 2018 update.
  Gouw M, Michael S, Sámano-Sánchez H, Kumar M, Zeke A, Lang B, Bely B, Chemes LB, Davey NE, Deng Z, Diella F, Gürth CM, Huber AK, Kleinsorg S, Schlegel LS, Palopoli N, Roey KV, Altenberg B, Reményi A, Dinkel H, Gibson TJ
  Nucleic Acids Res 2018, 46(D1), D428-34
  
• Effects of allelic variations in the human Myxovirus resistance protein A on its antiviral activity.
  Graf L, Dick A, Sendker F, Barth E, Marz M, Daumke O, Kochs G
  J Biol Chem 2018, 293(9), 3056-72
  
• Molecular mechanisms of photoadaptation of photosystem I supercomplex of in an evolutionary cyanobacterial/algal intermediate.
  Haniewicz P, Abram M, Nosek L, Kirkpatrick J, El-Mohsnawy E, Janna Olmos JD, Kouril R, Kargul JM
  Plant Physiol 2018, 176(2), 1433-51
  
• Influence of Scribble polarity complex on hematopoiesis and leukemia - a matter of where, when and how.
  Heidel FH, Ellis S
  Oncotarget 2018, 9(78), 34642-3
  
• Managing myeloproliferative neoplasms evidence based on the ELN treatment recommendations 2018.
  Heidel FH, Gale RP, Hochhaus A
  Leukemia 2018, 32(5), 1055-6
  
• Conformational µ-conotoxin PIIIA isomers revisited: The impact of cysteine pairing on disulfide bond assignment and structure elucidation.
  Heimer P, Tietze AA, Bäuml CA, Resemann A, Mayer FJ, Suckau D, Ohlenschläger O, Tietze D, Imhof D
  Anal Chem 2018, 90(5), 3321-7
  
• Retinal S-opsin dominance in Ansell's mole-rats (Fukomys anselli) is a consequence of naturally low serum thyroxine.
  Henning Y, Mladěnková N, Burda H, Szafranski* K, Begall* S
  Sci Rep 2018, 8(1), 4337 * equal contribution
  
• The fate of ribosomal RNA genes in spontaneous polyploid dogrose hybrids (Rosa L. sect. Caninae (DC.) Ser.) exhibiting non-symmetrical meiosis.
  Herklotz V, Kovařík A, Lunerová J, Lippitsch S, Groth M, Ritz CM
  Plant J 2018, 94(1), 77-90
  
• sAPPβ and sAPPα increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Ca2+ homeostasis and CREB1-signaling
  Hesse R, von Einem B, Wagner F, Bott P, Schwanzar D, Jackson RJ, Föhr KJ, Lausser L, Kroker KS, Proepper C, Walther P, Kestler HA, Spires-Jones TL, Boeckers T, Rosenbrock H, von Arnim CAF
  Exp Neurol 2018, 304, 1-13
  
• Multiple roots of fruiting body formation in Amoebozoa.
  Hillmann F, Forbes G, Novohradská S, Ferling I, Riege K, Groth M, Westermann M, Marz M, Spaller T, Winckler T, Schaap P, Glöckner G
  Genome Biol Evol 2018, 10(2), 591-606
  
• Multimodal Light Microscopy Approaches to Reveal Structural and Functional Properties of Promyelocytic Leukemia Nuclear Bodies.
  Hoischen C, Monajembashi S, Weisshart K, Hemmerich P
  Front Oncol 2018, 8, 125
  
• CENP-C/H/I/K/M/T/W/N/L and hMis12 but not CENP-S/X participate in complex formation in the nucleoplasm of living human interphase cells outside centromeres.
  Hoischen* C, Yavas* S, Wohland T, Diekmann S
  PLoS One 2018, 13(3), e0192572 * equal contribution
  
• The microenvironment of naked mole-rat burrows in East Africa
  Holtze S, Braude S, Lemma A, Koch R, Morhart M, Szafranski K, Platzer M, Alemayehu F, Goeritz F, Hildebrandt TB
  Afr J Ecol 2018, 56(2), 279-89
  
• Virologists-Heroes need weapons.
  Hufsky F, Ibrahim B, Beer M, Deng L, Mercier PL, McMahon DP, Palmarini M, Thiel V, Marz M
  PLoS Pathog 2018, 14(2), e1006771
  
• 3D Network exploration and visualisation for lifespan data.
  Hühne* R, Kessler* V, Fürstberger* A, Kühlwein S, Platzer M, Sühnel J, Lausser L, Kestler HA
  BMC Bioinformatics 2018, 19(1), 390 * equal contribution
  
• Bioinformatics Meets Virology: The European Virus Bioinformatics Center's Second Annual Meeting.
  Ibrahim B, Arkhipova K, Andeweg AC, Posada-Céspedes S, Enault F, Gruber A, Koonin EV, Kupczok A, Lemey P, McHardy AC, McMahon DP, Pickett BE, Robertson DL, Scheuermann RH, Zhernakova A, Zwart MP, Schönhuth A, Dutilh BE, Marz M
  Viruses 2018, 10(5, 256; https://doi.org/10.33
  
• Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies.
  Juenemann K, Jansen AHP, van Riel L, Merkx R, Mulder MPC, An H, Statsyuk A, Kirstein J, Ovaa H, Reits EA
  Sci Rep 2018, 8(1), 1405
  
• Synthesis and biochemical evaluation of two novel N-hydroxyalkylated cyclosporin A analogs.
  Kahlert V, Prell E, Ohlenschläger O, Melesina J, Schumann M, Lücke C, Fischer G, Malešević M
  Org Biomol Chem 2018, 16(23), 4338-49
  
• Big data and precision medicine: challenges and strategies with healthcare data
  Kraus JM, Lausser L, Kuhn P, Jobst F, Bock M, Halanke C, Hummel M, Heuschmann P, Kestler HA
  Int J Data Sci Anal 2018
  
• Identification of biological mechanisms by semantic classifier systems.
  Lausser L, Schmid F, Siegle L, Hühne R, Buchholz M, Kestler HA
  bioRxiv 2018, https://doi.org/10.1101/335737
  
• The Influence of Multi-class Feature Selection on the Prediction of Diagnostic Phenotypes
  Lausser L, Szekely R, Schirra LR, Kestler HA
  Neural Process Lett 2018, 48(2), 863–880
  
• Deletion of Menin in craniofacial osteogenic cells in mice elicits development of mandibular ossifying fibroma.
  Lee S, Liu P, Teinturier R, Jakob J, Tschaffon M, Tasdogan A, Wittig R, Hoeller S, Baumhoer D, Frappart L, Vettorazzi S, Bertolino P, Zhang C, Tuckermann J
  Oncogene 2018, 37(5), 616-26
  
• Heat Shock Factor 1 Epigenetically Stimulates Glutaminase-1-Dependent mTOR Activation to Promote Colorectal Carcinogenesis.
  Li J, Song P, Jiang T, Dai D, Wang H, Sun J, Zhu L, Xu W, Feng L, Shin VY, Morrison H, Wang X, Jin H
  Mol Ther 2018, 26(7), 1828-39
  
• Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair.
  Lopez-Baez JC, Simpson DJ, LLeras Forero L, Zeng Z, Brunsdon H, Salzano A, Brombin A, Wyatt C, Rybski W, Huitema LFA, Dale RM, Kawakami K, Englert C, Chandra T, Schulte-Merker S, Hastie ND, Patton EE
  Elife 2018, 7, e30657
  
• Cystatin A suppresses tumor cell growth through inhibiting epithelial to mesenchymal transition in human lung cancer.
  Ma Y, Chen Y, Li Y, Grün K, Berndt A, Zhou Z, Petersen I
  Oncotarget 2018, 9(18), 14084-98
  
• Structural and functional conservation of cis-acting RNA elements in coronavirus 5'-terminal genome regions.
  Madhugiri R, Karl N, Petersen D, Lamkiewicz K, Fricke M, Wend U, Scheuer R, Marz M, Ziebuhr J
  Virology 2018, 517, 44-55
  
• Internal tandem duplication mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation.
  Marhäll A, Heidel F, Fischer T, Rönnstrand L
  Ann Hematol 2018, 97(5), 773-80
  
• The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing's sarcoma cell line.
  Marx C, Marx-Blümel L, Lindig N, Thierbach R, Hoelzer D, Becker S, Wittig S, Lehmann R, Slevogt H, Heinzel T, Wang ZQ, Beck JF, Sonnemann J
  Invest New Drugs 2018, 36(3), 396-406
  
• Reduced expression of C/EBPβ-LIP extends health- and lifespan in mice.
  Müller* C, Zidek* LM, Ackermann T, de Jong T, Liu P, Kliche V, Zaini MA, Kortman G, Harkema L, Verbeek DS, Tuckermann JP, von Maltzahn J, de Bruin A, Guryev V, Wang ZQ, Calkhoven CF
  Elife 2018, 7, e34985 * equal contribution
  
• Dispersion/reaggregation in early development of annual killifishes: Phylogenetic distribution and evolutionary significance of a unique feature.
  Naumann B, Englert C
  Dev Biol 2018, 442(1), 69-79
  
• Exploratory Investigation of Intestinal Function and Bacterial Translocation After Focal Cerebral Ischemia in the Mouse.
  Oyama* N, Winek* K, Bäcker-Koduah P, Zhang T, Dames C, Werich M, Kershaw O, Meisel C, Meisel A, Dirnagl U
  Front Neurol 2018, 9, 937 * equal contribution, * corresponding author
  
• Efficacy and safety of ruxolitinib in intermediate-1 IPSS risk myelofibrosis patients: Results from an independent study.
  Palandri F, Tiribelli M, Benevolo G, Tieghi A, Cavazzini F, Breccia M, Bergamaschi M, Sgherza N, Polverelli N, Crugnola M, Isidori A, Binotto G, Heidel FH, Buccisano F, Martino B, Latagliata R, Spinsanti M, Kallenberg L, Palumbo GA, Abruzzese E, Scaffidi L, Cuneo A, Cavo M, Vianelli N, Bonifacio M
  Hematol Oncol 2018, 36(1), 285-90
  
• Quantifying compartment-associated variations of protein abundance in proteomics data.
  Parca L, Beck M, Bork P, Ori A
  Mol Syst Biol 2018, 14(7), e8131
  
• Dysregulation of chemokine receptor expression and function in leukocytes from ALS patients.
  Perner C, Perner F, Stubendorff B, Förster M, Witte OW, Heidel FH, Prell T, Grosskreutz J
  J Neuroinflammation 2018, 15(1), 99
  
• The Pseudogenes of Barley.
  Prade VM, Gundlach H, Twardziok S, Chapman B, Tan C, Langridge P, Schulman AH, Stein N, Waugh R, Zhang G, Platzer M, Li C, Spannagl M, Mayer KFX
  Plant J 2018, 93(3), 502-14
  
• Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms.
  Prestipino A, Emhardt AJ, Aumann K, O'Sullivan D, Gorantla SP, Duquesne S, Melchinger W, Braun L, Vuckovic S, Boerries M, Busch H, Halbach S, Pennisi S, Poggio T, Apostolova P, Veratti P, Hettich M, Niedermann G, Bartholomä M, Shoumariyeh K, Jutzi JS, Wehrle J, Dierks C, Becker H, Schmitt-Graeff A, Follo M, Pfeifer D, Rohr J, Fuchs S, Ehl S, Hartl FA, Minguet S, Miething C, Heidel FH, Kröger N, Triviai I, Brummer T, Finke J, Illert AL, Ruggiero E, Bonini C, Duyster J, Pahl HL, Lane SW, Hill GR, Blazar BR, von Bubnoff N, Pearce EL, Zeiser R
  SCI TRANSL MED 2018, 10(429)
  
• Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity.
  Prigent J, Jarossay A, Planchais C, Eden C, Dufloo J, Kök A, Lorin V, Vratskikh O, Couderc T, Bruel T, Schwartz O, Seaman MS, Ohlenschläger** O, Dimitrov** JD, Mouquet** H
  Cell Rep 2018, 23(9), 2568-81 ** co-corresponding authors
  
• RBFOX2 and alternative splicing in B-cell lymphoma.
  Quentmeier H, Pommerenke C, Bernhart SH, Dirks WG, Hauer V, Hoffmann S, Nagel S, Siebert R, Uphoff CC, Zaborski M, Drexler HG, ICGC MMML-Seq Consortium
  Blood Cancer J 2018, 8(8), 77
  
• Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis.
  Ravichandran M, Priebe S, Grigolon G, Rozanov L, Groth M, Laube B, Guthke R, Platzer M, Zarse K, Ristow M
  Cell Metab 2018, 27(4), 914-25
  
• Haplotypes composed of minor frequency single nucleotide polymorphism of tnf gene protect from progression into sepsis: A study using the new sepsis classification.
  Retsas T, Huse K, Lazaridis LD, Karampela N, Bauer M, Platzer M, Kolonia V, Papageorgiou E, Giamarellos-Bourboulis EJ, Dimopoulos G
  Int J Infect Dis 2018, 67, 102-6
  
• Neuropathies in the setting of Neurofibromatosis tumor syndromes: Complexities and opportunities.
  Schulz A, Grafe P, Hagel C, Bäumer P, Morrison H, Mautner VF, Farschtschi S
  Exp Neurol 2018, 299(Pt B), 334-44
  
• Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex.
  Scior A, Buntru A, Arnsburg K, Ast A, Iburg M, Juenemann K, Pigazzini ML, Mlody B, Puchkov D, Priller J, Wanker EE, Prigione A, Kirstein J
  EMBO J 2018, 37(2), 282
  
• The role of the gut microbiome during host ageing.
  Seidel J, Valenzano DR
  F1000Res 2018, 7
  
• Aspergillus fumigatus conidial metalloprotease Mep1p cleaves host complement proteins.
  Shende R, Wong SSW, Rapole S, Beau R, Ibrahim-Granet O, Monod M, Gührs KH, Pal JK, Latgé JP, Madan T, Aimanianda V, Sahu A
  J Biol Chem 2018, 293(40), 15538-55
  
• The Definition of Open Reading Frame Revisited.
  Sieber P, Platzer M, Schuster S
  Trends Genet 2018, 34(3), 167-70
  
• A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells.
  Siegle* L, Schwab* JD, Kühlwein* SD, Lausser L, Tümpel S, Pfister AS, Kühl** M, Kestler** HA
  PLoS One 2018, 13(3), e0195126 * equal contribution, ** co-senior authors
  
• LSD1 (KDM1A)-independent effects of the LSD1 inhibitor SP2509 in cancer cells.
  Sonnemann J, Zimmermann M, Marx C, Ebert F, Becker S, Lauterjung ML, Beck JF
  Br J Haematol 2018, 183(4), 494-7
  
• The microRNA miR-21 Is a Mediator of FGF8 Action on Cortical COUP-TFI Translation.
  Terrigno M, Bertacchi M, Pandolfini L, Baumgart M, Calvello M, Cellerino A, Studer M, Cremisi F
  Stem Cell Reports 2018, 11(3), 756-69
  
• Neurofibromatosis type 2 tumor suppressor protein is expressed in oligodendrocytes and regulates cell proliferation and process formation.
  Toledo* A, Grieger* E, Karram K, Morrison H, Baader SL
  PLoS One 2018, 13(5), e0196726 * equal contribution
  
• Induction chemoradiotherapy versus induction chemotherapy for potentially resectable stage IIIA (N2) non-small cell lung cancer: a systematic review and meta-analysis.
  Tong S, Qin Z, Wan M, Zhang L, Cui Y, Yao Y
  J Thorac Dis 2018, 10(4), 2428-36
  
• Rapidly evolving changes and gene loss associated with host switching in Corynebacterium pseudotuberculosis.
  Viana MVC, Sahm A, Góes Neto A, Figueiredo HCP, Wattam AR, Azevedo V
  PLoS One 2018, 13(11), e0207304
  
• A subset of chemosensory genes differs between two populations of a specialized leaf beetle after host plant shift.
  Wang D, Pentzold S, Kunert M, Groth M, Brandt W, Pasteels JM, Boland W, Burse A
  Ecol Evol 2018, 8(16), 8055-75
  
• NUFIP1 is a ribosome receptor for starvation-induced ribophagy.
  Wyant* GA, Abu-Remaileh* M, Frenkel EM, Laqtom NN, Dharamdasani V, Lewis CA, Chan SH, Heinze I, Ori** A, Sabatini** DM
  Science 2018, 360(6390), 751-8 * equal contribution, ** co-corresponding authors
  

Publications 2017:

• Common Fibril Structures Imply Systemically Conserved Protein Misfolding Pathways In Vivo.
  Annamalai K, Liberta F, Vielberg MT, Close W, Lilie H, Gührs KH, Schierhorn A, Koehler R, Schmidt A, Haupt C, Hegenbart U, Schönland S, Schmidt M, Groll M, Fändrich M
  Angew Chem Int Ed Engl 2017, 56(26), 7510-4
  
• Mutations in NOTCH1 PEST domain orchestrate CCL19-driven homing of chronic lymphocytic leukemia cells by modulating the tumor suppressor gene DUSP22.
  Arruga F, Gizdic B, Bologna C, Cignetto S, Buonincontri R, Serra S, Vaisitti T, Gizzi K, Vitale N, Garaffo G, Mereu E, Diop F, Neri F, Incarnato D, Coscia M, Allan J, Piva R, Oliviero S, Furman RR, Rossi D, Gaidano G, Deaglio S
  Leukemia 2017, 31(9), 1882-93 published during change of institution
  
• PD-L1 up-regulation in melanoma increases disease aggressiveness and is mediated through miR-17-5p.
  Audrito V, Serra S, Stingi A, Orso F, Gaudino F, Bologna C, Neri F, Garaffo G, Nassini R, Baroni G, Rulli E, Massi D, Oliviero S, Piva R, Taverna D, Mandalà M, Deaglio S
  Oncotarget 2017, 8(9), 15894-911 published during change of institution
  
• Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma.
  Barth TFE, Kraus JM, Lausser L, Flossbach L, Schulte L, Holzmann K, Kestler** HA, Möller** P
  Sci Rep 2017, 7(1), 5963 ** co-senior authors
  
• Construction of a map-based reference genome sequence for barley, Hordeum vulgare L.
  Beier S, Himmelbach A, Colmsee C, Zhang XQ, Barrero RA, Zhang Q, Li L, Bayer M, Bolser D, Taudien S, Groth M, Felder M, Hastie A, Šimková H, Staňková H, Vrána J, Chan S, Muñoz-Amatriaín M, Ounit R, Wanamaker S, Schmutzer T, Aliyeva-Schnorr L, Grasso S, Tanskanen J, Sampath D, Heavens D, Cao S, Chapman B, Dai F, Han Y, Li H, Li X, Lin C, McCooke JK, Tan C, Wang S, Yin S, Zhou G, Poland JA, Bellgard MI, Houben A, Doležel J, Ayling S, Lonardi S, Langridge P, Muehlbauer GJ, Kersey P, Clark MD, Caccamo M, Schulman AH, Platzer M, Close TJ, Hansson M, Zhang G, Braumann I, Li C, Waugh R, Scholz U, Stein N, Mascher M
  Sci Data 2017, 4, 170044
  
• Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly.
  Bianchi FT, Tocco C, Pallavicini G, Liu Y, Vernì F, Merigliano C, Bonaccorsi S, El-Assawy N, Priano L, Gai M, Berto GE, Chiotto AMA, Sgrò F, Caramello A, Tasca L, Ala U, Neri F, Oliviero S, Mauro A, Geley S, Gatti M, Di Cunto F
  Cell Rep 2017, 18(7), 1674-86 published during change of institution
  
• Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome.
  Binder H, Hopp L, Schweiger MR, Hoffmann S, Jühling F, Kerick M, Timmermann B, Siebert S, Grimm C, Nersisyan L, Arakelyan A, Herberg M, Buske P, Loeffler-Wirth H, Rosolowski M, Engel C, Przybilla J, Peifer M, Friedrichs N, Moeslein G, Odenthal M, Hussong M, Peters S, Holzapfel S, Nattermann J, Hueneburg R, Schmiegel W, Royer-Pokora B, Aretz S, Kloth M, Kloor M, Buettner R, Galle J, Loeffler M
  J Pathol 2017
  
• Repeated intra-specific divergence in lifespan and ageing of African annual fishes along an aridity gradient.
  Blažek R, Polačik M, Kačer P, Cellerino A, Řežucha R, Methling C, Tomášek O, Syslová K, Tozzini ET, Albrecht T, Vrtílek M, Reichard M
  Evolution Int J Org Evolution 2017, 71(2), 386-402
  
• Toxic effects of zinc ions on kinesin - Potential molecular cause of impaired intracellular transport.
  Böhm KJ
  Toxicol Lett 2017, 268, 58-62
  
• DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats.
  Brocks D, Schmidt CR, Daskalakis M, Jang HS, Shah NM, Li D, Li J, Zhang B, Hou Y, Laudato S, Lipka DB, Schott J, Bierhoff H, Assenov Y, Helf M, Ressnerova A, Islam MS, Lindroth AM, Haas S, Essers M, Imbusch CD, Brors B, Oehme I, Witt O, Lübbert M, Mallm JP, Rippe K, Will R, Weichenhan D, Stoecklin G, Gerhäuser C, Oakes CC, Wang T, Plass C
  Nat Genet 2017, 49(7), 1052-60 published during change of institution
  
• Renal regenerative potential of different extra-cellular vesicle populations derived from bone marrow mesenchymal stromal cells.
  Bruno S, Tapparo M, Collino F, Chiabotto G, Deregibus MC, Soares Lindoso R, Neri F, Kholia S, Giunti S, Wen S, Quesenberry P, Camussi G
  TISSUE ENG PART A 2017, 23(21-22), 1262-73
  
• Ordinal Prototype-Based Classifiers
  Burkovski A, Schirra LR, Schmid F, Lausser L, Kestler HA
  Data Science Series A (Online-First) 2017, 2/1(http://dx.doi.org/10.5445/KS
  
• What have we learned on aging from omics studies?
  Cellerino A, Ori A
  Semin Cell Dev Biol 2017, 70, 177-89
  
• MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.
  Chen Y, Anastassiadis K, Kranz A, Stewart AF, Arndt K, Waskow C, Yokoyama A, Jones K, Neff T, Lee Y, Ernst P
  Cancer Cell 2017, 31(6), 755-770.e6
  
• New insights into the operative network of FaEO, an enone oxidoreductase from Fragaria x ananassa Duch.
  Collu G, Farci D, Esposito F, Pintus F, Kirkpatrick J, Piano D
  Plant Mol Biol 2017, 94(1-2), 125-36
  
• HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development.
  Connell M, Chen H, Jiang J, Kuan CW, Fotovati A, Chu T, He Z, Lengyell TC, Li H, Kroll T, Li AM, Goldowitz D, Frappart L, Ploubidou A, Patel M, Pilarski LM, Simpson EM, Lange P, Allan DW, Maxwell CA
  Elife 2017, 6, e28672
  
• Depletion of mitochondria in mammalian cells through enforced mitophagy.
  Correia-Melo C, Ichim G, Tait SWG, Passos JF
  Nat Protoc 2017, 12(1), 183–194
  
• Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.
  Dahms SO, Jiao** GS, Than** ME
  ACS Chem Biol 2017, 12(5), 1211-6 ** co-corresponding authors
  
• Architecture of the yeast Elongator complex.
  Dauden MI, Kosinski J, Kolaj-Robin O, Desfosses A, Ori A, Faux C, Hoffmann NA, Onuma OF, Breunig KD, Beck M, Sachse C, Séraphin B, Glatt S, Müller CW
  EMBO Rep 2017, 18(2), 264-79
  
• Gene expression reversal toward pre-adult levels in the aging human brain and age-related loss of cellular identity.
  Dönertaş HM, İzgi H, Kamacıoğlu A, He Z, Khaitovich P, Somel M
  Sci Rep 2017, 7(1), 5894
  
• Raman and Infrared Spectroscopy Distinguishing Replicative Senescent from Proliferating Primary Human Fibroblast Cells by Detecting Spectral Differences Mainly Due to Biomolecular Alterations.
  Eberhardt K, Beleites C, Marthandan S, Matthäus C, Diekmann S, Popp J
  Anal Chem 2017, 89(5), 2937-47
  
• Raman and infrared spectroscopy differentiate senescent from proliferating cells in a human dermal fibroblast 3D skin model.
  Eberhardt K, Matthäus C, Winter D, Wiegand C, Hipler UC, Diekmann S, Popp J
  Analyst 2017, 142(23), 4405-14
  
• Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models.
  Evsyukov V, Domanskyi A, Bierhoff H, Gispert S, Mustafa R, Schlaudraff F, Liss B, Parlato R
  Dis Model Mech 2017, 10(5), 633-43
  
• A new procedure for a fast soft staining of BN-PAGEs on photosynthetic complexes.
  Farci D, Kirkpatrick J, Piano D
  Electrophoresis 2017, 38(3-4), 441-6
  
• Transcriptional profiling reveals protective mechanisms in brains of long-lived mice.
  Frahm C, Srivastava A, Schmidt S, Mueller J, Groth M, Guenther M, Ji Y, Priebe S, Platzer M, Witte OW
  Neurobiol Aging 2017, 52, 23-31
  
• Evolution and antiviral specificity of interferon-induced Mx proteins of bats against Ebola-, Influenza-, and other RNA viruses.
  Fuchs J, Hölzer M, Schilling M, Patzina C, Schoen A, Hoenen T, Zimmer G, Marz M, Weber F, Müller MA, Kochs G
  J Virol 2017, 91(15), e00361-17
  
• microRNA-122 target sites in the hepatitis C virus RNA NS5B coding region and 3' untranslated region: function in replication and influence of RNA secondary structure.
  Gerresheim GK, Dünnes N, Nieder-Röhrmann A, Shalamova LA, Fricke M, Hofacker I, Höner Zu Siederdissen C, Marz M, Niepmann M
  Cell Mol Life Sci 2017, 74(4), 747-60
  
• RSK-mediated nuclear accumulation of the cold-shock Y-box protein-1 controls proliferation of T cells and T-ALL blasts.
  Gieseler-Halbach S, Meltendorf S, Pierau M, Weinert S, Heidel FH, Fischer T, Handschuh J, Braun-Dullaeus RC, Schrappe M, Lindquist JA, Mertens PR, Thomas U, Brunner-Weinzierl MC
  Cell Death Differ 2017, 24(2), 371-83
  
• Exploring Short Linear Motifs Using the ELM Database and Tools.
  Gouw M, Sámano-Sánchez H, Van Roey K, Diella F, Gibson TJ, Dinkel H
  Curr Protoc Bioinformatics 2017, 58, 8.22.1-8.22.35
  
• Combined microRNA and mRNA microfluidic TaqMan array cards for the diagnosis of malignancy of multiple types of pancreatico-biliary tumors in fine-needle aspiration material.
  Gress* TM, Lausser* L, Schirra LR, Ortmüller L, Diels R, Kong B, Michalski CW, Hackert T, Strobel O, Giese NA, Schenk M, Lawlor RT, Scarpa A, Kestler** HA, Buchholz** M
  Oncotarget 2017, 8(64), 108223-37 * equal contribution, ** co-senior authors
  
• Manipulation of cells with laser microbeam scissors and optical tweezers: a review.
  Greulich KO
  Rep Prog Phys 2017, 80(2), 026601
  
• The RNA workbench: best practices for RNA and high-throughput sequencing bioinformatics in Galaxy.
  Grüning BA, Fallmann J, Yusuf D, Will S, Erxleben A, Eggenhofer F, Houwaart T, Batut B, Videm P, Bagnacani A, Wolfien M, Lott SC, Hoogstrate Y, Hess WR, Wolkenhauer O, Hoffmann S, Akalin A, Ohler U, Stadler PF, Backofen R
  Nucleic Acids Res 2017, 45(W1), W560–W566
  
• JAK2-V617F activates β1-integrin-mediated adhesion of granulocytes to vascular cell adhesion molecule 1 (VCAM1).
  Gupta* N, Edelmann* B, Schnoeder TM, Saalfeld FC, Wolleschak D, Kliche S, Schraven B, Heidel** FH, Fischer** T
  Leukemia 2017, 31(5), 1223-6 * equal contribution, ** co-senior authors
  
• mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance.
  Haller S, Kapuria S, Riley RR, O'Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H
  Cell Stem Cell 2017, 21(6), 806-818.e5
  
• Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice.
  Hartmann K, Illing A, Leithäuser F, Baisantry A, Quintanilla-Martinez L, Rudolph KL
  Leukemia 2017, 31(12), 2853 Erratum for Leukemia 2016 volume 30 page 749
  
• Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health.
  Heid* J, Cencioni* C, Ripa* R, Baumgart* M, Atlante S, Milano G, Scopece A, Kuenne C, Guenther S, Azzimato V, Farsetti A, Rossi G, Braun T, Pompilio G, Martelli F, Zeiher AM, Cellerino** A, Gaetano** C, Spallotta** F
  Sci Rep 2017, 7(1), 16839 * equal contribution, ** co-senior authors
  
• ADAM Metalloprotease-Released Cancer Biomarkers.
  Herrlich P, Herrlich A
  Trends Cancer 2017, 3(7), 482-90
  
• Protein phosphatase 4 regulatory subunit 2 (PPP4R2) is recurrently deleted in acute myeloid leukemia and required for efficient DNA double strand break repair.
  Herzig JK, Bullinger L, Tasdogan A, Zimmermann P, Schlegel M, Teleanu V, Weber D, Rücker FG, Paschka P, Dolnik A, Schneider E, Kuchenbauer F, Heidel FH, Buske C, Döhner H, Döhner K, Gaidzik VI
  Oncotarget 2017, 8(56), 95038-53
  
• Reduced cGMP levels in CSF of AD patients correlate with severity of dementia and current depression.
  Hesse R, Lausser L, Gummert P, Schmid F, Wahler A, Schnack C, Kroker KS, Otto M, Tumani H, Kestler** HA, Rosenbrock** H, von Arnim** CAF
  Alzheimers Res Ther 2017, 9(1), 17 ** co-corresponding authors
  
• XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia.
  Hoch NC, Hanzlikova H, Rulten SL, Tétreault M, Komulainen E, Ju L, Hornyak P, Zeng Z, Gittens W, Rey SA, Staras K, Mancini GMS, McKinnon PJ, Wang ZQ, Wagner JD, Care4Rare Canada Consortium, Yoon G, Caldecott KW
  Nature 2017, 541(7635), 87-91
  
• Trifunctional lipid probes for comprehensive studies of single lipid species in living cells.
  Höglinger D, Nadler A, Haberkant P, Kirkpatrick J, Schifferer M, Stein F, Hauke S, Porter FD, Schultz C
  Proc Natl Acad Sci U S A 2017, 114(7), 1566-71
  
• Proteomic Analysis Reveals GMP Synthetase as p53 Repression Target in Liver Cancer.
  Holzer K, Drucker E, Roessler S, Dauch D, Heinzmann F, Waldburger N, Eiteneuer EM, Herpel E, Breuhahn K, Zender L, Schirmacher P, Ori A, Singer S
  Am J Pathol 2017, 187(2), 228-35
  
• Corrigendum: Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells.
  Hölzer M, Krähling V, Amman F, Barth E, Bernhart SH, Carmelo VAO, Collatz M, Doose G, Eggenhofer F, Ewald J, Fallmann J, Feldhahn LM, Fricke M, Gebauer J, Gruber AJ, Hufsky F, Indrischek H, Kanton S, Linde J, Mostajo N, Ochsenreiter R, Riege K, Rivarola-Duarte L, Sahyoun AH, Saunders SJ, Seemann SE, Tanzer A, Vogel B, Wehner S, Wolfinger MT, Backofen R, Gorodkin J, Grosse I, Hofacker I, Hoffmann S, Kaleta C, Stadler PF, Becker S, Marz M
  Sci Rep 2017, 7, 39421 Erratum for Sci Rep 2016 volume 6 page 34589
  
• Software Dedicated to Virus Sequence Analysis "Bioinformatics Goes Viral".
  Hölzer M, Marz M
  In: Advances in Virus Research (edited by Beer M, Höper D) 2017, 99, 233-257, Academic Press, London
  
• PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells.
  Hsieh MH, Chen YT, Chen YT, Lee YH, Lu J, Chien CL, Chen HF, Ho HN, Yu CJ, Wang ZQ, Teng SC
  Nucleic Acids Res 2017, 45(18), 10492-503
  
• High-throughput single-base resolution mapping of RNA 2'-O-methylated residues.
  Incarnato D, Anselmi F, Morandi E, Neri F, Maldotti M, Rapelli S, Parlato C, Basile G, Oliviero S
  Nucleic Acids Res 2017, 45(3), 1433–1441 published during change of institution
  
• Optimization of Substrate-Analogue Furin Inhibitors.
  Ivanova T, Hardes K, Kallis S, Dahms SO, Than ME, Künzel S, Böttcher-Friebertshäuser E, Lindberg I, Jiao GS, Bartenschlager R, Steinmetzer T
  ChemMedChem 2017, 12(23), 1953-68
  
• OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.
  Jung LA, Gebhardt A, Koelmel W, Ade CP, Walz S, Kuper J, von Eyss B, Letschert S, Redel C, d'Artista L, Biankin A, Zender L, Sauer M, Wolf E, Evan G, Kisker C, Eilers M
  Oncogene 2017, 36(14), 1911-24 published during change of institution
  
• Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays.
  Kaspar M, Bohn-Wippert K, Bellstedt P, Häfner S, Görlach M, Sauerbrei A
  J Virol Methods 2017, 247, 51-7
  
• In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging.
  Kirstein J, Arnsburg K, Scior A, Szlachcic A, Guilbride DL, Morimoto RI, Bukau B, Nillegoda NB
  Aging Cell 2017, 16(6), 1414
  
• Archaeogenomic analysis of the first steps of Neolithization in Anatolia and the Aegean.
  Kılınç GM, Koptekin D, Atakuman Ç, Sümer AP, Dönertaş HM, Yaka R, Bilgin CC, Büyükkarakaya AM, Baird D, Altınışık E, Flegontov P, Götherström A, Togan İ, Somel M
  Proc Biol Sci 2017, 284(1867)
  
• Differential Effects of Vitamins A and D on the Transcriptional Landscape of Human Monocytes during Infection.
  Klassert TE, Bräuer J, Hölzer M, Stock M, Riege K, Zubiría-Barrera C, Müller MM, Rummler S, Skerka C, Marz M, Slevogt H
  Sci Rep 2017, 7, 40599
  
• Developmental stage-dependent regulation of spine formation by calcium-calmodulin-dependent protein kinase IIα and Rap1.
  Koeberle SC, Tanaka S, Kuriu T, Iwasaki H, Koeberle A, Schulz A, Helbing DL, Yamagata Y, Morrison H, Okabe S
  Sci Rep 2017, 7(1), 13409
  
• Verification and characterization of an alternative low density lipoprotein receptor-related protein 1 splice variant.
  Kolb M, Kurz S, Schäfer A, Huse K, Dietz A, Wichmann G, Birkenmeier G
  PLoS One 2017, 12(6), e0180354
  
• BAT: Bisulfite Analysis Toolkit: BAT is a toolkit to analyze DNA methylation sequencing data accurately and reproducibly. It covers standard processing and analysis steps from raw read mapping up to annotation data integration and calculation of correlati
  Kretzmer H, Otto C, Hoffmann S
  F1000Res 2017, 1490
  
• Genome Sequence of a Novel Picorna-Like RNA Virus from Feces of the Antarctic Fur Seal (Arctocephalus gazella).
  Krumbholz A, Groth M, Esefeld J, Peter HU, Zell R
  Genome Announc 2017, 5(36)
  
• The anti-tumorigenic activity of A2M-A lesson from the naked mole-rat.
  Kurz S, Thieme R, Amberg R, Groth M, Jahnke HG, Pieroh P, Horn LC, Kolb M, Huse K, Platzer M, Volke D, Dehghani F, Buzdin A, Engel K, Robitzki A, Hoffmann R, Gockel I, Birkenmeier G
  PLoS One 2017, 12(12), e0189514
  
• Hacking the stem cell niche.
  Lane SW, Heidel FH
  Blood 2017, 129(22), 2951-2
  
• Ustilago maydis effectors and their impact on virulence.
  Lanver D, Tollot M, Schweizer G, Lo Presti L, Reissmann S, Ma LS, Schuster M, Tanaka S, Liang L, Ludwig N, Kahmann R
  Nat Rev Microbiol 2017, 15(7), 409-21
  
• Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging.
  Lechler MC, Crawford ED, Groh N, Widmaier K, Jung R, Kirstein J, Trinidad JC, Burlingame AL, David DC
  Cell Rep 2017, 18(2), 454
  
• Spindle Misorientation of Cerebral and Cerebellar Progenitors Is a Mechanistic Cause of Megalencephaly.
  Li H, Kroll T, Moll J, Frappart L, Herrlich P, Heuer H, Ploubidou A
  Stem Cell Reports 2017, 9(4), 1071-80
  
• The E3 ubiquitin ligase APC/C(C)(dh1) degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis.
  Liu X, Zong W, Li T, Wang Y, Xu X, Zhou** ZW, Wang** ZQ
  EMBO J 2017, 36(24), 3666-81 ** co-corresponding authors
  
• Customized workflow development and data modularization concepts for RNA-Sequencing and metatranscriptome experiments.
  Lott SC, Wolfien M, Riege K, Bagnacani A, Wolkenhauer O, Hoffmann S, Hess WR
  J Biotechnol 2017
  
• Generalized enhanced suffix array construction in external memory.
  Louza FA, Telles GP, Hoffmann S, Ciferri CDA
  Algorithms Mol Biol 2017, 12, 26
  
• Landscape of nuclear transport receptor cargo specificity.
  Mackmull MT, Klaus B, Heinze I, Chokkalingam M, Beyer A, Russell RB, Ori** A, Beck** M
  Mol Syst Biol 2017, 13(12), 962 ** co-corresponding authors, highlighted in the “Principle of Systems Biology” - Cell Systems 6 - 2018
  
• A chromosome conformation capture ordered sequence of the barley genome.
  Mascher M, Gundlach H, Himmelbach A, Beier S, Twardziok SO, Wicker T, Radchuk V, Dockter C, Hedley PE, Russell J, Bayer M, Ramsay L, Liu H, Haberer G, Zhang XQ, Zhang Q, Barrero RA, Li L, Taudien S, Groth M, Felder M, Hastie A, Šimková H, Staňková H, Vrána J, Chan S, Muñoz-Amatriaín M, Ounit R, Wanamaker S, Bolser D, Colmsee C, Schmutzer T, Aliyeva-Schnorr L, Grasso S, Tanskanen J, Chailyan A, Sampath D, Heavens D, Clissold L, Cao S, Chapman B, Dai F, Han Y, Li H, Li X, Lin C, McCooke JK, Tan C, Wang P, Wang S, Yin S, Zhou G, Poland JA, Bellgard MI, Borisjuk L, Houben A, Doležel J, Ayling S, Lonardi S, Kersey P, Langridge P, Muehlbauer GJ, Clark MD, Caccamo M, Schulman AH, Mayer KFX, Platzer M, Close TJ, Scholz U, Hansson M, Zhang G, Braumann I, Spannagl M, Li C, Waugh R, Stein N
  Nature 2017, 544(7651), 427-33
  
• A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence.
  Meyer P, Maity P, Burkovski A, Schwab J, Müssel C, Singh K, Ferreira FF, Krug L, Maier HJ, Wlaschek M, Wirth T, Kestler** HA, Scharffetter-Kochanek** K
  PLoS Comput Biol 2017, 13(12), e1005741 ** co-corresponding authors
  
• Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity.
  Mindos T, Dun XP, North K, Doddrell RDS, Schulz A, Edwards P, Russell J, Gray B, Roberts SL, Shivane A, Mortimer G, Pirie M, Zhang N, Pan D, Morrison H, Parkinson DB
  J Cell Biol 2017, 216(2), 495-510
  
• Central nervous system involvement in acute lymphoblastic leukemia is mediated by vascular endothelial growth factor.
  Münch V, Trentin L, Herzig J, Demir S, Seyfried F, Kraus JM, Kestler HA, Köhler R, Barth TFE, Te Kronnie G, Debatin KM, Meyer LH
  Blood 2017, 130(5), 643-54
  
• Intragenic DNA methylation prevents spurious transcription initiation.
  Neri F, Rapelli S, Krepelova A, Incarnato D, Parlato C, Basile G, Maldotti M, Anselmi F, Oliviero S
  Nature 2017, 543(7643), 72-7
  
• Rejuvenating Strategies for Stem Cell-Based Therapies in Aging.
  Neves J, Sousa-Victor P, Jasper H
  Cell Stem Cell 2017, 20(2), 161-75
  
• Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
  Pein* H, Koeberle* SC, Voelkel M, Schneider F, Rossi A, Thürmer M, Loeser K, Sautebin L, Morrison H, Werz O, Koeberle A
  FASEB J 2017, 31(10), 4566-77 * equal contribution
  
• The DNA Methyltransferase 1 (DNMT1) Controls the Shape and Dynamics of Migrating POA-Derived Interneurons Fated for the Murine Cerebral Cortex.
  Pensold D, Symmank J, Hahn A, Lingner T, Salinas-Riester G, Downie BR, Ludewig F, Rotzsch A, Haag N, Andreas N, Schubert K, Hübner CA, Pieler T, Zimmer G
  Cereb Cortex 2017, 27, 5696-714
  
• N-Heterocyclic (4-Phenylpiperazin-1-yl)methanones Derived from Phenoxazine and Phenothiazine as Highly Potent Inhibitors of Tubulin Polymerization.
  Prinz H, Ridder AK, Vogel K, Böhm KJ, Ivanov I, Ghasemi J, Aghaee E, Müller K:
  J Med Chem 2017, 60(2), 749-66
  
• Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.
  Ranjan S, Goihl A, Kohli S, Gadi I, Pierau M, Shahzad K, Gupta D, Bock F, Wang H, Shaikh H, Kähne T, Reinhold D, Bank U, Zenclussen AC, Niemz J, Schnöder TM, Brunner-Weinzierl M, Fischer T, Kalinski T, Schraven B, Luft T, Huehn J, Naumann M, Heidel FH, Isermann B
  Nat Commun 2017, 8(1), 311
  
• Mitochondrial BAX Determines the Predisposition to Apoptosis in Human AML.
  Reichenbach F, Wiedenmann C, Schalk E, Becker D, Funk K, Scholz-Kreisel P, Todt F, Wolleschak D, Döhner K, Marquardt** JU, Heidel** F, Edlich** F
  Clin Cancer Res 2017, 23(16), 4805-16 ** co-corresponding authors
  
• Alternative splicing of SMPD1 coding for acid sphingomyelinase in major depression.
  Rhein C, Reichel M, Kramer M, Rotter A, Lenz B, Mühle C, Gulbins E, Kornhuber J
  J Affect Disord 2017, 209, 10-5
  
• Central immune tolerance depends on crosstalk between the classical and alternative NF-κB pathways in medullary thymic epithelial cells.
  Riemann M, Andreas N, Fedoseeva M, Meier E, Weih D, Freytag H, Schmidt-Ullrich R, Klein U, Wang ZQ, Weih F
  J Autoimmun 2017, 81, 56-67
  
• MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging.
  Ripa R, Dolfi L, Terrigno M, Pandolfini L, Savino A, Arcucci V, Groth M, Terzibasi Tozzini E, Baumgart M, Cellerino A
  BMC Biol 2017, 15(1), 9
  
• Pomalidomide in myeloproliferative neoplasm-associated myelofibrosis.
  Schlenk RF, Stegelmann F, Reiter A, Jost E, Gattermann N, Hebart H, Waller C, Hochhaus A, Platzbecker U, Schafhausen P, Blau IW, Verbeek W, Heidel FH, Werner M, Kreipe H, Teleanu V, Benner A, Döhner H, Grießhammer M, Döhner K
  Leukemia 2017, 31(4), 889-95
  
• Macrophage's little helper: vitamin A directs alternatively activated monocyte-derived macrophages to tissue-resident macrophages.
  Schlüter D, Heidel FH
  Cell Mol Immunol 2017, 14(10), 805-8
  
• The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase.
  Schneble N, Müller J, Kliche S, Bauer R, Wetzker R, Böhmer FD, Wang ZQ, Müller JP
  Glia 2017, 65(2), 416-28
  
• Phosphoinositide 3-kinase γ ties chemoattractant- and adrenergic control of microglial motility.
  Schneble N, Schmidt C, Bauer R, Müller JP, Monajembashi S, Wetzker R
  Mol Cell Neurosci 2017, 78, 1-8
  
• Cell autonomous expression of CXCL-10 in JAK2V617F-mutated MPN.
  Schnöder TM, Eberhardt J, Koehler M, Bierhoff HB, Weinert S, Pandey AD, Nimmagadda SC, Wolleschak D, Jöhrens K, Fischer T, Heidel FH
  J Cancer Res Clin Oncol 2017, 143(5), 807-20
  
• Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells.
  Schreck C, Istvánffy R, Ziegenhain C, Sippenauer T, Ruf F, Henkel L, Gärtner F, Vieth B, Florian MC, Mende N, Taubenberger A, Prendergast Á, Wagner A, Pagel C, Grziwok S, Götze KS, Guck J, Dean DC, Massberg S, Essers M, Waskow C, Geiger H, Schiemann M, Peschel C, Enard W, Oostendorp RAJ
  J Exp Med 2017, 214(1), 165-81
  
• ViSiBooL - visualization and simulation of Boolean networks with temporal constraints.
  Schwab J, Burkovski A, Siegle L, Müssel** C, Kestler** HA
  Bioinformatics 2017, 33(4), 601-4 ** co-senior authors
  
• Stability of Signaling Pathways during Aging-A Boolean Network Approach.
  Schwab JD, Siegle L, Kühlwein SD, Kühl M, Kestler HA
  Biology (Basel) 2017, 6(4)
  
• An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.
  Scott RA, Scott LJ, Mägi R, Marullo L, Gaulton KJ, Kaakinen M, Pervjakova N, Pers TH, Johnson AD, Eicher JD, Jackson AU, Ferreira T, Lee Y, Ma C, Steinthorsdottir V, Thorleifsson G, Qi L, Van Zuydam NR, Mahajan A, Chen H, Almgren P, Voight BF, Grallert H, Müller-Nurasyid M, Ried JS, Rayner WN, Robertson N, Karssen LC, van Leeuwen EM, Willems SM, Fuchsberger C, Kwan P, Teslovich TM, Chanda P, Li M, Lu Y, Dina C, Thuillier D, Yengo L, Jiang L, Sparso T, Kestler HA, Chheda H, Eisele L, Gustafsson S, Frånberg M, Strawbridge RJ, Benediktsson R, Hreidarsson AB, Kong A, Sigurðsson G, Kerrison ND, Luan J, Liang L, Meitinger T, Roden M, Thorand B, Esko T, Mihailov E, Fox C, Liu CT, Rybin D, Isomaa B, Lyssenko V, Tuomi T, Couper DJ, Pankow JS, Grarup N, Have CT, Jørgensen ME, Jørgensen T, Linneberg A, Cornelis MC, van Dam RM, Hunter DJ, Kraft P, Sun Q, Edkins S, Owen KR, Perry JR, Wood AR, Zeggini E, Tajes-Fernandes J, Abecasis GR, Bonnycastle LL, Chines PS, Stringham HM, Koistinen HA, Kinnunen L, Sennblad B, Mühleisen TW, Nöthen MM, Pechlivanis S, Baldassarre D, Gertow K, Humphries SE, Tremoli E, Klopp N, Meyer J, Steinbach G, Wennauer R, Eriksson JG, Mӓnnistö S, Peltonen L, Tikkanen E, Charpentier G, Eury E, Lobbens S, Gigante B, Leander K, McLeod O, Bottinger EP, Gottesman O, Ruderfer D, Blüher M, Kovacs P, Tonjes A, Maruthur NM, Scapoli C, Erbel R, Jöckel KH, Moebus S, de Faire U, Hamsten A, Stumvoll M, Deloukas P, Donnelly PJ, Frayling TM, Hattersley AT, Ripatti S, Salomaa V, Pedersen NL, Boehm BO, Bergman RN, Collins FS, Mohlke KL, Tuomilehto J, Hansen T, Pedersen O, Barroso I, Lannfelt L, Ingelsson E, Lind L, Lindgren CM, Cauchi S, Froguel P, Loos RJ, Balkau B, Boeing H, Franks PW, Gurrea AB, Palli D, van der Schouw YT, Altshuler D, Groop LC, Langenberg C, Wareham NJ, Sijbrands E, van Duijn CM, Florez JC, Meigs JB, Boerwinkle E, Gieger C, Strauch K, Metspalu A, Morris AD, Palmer CN, Hu FB, Thorsteinsdottir U, Stefansson K, Dupuis J, Morris AP, Boehnke M, McCarthy MI, Prokopenko I, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
  Diabetes 2017, 66(11), 2888-902
  
• Regulation of life span by the gut microbiota in the short-lived African turquoise killifish.
  Smith P, Willemsen D, Popkes M, Metge F, Gandiwa E, Reichard M, Valenzano DR
  Elife 2017, 6
  
• TRE5-A retrotransposition profiling reveals putative RNA polymerase III transcription complex binding sites on the Dictyostelium extrachromosomal rDNA element.
  Spaller T, Groth M, Glöckner G, Winckler T
  PLoS One 2017, 12(4), e0175729
  
• Candidate Brocadiales dominates C, N and S cycling in anoxic groundwater of a pristine limestone-fracture aquifer.
  Starke R, Müller M, Gaspar M, Marz M, Küsel K, Totsche KU, von Bergen M, Jehmlich N
  J PROTEOMICS 2017, 152, 153-60
  
• Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development.
  Stopp S, Gründl M, Fackler M, Malkmus J, Leone M, Naumann R, Frantz S, Wolf E, von Eyss B, Engel FB, Gaubatz S
  Proc Natl Acad Sci U S A 2017, 114(30), 8029-34 published during change of institution
  
• Switch-like behavior enables Wnt11 concentration specific response during dorso-ventral axis formation in Xenopus laevis.
  Sträng JE, Schuler R, Kühl** M, Kestler** HA
  J Theor Biol 2017, 429, 82-94 ** co-senior authors
  
• Cdc45-induced loading of human RPA onto single-stranded DNA.
  Szambowska A, Tessmer I, Prus P, Schlott B, Pospiech H, Grosse F
  Nucleic Acids Res 2017, 45(6), 3217-30
  
• Lysine Acetylation and Deacetylation in Brain Development and Neuropathies.
  Tapias A, Wang ZQ
  Genomics Proteomics Bioinformatics 2017, 15(1), 19-36
  
• Variation and Functional Impact of Neanderthal Ancestry in Western Asia.
  Taskent RO, Alioglu ND, Fer E, Melike Donertas H, Somel M, Gokcumen O
  Genome Biol Evol 2017, 9(12), 3516
  
• Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis.
  Tassone B, Saoncella S, Neri F, Ala U, Brusa D, Magnuson MA, Provero P, Oliviero S, Riganti C, Calautti E
  Cell Death Differ 2017, 24(4), 731-46 published during change of institution
  
• RHEB1 insufficiency in aged male mice is associated with stress-induced seizures.
  Tian Q, Gromov P, Clement JH, Wang Y, Riemann M, Weih F, Sun XX, Dai MS, Fedorov LM
  Geroscience 2017, 39(5-6), 557-70
  
• Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation.
  Tsitsipatis D, Jayavelu AK, Müller JP, Bauer R, Schmidt-Arras D, Mahboobi S, Schnöder TM, Heidel F, Böhmer FD
  Oncotarget 2017, 8(16), 26613-24
  
• Keeping it complicated: Mitochondrial genome plasticity across diplonemids.
  Valach M, Moreira S, Hoffmann S, Stadler PF, Burger G
  Sci Rep 2017, 7(1), 14166
  
• Non-canonical aging model systems and why we need them.
  Valenzano DR, Aboobaker A, Seluanov A, Gorbunova V
  EMBO J 2017, 36(8), 959-63
  
• The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels.
  Valkova C, Liebmann L, Krämer A, Hübner CA, Kaether C
  Sci Rep 2017, 7, 41248
  
• NMR spectroscopic studies of a TAT-derived model peptide in imidazolium-based ILs: influence on chemical shifts and the cis/trans equilibrium state.
  Wiedemann C, Ohlenschläger O, Mrestani-Klaus C, Bordusa F
  Phys Chem Chem Phys 2017, 19(35), 24115-25
  
• Synthesis and Evaluation of Amyloid β Derived and Amyloid β Independent Enhancers of the Peroxidase-like Activity of Heme.
  Wißbrock A, Kühl T, Silbermann K, Becker AJ, Ohlenschläger** O, Imhof** D
  J Med Chem 2017, 60(1), 373-85 ** co-corresponding authors
  
• A Stably Protonated Adenine Nucleotide with a Highly Shifted pKa Value Stabilizes the Tertiary Structure of a GTP-Binding RNA Aptamer.
  Wolter AC, Weickhmann AK, Nasiri AH, Hantke K, Ohlenschläger O, Wunderlich CH, Kreutz C, Duchardt-Ferner E, Wöhnert J
  Angew Chem Int Ed Engl 2017, 56(1), 401-4
  
• Nucleosome Positioning Assay
  Zhao Z, Bierhoff H
  Bio-protocol 2017, 7(10), e2285
  

Publications 2016:

• Differential sensitivity of lipegfilgrastim and pegfilgrastim to neutrophil elastase correlates with differences in clinical pharmacokinetic profile.
  Abdolzade-Bavil A, von Kerczek A, Cooksey BA, Kaufman T, Krasney PA, Pukac L, Görlach M, Lammerich A, Scheckermann C, Allgaier H, Shen WD, Liu PM
  J Clin Pharmacol 2016, 56(2), 186-94
  
• Polymorphism of Amyloid Fibrils In Vivo.
  Annamalai K, Gührs KH, Koehler R, Schmidt M, Michel H, Loos C, Gaffney PM, Sigurdson CJ, Hegenbart U, Schönland S, Fändrich M
  Angew Chem Int Ed Engl 2016, 55(15), 4822-5
  
• Impact of FLT3-ITD location on sensitivity to TKI-therapy in vitro and in vivo.
  Arreba-Tutusaus P, Mack TS, Bullinger L, Schnöder TM, Polanetzki A, Weinert S, Ballaschk A, Wang Z, Deshpande AJ, Armstrong SA, Döhner K, Fischer T, Heidel FH
  Leukemia 2016, 30(5), 1220-5
  
• Multiplex sequencing of bacterial artificial chromosomes for assembling complex plant genomes.
  Beier S, Himmelbach A, Schmutzer T, Felder M, Taudien S, Mayer KFX, Platzer M, Stein N, Scholz U, Mascher M
  Plant Biotechnol J 2016, 14(7), 1511-22
  
• Changes of bivalent chromatin coincide with increased expression of developmental genes in cancer.
  Bernhart SH, Kretzmer H, Holdt LM, Jühling F, Ammerpohl O, Bergmann AK, Northoff BH, Doose G, Siebert R, Stadler PF, Hoffmann S
  Sci Rep 2016, 6, 37393
  
• Blood stem cells: from beginning to end.
  Bigas A, Waskow C
  Development 2016, 143(19), 3429-33
  
• From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology.
  Cellerino A, Valenzano DR, Reichard M
  Biol Rev Camb Philos Soc 2016, 91(2), 511-33
  
• Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing.
  Chandel NS, Jasper H, Ho TT, Passegué E
  Nat Cell Biol 2016, 18(8), 823-32
  
• Powering senescence: The ugly side of mitochondria.
  Correia-Melo C, Birch J, Passos JF
  Cell Cycle 2016, 15(19), 2541
  
• Mitochondria are required for pro-ageing features of the senescent phenotype.
  Correia-Melo C, Marques FDM, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SWG, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF
  EMBO J 2016, 35(7), 724
  
• Demystifying the role of mitochondria in senescence.
  Correia-Melo C, Passos JF
  Mol Cell Oncol 2016, 3(4), e1162896
  
• Discovering miRNA regulatory networks in Holt-Oram Syndrome using a Zebrafish model
  D'Aurizio R, Russo F, Chiavacci E, Baumgart M, Groth M, D'Onofrio M, Arisi I, Rainaldi G, Pitto L, Pellegrini M
  Front. Bioeng. Biotechnol. 2016, 4, Article 60
  
• Boolean modeling identifies greatwall/MASTL as an important regulator in the AURKA network of neuroblastoma.
  Dahlhaus M, Burkovski A, Hertwig F, Mussel C, Volland R, Fischer M, Debatin KM, Kestler** HA, Beltinger** C
  Cancer Lett 2016, 371(1), 79-89 ** co-corresponding authors
  
• The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.
  Dahms SO, Creemers JWM, Schaub Y, Bourenkov GP, Zögg T, Brandstetter H, Than ME
  Sci Rep 2016, 6, 34303.doi:10.1038/srep303
  
• Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
  Dahms* SO, Arciniega* M, Steinmetzer T, Huber** R, Than** ME
  Proc Natl Acad Sci U S A 2016, 113(40), 11196-201 * equal contribution, ** co-corresponding authors
  
• The role of hypothalamic NF-κB signaling in the response of the HPT-axis to acute inflammation in female mice.
  de Vries EM, Nagel S, Haenold R, Sundaram SM, Pfrieger FW, Fliers E, Heuer H, Boelen A
  Endocrinology 2016, 157(7), 2947-56
  
• Analysis of cultivable microbiota and diet intake pattern of the long-lived naked mole-rat.
  Debebe T, Holtze S, Morhart M, Hildebrandt TB, Rodewald S, Huse K, Platzer M, Wyohannes D, Yirga S, Lemma A, Thieme R, König B, Birkenmeier G
  Gut Pathog 2016, 8, 25
  
• Ethyl Pyruvate: An Anti-Microbial Agent that Selectively Targets Pathobionts and Biofilms.
  Debebe T, Krüger M, Huse K, Kacza J, Mühlberg K, König B, Birkenmeier G
  PLoS One 2016, 11(9), e0162919
  
• Sexual Dimorphism: How Female Cells Win the Race.
  Deng H, Jasper H
  Curr Biol 2016, 26(5), R212-5
  
• Characterising Complex Enzyme Reaction Data.
  Dönertaş* HM, Martínez Cuesta* S, Rahman SA, Thornton JM
  PLoS One 2016, 11(2), e0147952 * equal contribution
  
• Reply to Hart et al.: MINCR and MYC: More than expression correlation.
  Doose G, Hoffmann S, Iaccarino I
  Proc Natl Acad Sci U S A 2016, 113(5), E498
  
• What a Difference an OH Makes: Conformational Dynamics as the Basis for the Ligand Specificity of the Neomycin-Sensing Riboswitch.
  Duchardt-Ferner E, Gottstein-Schmidtke SR, Weigand JE, Ohlenschläger O, Wurm JP, Hammann C, Suess B, Wöhnert J
  Angew Chem Int Ed Engl 2016, 55(4), 1527-30
  
• Expression and function of ABC-transporter protein ABCB1 correlates with inhibitory capacity of Ruxolitinib in vitro and in vivo.
  Ebert C, Perner F, Wolleschak D, Schnöder TM, Fischer T, Heidel FH
  Haematologica 2016, 101(3), e81-5
  
• DNA Damage as a Critical Factor of Stem Cell Aging and Organ Homeostasis
  Espada L, Ermolaeva MA
  Curr Stem Cell Rep 2016, 2, 290-8
  
• Multifocal Nerve Lesions and LZTR1 Germline Mutations in Segmental Schwannomatosis.
  Farschtschi S, Mautner VF, Pham M, Nguyen R, Kehrer-Sawatzki H, Hutter S, Friedrich RE, Schulz A, Morrison H, Jones DTW, Bendszus M, Bäumer P
  Ann Neurol 2016, 80(4), 625-8
  
• Interplay between redox and protein homeostasis.
  Feleciano DR, Arnsburg K, Kirstein J
  Worm 2016, 5(2), e1170273
  
• Collapse of redox homeostasis during aging and stress.
  Feleciano DR, Kirstein J
  Mol Cell Oncol 2016, 3(2), e1091060
  
• Automated structure modeling of large protein assemblies using crosslinks as distance restraints.
  Ferber M, Kosinski J, Ori A, Rashid UJ, Moreno-Morcillo M, Simon B, Bouvier G, Batista PR, Müller CW, Beck M, Nilges M
  Nat Methods 2016, 13(6), 515-20 published during change of institution
  
• The tumour suppressor CYLD regulates the p53 DNA damage response.
  Fernández-Majada V, Welz PS, Ermolaeva MA, Schell M, Adam A, Dietlein F, Komander D, Büttner R, Thomas RK, Schumacher B, Pasparakis M
  Nat Commun 2016, 7, 12508 published during change of institution
  
• S100A11 plays a role in homologous recombination and genome maintenance by influencing the persistence of RAD51 in DNA repair foci.
  Foertsch F, Szambowska A, Weise A, Zielinski A, Schlott B, Kraft F, Mrasek K, Borgmann K, Pospiech** H, Grosse F, Melle** C
  Cell Cycle 2016, 15(20), 2766-79 ** co-corresponding authors
  
• Prediction of conserved long-range RNA-RNA interactions in full viral genomes.
  Fricke M, Marz M
  Bioinformatics 2016, 32(19), 2928-35
  
• High Copy Numbers of Beta-Defensin Cluster on 8p23.1 Confer Genetic Susceptibility and Modulate the Physical Course of Hidradenitis Suppurativa/Acne Inversa.
  Giamarellos-Bourboulis* EJ, Platzer* M, Karagiannidis* I, Kanni T, Nikolakis G, Ulrich J, Bellutti M, Gollnick H, Bauer M, Zouboulis CC, Huse K
  J Invest Dermatol 2016, 136(8), 1592-8 * equal contribution
  
• You Are What You Eat: Linking High-Fat Diet to Stem Cell Dysfunction and Tumorigenesis.
  Haller S, Jasper H
  Cell Stem Cell 2016, 18(5), 564-6
  
• DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression.
  Hampp S, Kiessling T, Buechle K, Mansilla SF, Thomale J, Rall M, Ahn J, Pospiech H, Gottifredi V, Wiesmüller L
  Proc Natl Acad Sci U S A 2016, 113(30), E4311-9
  
• Efficient genome engineering approaches for the short-lived African turquoise killifish.
  Harel I, Valenzano DR, Brunet A
  Nat Protoc 2016, 11(10), 2010-28
  
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• Olfactory phenotypic expression unveils human aging.
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• Chronic myelogenous leukemia evolving after treatment of multiple myeloma.
  Wolleschak D, Heidel FH
  Blood 2016, 128(1), 146
  
• Attenuated LKB1-SIK1 signaling promotes epithelial-mesenchymal transition and radioresistance of non-small cell lung cancer cells.
  Yao YH, Cui Y, Qiu XN, Zhang LZ, Zhang W, Li H, Yu JM
  Chin J Cancer 2016, 35(1), 50
  
• Inhibition of cargo export at ER-exit sites and the trans-Golgi network by the secretion inhibitor FLI-06.
  Yonemura Y, Li X, Müller K, Krämer A, Atigbire P, Mentrup T, Feuerhake T, Kroll T, Shomron O, Nohl R, Arndt HD, Hoischen C, Hemmerich P, Hirschberg K, Kaether C
  J Cell Sci 2016, 129(20), 3868-77
  
• Age-Dependent Changes of Monocarboxylate Transporter 8 Availability in the Postnatal Murine Retina
  Yoshiyuki H, Szafranski K
  Front Cell Neurosci 2016, http://dx.doi.org/10.3389/fncel.
  
• lncRNA-Induced Nucleosome Repositioning Reinforces Transcriptional Repression of rRNA Genes upon Hypotonic Stress.
  Zhao Z, Dammert MA, Grummt I, Bierhoff H
  Cell Rep 2016, 14(8), 1876-82
  
• Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning.
  Zhao Z, Dammert MA, Hoppe S, Bierhoff H, Grummt I
  Nucleic Acids Res 2016, 44(17), 8144-52
  

Publications 2015:

• Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer.
  Adams* PD, Jasper* H, Rudolph* KL
  Cell Stem Cell 2015, 16(6), 601-12 ** co-corresponding authors
  
• Amyloid domains in the cell nucleus controlled by nucleoskeletal protein lamin B1 reveal a new pathway of mercury neurotoxicity.
  Arnhold F, Gührs KH, von Mikecz A
  PeerJ 2015, 3, e754
  
• Stem Cells and Aging: What’s Next?
  Artandi SE, Blau HM, de Haan G, Geiger H, Goodell MA, Jones L, Levine RL, Munoz-Canoves P, Rodewald HR, Wagers A, Wang ZQ, Yamashita Y
  Cell Stem Cell 2015, 16, 578-81
  
• Haemocytes control stem cell activity in the Drosophila intestine.
  Ayyaz A, Li H, Jasper H
  Nat Cell Biol 2015, 17(6), 736-48
  
• Differential Regulation of MicroRNAs in End-Stage Failing Hearts Is Associated with Left Ventricular Assist Device Unloading.
  Barsanti C, Trivella MG, D'Aurizio R, El Baroudi M, Baumgart M, Groth M, Caruso R, Verde A, Botta L, Cozzi L, Pitto L
  Biomed Res Int 2015, 2015, 592512
  
• Comparison of captive lifespan, age-associated liver neoplasias and age-dependent gene expression between two annual fish species: Nothobranchius furzeri and Nothobranchius korthause.
  Baumgart M, Di Cicco E, Rossi G, Cellerino A, Tozzini ET
  Biogerontology 2015, 16(1), 63-9
  
• DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease.
  Birch J, Anderson RK, Correia-Melo C, Jurk D, Hewitt G, Marques FM, Green NJ, Moisey E, Birrell MA, Belvisi MG, Black F, Taylor JJ, Fisher AJ, De Soyza A, Passos JF
  Am J Physiol Lung Cell Mol Physiol 2015, 309(10), L1124
  
• Elevated copper ion levels as potential cause of impaired kinesin-dependent transport processes.
  Böhm KJ
  Arch Toxicol 2015, 89(4), 565-72
  
• Aluminium-induced kinesin inactivation as potential molecular cause of impairment of neuronal transport processes.
  Böhm KJ, Shabanpour M, Kalchishkova N
  Chem Res Toxicol 2015, 28(6), 1275-81
  
• A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis.
  Buch S, Stickel F, Trépo E, Way M, Herrmann A, Nischalke HD, Brosch M, Rosendahl J, Berg T, Ridinger M, Rietschel M, McQuillin A, Frank J, Kiefer F, Schreiber S, Lieb W, Soyka M, Semmo N, Aigner E, Datz C, Schmelz R, Brückner S, Zeissig S, Stephan AM, Wodarz N, Devière J, Clumeck N, Sarrazin C, Lammert F, Gustot T, Deltenre P, Völzke H, Lerch MM, Mayerle J, Eyer F, Schafmayer C, Cichon S, Nöthen MM, Nothnagel M, Ellinghaus D, Huse K, Franke A, Zopf S, Hellerbrand C, Moreno C, Franchimont D, Morgan MY, Hampe J
  Nat Genet 2015, 47(12), 1443-8
  
• Phenotypic regulation of the sphingosine 1-phosphate receptor Miles Apart by GRK2.
  Burczyk MS, Burkhalter MD, Blätte T, Matysik S, Caron MG, Barak LS, Philipp M
  Biochemistry 2015, 54(3), 765-75
  
• Genome instability of ageing stem cells-Induction and defence mechanisms.
  Burkhalter MD, Rudolph KL, Sperka T
  Ageing Res Rev 2015, 23(Pt A), 29-36
  
• Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupying an essential rRNA-binding site.
  Calviño FR, Kharde S, Ori A, Hendricks A, Wild K, Kressler D, Bange G, Hurt E, Beck M, Sinning I
  Nat Commun 2015, 6, 6510
  
• Annual fishes of the genus Nothobranchius as an experimental model. p.93-99 in Annual Fishes
  Cellerino A
  In: Annual Fishes, Life History Strategy, Diversity and Evolution. (edited by Beiros N, García G, de Sá R) 2015, 93-99, CRC Press Taylor and Fran
  
• Editorial for "Regulatory RNAs in the nervous system".
  Cellerino A, Bally-Cuif L, Pizzorusso T
  Front Cell Neurosci 2015, 9, 38
  
• MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome.
  Chiavacci E, D'Aurizio R, Guzzolino E, Russo F, Baumgart M, Groth M, Mariani L, D'Onofrio M, Arisi I, Pellegrini M, Cellerino A, Cremisi F, Pitto L
  Sci Rep 2015, 5, 18240
  
• AKI Recovery Induced by Mesenchymal Stromal Cell-Derived Extracellular Vesicles Carrying MicroRNAs.
  Collino F, Bruno S, Incarnato D, Dettori D, Neri F, Provero P, Pomatto M, Oliviero S, Tetta C, Quesenberry PJ, Camussi G
  J Am Soc Nephrol 2015, 26(10), 2349-60
  
• Mitochondria: Are they causal players in cellular senescence?
  Correia-Melo C, Passos JF
  Biochim Biophys Acta 2015, 1847(11), 1373
  
• Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes.
  Dahms SO, Mayer MC, Roeser D, Multhaup G, Than ME
  Acta Crystallogr D Biol Crystallogr 2015, 71(Pt 3), 494-504
  
• Signal integration by Ca(2+) regulates intestinal stem-cell activity.
  Deng H, Gerencser AA, Jasper H
  Nature 2015, 528(7581), 212-7
  
• Mutants of Metal Binding Site M1 in APP E2 Show Metal Specific Differences in Binding of Heparin but Not of sorLA.
  Dienemann C, Coburger I, Mehmedbasic A, Andersen OM, Than ME
  Biochemistry 2015, 54(15), 2490-9
  
• MicroRNAs provide the first evidence of genetic link between diapause and aging in vertebrates
  Dolfi* L, Baumgart* M, Groth M, Platzer M, Cellerino A
  bioRxiv 2015, https://doi.org/10.1101/017848 * equal contribution
  
• MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells.
  Doose G, Haake A, Bernhart SH, López C, Duggimpudi S, Wojciech F, Bergmann AK, Borkhardt A, Burkhardt B, Claviez A, Dimitrova L, Haas S, Hoell JI, Hummel M, Karsch D, Klapper W, Kleo K, Kretzmer H, Kreuz M, Küppers R, Lawerenz C, Lenze D, Loeffler M, Mantovani-Löffler L, Möller P, Ott G, Richter J, Rohde M, Rosenstiel P, Rosenwald A, Schilhabel M, Schneider M, Scholz I, Stilgenbauer S, Stunnenberg HG, Szczepanowski M, Trümper L, Weniger MA, ICGC MMML-Seq Consortium, Hoffmann S, Siebert R, Iaccarino I
  Proc Natl Acad Sci U S A 2015, 112(38), E5261-70
  
• Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division.
  Dumont NA, Wang YX, von Maltzahn J, Pasut A, Bentzinger CF, Brun CE, Rudnicki MA
  Nat Med 2015, 21(12), 1455-63
  
• SPLIFF: A Single-Cell Method to Map Protein-Protein Interactions in Time and Space.
  Dünkler A, Rösler R, Kestler HA, Moreno-Andrés D, Johnsson N
  Methods Mol Biol 2015, 1346, 151-68 published during change of institution
  
• The butterfly plant arms-race escalated by gene and genome duplications.
  Edger PP, Heidel-Fischer HM, Bekaert M, Rota J, Glöckner G, Platts AE, Heckel DG, Der JP, Wafula EK, Tang M, Hofberger JA, Smithson A, Hall JC, Blanchette M, Bureau TE, Wright SI, dePamphilis CW, Schranz ME, Barker MS, Conant GC, Wahlberg N, Vogel H, Pires JC, Wheat CW
  Proc Natl Acad Sci U S A 2015, 112(27), 8362-6
  
• Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke.
  Engel O, Akyüz L, da Costa Goncalves AC, Winek K, Dames C, Thielke M, Herold S, Böttcher C, Priller J, Volk HD, Dirnagl U, Meisel C, Meisel A
  Stroke 2015, 46(11), 3232-40
  
• Quality control mechanisms in cellular and systemic DNA damage responses.
  Ermolaeva** MA, Dakhovnik A, Schumacher** B
  Ageing Res Rev 2015, 23(Pt A), 3-11 ** co-corresponding authors
  
• Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization.
  Eschbach J, von Einem B, Müller K, Bayer H, Scheffold A, Morrison BE, Rudolph KL, Thal DR, Witting A, Weydt P, Otto M, Fauler M, Liss B, McLean PJ, Spada ARL, Ludolph AC, Weishaupt JH, Danzer KM
  Ann Neurol 2015, 77(1), 15-32
  
• Telomeres and Stem Cell Aging
  Felix DA
  In: Adult Stem Cells in Aging, Diseases and Cancer (edited by Rudolph KL), Else Kröner-Fresenius Symposia 2015, 5, 69-73, Karger Verlag, Basel
  
• Stem Cells in Adult Intestine
  Feng J, Sperka T
  In: Adult Stem Cells in Aging, Diseases and Cancer (edited by Rudolph KL), Else Kröner-Fresenius Symposia 2015, 5, 18-24, Karger Verlag, Basel
  
• Engineering a Constrained Peptidic Scaffold towards Potent and Selective Furin Inhibitors.
  Fittler H, Depp A, Avrutina O, Dahms SO, Than ME, Empting M, Kolmar H
  Chembiochem 2015, 16(17), 2441-4
  
• VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice with Colitis.
  Foersch S, Sperka T, Lindner C, Taut A, Rudolph KL, Breier G, Boxberger F, Rau TT, Hartmann A, Stürzl M, Wittkopf N, Haep L, Wirtz S, Neurath MF, Waldner MJ
  Gastroenterology 2015, 149(1), 177-89
  
• Conserved RNA secondary structures and long-range interactions in hepatitis C viruses.
  Fricke M, Dünnes N, Zayas M, Bartenschlager R, Niepmann M, Marz M
  RNA 2015, 21(7), 1219-32
  
• Extended pairwise local alignment of wild card DNA/RNA sequences using dynamic programming
  Fürstenberg A, Maucher M, Kestler HA
  J Stat Comput Sim 2015, 85(1), 3-13 published during change of institution
  
• Structural basis for assembly and function of the Nup82 complex in the nuclear pore scaffold.
  Gaik M, Flemming D, von Appen A, Kastritis P, Mücke N, Fischer J, Stelter P, Ori A, Bui KH, Baßler J, Barbar E, Beck M, Hurt E
  J Cell Biol 2015, 208(3), 283-97
  
• Snai1 represses Nanog to promote embryonic stem cell differentiation.
  Galvagni F, Neri F
  Genom Data 2015, 4, 82-3
  
• Snai1 promotes ESC exit from the pluripotency by direct repression of self-renewal genes.
  Galvagni* F, Lentucci* C, Neri* F, Dettori D, De Clemente C, Orlandini M, Anselmi F, Rapelli S, Grillo M, Borghi S, Oliviero S
  Stem Cells 2015, 33(3), 742-50 * equal contribution
  
• Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
  Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, William Rayner N, Robertson N, Scott RA, Prokopenko I, Scott LJ, Green T, Sparso T, Thuillier D, Yengo L, Grallert H, Wahl S, Frånberg M, Strawbridge RJ, Kestler H, Chheda H, Eisele L, Gustafsson S, Steinthorsdottir V, Thorleifsson G, Qi L, Karssen LC, van Leeuwen EM, Willems SM, Li M, Chen H, Fuchsberger C, Kwan P, Ma C, Linderman M, Lu Y, Thomsen SK, Rundle JK, Beer NL, van de Bunt M, Chalisey A, Kang HM, Voight BF, Abecasis GR, Almgren P, Baldassarre D, Balkau B, Benediktsson R, Blüher M, Boeing H, Bonnycastle LL, Bottinger EP, Burtt NP, Carey J, Charpentier G, Chines PS, Cornelis MC, Couper DJ, Crenshaw AT, van Dam RM, Doney ASF, Dorkhan M, Edkins S, Eriksson JG, Esko T, Eury E, Fadista J, Flannick J, Fontanillas P, Fox C, Franks PW, Gertow K, Gieger C, Gigante B, Gottesman O, Grant GB, Grarup N, Groves CJ, Hassinen M, Have CT, Herder C, Holmen OL, Hreidarsson AB, Humphries SE, Hunter DJ, Jackson AU, Jonsson A, Jørgensen ME, Jørgensen T, Kao WHL, Kerrison ND, Kinnunen L, Klopp N, Kong A, Kovacs P, Kraft P, Kravic J, Langford C, Leander K, Liang L, Lichtner P, Lindgren CM, Lindholm E, Linneberg A, Liu CT, Lobbens S, Luan J, Lyssenko V, Männistö S, McLeod O, Meyer J, Mihailov E, Mirza G, Mühleisen TW, Müller-Nurasyid M, Navarro C, Nöthen MM, Oskolkov NN, Owen KR, Palli D, Pechlivanis S, Peltonen L, Perry JRB, Platou CGP, Roden M, Ruderfer D, Rybin D, van der Schouw YT, Sennblad B, Sigurðsson G, Stančáková A, Steinbach G, Storm P, Strauch K, Stringham HM, Sun Q, Thorand B, Tikkanen E, Tonjes A, Trakalo J, Tremoli E, Tuomi T, Wennauer R, Wiltshire S, Wood AR, Zeggini E, Dunham I, Birney E, Pasquali L, Ferrer J, Loos RJF, Dupuis J, Florez JC, Boerwinkle E, Pankow JS, van Duijn C, Sijbrands E, Meigs JB, Hu FB, Thorsteinsdottir U, Stefansson K, Lakka TA, Rauramaa R, Stumvoll M, Pedersen NL, Lind L, Keinanen-Kiukaanniemi SM, Korpi-Hyövälti E, Saaristo TE, Saltevo J, Kuusisto J, Laakso M, Metspalu A, Erbel R, Jöcke KH, Moebus S, Ripatti S, Salomaa V, Ingelsson E, Boehm BO, Bergman RN, Collins FS, Mohlke KL, Koistinen H, Tuomilehto J, Hveem K, Njølstad I, Deloukas P, Donnelly PJ, Frayling TM, Hattersley AT, de Faire U, Hamsten A, Illig T, Peters A, Cauchi S, Sladek R, Froguel P, Hansen T, Pedersen O, Morris AD, Palmer CNA, Kathiresan S, Melander O, Nilsson PM, Groop LC, Barroso I, Langenberg C, Wareham NJ, O'Callaghan CA, Gloyn AL, Altshuler D, Boehnke M, Teslovich TM, McCarthy MI, Morris AP, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
  Nat Genet 2015, 47(12), 1415-25
  
• Grundlagen der Durchflusszytometrie
  Gompf A
  In: Zelluläre Diagnostik und Therapie (edited by Sack U) 2015, 1-28, Walter de Gruyter GmbH, Be
  
• Predicting Variabilities in Cardiac Gene Expression with a Boolean Network Incorporating Uncertainty.
  Grieb M, Burkovski A, Sträng JE, Kraus JM, Groß A, Palm G, Kühl M, Kestler HA
  PLoS One 2015, 10(7), e0131832
  
• Novel Furin Inhibitors with Potent Anti-infectious Activity.
  Hardes K, Becker GL, Lu Y, Dahms SO, Köhler S, Beyer W, Sandvig K, Yamamoto H, Lindberg I, Walz L, von Messling V, Than ME, Garten W, Steinmetzer T
  ChemMedChem 2015, 10(7), 1218-31
  
• A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.
  Harel I, Benayoun BA, Machado B, Singh PP, Hu CK, Pech MF, Valenzano DR, Zhang E, Sharp SC, Artandi SE, Brunet A
  Cell 2015, 160(5), 1013-26
  
• Core cross-linked nanogels based on the self-assembly of double hydrophilic poly(2-oxazoline) block copolymers
  Hartlieb M, Pretzel D, Wagner M, Hoeppener S, Bellstedt P, Görlach M, Englert C, Kempe K, Schubert US
  J Mater Chem B 2015, 3, 1748-59
  
• Plasma N-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome.
  Hartmann D, von Figura G, Song Z, Harden S, Scott LC, Evans TJ, Rudolph KL, Bilsland AE, Keith WN
  Future Oncol 2015, 11(2), 193-203
  
• Evolutionarily conserved signaling pathways: acting in the shadows of acute myelogenous leukemia's genetic diversity.
  Heidel FH, Arreba-Tutusaus P, Armstrong SA, Fischer T
  Clin Cancer Res 2015, 21(2), 240-8
  
• Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response.
  Hein K, Mittler G, Cizelsky W, Kühl M, Ferrante F, Liefke R, Berger IM, Just S, Sträng JE, Kestler HA, Oswald F, Borggrefe T
  Sci Signal 2015, 8(369), ra30
  
• A simple data-adaptive probabilistic variant calling model.
  Hoffmann S, Stadler PF, Strimmer K
  Algorithms Mol Biol 2015, 10, 10
  
• High-throughput whole-genome sequencing of E14 mouse embryonic stem cells.
  Incarnato D, Neri F
  Genom Data 2015, 3, 6-7
  
• Exploring the physiology and pathology of aging in the intestine of Drosophila melanogaster.
  Jasper H
  Invertebr Reprod Dev 2015, 59(sup1), 51-8
  
• Proceedings of Reisensburg 2013 (Foreword).
  Kestler HA, Schmid M
  J Stat Comput Sim 2015, 85(1), 1-2
  
• Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments.
  Kirstein** J, Morito D, Kakihana T, Sugihara M, Minnen A, Hipp MS, Nussbaum-Krammer C, Kasturi P, Hartl** FU, Nagata** K, Morimoto** RI
  EMBO J 2015, 34(18), 2334 ** co-corresponding authors
  
• Polyketide synthesis genes associated with toxin production in two species of Gambierdiscus (Dinophyceae).
  Kohli GS, John U, Figueroa RI, Rhodes LL, Harwood DT, Groth M, Bolch CJS, Murray SA
  BMC Genomics 2015, 16, 410
  
• NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis.
  Kondylis V, Polykratis A, Ehlken H, Ochoa-Callejero L, Straub BK, Krishna-Subramanian S, Van TM, Curth HM, Heise N, Weih F, Klein U, Schirmacher P, Kelliher M, Pasparakis M
  Cancer Cell 2015, 28(5), 582-98
  
• Xlink Analyzer: software for analysis and visualization of cross-linking data in the context of three-dimensional structures.
  Kosinski J, von Appen A, Ori A, Karius K, Müller CW, Beck M
  J Struct Biol 2015, 189(3), 177-83
  
• Alternative Splicing of SMPD1 in Human Sepsis.
  Kramer M, Quickert S, Sponholz C, Menzel U, Huse K, Platzer M, Bauer M, Claus RA
  PLoS One 2015, 10(4), e0124503
  
• Exhaustive k-nearest-neighbour subspace clustering
  Krause JM, Lausser L, Kestler HA
  J Stat Comput Sim 2015, 85(1), 30–46 published during change of institution
  
• DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control.
  Kretzmer H, Bernhart SH, Wang W, Haake A, Weniger MA, Bergmann AK, Betts MJ, Carrillo-de-Santa-Pau E, Doose G, Gutwein J, Richter J, Hovestadt V, Huang B, Rico D, Jühling F, Kolarova J, Lu Q, Otto C, Wagener R, Arnolds J, Burkhardt B, Claviez A, Drexler HG, Eberth S, Eils R, Flicek P, Haas S, Humme M, Karsch D, Kerstens HHD, Klapper W, Kreuz M, Lawerenz C, Lenzek D, Loeffler M, López C, MacLeod RAF, Martens JHA, Kulis M, Martín-Subero JI, Möller P, Nage I, Picelli S, Vater I, Rohde M, Rosenstiel P, Rosolowski M, Russell RB, Schilhabel M, Schlesner M, Stadler PF, Szczepanowski M, Trümper L, Stunnenberg HG, Küppers R, Ammerpohl O, Lichter P, Siebert R, Hoffmann S, Radlwimmer B
  Nat Genet 2015, 47(11), 1316-25
  
• Survival of primary, but not of cancer cells after combined Plk1-HDAC inhibition.
  Lange L, Hemmerich P, Spänkuch B
  Oncotarget 2015, 6(28), 25801-14
  
• Defining the transcriptomic landscape of Candida glabrata by RNA-Seq.
  Linde J, Duggan S, Weber M, Horn F, Sieber P, Hellwig D, Riege K, Marz M, Martin R, Guthke R, Kurzai O
  Nucleic Acids Res 2015, 43(3), 1392-406
  
• Genomic and epigenomic co-evolution in follicular lymphomas.
  Loeffler M, Kreuz M, Haake A, Hasenclever D, Trautmann H, Arnold C, Winter K, Koch K, Klapper W, Scholtysik R, Rosolowski M, Hoffmann S, Ammerpohl O, Szczepanowski M, Herrmann D, Küppers R, Pott C, Siebert R, HaematoSys-Project
  Leukemia 2015, 29(2), 456-63
  
• Interventions to Slow Aging in Humans: Are We Ready?
  Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L
  Aging Cell 2015, 14(4), 497-510
  
• Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells.
  Lu Y, Hardes K, Dahms SO, Böttcher-Friebertshäuser E, Steinmetzer T, Than ME, Klenk HD, Garten W
  Antiviral Res 2015, 120, 89-100
  
• Histone Deacetylase Inhibitors (HDACi) Cause the Selective Depletion of Bromodomain Containing Proteins (BCPs).
  Mackmull MT, Iskar M, Parca L, Singer S, Bork P, Ori** A, Beck** M
  Mol Cell Proteomics 2015, 14(5), 1350-60 ** co-corresponding authors
  
• Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.
  Madhusudhan T, Wang H, Dong W, Ghosh S, Bock F, Thangapandi VR, Ranjan S, Wolter J, Kohli S, Shahzad K, Heidel F, Krueger M, Schwenger V, Moeller MJ, Kalinski T, Reiser J, Chavakis T, Isermann B
  Nat Commun 2015, 6, 6496
  
• Effects of ebselen and N-acetyl cysteine on replicative aging of primary human fibroblast strains.
  Marthandan S
  Immun Ageing 2015, 12, 8
  
• Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts.
  Marthandan S, Priebe S, Baumgart M, Groth M, Cellerino A, Guthke R, Hemmerich P, Diekmann S
  Biomed Res Int 2015, 2015, 731938
  
• Hormetic effect of rotenone in primary human fibroblasts.
  Marthandan S, Priebe S, Groth M, Guthke R, Platzer M, Hemmerich P, Diekmann S
  Immun Ageing 2015, 12, 11
  
• MicroRNAs as biomarker of Parkinson disease? Small but mighty.
  Marz M, Ferracin M, Klein C
  Neurology 2015, 84(7), 636-8
  
• Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.
  Matthews LC, Berry AA, Morgan DJ, Poolman TM, Bauer K, Kramer F, Spiller DG, Richardson RV, Chapman KE, Farrow SN, Norman MR, Williamson AJK, Whetton AD, Taylor SS, Tuckermann JP, White MRH, Ray DW
  Proc Natl Acad Sci U S A 2015, 112(17), 5479-84
  
• CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo.
  Mende N, Kuchen EE, Lesche M, Grinenko T, Kokkaliaris KD, Hanenberg H, Lindemann D, Dahl A, Platz A, Höfer T, Calegari F, Waskow C
  J Exp Med 2015, 212(8), 1171-83
  
• Comprehensive insights in the Mycobacterium avium subsp. paratuberculosis genome using new WGS data of sheep strain JIII-386 from Germany.
  Möbius P, Hölzer M, Felder M, Nordsiek G, Groth M, Köhler H, Reichwald K, Platzer M, Marz M
  Genome Biol Evol 2015, 7(9), 2585-601
  
• Mechanism of Functional Alterations in Hematopoietic Stem Cell Aging
  Morita Y
  In: Adult Stem Cells in Aging, Diseases and Cancer (edited by Rudolph KL), Else Kröner-Fresenius Symposia 2015, 5, 40-59, Karger Verlag, Basel
  
• Space constraints govern fate of hematopoietic stem and progenitor cells in vitro.
  Müller E, Grinenko T, Pompe T, Waskow C, Werner C
  Biomaterials 2015, 53, 709-15
  
• The function of embryonic stem cell-expressed Ras (E-Ras), a unique Ras family member, correlates with its additional motifs and its structural properties.
  Nakhaei-Rad S, Nakhaeizadeh H, Kordes C, Cirstea IC, Schmick M, Dvorsky R, Bastiaens PIH, Häussinger D, Ahmadian MR
  J Biol Chem 2015, 290(25), 15892-903
  
• Cooperative development of logical modelling standards and tools with CoLoMoTo.
  Naldi A, Monteiro PT, Müssel C, the Consortium for Logical Models and Tools, Kestler HA, Thieffry D, Xenarios I, Saez-Rodriguez J, Helikar T, Chaouiya C
  Bioinformatics 2015, 31(7), 1154-9
  
• TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway.
  Neri F, Dettori D, Incarnato D, Krepelova A, Rapelli S, Maldotti M, Parlato C, Paliogiannis P, Oliviero S
  Oncogene 2015, 34(32), 4168-76
  
• TET1 is controlled by pluripotency-associated factors in ESCs and downmodulated by PRC2 in differentiated cells and tissues.
  Neri F, Incarnato D, Krepelova A, Dettori D, Rapelli S, Maldotti M, Parlato C, Anselmi F, Galvagni F, Oliviero S
  Nucleic Acids Res 2015, 43(14), 6814-26
  
• DNA methylation and demethylation dynamics.
  Neri F, Incarnato D, Oliviero S
  Oncotarget 2015, 6(33), 34049-50
  
• Murine Embryonic Stem Cells Synthesize Retinoic Acid to Promote their Own Differentiation
  Neri* F, De Clemente* C, Orlandini M, Lentucci C, Anselmi F, Galvagni F
  J Stem Cell Res Ther 2015, 5(7), 293 * equal contribution
  
• Single-Base Resolution Analysis of 5-Formyl and 5-Carboxyl Cytosine Reveals Promoter DNA Methylation Dynamics.
  Neri* F, Incarnato* D, Krepelova A, Rapelli S, Anselmi F, Parlato C, Medana C, Dal Bello F, Oliviero S
  Cell Rep 2015, 10(5), 674–683 * equal contribution
  
• Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging.
  Neves J, Demaria M, Campisi J, Jasper H
  Dev Cell 2015, 32(1), 9-18
  
• Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation.
  Nillegoda NB, Kirstein J, Szlachcic A, Berynskyy M, Stank A, Stengel F, Arnsburg K, Gao X, Scior A, Aebersold R, Guilbride DL, Wade RC, Morimoto RI, Mayer MP, Bukau B
  Nature 2015, 524(7564), 247
  
• Stat5 gene dosage in T cells modulates CD8+ T-cell homeostasis and attenuates contact hypersensitivity response in mice.
  Nivarthi H, Prchal-Murphy M, Swoboda A, Hager M, Schlederer M, Kenner L, Tuckermann J, Sexl V, Moriggl R, Ermakova O
  Allergy 2015, 70(1), 67-79 published during change of institution
  
• Identification of ageing-associated naturally occurring peptides in human urine.
  Nkuipou-Kenfack E, Bhat A, Klein J, Jankowski V, Mullen W, Vlahou A, Dakna M, Koeck T, Schanstra JP, Zürbig P, Rudolph KL, Schumacher B, Pich A, Mischak H
  Oncotarget 2015, 6(33), 34106-17
  
• Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats
  Ori* A, Toyama* BH, Harris MS, Bock T, Iskar M, Bork P, Ingolia NT, Hetzer MW, Beck M
  Cell Syst 2015, 1(3), 224–237 * equal contribution, published during change of institution
  
• High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation.
  Parplys AC, Seelbach JI, Becker S, Behr M, Jend C, Mansour WY, Joosse S, Stuerzbecher HW, Pospiech H, Petersen C, Dikomey E, Borgmann K
  Cell Cycle 2015, 14(19), 3190-202
  
• Distinct Intracellular Domain Substrate Modifications Selectively Regulate Ectodomain Cleavage of NRG1 or CD44
  Parra* LM, Hartmann* M, Schubach S, Li Y, Herrlich P, Herrlich A
  Mol Cell Biol 2015, 35(19), 3381-95 * equal contribution
  
• Deficiency of the protein-tyrosine phosphatase DEP-1/PTPRJ promotes matrix metalloproteinase-9 expression in meningioma cells.
  Petermann A, Stampnik Y, Cui Y, Morrison H, Pachow D, Kliese N, Mawrin C, Böhmer FD
  J Neurooncol 2015, 122(3), 451-9
  
• Characterization and quantification of proteins secreted by single human embryos prior to implantation.
  Poli* M, Ori* A, Child T, Jaroudi S, Spath K, Beck M, Wells D
  EMBO Mol Med 2015, 7(11), 1465-79 * equal contribution, published during change of institution
  
• Glandular ß-glucosidases in juvenile Chrysomelina leaf beetles support the evolution of a host-plant-dependent chemical defense.
  Rahfeld P, Haeger W, Kirsch R, Pauls G, Becker T, Schulze E, Wielsch N, Wang D, Groth M, Brandt W, Boland W, Burse A
  Insect Biochem Mol Biol 2015, 58, 28-38
  
• Turquoise killifish.
  Reichard M, Cellerino A, Valenzano DR
  Curr Biol 2015, 25(17), R741-2
  
• The deubiquitinating enzyme CYLD regulates the differentiation and maturation of thymic medullary epithelial cells.
  Reissig S, Hövelmeyer N, Tang Y, Weih D, Nikolaev A, Riemann M, Weih F, Waisman A
  Immunol Cell Biol 2015, 93(6), 558-66
  
• Blocking stroke-induced immunodeficiency increases CNS antigen-specific autoreactivity but does not worsen functional outcome after experimental stroke.
  Römer C, Engel O, Winek K, Hochmeister S, Zhang T, Royl G, Klehmet J, Dirnagl U, Meisel C, Meisel A
  J Neurosci 2015, 35(20), 7777-94
  
• The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection.
  Roquis D, Lepesant JMJ, Picard MAL, Freitag M, Parrinello H, Groth M, Emans R, Cosseau C, Grunau C
  PLoS Negl Trop Dis 2015, 9(8), e0003853
  
• Adult Stem Cells in Aging, Diseases and Cancer
  Rudolph KL (ed)
  Book series: Else Kröner-Fresenius Symposia 2015, 5, Karger Verlag, Basel, Switzerlan
  
• Loss of ATM accelerates pancreatic cancer formation and epithelial-mesenchymal transition.
  Russell R, Perkhofer L, Liebau S, Lin Q, Lechel A, Feld FM, Hessmann E, Gaedcke J, Güthle M, Zenke M, Hartmann D, von Figura G, Weissinger SE, Rudolph KL, Möller P, Lennerz JK, Seufferlein T, Wagner M, Kleger A
  Nat Commun 2015, 6, 7677
  
• Towards a comprehensive picture of alloacceptor tRNA remolding in metazoan mitochondrial genomes.
  Sahyoun AH, Hölzer M, Jühling F, Höner zu Siederdissen C, Al-Arab M, Tout K, Marz M, Middendorf M, Stadler PF, Bernt M
  Nucleic Acids Res 2015, 43(16), 8044-56
  
• Central Venous Catheter-Related Bloodstream Infections in Obese Hematologic Patients.
  Schalk E, Färber J, Fischer T, Heidel FH
  Infect Control Hosp Epidemiol 2015, 36(8), 995-6
  
• Prediction of central venous catheter-related bloodstream infections (CRBSIs) in patients with haematologic malignancies using a modified Infection Probability Score (mIPS).
  Schalk E, Hanus L, Färber J, Fischer T, Heidel FH
  Ann Hematol 2015, 94(9), 1451-6
  
• On the validity of time-dependent AUC estimators.
  Schmid M, Kestler HA, Potapov S
  Brief Bioinform 2015, 16(1), 153-68 published during change of institution
  
• Epo-induced erythroid maturation is dependent on Plcγ1 signaling.
  Schnöder TM, Arreba-Tutusaus P, Griehl I, Bullinger L, Buschbeck M, Lane SW, Döhner K, Plass C, Lipka DB, Heidel FH, Fischer T
  Cell Death Differ 2015, 22(6), 974-85
  
• Mast cell promotion of T cell-driven antigen-induced arthritis despite being dispensable for antibody-induced arthritis in which T cells are bypassed.
  Schubert N, Dudeck J, Liu P, Karutz A, Speier S, Maurer M, Tuckermann J, Dudeck A
  Arthritis Rheumatol 2015, 67(4), 903-13 published during change of institution
  
• High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation.
  Sokka M, Rilla K, Miinalainen I, Pospiech H, Syväoja JE
  Nucleic Acids Res 2015, 43(10), 4975-89
  
• It's a bit over, is that ok? The subtle surplus from tandem alternative splicing.
  Szafranski K, Kramer M
  RNA BIOL 2015, 12(2), 115-22
  
• Sestrins in Aging and Metabolism
  Tang D, Tao S
  In: Adult Stem Cells in Aging, Diseases and Cancer (edited by Rudolph KL), Else Kröner-Fresenius Symposia 2015, 5, 60-65, Karger Verlag, Basel
  
• Internalization of near-infrared fluorescently labeled activatable cell-penetrating peptide and of proteins into human fibrosarcoma cell line HT-1080.
  Tansi F, Kallweit E, Kaether C, Kappe K, Schumann C, Hilger I, Reissmann S
  J Cell Biochem 2015, 116(7), 1222-31
  
• Left-right asymmetry in the light of TOR: An update on what we know so far.
  Tena TC, Burkhalter** MD, Philipp** M
  Biol Cell 2015, 107(9), 306-18 ** co-corresponding authors
  
• A Branch-and-Bound Approach for Tautomer Enumeration
  Thalheim T, Wagner B, Kühne R, Middendorf M, Schüürmann G
  Mol Inform 2015, 34, 263–75
  
• Analysis of Alpha-2 Macroglobulin from the Long-Lived and Cancer-Resistant Naked Mole-Rat and Human Plasma.
  Thieme R, Kurz S, Kolb M, Debebe T, Holtze S, Morhart M, Huse K, Szafranski K, Platzer M, Hildebrandt TB, Birkenmeier G
  PLoS One 2015, 10(6), e0130470
  
• The African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan.
  Valenzano DR, Benayoun BA, Singh PP, Zhang E, Etter PD, Hu CK, Clément-Ziza M, Willemsen D, Cui R, Harel I, Machado BE, Yee MC, Sharp SC, Bustamante CD, Beyer A, Johnson EA, Brunet A
  Cell 2015, 163(6), 1539-54
  
• A pooled analysis of overall survival in COMFORT-I and COMFORT-II, 2 randomized phase III trials of ruxolitinib for the treatment of myelofibrosis.
  Vannucchi AM, Kantarjian HM, Kiladjian JJ, Gotlib J, Cervantes F, Mesa RA, Sarlis NJ, Peng W, Sandor V, Gopalakrishna P, Hmissi A, Stalbovskaya V, Gupta V, Harrison C, Verstovsek S, COMFORT Investigators
  Haematologica 2015, 100(9), 1139-45
  
• Sputnik: Ad hoc distributed computation.
  Völkel G, Lausser L, Schmid F, Kraus JM, Kestler HA
  Bioinformatics 2015, 31(8), 1298-301
  
• In situ structural analysis of the human nuclear pore complex.
  von Appen A, Kosinski J, Sparks L, Ori A, DiGuilio AL, Vollmer B, Mackmull MT, Banterle N, Parca L, Kastritis P, Buczak K, Mosalaganti S, Hagen W, Andres-Pons A, Lemke EA, Bork P, Antonin W, Glavy JS, Bui KH, Beck M
  Nature 2015, 526(7571), 140-3 published during change of institution
  
• A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer.
  von Eyss B, Jaenicke LA, Kortlever RM, Royla N, Wiese KE, Letschert S, McDuffus LA, Sauer M, Rosenwald A, Evan GI, Kempa S, Eilers M
  Cancer Cell 2015, 28(6), 743-57
  
• The PCBP1 gene encoding poly(rC) binding protein I is recurrently mutated in Burkitt lymphoma.
  Wagener R, Aukema SM, Schlesner M, Haake A, Burkhardt B, Claviez A, Drexler HG, Hummel M, Kreuz M, Loeffler M, Rosolowski M, López C, Möller P, Richter J, Rohde M, Betts MJ, Russell RB, Bernhart SH, Hoffmann S, Rosenstiel P, Schilhabel M, Szczepanowski M, Trümper L, Klapper W, Siebert R, ICGC MMML-Seq-Project, "Molecular Mechanisms in Malignant Lymphomas" Network Project of the Deutsche Krebshilfe
  Genes Chromosomes Cancer 2015, 54(9), 555-64
  
• Sumoylation of HDAC2 promotes NF-κB-dependent gene expression.
  Wagner T, Kiweler N, Wolff K, Knauer SK, Brandl A, Hemmerich P, Dannenberg JH, Heinzel T, Schneider G, Krämer OH
  Oncotarget 2015, 6(9), 7123-35
  
• PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress.
  Wang L, Ryoo HD, Qi Y, Jasper H
  PLoS Genet 2015, 11(5), e1005220
  
• Structure and regulatory role of the C-terminal winged helix domain of the archaeal minichromosome maintenance complex.
  Wiedemann C, Szambowska A, Häfner S, Ohlenschläger O, Gührs KH, Görlach M
  Nucleic Acids Res 2015, 43(5), 2958-67
  
• Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells.
  Wiese* KE, Haikala* HM, von Eyss* B, Wolf E, Esnault C, Rosenwald A, Treisman R, Klefström J, Eilers M
  EMBO J 2015, 34(11), 1554-71 * equal contribution
  
• Generation of Aorta Transcript Atlases of Wild-Type and Apolipoprotein E-null Mice by Laser Capture Microdissection-Based mRNA Expression Microarrays.
  Yin C, Mohanta S, Ma Z, Weber C, Hu D, Weih F, Habenicht A
  Methods Mol Biol 2015, 1339, 297-308
  
• Inhibition of Wild-type p53-induced phosphatase 1 promotes liver regeneration in mice by direct activation of mTOR.
  Zhang L, Liu L, He Z, Li G, Liu J, Song Z, Jin H, Rudolph KL, Yang H, Mao Y, Zhang L, Zhang H, Xiao Z, Ju Z
  Hepatology 2015, 61(6), 2030-41
  
• Merlin's wizardry guides cohesive migration.
  Zoch A, Morrison H
  Nat Cell Biol 2015, 17(3), 212-3
  

Publications 2014:

• A sequence-ready physical map of barley anchored genetically by two million single-nucleotide polymorphisms.
  Ariyadasa R, Mascher M, Nussbaumer T, Schulte D, Frenkel Z, Poursarebani N, Zhou R, Steuernagel B, Gundlach H, Taudien S, Felder M, Platzer M, Himmelbach A, Schmutzer T, Hedley P, Muehlbauer G, Scholz U, Korol A, Mayer K, Waugh R, Langridge P, Graner A, Stein N
  Plant Physiol 2014, 164(1), 412-23
  
• Interrelation between protein synthesis, proteostasis and life span.
  Arnsburg K, Kirstein-Miles J
  Curr Genomics 2014, 15(1), 66
  
• HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization.
  Azoitei N, Diepold K, Brunner C, Rouhi A, Genze F, Becher A, Kestler H, van Lint J, Chiosis G, Koren J, Fröhling S, Scholl C, Seufferlein T
  Cancer Res 2014, 74(23), 7125-36 published during change of institution
  
• Transcriptomic immune response of the cotton stainer Dysdercus fasciatus to experimental elimination of vitamin-supplementing intestinal symbionts.
  Bauer E, Salem H, Marz M, Vogel H, Kaltenpoth M
  PLoS One 2014, 9(12), e114865
  
• RNA-seq of the aging brain in the short-lived fish N. furzeri - conserved pathways and novel genes associated with neurogenesis.
  Baumgart* M, Groth* M, Priebe* S, Savino A, Testa G, Dix A, Ripa R, Spallotta F, Gaetano C, Ori M, Terzibasi Tozzini E, Guthke R, Platzer M, Cellerino A
  Aging Cell 2014, 13(6), 965-74 * equal contribution
  
• Explorative Analysis of Heterogeneous, Unstructured, and Uncertain Data: A Computer Science Perspective on Biodiversity Research
  Beckstein C, Böcker S, Bogdan M, Bücker HM.Bruelheide H, Denzler J, Dittrich P, Grosse I, Hinneburg A, König-Ries B, Löffler F, Marz M, Müller-Hannemann M, Winter M, Zimmermann W
  In: Proceedings of 3rd International Conference on Data Management Technologies and Applications (DATA-2014) 2014, 251-257, Science and Technology
  
• Impact of genomic damage and ageing on stem cell function.
  Behrens A, van Deursen JM, Rudolph* KL, Schumacher B
  Nat Cell Biol 2014, 16(3), 201-7 * corresponding author, based on the Else Kröner-Fresenius-Symposium in Molecular Medicine
  
• Analysis of disorder in tricalcium silicate by 29Si NMR spectroscopy and additional methods
  Bellmann F, Leppert J, Görlach M, Krbetschek M, Damidot D, Ludwig HM
  Cement Concrete Res 2014, 57, 105-16
  
• Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength.
  Bentzinger* CF, von Maltzahn* J, Dumont NA, Stark DA, Wang YX, Nhan K, Frenette J, Cornelison DDW, Rudnicki MA
  J Cell Biol 2014, 205(1), 97-111 * equal contribution, published during change of institution
  
• Slit/Robo signaling regulates cell fate decisions in the intestinal stem cell lineage of Drosophila.
  Biteau B, Jasper H
  Cell Rep 2014, 7(6), 1867-75
  
• Chlamydia psittaci inclusion membrane protein IncB associates with host protein Snapin.
  Böcker S, Heurich A, Franke C, Monajembashi S, Sachse K, Saluz HP, Hänel F
  Int J Med Microbiol 2014, 304(5-6), 542-53
  
• Kinesin-dependent motility generation as target mechanism of cadmium intoxication.
  Böhm KJ
  Toxicol Lett 2014, 224(3), 356-61
  
• Novel Insights into Structure and Function of Factor XIIIa-Inhibitor Tridegin.
  Böhm M, Bäuml CA, Hardes K, Steinmetzer T, Roeser D, Schaub Y, Than ME, Biswas A, Imhof D
  J Med Chem 2014, 57(24), 10355-65
  
• The Wilms' tumor suppressor WT1 enhances CD95L expression and promotes activation-induced cell death in leukemic T cells.
  Bourkoula K, Englert C, Giaisi M, Koehler R, Krammer PH, Li-Weber M
  Int J Cancer 2014, 134(2), 291-300
  
• A 'telomere-associated secretory phenotype' cooperates with BCR-ABL to drive malignant proliferation of leukemic cells.
  Braig M, Pällmann N, Preukschas M, Steinemann D, Hofmann W, Gompf A, Streichert T, Braunschweig T, Copland M, Rudolph KL, Bokemeyer C, Koschmieder S, Schuppert A, Balabanov S, Brümmendorf TH
  Leukemia 2014, 28(10), 2028-39
  
• Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.
  Bruedigam C, Bagger FO, Heidel FH, Paine Kuhn C, Guignes S, Song A, Austin R, Vu T, Lee E, Riyat S, Moore AS, Lock RB, Bullinger L, Hill GR, Armstrong SA, Williams DA, Lane SW
  Cell Stem Cell 2014, 15(6), 775-90
  
• Lin28a - boost your energy for youthful regeneration.
  Burkhalter MD, Morita Y, Rudolph KL
  EMBO J 2014, 33(1), 5–6
  
• Control of metabolic adaptation to fasting by dILP6-induced insulin signaling in Drosophila oenocytes.
  Chatterjee D, Katewa SD, Qi Y, Jackson SA, Kapahi P, Jasper H
  Proc Natl Acad Sci U S A 2014, 111(50), 17959-64
  
• Gadd45a Regulates Hematopoietic Stem Cell Stress Responses in Mice.
  Chen Y, Ma X, Zhang M, Wang X, Wang C, Wang H, Guo P, Yuan W, Rudolph KL, Zhan Q, Ju Z
  Blood 2014, 123(6), 851-62
  
• Gender identity rather than sexual orientation impacts on facial preferences.
  Ciocca G, Limoncin E, Cellerino A, Fisher AD, Gravina GL, Carosa E, Mollaioli D, Valenzano DR, Mennucci A, Bandini E, Di Stasi SM, Maggi M, Lenzi A, Jannini EA
  J Sex Med 2014, 11(10), 2500-7
  
• Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?
  Correia-Melo C, Hewitt G, Passos JF
  Longev Healthspan 2014, 3(1), 1
  
• Kit regulates HSC engraftment across the human-mouse species barrier.
  Cosgun KN, Rahmig S, Mende N, Reinke S, Hauber I, Schäfer C, Petzold A, Weisbach H, Heidkamp G, Purbojo A, Cesnjevar R, Platz A, Bornhäuser M, Schmitz M, Dudziak D, Hauber J, Kirberg J, Waskow C
  Cell Stem Cell 2014, 15(2), 227-38
  
• Nerve growth factor in the adult brain of a teleostean model for aging research: Nothobranchius furzeri.
  D'Angelo L, Castaldo L, Cellerino A, de Girolamo P, Lucini C
  Ann Anat 2014, 196(4), 183-91
  
• Brain derived neurotrophic factor: mRNA expression and protein distribution in the brain of the teleost Nothobranchius furzeri.
  D'Angelo L, de Girolamo P, Lucini C, Terzibasi ET, Baumgart M, Castaldo L, Cellerino A
  J Comp Neurol 2014, 522(5), 1004-30
  
• X-ray structures of human furin in complex with competitive inhibitors.
  Dahms SO, Hardes K, Becker GL, Steinmetzer T, Brandstetter H, Than ME
  ACS Chem Biol 2014, 9(5), 1113-18
  
• FACS-FRET: Reply to comments on "Biomolecular dynamics and binding studies in the living cell".
  Diekmann S, Hoischen C
  Phys Life Rev 2014, 11(1), 38
  
• Biomolecular dynamics and binding studies in the living cell.
  Diekmann S, Hoischen C
  Phys Life Rev 2014, 11(1), 1-30
  
• Transition to annual life history coincides with reduction in cell cycle speed during early cleavage in three independent clades of annual killifish.
  Dolfi L, Ripa R, Cellerino A
  Evodevo 2014, 5, 32
  
• Expression of the lymphoid enhancer factor 1 is required for normal hematopoietic stem and progenitor cell function.
  Edmaier KE, Stahnke K, Vegi N, Mulaw M, Ihme S, Scheffold A, Rudolph KL, Buske C
  Leukemia 2014, 28(1), 227-30 published during change of institution
  
• The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells.
  Eguether T, Ermolaeva MA, Zhao Y, Bonnet MC, Jain A, Pasparakis M, Courtois G, Tassin AM
  Nat Commun 2014, 5, 4585
  
• Systemic DNA damage responses: organismal adaptations to genome instability.
  Ermolaeva MA, Schumacher B
  Trends Genet 2014, 30(3), 95-102
  
• Insights from the worm: the C. elegans model for innate immunity.
  Ermolaeva MA, Schumacher B
  Semin Immunol 2014, 26(4), 303-9
  
• Functional Mutation Analysis Provides Evidence for a Role of REEP1 in Lipid Droplet Biology.
  Falk J, Rohde M, Bekhite MM, Sophie Neugebauer, Hemmerich P, Kiehntopf M, Deufel T, Hübner CA, Beetz C
  Hum Mutat 2014, 35(4), 497-504
  
• Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2α and ETS1.
  Fiorito V, Neri F, Pala V, Silengo L, Oliviero S, Altruda F, Tolosano E
  Biochim Biophys Acta 2014, 1839(4), 259-64
  
• Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis.
  Flex E, Jaiswal M, Pantaleoni F, Martinelli S, Strullu M, Fansa EK, Caye A, De Luca A, Lepri F, Dvorsky R, Pannone L, Paolacci S, Zhang SC, Fodale V, Bocchinfuso G, Rossi C, Burkitt-Wright EMM, Farrotti A, Stellacci E, Cecchetti S, Ferese R, Bottero L, Castro S, Fenneteau O, Brethon B, Sanchez M, Roberts AE, Yntema HG, Van Der Burgt I, Cianci P, Bondeson ML, Cristina Digilio M, Zampino G, Kerr B, Aoki Y, Loh ML, Palleschi A, Di Schiavi E, Carè A, Selicorni A, Dallapiccola B, Cirstea IC, Stella L, Zenker M, Gelb BD, Cavé H, Ahmadian MR, Tartaglia M
  Hum Mol Genet 2014, 23(16), 4315-27
  
• Brain derived neurotrophic factor in the retina of the teleost N. furzeri.
  Gatta C, Castaldo L, Cellerino A, de Girolamo P, Lucini C, D'Angelo L
  Ann Anat 2014, 196(4), 192-6
  
• The Genome of the Foraminiferan Reticulomyxa filosa.
  Glöckner G, Hülsmann N, Schleicher M, Noegel AA, Eichinger L, Gallinger C, Pawlowski J, Sierra R, Euteneuer U, Pillet L, Moustafa A, Platzer M, Groth M, Szafranski K, Schliwa M
  Curr Biol 2014, 24, 11-8
  
• Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cells.
  Grinenko T, Arndt K, Portz M, Mende N, Günther M, Cosgun KN, Alexopoulou D, Lakshmanaperumal N, Henry I, Dahl A, Waskow C
  J Exp Med 2014, 211(2), 209-15
  
• The genome of an influenza virus from a pilot whale: Relation to influenza viruses of gulls and marine mammals.
  Groth M, Lange J, Kanrai P, Pleschka S, Scholtissek C, Krumbholz A, Platzer M, Sauerbrei A, Zell R
  Infect Genet Evol 2014, 24, 183-6
  
• Transkriptom-Sequenzierung in der Alternsforschung
  Groth M, Reichwald K, Szafranski K, Taudien S, Platzer M
  BIOspektrum 2014, 20(2), 163-6
  
• PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan.
  Guo L, Karpac J, Tran SL, Jasper H
  Cell 2014, 156(1-2), 109-22
  
• Manganese-Enhanced MRI: In Vivo Imaging of CNS Anatomy, Fiber Connectivity and Functional Activity
  Haenold R
  In: In Vivo Imaging: New Research (edited by Rick Hough and Jared Camarillo), Biotechnology in Agriculture, Industry and Medicine 2014, 49-86, Nova Science Publishers
  
• Studying aging in Drosophila.
  He Y, Jasper H
  Methods 2014, 68(1), 129-33
  
• A multi-split mapping algorithm for circular RNA, splicing, trans-splicing and fusion detection.
  Hoffmann S, Otto C, Doose G, Tanzer A, Langenberger D, Christ S, Kunz M, Holdt LM, Teupser D, Hackermüller J, Stadler PF
  Genome Biol 2014, 15(2), R34
  
• AgeFactDB – The JenAge Ageing Factor Database – Towards data integration in ageing research
  Huehne R, Thalheim T, Suehnel J
  Nucleic Acids Res 2014, 42(1), D892-6
  
• Telomerase exerts physiological and tumor promoting functions by stimulating ribosomal biogenesis
  Iben S, Günes C
  Telomere and Telomerases 2014, 1, e433
  
• Mutation in ST6GALNAC5 identified in family with coronary artery disease.
  Inanloorahatloo K, Parsa AFZ, Huse K, Rasooli P, Davaran S, Platzer M, Kramer M, Fan JB, Turk C, Amini S, Steemers F, Gunderson K, Ronaghi M, Elahi E
  Sci Rep 2014, 4, 3595
  
• High-throughput single nucleotide variant discovery in E14 mouse embryonic stem cells provides a new reference genome assembly.
  Incarnato D, Krepelova A, Neri F
  Genomics 2014, 104(2), 121-7
  
• Genome-wide profiling of mouse RNA secondary structures reveals key features of the mammalian transcriptome.
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• Challenges in RNA virus bioinformatics.
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• DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage.
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• Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.
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• Inhibition of JAK-STAT signaling stimulates adult satellite cell function.
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• The Ca2+ sensor protein swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons.
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• Graph-distance distribution of the Boltzmann ensemble of RNA secondary structures.
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• Independently recruited oxidases from the glucose-methanol-choline oxidoreductase family enabled chemical defences in leaf beetle larvae (subtribe Chrysomelina) to evolve.
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• Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans.
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• Evidence for the existence of two new members of the family Chlamydiaceae and proposal of Chlamydia avium sp. nov. and Chlamydia gallinacea sp. nov.
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• Germ and hematology: underlying disease influences diversity of germ spectra and antibiotic therapy.
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• Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres.
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• A rare cause of lower back pain.
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• Clinically relevant doses of FLT3-kinase inhibitors quizartinib and midostaurin do not impair T-cell reactivity and function.
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• Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutants.
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• Quantitative Dissection and Modeling of the NF-κB p100-p105 Module Reveals Interdependent Precursor Proteolysis.
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• Exonuclease 1 is essential for maintaining genomic stability and the proliferative capacity of neural but not hematopoietic stem cells.
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• Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1.
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• 8p23 beta-defensin copy number determination by single-locus pseudogene-based paralog ratio tests risk bias due to low-frequency sequence variations.
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