Publications 2022:

• Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing.
  Ahmad M, Krüger BT, Kroll T, Vettorazzi S, Dorn AK, Mengele F, Lee S, Nandi S, Yilmaz D, Stolz M, Tangudu NK, Vázquez DC, Pachmayr J, Cirstea IC, Spasic MV, Ploubidou A, Ignatius A, Tuckermann J
  Bone Res 2022, 10(1), 33
  
• Membrane lipids and maximum lifespan in clownfish.
  Almaida-Pagan PF, Lucas-Sanchez A, Martinez-Nicolas A, Terzibasi E, de Lama MAR, Cellerino A, Mendiola P, de Costa J
  Fish Physiol Biochem 2022, 48(1), 53-65
  
• Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish.
  Bradshaw WJ, Poeschla M, Placzek A, Kean S, Valenzano DR
  Elife 2022, 11
  
• Impaired formation of neutrophil extracellular traps (NETs) in patients with myelodysplastic syndrome.
  Brings C, Fröbel J, Cadeddu RP, Germing U, Haas R, Gattermann N
  BLOOD ADV 2022, 6(1), 129-37
  
• Disruption of amphetamine sensitization by alteration of dendritic thin spines in the nucleus accumbens core.
  Cai WT, Kim WY, Kwak MJ, Rim H, Lee SE, Riecken LB, Morrison H, Kim JH
  J Neurochem 2022, 161(3), 266-80
  
• Upf3a is dispensable for nonsense-mediated mRNA decay in mouse pluripotent and somatic cells
  Chen C, Shen Y, Li L, Wang ZQ, Li T
  bioRxiv 2022, https://doi.org/10.1101/2022.07.
  
• A Primeval Mechanism of Tolerance to Desiccation Based on Glycolic Acid Saves Neurons in Mammals from Ischemia by Reducing Intracellular Calcium-Mediated Excitotoxicity.
  Chovsepian A, Berchtold D, Winek K, Mamrak U, Ramírez Álvarez I, Dening Y, Golubczyk D, Weitbrecht L, Dames C, Aillery M, Fernandez-Sanz C, Gajewski Z, Dieterich M, Janowski M, Falkai P, Walczak P, Plesnila N, Meisel A, Pan-Montojo F
  Adv Sci (Weinh) 2022, 9(4), e2103265
  
• p53-mediated AKT and mTOR inhibition requires RFX7 and DDIT4 and depends on nutrient abundance.
  Coronel* L, Häckes* D, Schwab* K, Riege K, Hoffmann** S, Fischer** M
  Oncogene 2022, 41(7), 1063-9 * equal contribution, ** co-corresponding authors
  
• Cytoreductive treatment in real life: a chart review analysis on 1440 patients with polycythemia vera.
  Crodel CC, Jentsch-Ullrich K, Reiser M, Jacobasch L, Sauer A, Tesch H, Ulshöfer T, Wunschel R, Palandri F, Heidel FH
  J Cancer Res Clin Oncol 2022 (epub ahead of print)
  
• Career pathways, part 8.
  Ermolaeva M, Boyman L
  Nat Metab 2022, 4(4), 407-9
  
• Histone demethylase KDM4C is a functional dependency in JAK2-mutated neoplasms.
  Ernst P, Schnöder TM, Huber N, Perner F, Jayavelu AK, Eifert T, Hsu CJ, Tubío-Santamaría N, Crodel CC, Ungelenk M, Hübner CA, Clement JH, Hochhaus A, Heidel FH
  Leukemia 2022, 36(7), 1843-9
  
• Synthesizing genome regulation data with vote-counting.
  Fischer M, Hoffmann S
  Trends Genet 2022 (epub ahead of print)
  
• Coordinating gene expression during the cell cycle.
  Fischer M, Schade AE, Branigan TB, Müller GA, DeCaprio JA
  Trends Biochem Sci 2022 (epub ahead of print)
  
• Comparative study of ten thogotovirus isolates and their distinct in vivo characteristics.
  Fuchs J, Lamkiewicz K, Kolesnikova L, Hölzer M, Marz M, Kochs G
  J Virol 2022, 96(5), e0155621
  
• Recurrent Upper Gastrointestinal Bleeding from Isolated Gastric Varices as Primary Symptom of Myelofibrosis: A Case Report on Combining Interventional and Pharmacologic Treatment Options.
  Giszas B, Weber M, Heidel FH, Reuken PA
  Dig Dis 2022 (epub ahead of print)
  
• Immediate predation risk alters the relationship between potential and realised selection on male traits in the Trinidad guppy Poecilia reticulata
  Glavaschi A, Cattelan S, Devigili A, Pilastro A
  bioRxiv 2022, https://doi.org/10.1101/2022.04.
  
• Tight association of autophagy and cell cycle in leukemia cells.
  Gschwind* A, Marx* C, Just MD, Severin P, Behring H, Marx-Blümel L, Becker S, Rothenburger L, Förster M, Beck JF, Sonnemann J
  Cell Mol Biol Lett 2022, 27(1), 32 * equal contribution
  
• LINC00892 Is an lncRNA Induced by T Cell Activation and Expressed by Follicular Lymphoma-Resident T Helper Cells.
  Iaccarino I, Mourtada F, Reinke S, Patil P, Doose G, Monaco G, Hoffmann S, Siebert R, Klapper W
  Noncoding RNA 2022, 8(3)
  
• Discrete Logic Modeling of Cell Signaling Pathways
  Ikonomi N, Werle SD, Schwab JD, Kestler HA
  In: TGF-Beta Signaling (edited by Zi Z, Liu X), Methods in Molecular Biology 2022, 2488, 159-181, Humana Press Inc., Toto
  
• Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity.
  Izgi H, Han D, Isildak U, Huang S, Kocabiyik E, Khaitovich** P, Somel** M, Dönertaş** HM
  Elife 2022, 11, e68048 ** co-corresponding authors
  
• Lessons from a ten-year-long journey: building a student-driven computational biology society across Turkey.
  Kaya Y, Karakulak T, Can Saylan C, Gür ER, Tatlıdil E, Güleşen S, Betül Dinçaslan F, Dönertaş HM
  F1000Res 2022, 11
  
• High-yield production of coenzyme F420 in Escherichia coli by fluorescence-based screening of multi-dimensional gene expression space.
  Last D, Hasan M, Rothenburger L, Braga D, Lackner G
  Metab Eng 2022 (epub ahead of print)
  
• CHD5 inhibits metastasis of neuroblastoma.
  Laut AK, Dorneburg C, Fürstberger A, Barth TFE, Kestler HA, Debatin KM, Beltinger C
  Oncogene 2022, 41(5), 622-33
  
• Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B cell lymphomas.
  Lopez C, Schleussner N, Bernhart SH, Kleinheinz K, Sungalee S, Sczakiel HL, Kretzmer H, Toprak UH, Glaser S, Wagener R, Ammerpohl O, Bens S, Giefing M, Sanchez JCG, Apic G, Hubschmann D, Janz M, Kreuz M, Mottok A, Muller JM, Seufert J, Hoffmann S, Korbel JO, Russell RB, Schule R, Trumper L, Klapper W, Radlwimmer B, Lichter P, Kuppers R, Schlesner M, Mathas S, Siebert R
  Haematologica 2022 (epub ahead of print)
  
• New lessons on TDP-43 from old N. furzeri killifish.
  Louka A, Bagnoli S, Rupert J, Esapa B, Tartaglia GG, Cellerino A, Pastore A, Terzibasi Tozzini E
  Aging Cell 2022, 21(1), e13517
  
• ADP-ribosyltransferases, an update on function and nomenclature.
  Lüscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, Cohen M, Corda D, Dantzer F, Daugherty MD, Dawson TM, Dawson VL, Deindl S, Fehr AR, Feijs KLH, Filippov DV, Gagné JP, Grimaldi G, Guettler S, Hoch NC, Hottiger MO, Korn P, Kraus WL, Ladurner A, Lehtiö L, Leung AKL, Lord CJ, Mangerich A, Matic I, Matthews J, Moldovan GL, Moss J, Natoli G, Nielsen ML, Niepel M, Nolte F, Pascal J, Paschal BM, Pawłowski K, Poirier GG, Smith S, Timinszky G, Wang ZQ, Yélamos J, Yu X, Zaja R, Ziegler M
  FEBS J 2022 (epub ahead of print)
  
• Role of CD44 in metastasis formation of spontaneous osteosarcoma of Nf2-deficient mice
  Ma J
  Dissertation 2022, Jena, Germany
  
• Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease.
  Marengo L, Armbrust F, Schoenherr C, Storck SE, Schmitt U, Zampar S, Wirths O, Altmeppen H, Glatzel M, Kaether C, Weggen S, Becker-Pauly C, Pietrzik CU
  Cell Mol Life Sci 2022, 79(3), 168
  
• Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress.
  Marx C, Sonnemann J, Maddocks ODK, Marx-Blümel L, Beyer M, Hoelzer D, Thierbach R, Maletzki C, Linnebacher M, Heinzel T, Krämer OH
  Cancer Metab 2022, 10(1), 10
  
• In vivo inactivation of RAD51-mediated homologous recombination leads to premature aging, but not to tumorigenesis
  Matos-Rodrigues G, Barroca V, Muhammad AA, Allouch A, Koundrioukoff S, Lewandowski D, Despras E, Guirouilh-Barbat J, Frappart L, Kannouche P, Dupaigne P, Le Cam E, Perfettini JL, Romeo PH, Debatisse M, Jasin M, Livera G, Martini E, S.Lopez B
  bioRxiv 2022, https://doi.org/10.1101/2022.01.
  
• Telomerase deficiency reflects age-associated changes in CD4+ T cells.
  Matthe DM, Thoma OM, Sperka T, Neurath MF, Waldner MJ
  Immun Ageing 2022, 19(1), 16
  
• Meeting Report: Aging Research and Drug Discovery
  Meron E, Thaysen M, Angeli S, Antebi A, Barzilai N, Baur JA, Bekker-Jensen S, Birkisdottir M, Bischof E, Bruening J, Brunet A, Buchwalter A, Cabreiro F, Cai S, Chen BH, Ermolaeva M, Ewald Collin Y, Ferrucci L, Florian MC, Fortney K, Freund A, Georgievskaya A, Gladyshev VN, Glass D, Golato T, Gorbunova V, Hoejimakers J, Houtkooper RH, Jager S, Jaksch F, Janssens G, Borch Jensen M, Kaeberlein M, Karsenty G, de Keizer P, Kennedy B, Kirkland JL, Kjaer M, Kroemer G, Lee KF, Lemaitre JM, Liaskos D, Longo VD, Lu YX, MacArthur MR, Maier AB, Manakanatas C, Mitchell SJ, Moskalev A, Niedernhofer L, Ozerov I, Partridge L, Passegué E, Petr MA, Peyer J, Radenkovic D, Rando TA, Rattan S, Riedel CG, Rudolph L, Ai R, Serrano M, Schumacher B, Sinclair DA, Smith R, Suh Y, Taub P, Trapp A, Trendelenburg AU, Valenzano DR, Verburgh K, Verdin E, Vijg J, Westendorp RGJ, Zonari A, Bakula D, Zhavoronkov A, Scheibye-Knudsen M
  Aging (Albany NY) 2022, 14(2), 530–543
  
• Sendungsregister
  Mohnheim F, Weinzierl I, Hoppe B, Bösger J
  2022, URL https://github.com/mohnbroet
  
• Small Extracellular Vesicles from Peripheral Blood of Aged Mice Pass the Blood-Brain Barrier and Induce Glial Cell Activation.
  Morales-Prieto DM, Murrieta-Coxca JM, Stojiljkovic M, Diezel C, Streicher PE, Henao-Restrepo JA, Röstel F, Lindner J, Witte OW, Weis S, Schmeer C, Marz M
  Cells 2022, 11(4)
  
• Enhanced C/EBPβ function promotes hypertrophic versus hyperplastic fat tissue growth and prevents steatosis in response to high-fat diet feeding.
  Müller* C, Zidek* LM, Eichwald S, Kortman G, Koster MH, Calkhoven CF
  Elife 2022, 11, e62625. * equal contribution
  
• Peripheral blasts are associated with responses to ruxolitinib and outcomes in patients with chronic-phase myelofibrosis.
  Palandri F, Bartoletti D, Iurlo A, Bonifacio M, Abruzzese E, Caocci G, Elli EM, Auteri G, Tiribelli M, Polverelli N, Miglino M, Heidel FH, Tieghi A, Benevolo G, Beggiato E, Fava C, Cavazzini F, Pugliese N, Binotto G, Bosi C, Martino B, Crugnola M, Ottaviani E, Micucci G, Trawinska MM, Cuneo A, Bocchia M, Krampera M, Pane F, Lemoli RM, Cilloni D, Vianelli N, Cavo M, Palumbo GA, Breccia M
  Cancer 2022, 128(13), 2449-54
  
• YBX1 mediates translation of oncogenic transcripts to control cell competition in AML.
  Perner F, Schnoeder TM, Xiong Y, Jayavelu AK, Mashamba N, Santamaria NT, Huber N, Todorova K, Hatton C, Perner B, Eifert T, Murphy C, Hartmann M, Hoell JI, Schröder N, Brandt S, Hochhaus A, Mertens PR, Mann M, Armstrong SA, Mandinova A, Heidel FH
  Leukemia 2022, 36(2), 426-37
  
• A gene dosage-dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH-medulloblastoma.
  Petroni M, Fabretti F, Giulio SD, Robilant VND, Monica VL, Moretti M, Belardinilli F, Bufalieri F, Anna C, Paci P, Corsi A, Smaele ED, Coni S, Canettieri G, Marcotullio LD, Wang ZQ, Giannini G
  Neuropathol Appl Neurobiol 2022 (epub ahead of print)
  
• Resilience integrates concepts in aging research.
  Promislow D, Anderson RM, Scheffer M, Crespi B, DeGregori J, Harris K, Horowitz BN, Levine ME, Riolo MA, Schneider DS, Spencer SL, Valenzano DR, Hochberg ME
  iScience 2022, 25(5), 104199
  
• DNA damage response in neurodevelopment and neuromaintenance.
  Qing* X, Zhang* G, Wang ZQ
  FEBS J 2022 (epub ahead of print) * equal contribution
  
• The genomic and transcriptional landscape of primary central nervous system lymphoma.
  Radke J, Ishaque N, Koll R, Gu Z, Schumann E, Sieverling L, Uhrig S, Hübschmann D, Toprak UH, López C, Hostench XP, Borgoni S, Juraeva D, Pritsch F, Paramasivam N, Balasubramanian GP, Schlesner M, Sahay S, Weniger M, Pehl D, Radbruch H, Osterloh A, Korfel A, Misch M, Onken J, Faust K, Vajkoczy P, Moskopp D, Wang Y, Jödicke A, Trümper L, Anagnostopoulos I, Lenze D, Küppers R, Hummel M, Schmitt CA, Wiestler OD, Wolf S, Unterberg A, Eils R, Herold-Mende C, Brors B, ICGC MMML-Seq Consortium, Siebert R, Wiemann S, Heppner FL
  Nat Commun 2022, 13(1), 2558
  
• The sources of sex differences in aging in annual fishes.
  Reichard M, Blažek R, Žák J, Cellerino A, Polačik M
  J Anim Ecol 2022, 91(3), 540-50
  
• Aging Activates the Immune System and Alters the Regenerative Capacity in the Zebrafish Heart.
  Reuter H, Perner B, Wahl F, Rohde L, Koch P, Groth M, Buder K, Englert C
  Cells 2022, 11(3), 345. doi: 10.3390/cells11030345.
  
• Rhodopsins build up the birefringent bodies of the dinoflagellate Oxyrrhis marina.
  Rhiel E, Hoischen C, Westermann M
  Protoplasma 2022, 259(4), 1047-60
  
• Human NMDAR autoantibodies disrupt excitatory-inhibitory balance leading to hippocampal network hypersynchrony
  Schmidl L, Hunter D, Kreye J, Prüss H, Groc L, Hallermann S, Dalmau J, Ori A, Heckmann M, Geis C
  bioRxiv 2022, https://doi.org/10.1101/2022.03.
  
• Association of Telomere Length With Risk of Disease and Mortality.
  Schneider CV, Schneider KM, Teumer A, Rudolph KL, Hartmann D, Rader DJ, Strnad P
  JAMA INTERN MED 2022, 182(3), 291-300
  
• PLCG1 is required for AML1-ETO leukemia stem cell self-renewal.
  Schnoeder TM, Schwarzer A, Jayavelu AK, Hsu CJ, Kirkpatrick J, Döhner K, Perner F, Eifert T, Huber N, Arreba-Tutusaus P, Dolnik A, Assi SA, Nafria M, Jiang L, Dai YT, Chen Z, Chen SJ, Kellaway SG, Ptasinska A, Ng ES, Stanley EG, Elefanty AG, Buschbeck M, Bierhoff H, Brodt S, Matziolis G, Fischer KD, Hochhaus A, Chen CW, Heidenreich O, Mann M, Lane SW, Bullinger L, Ori A, Eyss Bv, Bonifer C, Heidel F
  Blood 2022, 139(7), 1080-97
  
• A comparative study of pre-alpha islands in the entorhinal cortex from selected primates and in lissencephaly.
  Schön M, Nosanova A, Jacob C, Kraus JM, Kestler HA, Mayer B, Feldengut S, Amunts K, Del Tredici K, Boeckers TM, Braak H
  J Comp Neurol 2022, 530(4), 683-704
  
• Dynamic DNA methylation reveals novel cis-regulatory elements in murine hematopoiesis
  Schönung M, Hartmann M, Krämer S, Stäble S, Hakobyan M, Kleinert E, Aurich T, Cobanoglu D, Heidel FH, Fröhling S, Milsom MD, Schlesner M, Lutsik P, Lipka DB
  bioRxiv 2022, 10.1101/2022.06.02.493896
  
• A genome-wide CRISPR activation screen reveals Hexokinase 1 as a critical factor in promoting resistance to multi-kinase inhibitors in hepatocellular carcinoma cells.
  Sofer S, Lamkiewicz K, Armoza Eilat S, Partouche S, Marz M, Moskovits N, Stemmer SM, Shlomai A, Sklan EH
  FASEB J 2022, 36(3), e22191
  
• PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling.
  Thürmer M, Gollowitzer A, Pein H, Neukirch K, Gelmez E, Waltl L, Wielsch N, Winkler R, Löser K, Grander J, Hotze M, Harder S, Döding A, Meßner M, Troisi F, Ardelt M, Schlüter H, Pachmayr J, Gutiérrez-Gutiérrez Ó, Rudolph KL, Thedieck K, Schulze-Späte U, González-Estévez C, Kosan C, Svatoš A, Kwiatkowski M, Koeberle A
  Nat Commun 2022, 13(1), 2982
  
• Characterization of SARS-CoV-2 infection clusters based on integrated genomic surveillance, outbreak analysis and contact tracing in an urban setting.
  Walker A, Houwaart T, Finzer P, Ehlkes L, Tyshaieva A, Damagnez M, Strelow D, Duplessis A, Nicolai J, Wienemann T, Tamayo T, Kohns Vasconcelos M, Hülse L, Hoffmann K, Lübke N, Hauka S, Andree M, Däumer MP, Thielen A, Kolbe-Busch S, Göbels K, Zotz R, Pfeffer K, Timm J, Dilthey AT, German COVID-19 OMICS Initiative (DeCOI)
  Clin Infect Dis 2022, 74(6), 1039-46
  
• Light and prey influence the abundances of two rhodopsins in the dinoflagellate Oxyrrhis marina.
  Westermann M, Hoischen C, Wöhlbrand L, Rabus R, Rhiel E
  Protoplasma 2022 (epub ahead of print)
  
• Backbone and side chain resonance assignment of the intrinsically disordered human DBNDD1 protein.
  Wiedemann C, Obika KB, Liebscher S, Jirschitzka J, Ohlenschläger O, Bordusa F
  Biomol NMR Assign 2022 (epub ahead of print)
  
• Picorna-Like Viruses of the Havel River, Germany.
  Zell R, Groth M, Selinka L, Selinka HC
  Front Microbiol 2022, 13, 865287
  

Publications 2021:

• BCL3 couples cancer stem cell enrichment with pancreatic cancer molecular subtypes.
  Ai J, Wörmann SM, Görgülü K, Vallespinos M, Zagorac S, Alcala S, Wu N, Kabacaoglu D, Berninger A, Navarro D, Kaya-Aksoy E, Ruess DA, Ciecielski KJ, Kowalska M, Demir EI, Ceyhan GO, Heid I, Braren R, Riemann M, Schreiner S, Hofmann S, Kutschke M, Jastroch M, Slotta-Huspenina J, Muckenhuber A, Schlitter AM, Schmid RM, Steiger K, Diakopoulos KN, Lesina M, Sainz B, Algül H
  Gastroenterology 2021, 161(1), 318-32
  
• Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications.
  Altincekic N, Korn SM, Qureshi NS, Dujardin M, Ninot-Pedrosa M, Abele R, Abi Saad MJ, Alfano C, Almeida FCL, Alshamleh I, de Amorim GC, Anderson TK, Anobom CD, Anorma C, Bains JK, Bax A, Blackledge M, Blechar J, Böckmann A, Brigandat L, Bula A, Bütikofer M, Camacho-Zarco AR, Carlomagno T, Caruso IP, Ceylan B, Chaikuad A, Chu F, Cole L, Crosby MG, de Jesus V, Dhamotharan K, Felli IC, Ferner J, Fleischmann Y, Fogeron ML, Fourkiotis NK, Fuks C, Fürtig B, Gallo A, Gande SL, Gerez JA, Ghosh D, Gomes-Neto F, Gorbatyuk O, Guseva S, Hacker C, Häfner S, Hao B, Hargittay B, Henzler-Wildman K, Hoch JC, Hohmann KF, Hutchison MT, Jaudzems K, Jović K, Kaderli J, Kalniņš G, Kaņepe I, Kirchdoerfer RN, Kirkpatrick J, Knapp S, Krishnathas R, Kutz F, Zur Lage S, Lambertz R, Lang A, Laurents D, Lecoq L, Linhard V, Löhr F, Malki A, Bessa LM, Martin RW, Matzel T, Maurin D, McNutt SW, Mebus-Antunes NC, Meier BH, Meiser N, Mompeán M, Monaca E, Montserret R, Mariño Perez L, Moser C, Muhle-Goll C, Neves-Martins TC, Ni X, Norton-Baker B, Pierattelli R, Pontoriero L, Pustovalova Y, Ohlenschläger O, Orts J, Da Poian AT, Pyper DJ, Richter C, Riek R, Rienstra CM, Robertson A, Pinheiro AS, Sabbatella R, Salvi N, Saxena K, Schulte L, Schiavina M, Schwalbe H, Silber M, Almeida MdS, Sprague-Piercy MA, Spyroulias GA, Sreeramulu S, Tants JN, Tārs K, Torres F, Töws S, Treviño MÁ, Trucks S, Tsika AC, Varga K, Wang Y, Weber ME, Weigand JE, Wiedemann C, Wirmer-Bartoschek J, Wirtz Martin MA, Zehnder J, Hengesbach M, Schlundt A
  Front Mol Biosci 2021, 8, 653148
  
• Predicting disease progression in behavioral variant frontotemporal dementia.
  Anderl-Straub S, Lausser L, Lombardi J, Uttner I, Fassbender K, Fliessbach K, Huppertz HJ, Jahn H, Kornhuber J, Obrig H, Schneider A, Semler E, Synofzik M, Danek A, Prudlo J, Kassubek J, Landwehrmeyer B, Lauer M, Volk AE, Wiltfang J, Diehl-Schmid J, Ludolph AC, Schroeter ML, Kestler HA, Otto M, FTLD consortium
  Alzheimers Dement (Amst) 2021, 13(1), e12262
  
• RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve Cellular Homeostasis in Pancreatic Cancer.
  Arnold F, Gout J, Wiese H, Weissinger SE, Roger E, Perkhofer L, Walter K, Scheible J, Prelli Bozzo C, Lechel A, Ettrich TJ, Azoitei N, Hao L, Fürstberger A, Kaminska EK, Sparrer KMJ, Rasche V, Wiese S, Kestler HA, Möller P, Seufferlein T, Frappart PO, Kleger A
  Cancer Res 2021, 81(7), 1758-74
  
• Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration.
  Arnold F, Mahaddalkar PU, Kraus JM, Zhong X, Bergmann W, Srinivasan D, Gout J, Roger E, Beutel AK, Zizer E, Tharehalli U, Daiss N, Russell R, Perkhofer L, Oellinger R, Lin Q, Azoitei N, Weiss FU, Lerch MM, Liebau S, Katz SF, Lechel A, Rad R, Seufferlein T, Kestler HA, Ott M, Sharma AD, Hermann PC, Kleger A
  Adv Sci (Weinh) 2021, 8(14), 2100626
  
• Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
  Aschenbrenner AC, Mouktaroudi M, Krämer B, Oestreich M, Antonakos N, Nuesch-Germano M, Gkizeli K, Bonaguro L, Reusch N, Baßler K, Saridaki M, Knoll R, Pecht T, Kapellos TS, Doulou S, Kröger C, Herbert M, Holsten L, Horne A, Gemünd ID, Rovina N, Agrawal S, Dahm K, van Uelft M, Drews A, Lenkeit L, Bruse N, Gerretsen J, Gierlich J, Becker M, Händler K, Kraut M, Theis H, Mengiste S, De Domenico E, Schulte-Schrepping J, Seep L, Raabe J, Hoffmeister C, ToVinh M, Keitel V, Rieke G, Talevi V, Skowasch D, Aziz NA, Pickkers P, van de Veerdonk FL, Netea MG, Schultze JL, Kox M, Breteler MMB, Nattermann J, Koutsoukou A, Giamarellos-Bourboulis EJ, Ulas T, German COVID-19 Omics Initiative (DeCOI)
  Genome Med 2021, 13(1), 7
  
• Aging is associated with a degeneration of noradrenergic-, but not dopaminergic-neurons, in the short-lived killifish Nothobranchius furzeri
  Bagnoli S, Fronte B, Bibbiani C, Terzibasi Tozzini E, Cellerino A
  bioRxiv 2021
  
• Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging.
  Barth E, Srivastava A, Wengerodt D, Stojiljkovic M, Axer H, Witte OW, Kretz** A, Marz** M
  Aging (Albany NY) 2021, 13(24), 25694-716
  
• Life expectancy, family constellation and stress in giant mole-rats ( Fukomys mechowii).
  Begall S, Nappe R, Hohrenk L, Schmidt TC, Burda H, Sahm A, Szafranski K, Dammann P, Henning Y
  Philos Trans R Soc Lond B Biol Sci 2021, 376(1823), 20200207
  
• Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis.
  Begus-Nahrmann Y, Hartmann D, Kraus J, Eshraghi P, Scheffold A, Grieb M, Rasche V, Schirmacher P, Lee HW, Kestler HA, Lechel A, Rudolph KL
  J Clin Invest 2021, 131(1) Corrigendum for J Clin Invest. 2012;122(6):2283–2288
  
• Corona Health-A Study- and Sensor-Based Mobile App Platform Exploring Aspects of the COVID-19 Pandemic.
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• Introducing Bidirectional Ordinal Classifier Cascades Based on a Pain Intensity Recognition Scenario.
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• Experimental Analysis of Bidirectional Pairwise Ordinal Classifier Cascades
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• Impact of comorbidities and body mass index on the outcome of polycythemia vera patients.
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• A Prospective Feasibility Trial to Challenge Patient-Derived Pancreatic Cancer Organoids in Predicting Treatment Response.
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• Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study.
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• Surprisingly long survival of premature conclusions about naked mole-rat biology.
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• β-Glucans as Dietary Supplement to Improve Locomotion and Mitochondrial Respiration in a Model of Duchenne Muscular Dystrophy.
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  Nutrients 2021, 13(5)
  
• Epigenetic Modifications Associated with Maternal Anxiety during Pregnancy and Children's Behavioral Measures.
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  Cells 2021, 10(9)
  
• A marine Chlamydomonas sp. emerging as an algal model.
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• Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK.
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• The economical lifestyle of CPR bacteria in groundwater allows little preference for environmental drivers
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• Granulocyte colony-stimulating factor acts on lymphoid-biased, short-term hematopoietic stem cells.
  Chen Y, Rudolph KL
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• Nbs1-mediated DNA damage repair pathway regulates haematopoietic stem cell development and embryonic haematopoiesis.
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• Hepatectomy-Induced Alterations in Hepatic Perfusion and Function - Toward Multi-Scale Computational Modeling for a Better Prediction of Post-hepatectomy Liver Function.
  Christ B, Collatz M, Dahmen U, Herrmann KH, Höpfl S, König M, Lambers L, Marz M, Meyer D, Radde N, Reichenbach JR, Ricken T, Tautenhahn HM
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• Novel biochemical, structural and systems insights into inflammatory signaling revealed by contextual interaction proteomics
  Ciuffa R, Uliana F, Mehnert M, Marulli C, Satanowski A, Rodilla Ramírez PN, Meier P, Ori A, Gstaiger M, Aebersold R
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• EpiDope: A Deep Neural Network for linear B-cell epitope prediction.
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• Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7.
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  Leukemia 2021, 35(12), 3561-7 * equal contribution, ** co-senior authors
  
• Transcription factor RFX7 governs a tumor suppressor network in response to p53 and stress.
  Coronel L, Riege K, Schwab K, Förste S, Häckes D, Semerau L, Bernhart SH, Siebert R, Hoffmann** S, Fischer** M
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• Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).
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• Ancestral transoceanic colonization and recent population reduction in a nonannual killifish from the Seychelles archipelago.
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• Merlin cooperates with neurofibromin and Spred1 to suppress the Ras-Erk pathway.
  Cui** Y, Ma L, Schacke S, Yin JC, Hsueh YP, Jin H, Morrison** H
  Hum Mol Genet 2021, 29(23), 3793-806 ** co-corresponding authors
  
• Iron Oxide Nanoparticles Carrying 5-Fluorouracil in Combination with Magnetic Hyperthermia Induce Thrombogenic Collagen Fibers, Cellular Stress, and Immune Responses in Heterotopic Human Colon Cancer in Mice.
  Dabaghi M, Rasa SMM, Cirri E, Ori A, Neri F, Quaas R, Hilger I
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• Molekularbiologische Beschreibung des Alterungsprozesses
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• Anti-Proliferative and Apoptotic Effect of Gemini Curcumin in p53-Wild Type and p53-Mutant Colorectal Cancer Cell Lines.
  Ebrahimi M, Babaei E, Neri F, Ali Hosseinpour Feizi M
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• Modulation of FLT3-ITD Localization and Targeting of Distinct Downstream Signaling Pathways as Potential Strategies to Overcome FLT3-Inhibitor Resistance.
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• Altered Glycosylation in the Aging Heart.
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• Is there a role for statistics in artificial intelligence?
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• Virus Bioinformatics
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• The Hematopoietic Bone Marrow Niche Ecosystem.
  Fröbel J, Landspersky T, Percin G, Schreck C, Rahmig S, Ori A, Nowak D, Essers M, Waskow C, Oostendorp RAJ
  Front Cell Dev Biol 2021, 9, 705410
  
• Identifying Cell-Type-Specific Metabolic Signatures Using Transcriptome and Proteome Analyses.
  Gebert N, Rahman S, Lewis CA, Ori** A, Cheng** CW
  Curr Protoc 2021, 1(9), e245 ** co-corresponding authors
  
• Kidney Dysfunction Is Associated with Thrombosis and Disease Severity in Myeloproliferative Neoplasms: Implications from the German Study Group for MPN Bioregistry.
  Gecht J, Tsoukakis I, Kricheldorf K, Stegelmann F, Klausmann M, Griesshammer M, Schulz H, Hollburg W, Göthert JR, Sockel K, Heidel FH, Gattermann N, Maintz C, Al-Ali HK, Platzbecker U, Hansen R, Hänel M, Parmentier S, Bommer M, Pahl HL, Lang F, Kirschner M, Isfort S, Brümmendorf TH, Döhner K, Koschmieder S
  Cancers (Basel) 2021, 13(16)
  
• ITN-VIROINF: Understanding (Harmful) Virus-Host Interactions by Linking Virology and Bioinformatics.
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• Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer.
  Gout J, Perkhofer L, Morawe M, Arnold F, Ihle M, Biber S, Lange S, Roger E, Kraus JM, Stifter K, Hahn SA, Zamperone A, Engleitner T, Müller M, Walter K, Rodriguez-Aznar E, Sainz B, Hermann PC, Hessmann E, Müller S, Azoitei N, Lechel A, Liebau S, Wagner M, Simeone DM, Kestler HA, Seufferlein T, Wiesmüller L, Rad R, Frappart PO, Kleger A
  Gut 2021, 70(4), 743-60
  
• Epigenetic State Changes Underlie Metabolic Switch in Mouse Post-Infarction Border Zone Cardiomyocytes.
  Günthel M, van Duijvenboden K, de Bakker DEM, Hooijkaas IB, Bakkers J, Barnett P, Christoffels VM
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• Power and Weakness of Repetition - Evaluating the Phylogenetic Signal From Repeatomes in the Family Rosaceae With Two Case Studies From Genera Prone to Polyploidy and Hybridization ( Rosa and Fragaria).
  Herklotz V, Kovařík A, Wissemann V, Lunerová J, Vozárová R, Buschmann S, Olbricht K, Groth M, Ritz CM
  Front Plant Sci 2021, 12, 738119
  
• High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
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  Proc Natl Acad Sci U S A 2021, 118(22)
  
• Alternative Animal Models of Aging Research
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• PoSeiDon: a Nextflow pipeline for the detection of evolutionary recombination events and positive selection.
  Hölzer M, Marz M
  Bioinformatics 2021, 37(7), 1018-20
  
• The Role of MacroH2A Histone Variants in Cancer.
  Hsu CJ, Meers O, Buschbeck M, Heidel FH
  Cancers (Basel) 2021, 13(12)
  
• Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas.
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• Computational strategies to combat COVID-19: useful tools to accelerate SARS-CoV-2 and coronavirus research.
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• Fetal-like reversion in the regenerating intestine is regulated by mesenchymal Asporin
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• ATP/IL-33-triggered hyperactivation of mast cells results in an amplified production of pro-inflammatory cytokines and eicosanoids.
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• Rfam 14: expanded coverage of metagenomic, viral and microRNA families.
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• DNA-binding properties of the MADS-domain transcription factor SEPALLATA3 and mutant variants characterized by SELEX-seq.
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• Reduced Rate of Inpatient Hospital Admissions in 18 German University Hospitals During the COVID-19 Lockdown.
  Kapsner LA, Kampf MO, Seuchter SA, Gruendner J, Gulden C, Mate S, Mang JM, Schüttler C, Deppenwiese N, Krause L, Zöller D, Balig J, Fuchs T, Fischer P, Haverkamp C, Holderried M, Mayer G, Stenzhorn H, Stolnicu A, Storck M, Storf H, Zohner J, Kohlbacher O, Strzelczyk A, Schüttler J, Acker T, Boeker M, Kaisers UX, Kestler HA, Prokosch HU
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• Digitalization of adverse event management in oncology to improve treatment outcome-A prospective study protocol.
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• Large-scale characterization of sex pheromone communication systems in Drosophila.
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• Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.
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• Direct RNA Sequencing for Complete Viral Genomes
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• Low-Input Whole-Genome Bisulfite Sequencing.
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• Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence.
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• [Tumor biology of oropharyngeal carcinoma].
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• Systems Analysis Reveals Ageing-Related Perturbations in Retinoids and Sex Hormones in Alzheimer's and Parkinson's Diseases.
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• Isolation, ‘omics characterization and organotypic culture of alveolar type II pulmonary epithelial cells
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• Post-Translational Modification of MRE11: Its Implication in DDR and Diseases.
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• An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness.
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• Molecular characterization of hematopoietic stem cells after in vitro amplification on biomimetic 3D PDMS cell culture scaffolds.
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• Implementing FAIR data management within the German Network for Bioinformatics Infrastructure (de.NBI) exemplified by selected use cases.
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• Butyrate and Metformin Affect Energy Metabolism Independently of the Metabolic Phenotype in the Tumor Therapy Model.
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• Sequence Classification with Machine Learning at the Example of Viral Host Prediction
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• VIDHOP, viral host prediction with Deep Learning.
  Mock F, Viehweger A, Barth E, Marz M
  Bioinformatics 2021, 37(3), 318-25
  
• BERTax: taxonomic classification of DNA sequences with Deep Neural Networks
  Mock* F, Kretschmer* F, Kriese A, Böcker S, Marz M
  bioRxiv 2021 * equal contribution
  
• Intrasexual cuticular hydrocarbon dimorphism in a wasp sheds light on hydrocarbon biosynthesis genes in Hymenoptera
  Moris VC, Podsiadlowski L, Martin S, Oeyen JP, Donath A, Petersen M, Wilbrandt J, Misof B, Liedtke D, Thamm M, Scheiner R, Schmitt T, Niehuis O
  bioRxiv 2021, https://doi.org/10.1101/2021.11.
  
• A perceptually optimised bivariate visualisation scheme for high-dimensional fold-change data
  Müller* A, Lausser* L, Wilhelm A, Ropinski T, Platzer M, Neumann** H, Kestler** HA
  Adv Data Anal Classif 2021, https://doi.org/10.1007/s11634-0 * equal contribution, ** co-corresponding authors
  
• Silicon-rhodamine isothiocyanate for fluorescent labelling.
  Nasufović V, Then P, Dröge F, Duong M, Kaether C, Dietzek B, Heintzmann R, Arndt HD
  Org Biomol Chem 2021, 19(3), 574-8
  
• QUAREP-LiMi: A community-driven initiative to establish guidelines for quality assessment and reproducibility for instruments and images in light microscopy
  Nelson G, Boehm U, Bagley S, Bajcsy P, Bischof J, Brown CM, Dauphin A, Dobbie IM, Eriksson JE, Faklaris O, Fernandez-Rodriguez J, Ferrand A, Gelman L, Gheisari A, Hartmann H, Kukat C, Laude A, Mitkovski M, Munck S, North Alison J, Rasse TM, Resch-Genger U, Schuetz LC, Seitz A, Strambio-De-Castillia C, Swedlow Jason R, Alexopoulos I, Aumayr K, Avilov S, Bakker GJ, Bammann Rodrigo R, Bassi A, Beckert H, Beer S, Belyaev Y, Bierwagen J, Birngruber KA, Bosch M, Breitlow J, Cameron LA, Chalfoun J, Chambers JJ, Chen CL, Conde-Sousa E, Corbett AD, Cordelieres FP, Nery ED, Dietzel R, Eismann F, Fazeli E, Felscher A, Fried H, Gaudreault N, Goh WI, Guilbert T, Hadleigh R, Hemmerich P, Holst GA, Itano MS, Jaffe CB, Jambor HK, Jarvis Stuart C, Keppler A, Kirchenbuechler D, Kirchner M, Kobayashi N, Krens G, Kunis S, Lacoste J, Marcello M, Martins Gabriel G, Metcalf DJ, Mitchell CA, Moore J, Mueller T, Nelson MS, Ogg S, Onami S, Palmer AL, Paul-Gilloteaux P, Pimentel Jaime A, Plantard L, Podder S, Rexhepaj E, Royon A, Saari Markku A, Schapman D, Schoonderwoert V, Schroth-Diez B, Schwartz S, Shaw M, Spitaler M, Stoeckl MT, Sudar D, Teillon J, Terjung S, Thuenauer R, Wilms CD, Wright Graham D, Nitschke R
  arXiv 2021, arXiv:2101.09153
  
• Significance of BK Polyomavirus in Long-Term Survivors after Adult Allogeneic Stem Cell Transplantation.
  Neumann T, Peters N, Kranz J, Dräger DL, Heidel FH, Krüger W, Schneidewind L
  Biology (Basel) 2021, 10(6)
  
• Comprehensive Characterization of Multitissue Expression Landscape, Co-Expression Networks and Positive Selection in Pikeperch.
  Nguinkal JA, Verleih M, de Los Ríos-Pérez L, Brunner RM, Sahm A, Bej S, Rebl A, Goldammer T
  Cells 2021, 10(9)
  
• NADH Fluorescence Lifetime Imaging Microscopy Reveals Selective Mitochondrial Dysfunction in Neurons Overexpressing Alzheimer's Disease-Related Proteins.
  Niederschweiberer MA, Schaefer PM, Singh LN, Lausser L, Bhosale D, Hesse R, Calzia E, Kestler HA, Rueck A, Wallace DC, von Einem B, von Arnim CAF
  Front Mol Biosci 2021, 8, 671274
  
• The LIM domain protein nTRIP6 modulates the dynamics of myogenic differentiation.
  Norizadeh Abbariki T, Gonda Z, Kemler D, Urbanek P, Wagner T, Litfin M, Wang ZQ, Herrlich P, Kassel O
  Sci Rep 2021, 11(1), 12904
  
• Rates of primary production in groundwater rival those in oligotrophic marine systems
  Overholt WA, Trumbore S, Xu X, Bornemann TLV, Probst AJ, Krüger M, Herrmann M, Thamdrup B, Bristow L, Taubert M, Schwab VF, Hölzer M, Marz M, Küsel K
  bioRxiv 2021, https://doi.org/10.1101/2021.10.
  
• Ruxolitinib rechallenge in resistant or intolerant patients with myelofibrosis: Frequency, therapeutic effects, and impact on outcome.
  Palandri F, Tiribelli M, Breccia M, Bartoletti D, Elli EM, Benevolo G, Martino B, Cavazzini F, Tieghi A, Iurlo A, Abruzzese E, Pugliese N, Binotto G, Caocci G, Auteri G, Cattaneo D, Trawinska MM, Stella R, Scaffidi L, Polverelli N, Micucci G, Masselli E, Crugnola M, Bosi C, Heidel FH, Latagliata R, Pane F, Cuneo A, Krampera M, Semenzato G, Lemoli RM, Cavo M, Vianelli N, Bonifacio M, Palumbo GA
  Cancer 2021, 127(15), 2657-65
  
• Virus Bioinformatics
  Pappas N, Roux S, Hölzer M, Lamkiewicz K, Mock F, Marz M, Dutilh BE
  In: Encyclopedia of Virology, The Virus as a Concept - Fundamentals of Virology (edited by Dennis H. Bamford and Mark Zuckerman) 2021, 1, 124-132, Elsevier, Amsterdam
  
• Second primary malignancy in myelofibrosis patients treated with ruxolitinib.
  Polverelli N, Elli EM, Abruzzese E, Palumbo GA, Benevolo G, Tiribelli M, Bonifacio M, Tieghi A, Caocci G, D'Adda M, Bergamaschi M, Binotto G, Heidel FH, Cavazzini F, Crugnola M, Pugliese N, Bosi C, Isidori A, Bartoletti D, Auteri G, Latagliata R, Gandolfi L, Martino B, Scaffidi L, Cattaneo D, D'Amore F, Trawinska MM, Stella R, Markovic U, Catani L, Pane F, Cuneo A, Krampera M, Semenzato G, Lemoli RM, Vianelli N, Breccia M, Russo D, Cavo M, Iurlo A, Palandri F
  Br J Haematol 2021, 193(2), 356-68
  
• Correction to: The proteorhodopsins of the dinoflagellate Oxyrrhis marina: ultrastructure and localization by immunofluorescence light microscopy and immunoelectron microscopy.
  Rhiel E, Westermann M, Steiniger F, Hoischen C
  Protoplasma 2021
  
• Distinct single-component adjuvants steer human DC-mediated T-cell polarization via Toll-like receptor signaling toward a potent antiviral immune response.
  Roßmann L, Bagola K, Stephen T, Gerards AL, Walber B, Ullrich A, Schülke S, Kamp C, Spreitzer I, Hasan M, David-Watine B, Shorte SL, Bastian M, van Zandbergen G
  Proc Natl Acad Sci U S A 2021, 118(39)
  
• DNA-methylation aging at single-cell level
  Rudolph KL
  Nature Aging 2021, 1, 1086–1087
  
• Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo.
  Rummelt C, Gorantla SP, Meggendorfer M, Charlet A, Endres C, Döhner K, Heidel FH, Fischer T, Haferlach T, Duyster J, von Bubnoff N
  Leukemia 2021, 35(7), 2017-29
  
• An analysis of methylome evolution in primates
  Sahm** A, Koch P, Horvath S, Hoffmann** S
  Mol Biol Evol 2021, 38(11), 4700-14 ** co-corresponding authors
  
• Aging drives organ-specific alterations of the inflammatory microenvironment guided by immunomodulatory mediators in mice.
  Schädel P, Troisi F, Czapka A, Gebert N, Pace S, Ori A, Werz O
  FASEB J 2021, 35(5), e21558
  
• NMR-Based Structural Characterization of a Two-Disulfide-Bonded Analogue of the FXIIIa Inhibitor Tridegin: New Insights into Structure-Activity Relationships.
  Schmitz T, Paul George AA, Nubbemeyer B, Bäuml CA, Steinmetzer T, Ohlenschläger O, Biswas A, Imhof D
  Int J Mol Sci 2021, 22(2)
  
• A JAK of all trades: how global phosphoproteomics reveal the Achilles heel of MPNs.
  Schnoeder TM, Perner F, Heidel FH
  Mol Cell Oncol 2021, 8(2), 1871172
  
• Supporting Medical Staff from Psycho-Oncology with Smart Mobile Devices: Insights into the Development Process and First Results.
  Schobel* J, Volz* M, Hörner K, Kuhn P, Jobst F, Schwab JD, Ikonomi N, Werle SD, Fürstberger A, Hoenig** K, Kestler** HA
  Int J Environ Res Public Health 2021, 18(10) * equal contribution, ** co-senior authors
  
• Letalität von Patienten mit COVID-19: Untersuchungen zu Ursachen und Dynamik an deutschen Univer- sitätsklinika
  Schüttler J, Mang JM, Kapsner LA, Seuchter SA, Binder H, Zöller D, Kohlbacher O, Boeker M, Zacharowski K, Rohde G, Balig J, Kampf MO, Röhrig R, Prokosch HU, MII-AG (Medizininformatik- Initiative) „COVID-19-Letalität (COV-LET-MII
  Anasth Intensivmed 2021, 62, 244–257.
  
• Reconstructing Boolean network ensembles from single-cell data for unraveling dynamics in the aging of human hematopoietic stem cells.
  Schwab JD, Ikonomi N, Werle SD, Weidner FM, Geiger H, Kestler HA
  Comput Struct Biotechnol J 2021, 19, 5321-32
  
• Perspective on mHealth Concepts to Ensure Users’ Empowerment–From Adverse Event Tracking for COVID-19 Vaccinations to Oncological Treatment
  Schwab* JD, Schobel* J, Werle* WD, Fürstberger* A, Ikonomi N, Azekely R, Thiam P, Hühne R, Jahn N, Schuler R, Kuhn P, Holderried M, Steger F, Reichert M, Kaisers UX, Kestler AMR, Seufferlein** T, Kestler** HA
  IEEE ACCESS 2021, 9, 83863-75 * equal contribution, ** co-senior authors
  
• Improved automatic detection of herpesvirus secondary envelopment stages in electron microscopy by augmenting training data with synthetic labelled images generated by a generative adversarial network.
  Shaga Devan K, Walther P, von Einem J, Ropinski T, A Kestler H, Read C
  Cell Microbiol 2021, 23(2), e13280
  
• Biogenesis of Iron-Sulfur Clusters and Their Role in DNA Metabolism.
  Shi R, Hou W, Wang ZQ, Xu X
  Front Cell Dev Biol 2021, 9, 735678
  
• COPII collar defines the boundary between ER and ER exit site and does not coat cargo containers
  Shomron O, Nevo-Yassaf I, Aviad T, Yaffe Y, Erez Zahavi E, Dukhovny A, Perlson E, Brodsky I, Yeheskel A, Pasmanik-Chor M, Mironov A, Beznoussenko GV, Mironov AA, Sklan EH, Patterson GH, Yonemura Y, Sannai M, Kaether** C, Hirschberg** K
  J Cell Biol 2021, 220(6), e201907224 ** co-corresponding authors
  
• TRIP6 functions in brain ciliogenesis.
  Shukla S, Haenold* R, Urbánek* P, Frappart L, Monajembashi S, Grigaravicius P, Nagel S, Min WK, Tapias A, Kassel O, Heuer H, Wang ZQ, Ploubidou** A, Herrlich** P
  Nat Commun 2021, 12(1), 5887 * equal contribution, ** co-senior authors
  
• SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells.
  Singh Y, Trautwein C, Fendel R, Krickeberg N, Berezhnoy G, Bissinger R, Ossowski S, Salker MS, Casadei N, Riess O, Deutsche COVID-19 OMICS Initiate (DeCOI)
  Heliyon 2021, 7(6), e07147
  
• Author Correction: Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction.
  Sperka T, Song Z, Morita Y, Nalapareddy K, Guachalla LM, Lechel A, Begus-Nahrmann Y, Burkhalter MD, Mach M, Schlaudraff F, Liss B, Ju Z, Speicher MR, Rudolph KL
  Nat Cell Biol 2021, 23(3), 292
  
• Loss of hepatic Mboat7 leads to liver fibrosis.
  Thangapandi VR, Knittelfelder O, Brosch M, Patsenker E, Vvedenskaya O, Buch S, Hinz S, Hendricks A, Nati M, Herrmann A, Rekhade DR, Berg T, Matz-Soja M, Huse K, Klipp E, Pauling JK, Wodke JA, Miranda Ackerman J, Bonin Mv, Aigner E, Datz C, von Schönfels W, Nehring S, Zeissig S, Röcken C, Dahl A, Chavakis T, Stickel F, Shevchenko A, Schafmayer C, Hampe J, Subramanian P
  Gut 2021, 70(5), 940-50
  
• Multi-Modal Pain Intensity Assessment Based on Physiological Signals: A Deep Learning Perspective.
  Thiam P, Hihn H, Braun DA, Kestler** HA, Schwenker** F
  Front Physiol 2021, 12, 720464 ** co-senior authors
  
• Immunoproteasome Function in Normal and Malignant Hematopoiesis.
  Tubío-Santamaría N, Ebstein F, Heidel FH, Krüger E
  Cells 2021, 10(7)
  
• Transcriptional Regulation
  Tuckermann J, Herrlich P, Caratti G
  In: Encyclopedia of Molecular Pharmacology (edited by Stefan Offermanns and Walter Rosenthal) 2021, Springer International Publishin
  
• Editorial for ADAC issue 1 of volume 15
  Vichi M, Cerioli A, Kestler H, Okada A, Weihs C
  Adv Data Anal Classif 2021, 1(15), 1-4
  
• Patient Empowerment During the COVID-19 Pandemic by Ensuring Safe and Fast Communication of Test Results: Implementation and Performance of a Tracking System.
  Völkel* G, Fürstberger* A, Schwab* JD, Werle* SD, Ikonomi* N, Gscheidmeier T, Kraus JM, Groß A, Holderried M, Balig J, Jobst F, Kuhn P, Kuhn KA, Kohlbacher O, Kaisers UX, Seufferlein* T, Kestler* HA
  J Med Internet Res 2021, 23(6), e27348 * equal contribution
  
• Metadata Correction: Patient Empowerment During the COVID-19 Pandemic by Ensuring Safe and Fast Communication of Test Results: Implementation and Performance of a Tracking System.
  Völkel* G, Fürstberger* A, Schwab* JD, Werle* SD, Ikonomi* N, Gscheidmeier T, Kraus JM, Groß A, Holderried M, Balig J, Jobst F, Kuhn P, Kuhn KA, Kohlbacher O, Kaisers UX, Seufferlein* T, Kestler* HA
  J Med Internet Res 2021, 23(6), e31253 * equal contribution
  
• Analysis, identification and visualization of subgroups in genomics.
  Völkel* G, Laban* S, Fürstberger* A, Kühlwein SD, Ikonomi N, Hoffman TK, Brunner C, Neuberg DS, Gaidzik V, Döhner H, Kraus** JM, Kestler** HA
  Brief Bioinform 2021, 22(3) * equal contribution, ** co-senior authors
  
• Erratum to: Analysis, identification and visualization of subgroups in genomics.
  Völkel* G, Laban* S, Fürstberger* A, Kühlwein* SD, Ikonomi* N, Hoffmann TK, Brunner C, Neuberg DS, Gaidzik V, Döhner H, Kraus** JM, Kestler** HA
  Brief Bioinform 2021, 22(6) * equal contribution, ** co-corresponding authors
  
• Chapter Nine - Regulation of muscle stem cell function
  von Maltzahn J
  In: Vitamins and Hormones, Hormones and Stem Cells (edited by Gerald Litwack) 2021, 16, 295-311, Elsevier, Amsterdam
  
• Prospective longitudinal study of immune checkpoint molecule (ICM) expression in immune cell subsets during curative conventional therapy of head and neck squamous cell carcinoma (HNSCC).
  von Witzleben* A, Fehn* A, Grages A, Ezić J, Jeske SS, Puntigam LK, Brunner C, Kraus JM, Kestler HA, Doescher J, Brand M, Theodoraki MN, Ottensmeier CH, Hoffmann TK, Schuler PJ, Laban S
  Int J Cancer 2021, 148(8), 2023-35 * equal contribution
  
• Swarm Learning for decentralized and confidential clinical machine learning.
  Warnat-Herresthal S, Schultze H, Shastry KL, Manamohan S, Mukherjee S, Garg V, Sarveswara R, Händler K, Pickkers P, Aziz NA, Ktena S, Tran F, Bitzer M, Ossowski S, Casadei N, Herr C, Petersheim D, Behrends U, Kern F, Fehlmann T, Schommers P, Lehmann C, Augustin M, Rybniker J, Altmüller J, Mishra N, Bernardes JP, Krämer B, Bonaguro L, Schulte-Schrepping J, De Domenico E, Siever C, Kraut M, Desai M, Monnet B, Saridaki M, Siegel CM, Drews A, Nuesch-Germano M, Theis H, Heyckendorf J, Schreiber S, Kim-Hellmuth S, COVID-19 Aachen Study (COVAS), Nattermann J, Skowasch D, Kurth I, Keller A, Bals R, Nürnberg P, Rieß O, Rosenstiel P, Netea MG, Theis F, Mukherjee S, Backes M, Aschenbrenner AC, Ulas T, Deutsche COVID-19 Omics Initiative (DeCOI), Breteler MMB, Giamarellos-Bourboulis EJ, Kox M, Becker M, Cheran S, Woodacre MS, Goh EL, Schultze JL
  Nature 2021, 594(7862), 265-70
  
• Capturing dynamic relevance in Boolean networks using graph theoretical measures.
  Weidner* FM, Schwab* JD, Werle* SD, Ikonomi* N, Lausser L, Kestler HA
  Bioinformatics 2021 (epub ahead of print) * equal contribution
  
• SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
  Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D, Deutsche COVID-19 OMICS Initiative (DeCOI), Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE
  Cell 2021, 184(26), 6243-6261.e27
  
• Unraveling the Molecular Tumor-Promoting Regulation of Cofilin-1 in Pancreatic Cancer.
  Werle* SD, Schwab* JD, Tatura* M, Kirchhoff S, Szekely R, Diels R, Ikonomi N, Sipos B, Sperveslage J, Gress TM, Buchholz** M, Kestler** HA
  Cancers (Basel) 2021, 13(4) * equal contribution, ** co-senior authors
  
• Backbone and nearly complete side-chain chemical shift assignments reveal the human uncharacterized protein CXorf51A as intrinsically disordered.
  Wiedemann C, Obika KB, Liebscher S, Jirschitzka J, Ohlenschlãger O, Bordusa F
  Biomol NMR Assign 2021, 15(2), 441-8
  
• Backbone and nearly complete side-chain chemical shift assignments of the human death-associated protein 1 (DAP1).
  Wiedemann C, Voigt J, Jirschitzka J, Häfner S, Ohlenschläger O, Bordusa F
  Biomol NMR Assign 2021, 15(1), 91-7
  
• De novo identification of maximally deregulated subnetworks based on multi-omics data with DeRegNet
  Winkler S, Winkler I, Figaschewski M, Tiede T, Nordheim A, Kohlbacher O
  bioRxiv 2021
  
• p63 and p53: Collaborative Partners or Dueling Rivals?
  Woodstock DL, Sammons MA, Fischer M
  Front Cell Dev Biol 2021, 9, 701986
  
• Shorter Leukocyte Telomere Length Is Associated with Worse Survival of Patients with Bladder Cancer and Renal Cell Carcinoma.
  Zheng X, Wezel F, Azoitei A, Meessen S, Wang W, Najjar G, Wang X, Kraus JM, Kestler HA, John A, Zengerling F, Bolenz C, Günes C
  Cancers (Basel) 2021, 13(15)
  

Publications 2020:

• Protein Kinase D1, Reduced in Human Pancreatic Tumors, Increases Secretion of Small Extracellular Vesicles From Cancer Cells That Promote Metastasis to Lung in Mice.
  Armacki M, Polaschek S, Waldenmaier M, Morawe M, Ruhland C, Schmid R, Lechel A, Tharehalli U, Steup C, Bektas Y, Li H, Kraus JM, Kestler HA, Kruger S, Ormanns S, Walther P, Eiseler T, Seufferlein T
  Gastroenterology 2020, 159(3), 1019-1035.e22
  
• Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations.
  Austin RJ, Straube J, Bruedigam C, Pali G, Jacquelin S, Vu T, Green J, Gräsel J, Lansink L, Cooper L, Lee SJ, Chen NT, Lee CW, Haque A, Heidel FH, D'Andrea R, Hill GR, Mullally A, Milsom MD, Bywater M, Lane SW
  Leukemia 2020, 34(4), 1075-89
  
• Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19.
  Bernardes JP, Mishra N, Tran F, Bahmer T, Best L, Blase JI, Bordoni D, Franzenburg J, Geisen U, Josephs-Spaulding J, Köhler P, Künstner A, Rosati E, Aschenbrenner AC, Bacher P, Baran N, Boysen T, Brandt B, Bruse N, Dörr J, Dräger A, Elke G, Ellinghaus D, Fischer J, Forster M, Franke A, Franzenburg S, Frey N, Friedrichs A, Fuß J, Glück A, Hamm J, Hinrichsen F, Hoeppner MP, Imm S, Junker R, Kaiser S, Kan YH, Knoll R, Lange C, Laue G, Lier C, Lindner M, Marinos G, Markewitz R, Nattermann J, Noth R, Pickkers P, Rabe KF, Renz A, Röcken C, Rupp J, Schaffarzyk A, Scheffold A, Schulte-Schrepping J, Schunk D, Skowasch D, Ulas T, Wandinger KP, Wittig M, Zimmermann J, Busch H, Hoyer BF, Kaleta C, Heyckendorf J, Kox M, Rybniker J, Schreiber S, Schultze JL, Rosenstiel P, HCA Lung Biological Network, Deutsche COVID-19 Omics Initiative (DeCOI)
  Immunity 2020, 53(6), 1296-1314.e9
  
• Extreme genomic volatility characterizes the evolution of the immunoglobulin heavy chain locus in cyprinodontiform fishes.
  Bradshaw WJ, Valenzano DR
  Proc Biol Sci 2020, 287(1927), 20200489
  
• Spatially resolved analysis of FFPE tissue proteomes by quantitative mass spectrometry.
  Buczak K, Kirkpatrick JM, Truckenmueller F, Santinha D, Ferreira L, Roessler S, Singer S, Beck** M, Ori** A
  Nat Protoc 2020, 15(9), 2956-79 ** co-corresponding authors
  
• Nothobranchius furzeri (African Turquoise Killifish).
  Cui R, Willemsen D, Valenzano DR
  Trends Genet 2020, 36(7), 540-1
  
• Optimization of blocking conditions for fluorescent Western blot.
  Cui Y
  Anal Biochem 2020, 593, 113598
  
• Structure of an RNA aptamer in complex with the fluorophore tetramethylrhodamine.
  Duchardt-Ferner E, Juen M, Bourgeois B, Madl T, Kreutz C, Ohlenschläger O, Wöhnert J
  Nucleic Acids Res 2020, 48(2), 949-61
  
• Structural insights into the main S-layer unit of Deinococcus radiodurans reveal a massive protein complex with porin-like features.
  Farci D, Aksoyoglu MA, Farci SF, Bafna JA, Bodrenko I, Ceccarelli M, Kirkpatrick J, Winterhalter M, Kereïche S, Piano D
  J Biol Chem 2020, 295(13), 4224-36
  
• MLL1 is required for maintenance of intestinal stem cells and the expression of the cell adhesion molecule JAML
  Goveas N, Waskow C, Arndt K, Heuberger J, Zhang Q, Alexopoulou D, Dahl A, Birchmeier W, Anastassiadis K, Stewart AF, Kranz A
  bioRxiv 2020, https://doi.org/10.1101/2020.11.
  
• miR-182-5p is an evolutionarily conserved Tbx5 effector that impacts cardiac development and electrical activity in zebrafish.
  Guzzolino E, Pellegrino M, Ahuja N, Garrity D, D'Aurizio R, Groth M, Baumgart M, Hatcher CJ, Mercatanti A, Evangelista M, Ippolito C, Tognoni E, Fukuda R, Lionetti V, Pellegrini M, Cremisi F, Pitto L
  Cell Mol Life Sci 2020, 77(16), 3215-29
  
• Awakening the HSC: Dynamic Modeling of HSC Maintenance Unravels Regulation of the TP53 Pathway and Quiescence.
  Ikonomi N, Kühlwein SD, Schwab JD, Kestler HA
  Front Physiol 2020, 11, 848
  
• Local and transient inhibition of p21 expression ameliorates age-related delayed wound healing.
  Jiang D, de Vries JC, Muschhammer J, Schatz S, Ye H, Hein T, Fidan M, Romanov VS, Rinkevich Y, Scharffetter-Kochanek K
  Wound Repair Regen 2020, 28(1), 49-60
  
• Cohesin controls intestinal stem cell identity by maintaining association of Escargot with target promoters.
  Khaminets A, Ronnen-Oron T, Baldauf M, Meier E, Jasper H
  Elife 2020, 9, e48160
  
• 1 H, 13 C, and 15 N backbone assignments of the C-terminal region of the human retinoic acid-induced protein 2.
  Lang A, Goradia N, Wikman H, Werner S, Wilmanns M, Ohlenschläger O
  Biomol NMR Assign 2020, 14(2), 271-5
  
• Detecting Ordinal Subcascades
  Lausser* L, Schäfer* LM, Kühlwein SD, Kestler AMR, Kestler HA
  Neural Process Lett 2020, 52, 2583–2605 * equal contribution
  
• Chained correlations for feature selection
  Lausser* L, Szekely* R, Kestler HA
  Adv Data Anal Classif 2020, 14, 871–884 * equal contribution
  
• The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
  Liu H, Ding J, Köhnlein K, Urban N, Ori A, Villavicencio-Lorini P, Walentek P, Klotz LO, Hollemann T, Pfirrmann T
  Autophagy 2020, 16(9), 1618-34
  
• Asymmetrical canina meiosis is accompanied by the expansion of a pericentromeric satellite in non-recombining univalent chromosomes.
  Lunerová J, Herklotz V, Laudien M, Vozárová R, Groth M, Kovařík A, Ritz CM
  Ann Bot (Lond) 2020, 125(7), 1025-38
  
• Virus Bioinformatics
  Marz M, Ibrahim B, Hufsky F, Robertson DL (eds)
  2020, pages 330. MDPI - Multidiscipli
  
• ARDD 2020: from aging mechanisms to interventions.
  Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M
  Aging (Albany NY) 2020, 12(24), 24484-503
  
• Ontogenetic Pattern Changes of Nucleobindin-2/Nesfatin-1 in the Brain and Intestinal Bulb of the Short Lived African Turquoise Killifish.
  Montesano* A, Felice* ED, Leggieri A, Palladino A, Lucini C, Scocco P, Girolamo Pd, Baumgart** M, D'Angelo** L
  J Clin Med 2020, 9(1) * equal contribution, ** co-corresponding authors
  
• Peripheral Cytokine Levels Differ by HPV Status and Change Treatment-Dependently in Patients with Head and Neck Squamous Cell Carcinoma.
  Mytilineos D, Ezić J, von Witzleben A, Mytilineos J, Lotfi R, Fürst D, Tsamadou C, Theodoraki MN, Oster A, Völkel G, Kestler HA, Brunner C, Schuler PJ, Doescher J, Hoffmann TK, Laban S
  Int J Mol Sci 2020, 21(17)
  
• Growth inhibitory role of the p53 activator SCH 529074 in non‑small cell lung cancer cells expressing mutant p53.
  Nenkov M, Ma Y, Haase D, Zhou Z, Li Y, Petersen I, Lu G, Chen Y
  Oncol Rep 2020, 43(2), 2073-82
  
• Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13.
  Pitrez PR, Estronca L, Monteiro LM, Colell G, Vazão H, Santinha D, Harhouri K, Thornton D, Navarro C, Egesipe AL, Carvalho T, Dos Santos RL, Lévy N, Smith JC, de Magalhães JP, Ori A, Bernardo A, De Sandre-Giovannoli A, Nissan X, Rosell A, Ferreira L
  Nat Commun 2020, 11(1), 4110
  
• The turquoise killifish: a genetically tractable model for the study of aging.
  Poeschla M, Valenzano DR
  J Exp Biol 2020, 223(Pt Suppl 1)
  
• Microbiota-host interactions shape ageing dynamics.
  Popkes M, Valenzano DR
  Philos Trans R Soc Lond B Biol Sci 2020, 375(1808), 20190596
  
• A virtual "Werkstatt" for digitization in the sciences
  Samuel S, Shadaydeh M, Böcker S, Brügmann B, Bucher SF, Deckert V, Denzler J, Dittrich P, Eggeling F, Güllmar D, Guntinas-Lichius O, König-Ries B, Löffler F, Maicher L, Marz M, Migliavacca M, Reichenbach JR, Reichstein M, Römermann C, Wittig A
  Res Ideas Outcomes 2020, 6, e54106
  
• Stem Cell Aging: The Upcoming Era of Proteins and Metabolites.
  Schüler* SC, Gebert* N, Ori A
  Mech Ageing Dev 2020, 190, 111288 * equal contribution
  
• The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival.
  Schulz A, Sekine Y, Oyeyemi MJ, Abrams AJ, Basavaraju M, Han SM, Groth M, Morrison H, Strittmatter SM, Hammarlund M
  J Cell Biol 2020, 219(2), doi: 10.1083/jcb.201807127
  
• Apoptosis of hematopoietic progenitor-derived adipose tissue-resident macrophages contributes to insulin resistance after myocardial infarction.
  Vasamsetti SB, Coppin E, Zhang X, Florentin J, Koul S, Götberg M, Clugston AS, Thoma F, Sembrat J, Bullock GC, Kostka D, St Croix CM, Chattopadhyay A, Rojas M, Mulukutla SR, Dutta P
  Sci Transl Med 2020, 12(553), eaaw0638
  
• Intra-species differences in population size shape life history and genome evolution.
  Willemsen D, Cui R, Reichard M, Valenzano DR
  Elife 2020, 9
  
• Identification of Ppar γ -modulated miRNA hubs that target the fibrotic tumor microenvironment.
  Winkler I, Bitter C, Winkler S, Weichenhan D, Thavamani A, Hengstler JG, Borkham-Kamphorst E, Kohlbacher O, Plass C, Geffers R, Weiskirchen R, Nordheim A
  Proc Natl Acad Sci U S A 2020, 117(1), 454-63
  
• Displacement of the Gent/1999 human-like swine H1N2 influenza A virus lineage by novel H1N2 reassortants in Germany.
  Zell R, Groth M, Krumbholz A, Lange J, Philipps A, Dürrwald R
  Arch Virol 2020, 165(1), 55-67
  

Publications 2019:

• Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart.
  Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling JE, Dodzian J, Lagerborg KA, Vargas NE, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano** DR, Kurian** L
  EMBO Rep 2019, 20(4) ** co-corresponding authors
  
• Microbiome evolution during host aging.
  Aleman FDD, Valenzano DR
  PLoS Pathog 2019, 15(7), e1007727
  
• BRCA1 mislocalization leads to aberrant DNA damage response in heterozygous ABRAXAS1 mutation carrier cells.
  Bose M, Sachsenweger J, Laurila N, Parplys AC, Willmann J, Jungwirth J, Groth M, Rapakko K, Nieminen P, Friedl TWP, Heiserich L, Meyer F, Tuppurainen H, Peltoketo H, Nevanlinna H, Pylkäs K, Borgmann K, Wiesmüller L, Winqvist** R, Pospiech** H
  Hum Mol Genet 2019, 28(24), 4148-60 ** co-corresponding authors
  
• Resting cells rely on the DNA helicase component MCM2 to build cilia.
  Casar Tena T, Maerz LD, Szafranski K, Groth M, Blätte TJ, Donow C, Matysik S, Walther P, Jeggo PA, Burkhalter MD, Philipp M
  Nucleic Acids Res 2019, 47(1), 134-51
  
• Early-life Pb exposure as a potential risk factor for Alzheimer's disease: are there hazards for the Mexican population?
  Chin-Chan M, Cobos-Puc L, Alvarado-Cruz I, Bayar M, Ermolaeva M
  J Biol Inorg Chem 2019, 24(8), 1285-303
  
• Relaxed Selection Limits Lifespan by Increasing Mutation Load.
  Cui R, Medeiros T, Willemsen D, Iasi LNM, Collier GE, Graef M, Reichard M, Valenzano DR
  Cell 2019, 178(2), 385-399.e20
  
• Construction of cloning-friendly mini-genes for mammalian expression of full-length human NF1 isoforms.
  Cui Y, Morrison H
  Hum Mutat 2019, 40(2), 187-92
  
• Comment on 'Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age'.
  Dammann* P, Scherag* A, Zak N, Szafranski K, Holtze S, Begall S, Burda H, Kestler HA, Hildebrandt T, Platzer M
  Elife 2019, 8 * corresponding author
  
• Cell cycle dynamics during diapause entry and exit in an annual killifish revealed by FUCCI technology.
  Dolfi L, Ripa R, Antebi A, Valenzano DR, Cellerino A
  Evodevo 2019, 10, 29
  
• Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer.
  Drucker E, Holzer K, Pusch S, Winkler J, Calvisi DF, Eiteneuer E, Herpel E, Goeppert B, Roessler S, Ori A, Schirmacher P, Breuhahn K, Singer S
  Cell Commun Signal 2019, 17(1), 159
  
• Global importance of RNA secondary structures in protein coding sequences.
  Fricke M, Gerst R, Ibrahim B, Niepmann M, Marz M
  Bioinformatics 2019, 35(4), 579-83
  
• Profiling of gallbladder carcinoma reveals distinct miRNA profiles and activation of STAT1 by the tumor suppressive miRNA-145-5p.
  Goeppert B, Truckenmueller F, Ori A, Fritz V, Albrecht T, Fraas A, Scherer D, Silos RG, Sticht C, Gretz N, Mehrabi A, Bewerunge-Hudler M, Pusch S, Bermejo JL, Dietrich P, Schirmacher P, Renner M, Roessler S
  Sci Rep 2019, 9(1), 4796
  
• Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines.
  Guo T, Luna A, Rajapakse VN, Koh CC, Wu Z, Liu W, Sun Y, Gao H, Menden MP, Xu C, Calzone L, Martignetti L, Auwerx C, Buljan M, Banaei-Esfahani A, Ori A, Iskar M, Gillet L, Bi R, Zhang J, Zhang H, Yu C, Zhong Q, Varma S, Schmitt U, Qiu P, Zhang Q, Zhu Y, Wild PJ, Garnett MJ, Bork P, Beck M, Liu K, Saez-Rodriguez J, Elloumi F, Reinhold WC, Sander C, Pommier Y, Aebersold R
  iScience 2019, 21, 664-80
  
• Nucleoporin Nup155 is part of the p53 network in liver cancer.
  Holzer K, Ori A, Cooke A, Dauch D, Drucker E, Riemenschneider P, Andres-Pons A, DiGuilio AL, Mackmull MT, Baßler J, Roessler S, Breuhahn K, Zender L, Glavy JS, Dombrowski F, Hurt E, Schirmacher P, Beck M, Singer S
  Nat Commun 2019, 10(1), 2147
  
• Inverse resource allocation between vision and olfaction across the genus Drosophila.
  Keesey IW, Grabe V, Gruber L, Koerte S, Obiero GF, Bolton G, Khallaf MA, Kunert G, Lavista-Llanos S, Valenzano DR, Rybak J, Barrett BA, Knaden M, Hansson BS
  Nat Commun 2019, 10(1), 1162
  
• Transduction and transfection of difficult-to-transfect cells: Systematic attempts for the transfection of protozoa Leishmania.
  Keller AA, Scheiding B, Breitling R, Licht A, Hemmerich P, Lorkowski S, Reissmann S
  J Cell Biochem 2019, 120(1), 14-27
  
• Macaca arctoides gammaherpesvirus 1 (strain herpesvirus Macaca arctoides): virus sequence, phylogeny and characterisation of virus-transformed macaque and rabbit cell lines.
  Krumbholz A, Roempke J, Liehr T, Groth M, Meerbach A, Schacke M, Maschkowitz G, Fickenscher H, Klapper W, Sauerbrei A, Wutzler P, Zell R
  Med Microbiol Immunol 2019, 208(1), 109-29
  
• Comparison of protein quantification in a complex background by DIA and TMT workflows with fixed instrument time.
  Muntel* J, Kirkpatrick* J, Bruderer R, Huang T, Vitek O, Ori** A, Reiter** L
  J Proteome Res 2019, 18(3), 1340-51 * equal contribution, ** co-senior authors
  
• Metastatic-niche labelling reveals parenchymal cells with stem features.
  Ombrato L, Nolan E, Kurelac I, Mavousian A, Bridgeman VL, Heinze I, Chakravarty P, Horswell S, Gonzalez-Gualda E, Matacchione G, Weston A, Kirkpatrick J, Husain E, Speirs V, Collinson L, Ori A, Lee JH, Malanchi I
  Nature 2019, 572(7771), 603-8
  
• Disentangling Genetic and Environmental Effects on the Proteotypes of Individuals.
  Romanov N, Kuhn M, Aebersold R, Ori A, Beck M, Bork P
  Cell 2019, 177(5), 1308-18
  
• RB, p130 and p107 differentially repress G1/S and G2/M genes after p53 activation.
  Schade AE, Fischer M, DeCaprio JA
  Nucleic Acids Res 2019, 47(21), 11197-208
  
• Direct RNA nanopore sequencing of full-length coronavirus genomes provides novel insights into structural variants and enables modification analysis.
  Viehweger* A, Krautwurst* S, Lamkiewicz K, Madhugiri R, Ziebuhr J, Hölzer M, Marz M
  Genome Res 2019, 29(9), 1545-54 * equal contribution
  

Publications 2018:

• Whither systems medicine?
  Apweiler R, Beissbarth T, Berthold MR, Blüthgen N, Burmeister Y, Dammann O, Deutsch A, Feuerhake F, Franke A, Hasenauer J, Hoffmann S, Höfer T, Jansen PL, Kaderali L, Klingmüller U, Koch I, Kohlbacher O, Kuepfer L, Lammert F, Maier D, Pfeifer N, Radde N, Rehm M, Roeder I, Saez-Rodriguez J, Sax U, Schmeck B, Schuppert A, Seilheimer B, Theis FJ, Vera J, Wolkenhauer O
  Exp Mol Med 2018, 50(3), e453
  
• Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly.
  Aramillo Irizar P, Schäuble S, Esser D, Groth M, Frahm C, Priebe S, Baumgart M, Hartmann N, Marthandan S, Menzel U, Müller J, Schmidt S, Ast V, Caliebe A, König R, Krawczak M, Ristow M, Schuster S, Cellerino A, Diekmann S, Englert C, Hemmerich P, Sühnel J, Guthke R, Witte OW, Platzer M, Ruppin E, Kaleta C
  Nat Commun 2018, 9(1), 327
  
• SETD1A protects HSCs from activation-induced functional decline in vivo.
  Arndt K, Kranz A, Fohgrub J, Jolly A, Bledau AS, Di Virgilio M, Lesche M, Dahl A, Höfer T, Stewart AF, Waskow C
  Blood 2018, 131(12), 1311-24
  
• Kidney regeneration in fish.
  Bates T, Naumann U, Hoppe B, Englert C
  Int J Dev Biol 2018, 62(6-7-8), 419-29
  
• Analysis of lncRNA-Protein Interactions by RNA-Protein Pull-Down Assays and RNA Immunoprecipitation (RIP).
  Bierhoff H
  Methods Mol Biol 2018, 1686, 241-50
  
• Spatial tissue proteomics quantifies inter- and intra-tumor heterogeneity in hepatocellular carcinoma.
  Buczak* K, Ori* A, Kirkpatrick JM, Holzer K, Dauch D, Roessler S, Endris V, Lasitschka F, Parca L, Schmidt A, Zender L, Schirmacher P, Krijgsveld J, Singer** S, Beck** M
  Mol Cell Proteomics 2018, 17(4), 810-25 * equal contribution, ** co-corresponding authors
  
• Computational pan-genomics: status, promises and challenges.
  Computational PGC, Marschall T, Marz M, Abeel T, Dijkstra L, Dutilh BE, Ghaffaari A, Kersey P, Kloosterman WP, Mäkinen V, Novak AM, Paten B, Porubsky D, Rivals E, Alkan C, Baaijens JA, De Bakker PIW, Boeva V, Bonnal RJP, Chiaromonte F, Chikhi R, Ciccarelli FD, Cijvat R, Datema E, Van Duijn CM, Eichler EE, Ernst C, Eskin E, Garrison E, El-Kebir M, Klau GW, Korbel JO, Lameijer EW, Langmead B, Martin M, Medvedev P, Mu JC, Neerincx P, Ouwens K, Peterlongo P, Pisanti N, Rahmann S, Raphael B, Reinert K, de Ridder D, de Ridder J, Schlesner M, Schulz-Trieglaff O, Sanders AD, Sheikhizadeh S, Shneider C, Smit S, Valenzuela D, Wang J, Wessels L, Zhang Y, Guryev V, Vandin F, Ye K, Schönhuth A
  Brief Bioinform 2018, 19(1), 118-35
  
• Sequential use of milk and bovine serum albumin for streptavidin-probed western blot.
  Cui Y, Ma L
  Biotechniques 2018, 65(3), 125-6
  
• X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
  Dahms SO, Hardes K, Steinmetzer T, Than ME
  Biochemistry 2018, 57(6), 925-34
  
• Telomeric epigenetic response mediated by Gadd45a regulates stem cell aging and lifespan.
  Diao D, Wang H, Li T, Shi Z, Jin X, Sperka T, Zhu X, Zhang M, Yang F, Cong Y, Shen L, Zhan Q, Yan J, Song Z, Ju Z
  EMBO Rep 2018, 19(10), e45494
  
• A Protocol for Laboratory Housing of Turquoise Killifish (Nothobranchius furzeri).
  Dodzian J, Kean S, Seidel J, Valenzano DR
  J Vis Exp 2018
  
• DIEGO: Detection of Differential Alternative Splicing using Aitchison's Geometry.
  Doose G, Bernhart SH, Wagener R, Hoffmann S
  Bioinformatics 2018, 34(6), 1066-8
  
• Cellular and epigenetic drivers of stem cell ageing.
  Ermolaeva** M, Neri** F, Ori** A, Rudolph** KL
  Nat Rev Mol Cell Biol 2018, 19(9), 594-610 ** co-corresponding authors
  
• On the S-layer of Thermus thermophilus and the assembling of its main protein SlpA.
  Farci D, Farci SF, Esposito F, Tramontano E, Kirkpatrick J, Piano D
  Biochim Biophys Acta 2018, 1860(8), 1554-62
  
• 2016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis.
  Fisher MJ, Belzberg AJ, de Blank P, De Raedt T, Elefteriou F, Ferner RE, Giovannini M, Harris GJ, Kalamarides M, Karajannis MA, Kim A, Lázaro C, Le LQ, Li W, Listernick R, Martin S, Morrison H, Pasmant E, Ratner N, Schorry E, Ullrich NJ, Viskochil D, Weiss B, Widemann BC, Zhu Y, Bakker A, Serra E
  Am J Med Genet A 2018, 176(5), 1258-69
  
• Integrative analysis of differentially expressed genes and miRNAs predicts complex T3-mediated protective circuits in a rat model of cardiac ischemia reperfusion.
  Forini F, Nicolini G, Kusmic C, D'Aurizio R, Rizzo M, Baumgart M, Groth M, Doccini S, Iervasi G, Pitto L
  Sci Rep 2018, 8(1), 13870
  
• The eukaryotic linear motif resource - 2018 update.
  Gouw M, Michael S, Sámano-Sánchez H, Kumar M, Zeke A, Lang B, Bely B, Chemes LB, Davey NE, Deng Z, Diella F, Gürth CM, Huber AK, Kleinsorg S, Schlegel LS, Palopoli N, Roey KV, Altenberg B, Reményi A, Dinkel H, Gibson TJ
  Nucleic Acids Res 2018, 46(D1), D428-34
  
• Effects of allelic variations in the human Myxovirus resistance protein A on its antiviral activity.
  Graf L, Dick A, Sendker F, Barth E, Marz M, Daumke O, Kochs G
  J Biol Chem 2018, 293(9), 3056-72
  
• Molecular mechanisms of photoadaptation of photosystem I supercomplex of in an evolutionary cyanobacterial/algal intermediate.
  Haniewicz P, Abram M, Nosek L, Kirkpatrick J, El-Mohsnawy E, Janna Olmos JD, Kouril R, Kargul JM
  Plant Physiol 2018, 176(2), 1433-51
  
• Influence of Scribble polarity complex on hematopoiesis and leukemia - a matter of where, when and how.
  Heidel FH, Ellis S
  Oncotarget 2018, 9(78), 34642-3
  
• Managing myeloproliferative neoplasms evidence based on the ELN treatment recommendations 2018.
  Heidel FH, Gale RP, Hochhaus A
  Leukemia 2018, 32(5), 1055-6
  
• Conformational µ-conotoxin PIIIA isomers revisited: The impact of cysteine pairing on disulfide bond assignment and structure elucidation.
  Heimer P, Tietze AA, Bäuml CA, Resemann A, Mayer FJ, Suckau D, Ohlenschläger O, Tietze D, Imhof D
  Anal Chem 2018, 90(5), 3321-7
  
• Retinal S-opsin dominance in Ansell's mole-rats (Fukomys anselli) is a consequence of naturally low serum thyroxine.
  Henning Y, Mladěnková N, Burda H, Szafranski* K, Begall* S
  Sci Rep 2018, 8(1), 4337 * equal contribution
  
• The fate of ribosomal RNA genes in spontaneous polyploid dogrose hybrids (Rosa L. sect. Caninae (DC.) Ser.) exhibiting non-symmetrical meiosis.
  Herklotz V, Kovařík A, Lunerová J, Lippitsch S, Groth M, Ritz CM
  Plant J 2018, 94(1), 77-90
  
• sAPPβ and sAPPα increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Ca2+ homeostasis and CREB1-signaling
  Hesse R, von Einem B, Wagner F, Bott P, Schwanzar D, Jackson RJ, Föhr KJ, Lausser L, Kroker KS, Proepper C, Walther P, Kestler HA, Spires-Jones TL, Boeckers T, Rosenbrock H, von Arnim CAF
  Exp Neurol 2018, 304, 1-13
  
• Multiple roots of fruiting body formation in Amoebozoa.
  Hillmann F, Forbes G, Novohradská S, Ferling I, Riege K, Groth M, Westermann M, Marz M, Spaller T, Winckler T, Schaap P, Glöckner G
  Genome Biol Evol 2018, 10(2), 591-606
  
• Multimodal Light Microscopy Approaches to Reveal Structural and Functional Properties of Promyelocytic Leukemia Nuclear Bodies.
  Hoischen C, Monajembashi S, Weisshart K, Hemmerich P
  Front Oncol 2018, 8, 125
  
• CENP-C/H/I/K/M/T/W/N/L and hMis12 but not CENP-S/X participate in complex formation in the nucleoplasm of living human interphase cells outside centromeres.
  Hoischen* C, Yavas* S, Wohland T, Diekmann S
  PLoS One 2018, 13(3), e0192572 * equal contribution
  
• The microenvironment of naked mole-rat burrows in East Africa
  Holtze S, Braude S, Lemma A, Koch R, Morhart M, Szafranski K, Platzer M, Alemayehu F, Goeritz F, Hildebrandt TB
  Afr J Ecol 2018, 56(2), 279-89
  
• Virologists-Heroes need weapons.
  Hufsky F, Ibrahim B, Beer M, Deng L, Mercier PL, McMahon DP, Palmarini M, Thiel V, Marz M
  PLoS Pathog 2018, 14(2), e1006771
  
• 3D Network exploration and visualisation for lifespan data.
  Hühne* R, Kessler* V, Fürstberger* A, Kühlwein S, Platzer M, Sühnel J, Lausser L, Kestler HA
  BMC Bioinformatics 2018, 19(1), 390 * equal contribution
  
• Bioinformatics Meets Virology: The European Virus Bioinformatics Center's Second Annual Meeting.
  Ibrahim B, Arkhipova K, Andeweg AC, Posada-Céspedes S, Enault F, Gruber A, Koonin EV, Kupczok A, Lemey P, McHardy AC, McMahon DP, Pickett BE, Robertson DL, Scheuermann RH, Zhernakova A, Zwart MP, Schönhuth A, Dutilh BE, Marz M
  Viruses 2018, 10(5, 256; https://doi.org/10.33
  
• Synthesis and biochemical evaluation of two novel N-hydroxyalkylated cyclosporin A analogs.
  Kahlert V, Prell E, Ohlenschläger O, Melesina J, Schumann M, Lücke C, Fischer G, Malešević M
  Org Biomol Chem 2018, 16(23), 4338-49
  
• Big data and precision medicine: challenges and strategies with healthcare data
  Kraus JM, Lausser L, Kuhn P, Jobst F, Bock M, Halanke C, Hummel M, Heuschmann P, Kestler HA
  Int J Data Sci Anal 2018
  
• Mutational impact of culturing human pluripotent and adult stem cells.
  Kuijk E, Jager M, van der Roest B, Locati M, Van Hoeck A, Korzelius J, Janssen R, Besselink N, Boymans S, van Boxtel R, Cuppen E
  bioRxiv 2018, http://dx.doi.org/10.1101/430165
  
• The Influence of Multi-class Feature Selection on the Prediction of Diagnostic Phenotypes
  Lausser L, Szekely R, Schirra LR, Kestler HA
  Neural Process Lett 2018, 48(2), 863–880
  
• Deletion of Menin in craniofacial osteogenic cells in mice elicits development of mandibular ossifying fibroma.
  Lee S, Liu P, Teinturier R, Jakob J, Tschaffon M, Tasdogan A, Wittig R, Hoeller S, Baumhoer D, Frappart L, Vettorazzi S, Bertolino P, Zhang C, Tuckermann J
  Oncogene 2018, 37(5), 616-26
  
• Heat Shock Factor 1 Epigenetically Stimulates Glutaminase-1-Dependent mTOR Activation to Promote Colorectal Carcinogenesis.
  Li J, Song P, Jiang T, Dai D, Wang H, Sun J, Zhu L, Xu W, Feng L, Shin VY, Morrison H, Wang X, Jin H
  Mol Ther 2018, 26(7), 1828-39
  
• Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair.
  Lopez-Baez JC, Simpson DJ, LLeras Forero L, Zeng Z, Brunsdon H, Salzano A, Brombin A, Wyatt C, Rybski W, Huitema LFA, Dale RM, Kawakami K, Englert C, Chandra T, Schulte-Merker S, Hastie ND, Patton EE
  Elife 2018, 7, e30657
  
• Cystatin A suppresses tumor cell growth through inhibiting epithelial to mesenchymal transition in human lung cancer.
  Ma Y, Chen Y, Li Y, Grün K, Berndt A, Zhou Z, Petersen I
  Oncotarget 2018, 9(18), 14084-98
  
• Structural and functional conservation of cis-acting RNA elements in coronavirus 5'-terminal genome regions.
  Madhugiri R, Karl N, Petersen D, Lamkiewicz K, Fricke M, Wend U, Scheuer R, Marz M, Ziebuhr J
  Virology 2018, 517, 44-55
  
• Internal tandem duplication mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation.
  Marhäll A, Heidel F, Fischer T, Rönnstrand L
  Ann Hematol 2018, 97(5), 773-80
  
• The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing's sarcoma cell line.
  Marx C, Marx-Blümel L, Lindig N, Thierbach R, Hoelzer D, Becker S, Wittig S, Lehmann R, Slevogt H, Heinzel T, Wang ZQ, Beck JF, Sonnemann J
  Invest New Drugs 2018, 36(3), 396-406
  
• Reduced expression of C/EBPβ-LIP extends health- and lifespan in mice.
  Müller* C, Zidek* LM, Ackermann T, de Jong T, Liu P, Kliche V, Zaini MA, Kortman G, Harkema L, Verbeek DS, Tuckermann JP, von Maltzahn J, de Bruin A, Guryev V, Wang ZQ, Calkhoven CF
  Elife 2018, 7, e34985 * equal contribution
  
• Dispersion/reaggregation in early development of annual killifishes: Phylogenetic distribution and evolutionary significance of a unique feature.
  Naumann B, Englert C
  Dev Biol 2018, 442(1), 69-79
  
• Efficacy and safety of ruxolitinib in intermediate-1 IPSS risk myelofibrosis patients: Results from an independent study.
  Palandri F, Tiribelli M, Benevolo G, Tieghi A, Cavazzini F, Breccia M, Bergamaschi M, Sgherza N, Polverelli N, Crugnola M, Isidori A, Binotto G, Heidel FH, Buccisano F, Martino B, Latagliata R, Spinsanti M, Kallenberg L, Palumbo GA, Abruzzese E, Scaffidi L, Cuneo A, Cavo M, Vianelli N, Bonifacio M
  Hematol Oncol 2018, 36(1), 285-90
  
• Quantifying compartment-associated variations of protein abundance in proteomics data.
  Parca L, Beck M, Bork P, Ori A
  Mol Syst Biol 2018, 14(7), e8131
  
• Dysregulation of chemokine receptor expression and function in leukocytes from ALS patients.
  Perner C, Perner F, Stubendorff B, Förster M, Witte OW, Heidel FH, Prell T, Grosskreutz J
  J Neuroinflammation 2018, 15(1), 99
  
• The Pseudogenes of Barley.
  Prade VM, Gundlach H, Twardziok S, Chapman B, Tan C, Langridge P, Schulman AH, Stein N, Waugh R, Zhang G, Platzer M, Li C, Spannagl M, Mayer KFX
  Plant J 2018, 93(3), 502-14
  
• Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms.
  Prestipino A, Emhardt AJ, Aumann K, O'Sullivan D, Gorantla SP, Duquesne S, Melchinger W, Braun L, Vuckovic S, Boerries M, Busch H, Halbach S, Pennisi S, Poggio T, Apostolova P, Veratti P, Hettich M, Niedermann G, Bartholomä M, Shoumariyeh K, Jutzi JS, Wehrle J, Dierks C, Becker H, Schmitt-Graeff A, Follo M, Pfeifer D, Rohr J, Fuchs S, Ehl S, Hartl FA, Minguet S, Miething C, Heidel FH, Kröger N, Triviai I, Brummer T, Finke J, Illert AL, Ruggiero E, Bonini C, Duyster J, Pahl HL, Lane SW, Hill GR, Blazar BR, von Bubnoff N, Pearce EL, Zeiser R
  SCI TRANSL MED 2018, 10(429)
  
• Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity.
  Prigent J, Jarossay A, Planchais C, Eden C, Dufloo J, Kök A, Lorin V, Vratskikh O, Couderc T, Bruel T, Schwartz O, Seaman MS, Ohlenschläger** O, Dimitrov** JD, Mouquet** H
  Cell Rep 2018, 23(9), 2568-81 ** co-corresponding authors
  
• RBFOX2 and alternative splicing in B-cell lymphoma.
  Quentmeier H, Pommerenke C, Bernhart SH, Dirks WG, Hauer V, Hoffmann S, Nagel S, Siebert R, Uphoff CC, Zaborski M, Drexler HG, ICGC MMML-Seq Consortium
  Blood Cancer J 2018, 8(8), 77
  
• Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis.
  Ravichandran M, Priebe S, Grigolon G, Rozanov L, Groth M, Laube B, Guthke R, Platzer M, Zarse K, Ristow M
  Cell Metab 2018, 27(4), 914-25
  
• Haplotypes composed of minor frequency single nucleotide polymorphism of tnf gene protect from progression into sepsis: A study using the new sepsis classification.
  Retsas T, Huse K, Lazaridis LD, Karampela N, Bauer M, Platzer M, Kolonia V, Papageorgiou E, Giamarellos-Bourboulis EJ, Dimopoulos G
  Int J Infect Dis 2018, 67, 102-6
  
• Neuropathies in the setting of Neurofibromatosis tumor syndromes: Complexities and opportunities.
  Schulz A, Grafe P, Hagel C, Bäumer P, Morrison H, Mautner VF, Farschtschi S
  Exp Neurol 2018, 299(Pt B), 334-44
  
• The role of the gut microbiome during host ageing.
  Seidel J, Valenzano DR
  F1000Res 2018, 7
  
• Aspergillus fumigatus conidial metalloprotease Mep1p cleaves host complement proteins.
  Shende R, Wong SSW, Rapole S, Beau R, Ibrahim-Granet O, Monod M, Gührs KH, Pal JK, Latgé JP, Madan T, Aimanianda V, Sahu A
  J Biol Chem 2018, 293(40), 15538-55
  
• The Definition of Open Reading Frame Revisited.
  Sieber P, Platzer M, Schuster S
  Trends Genet 2018, 34(3), 167-70
  
• A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells.
  Siegle* L, Schwab* JD, Kühlwein* SD, Lausser L, Tümpel S, Pfister AS, Kühl** M, Kestler** HA
  PLoS One 2018, 13(3), e0195126 * equal contribution, ** co-senior authors
  
• LSD1 (KDM1A)-independent effects of the LSD1 inhibitor SP2509 in cancer cells.
  Sonnemann J, Zimmermann M, Marx C, Ebert F, Becker S, Lauterjung ML, Beck JF
  Br J Haematol 2018, 183(4), 494-7
  
• The microRNA miR-21 Is a Mediator of FGF8 Action on Cortical COUP-TFI Translation.
  Terrigno M, Bertacchi M, Pandolfini L, Baumgart M, Calvello M, Cellerino A, Studer M, Cremisi F
  Stem Cell Reports 2018, 11(3), 756-69
  
• Neurofibromatosis type 2 tumor suppressor protein is expressed in oligodendrocytes and regulates cell proliferation and process formation.
  Toledo* A, Grieger* E, Karram K, Morrison H, Baader SL
  PLoS One 2018, 13(5), e0196726 * equal contribution
  
• Induction chemoradiotherapy versus induction chemotherapy for potentially resectable stage IIIA (N2) non-small cell lung cancer: a systematic review and meta-analysis.
  Tong S, Qin Z, Wan M, Zhang L, Cui Y, Yao Y
  J Thorac Dis 2018, 10(4), 2428-36
  
• Rapidly evolving changes and gene loss associated with host switching in Corynebacterium pseudotuberculosis.
  Viana MVC, Sahm A, Góes Neto A, Figueiredo HCP, Wattam AR, Azevedo V
  PLoS One 2018, 13(11), e0207304
  
• A subset of chemosensory genes differs between two populations of a specialized leaf beetle after host plant shift.
  Wang D, Pentzold S, Kunert M, Groth M, Brandt W, Pasteels JM, Boland W, Burse A
  Ecol Evol 2018, 8(16), 8055-75
  
• NUFIP1 is a ribosome receptor for starvation-induced ribophagy.
  Wyant* GA, Abu-Remaileh* M, Frenkel EM, Laqtom NN, Dharamdasani V, Lewis CA, Chan SH, Heinze I, Ori** A, Sabatini** DM
  Science 2018, 360(6390), 751-8 * equal contribution, ** co-corresponding authors
  

Publications 2017:

• Common Fibril Structures Imply Systemically Conserved Protein Misfolding Pathways In Vivo.
  Annamalai K, Liberta F, Vielberg MT, Close W, Lilie H, Gührs KH, Schierhorn A, Koehler R, Schmidt A, Haupt C, Hegenbart U, Schönland S, Schmidt M, Groll M, Fändrich M
  Angew Chem Int Ed Engl 2017, 56(26), 7510-4
  
• Mutations in NOTCH1 PEST domain orchestrate CCL19-driven homing of chronic lymphocytic leukemia cells by modulating the tumor suppressor gene DUSP22.
  Arruga F, Gizdic B, Bologna C, Cignetto S, Buonincontri R, Serra S, Vaisitti T, Gizzi K, Vitale N, Garaffo G, Mereu E, Diop F, Neri F, Incarnato D, Coscia M, Allan J, Piva R, Oliviero S, Furman RR, Rossi D, Gaidano G, Deaglio S
  Leukemia 2017, 31(9), 1882-93 published during change of institution
  
• PD-L1 up-regulation in melanoma increases disease aggressiveness and is mediated through miR-17-5p.
  Audrito V, Serra S, Stingi A, Orso F, Gaudino F, Bologna C, Neri F, Garaffo G, Nassini R, Baroni G, Rulli E, Massi D, Oliviero S, Piva R, Taverna D, Mandalà M, Deaglio S
  Oncotarget 2017, 8(9), 15894-911 published during change of institution
  
• Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma.
  Barth TFE, Kraus JM, Lausser L, Flossbach L, Schulte L, Holzmann K, Kestler** HA, Möller** P
  Sci Rep 2017, 7(1), 5963 ** co-senior authors
  
• Construction of a map-based reference genome sequence for barley, Hordeum vulgare L.
  Beier S, Himmelbach A, Colmsee C, Zhang XQ, Barrero RA, Zhang Q, Li L, Bayer M, Bolser D, Taudien S, Groth M, Felder M, Hastie A, Šimková H, Staňková H, Vrána J, Chan S, Muñoz-Amatriaín M, Ounit R, Wanamaker S, Schmutzer T, Aliyeva-Schnorr L, Grasso S, Tanskanen J, Sampath D, Heavens D, Cao S, Chapman B, Dai F, Han Y, Li H, Li X, Lin C, McCooke JK, Tan C, Wang S, Yin S, Zhou G, Poland JA, Bellgard MI, Houben A, Doležel J, Ayling S, Lonardi S, Langridge P, Muehlbauer GJ, Kersey P, Clark MD, Caccamo M, Schulman AH, Platzer M, Close TJ, Hansson M, Zhang G, Braumann I, Li C, Waugh R, Scholz U, Stein N, Mascher M
  Sci Data 2017, 4, 170044
  
• Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly.
  Bianchi FT, Tocco C, Pallavicini G, Liu Y, Vernì F, Merigliano C, Bonaccorsi S, El-Assawy N, Priano L, Gai M, Berto GE, Chiotto AMA, Sgrò F, Caramello A, Tasca L, Ala U, Neri F, Oliviero S, Mauro A, Geley S, Gatti M, Di Cunto F
  Cell Rep 2017, 18(7), 1674-86 published during change of institution
  
• Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome.
  Binder H, Hopp L, Schweiger MR, Hoffmann S, Jühling F, Kerick M, Timmermann B, Siebert S, Grimm C, Nersisyan L, Arakelyan A, Herberg M, Buske P, Loeffler-Wirth H, Rosolowski M, Engel C, Przybilla J, Peifer M, Friedrichs N, Moeslein G, Odenthal M, Hussong M, Peters S, Holzapfel S, Nattermann J, Hueneburg R, Schmiegel W, Royer-Pokora B, Aretz S, Kloth M, Kloor M, Buettner R, Galle J, Loeffler M
  J Pathol 2017
  
• Repeated intra-specific divergence in lifespan and ageing of African annual fishes along an aridity gradient.
  Blažek R, Polačik M, Kačer P, Cellerino A, Řežucha R, Methling C, Tomášek O, Syslová K, Tozzini ET, Albrecht T, Vrtílek M, Reichard M
  Evolution Int J Org Evolution 2017, 71(2), 386-402
  
• Toxic effects of zinc ions on kinesin - Potential molecular cause of impaired intracellular transport.
  Böhm KJ
  Toxicol Lett 2017, 268, 58-62
  
• DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats.
  Brocks D, Schmidt CR, Daskalakis M, Jang HS, Shah NM, Li D, Li J, Zhang B, Hou Y, Laudato S, Lipka DB, Schott J, Bierhoff H, Assenov Y, Helf M, Ressnerova A, Islam MS, Lindroth AM, Haas S, Essers M, Imbusch CD, Brors B, Oehme I, Witt O, Lübbert M, Mallm JP, Rippe K, Will R, Weichenhan D, Stoecklin G, Gerhäuser C, Oakes CC, Wang T, Plass C
  Nat Genet 2017, 49(7), 1052-60 published during change of institution
  
• Renal regenerative potential of different extra-cellular vesicle populations derived from bone marrow mesenchymal stromal cells.
  Bruno S, Tapparo M, Collino F, Chiabotto G, Deregibus MC, Soares Lindoso R, Neri F, Kholia S, Giunti S, Wen S, Quesenberry P, Camussi G
  TISSUE ENG PART A 2017, 23(21-22), 1262-73
  
• Ordinal Prototype-Based Classifiers
  Burkovski A, Schirra LR, Schmid F, Lausser L, Kestler HA
  Data Science Series A (Online-First) 2017, 2/1(http://dx.doi.org/10.5445/KS
  
• What have we learned on aging from omics studies?
  Cellerino A, Ori A
  Semin Cell Dev Biol 2017, 70, 177-89
  
• MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.
  Chen Y, Anastassiadis K, Kranz A, Stewart AF, Arndt K, Waskow C, Yokoyama A, Jones K, Neff T, Lee Y, Ernst P
  Cancer Cell 2017, 31(6), 755-770.e6
  
• New insights into the operative network of FaEO, an enone oxidoreductase from Fragaria x ananassa Duch.
  Collu G, Farci D, Esposito F, Pintus F, Kirkpatrick J, Piano D
  Plant Mol Biol 2017, 94(1-2), 125-36
  
• HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development.
  Connell M, Chen H, Jiang J, Kuan CW, Fotovati A, Chu T, He Z, Lengyell TC, Li H, Kroll T, Li AM, Goldowitz D, Frappart L, Ploubidou A, Patel M, Pilarski LM, Simpson EM, Lange P, Allan DW, Maxwell CA
  Elife 2017, 6, e28672
  
• Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.
  Dahms SO, Jiao** GS, Than** ME
  ACS Chem Biol 2017, 12(5), 1211-6 ** co-corresponding authors
  
• Architecture of the yeast Elongator complex.
  Dauden MI, Kosinski J, Kolaj-Robin O, Desfosses A, Ori A, Faux C, Hoffmann NA, Onuma OF, Breunig KD, Beck M, Sachse C, Séraphin B, Glatt S, Müller CW
  EMBO Rep 2017, 18(2), 264-79
  
• Raman and Infrared Spectroscopy Distinguishing Replicative Senescent from Proliferating Primary Human Fibroblast Cells by Detecting Spectral Differences Mainly Due to Biomolecular Alterations.
  Eberhardt K, Beleites C, Marthandan S, Matthäus C, Diekmann S, Popp J
  Anal Chem 2017, 89(5), 2937-47
  
• Raman and infrared spectroscopy differentiate senescent from proliferating cells in a human dermal fibroblast 3D skin model.
  Eberhardt K, Matthäus C, Winter D, Wiegand C, Hipler UC, Diekmann S, Popp J
  Analyst 2017, 142(23), 4405-14
  
• Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models.
  Evsyukov V, Domanskyi A, Bierhoff H, Gispert S, Mustafa R, Schlaudraff F, Liss B, Parlato R
  Dis Model Mech 2017, 10(5), 633-43
  
• A new procedure for a fast soft staining of BN-PAGEs on photosynthetic complexes.
  Farci D, Kirkpatrick J, Piano D
  Electrophoresis 2017, 38(3-4), 441-6
  
• Transcriptional profiling reveals protective mechanisms in brains of long-lived mice.
  Frahm C, Srivastava A, Schmidt S, Mueller J, Groth M, Guenther M, Ji Y, Priebe S, Platzer M, Witte OW
  Neurobiol Aging 2017, 52, 23-31
  
• Evolution and antiviral specificity of interferon-induced Mx proteins of bats against Ebola-, Influenza-, and other RNA viruses.
  Fuchs J, Hölzer M, Schilling M, Patzina C, Schoen A, Hoenen T, Zimmer G, Marz M, Weber F, Müller MA, Kochs G
  J Virol 2017, 91(15), e00361-17
  
• microRNA-122 target sites in the hepatitis C virus RNA NS5B coding region and 3' untranslated region: function in replication and influence of RNA secondary structure.
  Gerresheim GK, Dünnes N, Nieder-Röhrmann A, Shalamova LA, Fricke M, Hofacker I, Höner Zu Siederdissen C, Marz M, Niepmann M
  Cell Mol Life Sci 2017, 74(4), 747-60
  
• RSK-mediated nuclear accumulation of the cold-shock Y-box protein-1 controls proliferation of T cells and T-ALL blasts.
  Gieseler-Halbach S, Meltendorf S, Pierau M, Weinert S, Heidel FH, Fischer T, Handschuh J, Braun-Dullaeus RC, Schrappe M, Lindquist JA, Mertens PR, Thomas U, Brunner-Weinzierl MC
  Cell Death Differ 2017, 24(2), 371-83
  
• Exploring Short Linear Motifs Using the ELM Database and Tools.
  Gouw M, Sámano-Sánchez H, Van Roey K, Diella F, Gibson TJ, Dinkel H
  Curr Protoc Bioinformatics 2017, 58, 8.22.1-8.22.35
  
• Combined microRNA and mRNA microfluidic TaqMan array cards for the diagnosis of malignancy of multiple types of pancreatico-biliary tumors in fine-needle aspiration material.
  Gress* TM, Lausser* L, Schirra LR, Ortmüller L, Diels R, Kong B, Michalski CW, Hackert T, Strobel O, Giese NA, Schenk M, Lawlor RT, Scarpa A, Kestler** HA, Buchholz** M
  Oncotarget 2017, 8(64), 108223-37 * equal contribution, ** co-senior authors
  
• Manipulation of cells with laser microbeam scissors and optical tweezers: a review.
  Greulich KO
  Rep Prog Phys 2017, 80(2), 026601
  
• The RNA workbench: best practices for RNA and high-throughput sequencing bioinformatics in Galaxy.
  Grüning BA, Fallmann J, Yusuf D, Will S, Erxleben A, Eggenhofer F, Houwaart T, Batut B, Videm P, Bagnacani A, Wolfien M, Lott SC, Hoogstrate Y, Hess WR, Wolkenhauer O, Hoffmann S, Akalin A, Ohler U, Stadler PF, Backofen R
  Nucleic Acids Res 2017, 45(W1), W560–W566
  
• JAK2-V617F activates β1-integrin-mediated adhesion of granulocytes to vascular cell adhesion molecule 1 (VCAM1).
  Gupta* N, Edelmann* B, Schnoeder TM, Saalfeld FC, Wolleschak D, Kliche S, Schraven B, Heidel** FH, Fischer** T
  Leukemia 2017, 31(5), 1223-6 * equal contribution, ** co-senior authors
  
• mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance.
  Haller S, Kapuria S, Riley RR, O'Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H
  Cell Stem Cell 2017, 21(6), 806-818.e5
  
• Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice.
  Hartmann K, Illing A, Leithäuser F, Baisantry A, Quintanilla-Martinez L, Rudolph KL
  Leukemia 2017, 31(12), 2853 Erratum for Leukemia 2016 volume 30 page 749
  
• Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health.
  Heid* J, Cencioni* C, Ripa* R, Baumgart* M, Atlante S, Milano G, Scopece A, Kuenne C, Guenther S, Azzimato V, Farsetti A, Rossi G, Braun T, Pompilio G, Martelli F, Zeiher AM, Cellerino** A, Gaetano** C, Spallotta** F
  Sci Rep 2017, 7(1), 16839 * equal contribution, ** co-senior authors
  
• ADAM Metalloprotease-Released Cancer Biomarkers.
  Herrlich P, Herrlich A
  Trends Cancer 2017, 3(7), 482-90
  
• Protein phosphatase 4 regulatory subunit 2 (PPP4R2) is recurrently deleted in acute myeloid leukemia and required for efficient DNA double strand break repair.
  Herzig JK, Bullinger L, Tasdogan A, Zimmermann P, Schlegel M, Teleanu V, Weber D, Rücker FG, Paschka P, Dolnik A, Schneider E, Kuchenbauer F, Heidel FH, Buske C, Döhner H, Döhner K, Gaidzik VI
  Oncotarget 2017, 8(56), 95038-53
  
• Reduced cGMP levels in CSF of AD patients correlate with severity of dementia and current depression.
  Hesse R, Lausser L, Gummert P, Schmid F, Wahler A, Schnack C, Kroker KS, Otto M, Tumani H, Kestler** HA, Rosenbrock** H, von Arnim** CAF
  Alzheimers Res Ther 2017, 9(1), 17 ** co-corresponding authors
  
• XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia.
  Hoch NC, Hanzlikova H, Rulten SL, Tétreault M, Komulainen E, Ju L, Hornyak P, Zeng Z, Gittens W, Rey SA, Staras K, Mancini GMS, McKinnon PJ, Wang ZQ, Wagner JD, Care4Rare Canada Consortium, Yoon G, Caldecott KW
  Nature 2017, 541(7635), 87-91
  
• Trifunctional lipid probes for comprehensive studies of single lipid species in living cells.
  Höglinger D, Nadler A, Haberkant P, Kirkpatrick J, Schifferer M, Stein F, Hauke S, Porter FD, Schultz C
  Proc Natl Acad Sci U S A 2017, 114(7), 1566-71
  
• Proteomic Analysis Reveals GMP Synthetase as p53 Repression Target in Liver Cancer.
  Holzer K, Drucker E, Roessler S, Dauch D, Heinzmann F, Waldburger N, Eiteneuer EM, Herpel E, Breuhahn K, Zender L, Schirmacher P, Ori A, Singer S
  Am J Pathol 2017, 187(2), 228-35
  
• Corrigendum: Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells.
  Hölzer M, Krähling V, Amman F, Barth E, Bernhart SH, Carmelo VAO, Collatz M, Doose G, Eggenhofer F, Ewald J, Fallmann J, Feldhahn LM, Fricke M, Gebauer J, Gruber AJ, Hufsky F, Indrischek H, Kanton S, Linde J, Mostajo N, Ochsenreiter R, Riege K, Rivarola-Duarte L, Sahyoun AH, Saunders SJ, Seemann SE, Tanzer A, Vogel B, Wehner S, Wolfinger MT, Backofen R, Gorodkin J, Grosse I, Hofacker I, Hoffmann S, Kaleta C, Stadler PF, Becker S, Marz M
  Sci Rep 2017, 7, 39421 Erratum for Sci Rep 2016 volume 6 page 34589
  
• Software Dedicated to Virus Sequence Analysis "Bioinformatics Goes Viral".
  Hölzer M, Marz M
  In: Advances in Virus Research (edited by Beer M, Höper D) 2017, 99, 233-257, Academic Press, London
  
• PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells.
  Hsieh MH, Chen YT, Chen YT, Lee YH, Lu J, Chien CL, Chen HF, Ho HN, Yu CJ, Wang ZQ, Teng SC
  Nucleic Acids Res 2017, 45(18), 10492-503
  
• High-throughput single-base resolution mapping of RNA 2'-O-methylated residues.
  Incarnato D, Anselmi F, Morandi E, Neri F, Maldotti M, Rapelli S, Parlato C, Basile G, Oliviero S
  Nucleic Acids Res 2017, 45(3), 1433–1441 published during change of institution
  
• Optimization of Substrate-Analogue Furin Inhibitors.
  Ivanova T, Hardes K, Kallis S, Dahms SO, Than ME, Künzel S, Böttcher-Friebertshäuser E, Lindberg I, Jiao GS, Bartenschlager R, Steinmetzer T
  ChemMedChem 2017, 12(23), 1953-68
  
• OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.
  Jung LA, Gebhardt A, Koelmel W, Ade CP, Walz S, Kuper J, von Eyss B, Letschert S, Redel C, d'Artista L, Biankin A, Zender L, Sauer M, Wolf E, Evan G, Kisker C, Eilers M
  Oncogene 2017, 36(14), 1911-24 published during change of institution
  
• Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays.
  Kaspar M, Bohn-Wippert K, Bellstedt P, Häfner S, Görlach M, Sauerbrei A
  J Virol Methods 2017, 247, 51-7
  
• Differential Effects of Vitamins A and D on the Transcriptional Landscape of Human Monocytes during Infection.
  Klassert TE, Bräuer J, Hölzer M, Stock M, Riege K, Zubiría-Barrera C, Müller MM, Rummler S, Skerka C, Marz M, Slevogt H
  Sci Rep 2017, 7, 40599
  
• Developmental stage-dependent regulation of spine formation by calcium-calmodulin-dependent protein kinase IIα and Rap1.
  Koeberle SC, Tanaka S, Kuriu T, Iwasaki H, Koeberle A, Schulz A, Helbing DL, Yamagata Y, Morrison H, Okabe S
  Sci Rep 2017, 7(1), 13409
  
• Verification and characterization of an alternative low density lipoprotein receptor-related protein 1 splice variant.
  Kolb M, Kurz S, Schäfer A, Huse K, Dietz A, Wichmann G, Birkenmeier G
  PLoS One 2017, 12(6), e0180354
  
• BAT: Bisulfite Analysis Toolkit: BAT is a toolkit to analyze DNA methylation sequencing data accurately and reproducibly. It covers standard processing and analysis steps from raw read mapping up to annotation data integration and calculation of correlati
  Kretzmer H, Otto C, Hoffmann S
  F1000Res 2017, 1490
  
• Genome Sequence of a Novel Picorna-Like RNA Virus from Feces of the Antarctic Fur Seal (Arctocephalus gazella).
  Krumbholz A, Groth M, Esefeld J, Peter HU, Zell R
  Genome Announc 2017, 5(36)
  
• The anti-tumorigenic activity of A2M-A lesson from the naked mole-rat.
  Kurz S, Thieme R, Amberg R, Groth M, Jahnke HG, Pieroh P, Horn LC, Kolb M, Huse K, Platzer M, Volke D, Dehghani F, Buzdin A, Engel K, Robitzki A, Hoffmann R, Gockel I, Birkenmeier G
  PLoS One 2017, 12(12), e0189514
  
• Hacking the stem cell niche.
  Lane SW, Heidel FH
  Blood 2017, 129(22), 2951-2
  
• Ustilago maydis effectors and their impact on virulence.
  Lanver D, Tollot M, Schweizer G, Lo Presti L, Reissmann S, Ma LS, Schuster M, Tanaka S, Liang L, Ludwig N, Kahmann R
  Nat Rev Microbiol 2017, 15(7), 409-21
  
• Spindle Misorientation of Cerebral and Cerebellar Progenitors Is a Mechanistic Cause of Megalencephaly.
  Li H, Kroll T, Moll J, Frappart L, Herrlich P, Heuer H, Ploubidou A
  Stem Cell Reports 2017, 9(4), 1071-80
  
• The E3 ubiquitin ligase APC/C(C)(dh1) degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis.
  Liu X, Zong W, Li T, Wang Y, Xu X, Zhou** ZW, Wang** ZQ
  EMBO J 2017, 36(24), 3666-81 ** co-corresponding authors
  
• Customized workflow development and data modularization concepts for RNA-Sequencing and metatranscriptome experiments.
  Lott SC, Wolfien M, Riege K, Bagnacani A, Wolkenhauer O, Hoffmann S, Hess WR
  J Biotechnol 2017
  
• Generalized enhanced suffix array construction in external memory.
  Louza FA, Telles GP, Hoffmann S, Ciferri CDA
  Algorithms Mol Biol 2017, 12, 26
  
• Landscape of nuclear transport receptor cargo specificity.
  Mackmull MT, Klaus B, Heinze I, Chokkalingam M, Beyer A, Russell RB, Ori** A, Beck** M
  Mol Syst Biol 2017, 13(12), 962 ** co-corresponding authors, highlighted in the “Principle of Systems Biology” - Cell Systems 6 - 2018
  
• A chromosome conformation capture ordered sequence of the barley genome.
  Mascher M, Gundlach H, Himmelbach A, Beier S, Twardziok SO, Wicker T, Radchuk V, Dockter C, Hedley PE, Russell J, Bayer M, Ramsay L, Liu H, Haberer G, Zhang XQ, Zhang Q, Barrero RA, Li L, Taudien S, Groth M, Felder M, Hastie A, Šimková H, Staňková H, Vrána J, Chan S, Muñoz-Amatriaín M, Ounit R, Wanamaker S, Bolser D, Colmsee C, Schmutzer T, Aliyeva-Schnorr L, Grasso S, Tanskanen J, Chailyan A, Sampath D, Heavens D, Clissold L, Cao S, Chapman B, Dai F, Han Y, Li H, Li X, Lin C, McCooke JK, Tan C, Wang P, Wang S, Yin S, Zhou G, Poland JA, Bellgard MI, Borisjuk L, Houben A, Doležel J, Ayling S, Lonardi S, Kersey P, Langridge P, Muehlbauer GJ, Clark MD, Caccamo M, Schulman AH, Mayer KFX, Platzer M, Close TJ, Scholz U, Hansson M, Zhang G, Braumann I, Spannagl M, Li C, Waugh R, Stein N
  Nature 2017, 544(7651), 427-33
  
• A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence.
  Meyer P, Maity P, Burkovski A, Schwab J, Müssel C, Singh K, Ferreira FF, Krug L, Maier HJ, Wlaschek M, Wirth T, Kestler** HA, Scharffetter-Kochanek** K
  PLoS Comput Biol 2017, 13(12), e1005741 ** co-corresponding authors
  
• Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity.
  Mindos T, Dun XP, North K, Doddrell RDS, Schulz A, Edwards P, Russell J, Gray B, Roberts SL, Shivane A, Mortimer G, Pirie M, Zhang N, Pan D, Morrison H, Parkinson DB
  J Cell Biol 2017, 216(2), 495-510
  
• Central nervous system involvement in acute lymphoblastic leukemia is mediated by vascular endothelial growth factor.
  Münch V, Trentin L, Herzig J, Demir S, Seyfried F, Kraus JM, Kestler HA, Köhler R, Barth TFE, Te Kronnie G, Debatin KM, Meyer LH
  Blood 2017, 130(5), 643-54
  
• Intragenic DNA methylation prevents spurious transcription initiation.
  Neri F, Rapelli S, Krepelova A, Incarnato D, Parlato C, Basile G, Maldotti M, Anselmi F, Oliviero S
  Nature 2017, 543(7643), 72-7
  
• Rejuvenating Strategies for Stem Cell-Based Therapies in Aging.
  Neves J, Sousa-Victor P, Jasper H
  Cell Stem Cell 2017, 20(2), 161-75
  
• Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
  Pein* H, Koeberle* SC, Voelkel M, Schneider F, Rossi A, Thürmer M, Loeser K, Sautebin L, Morrison H, Werz O, Koeberle A
  FASEB J 2017, 31(10), 4566-77 * equal contribution
  
• The DNA Methyltransferase 1 (DNMT1) Controls the Shape and Dynamics of Migrating POA-Derived Interneurons Fated for the Murine Cerebral Cortex.
  Pensold D, Symmank J, Hahn A, Lingner T, Salinas-Riester G, Downie BR, Ludewig F, Rotzsch A, Haag N, Andreas N, Schubert K, Hübner CA, Pieler T, Zimmer G
  Cereb Cortex 2017, 27, 5696-714
  
• N-Heterocyclic (4-Phenylpiperazin-1-yl)methanones Derived from Phenoxazine and Phenothiazine as Highly Potent Inhibitors of Tubulin Polymerization.
  Prinz H, Ridder AK, Vogel K, Böhm KJ, Ivanov I, Ghasemi J, Aghaee E, Müller K:
  J Med Chem 2017, 60(2), 749-66
  
• Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.
  Ranjan S, Goihl A, Kohli S, Gadi I, Pierau M, Shahzad K, Gupta D, Bock F, Wang H, Shaikh H, Kähne T, Reinhold D, Bank U, Zenclussen AC, Niemz J, Schnöder TM, Brunner-Weinzierl M, Fischer T, Kalinski T, Schraven B, Luft T, Huehn J, Naumann M, Heidel FH, Isermann B
  Nat Commun 2017, 8(1), 311
  
• Mitochondrial BAX Determines the Predisposition to Apoptosis in Human AML.
  Reichenbach F, Wiedenmann C, Schalk E, Becker D, Funk K, Scholz-Kreisel P, Todt F, Wolleschak D, Döhner K, Marquardt** JU, Heidel** F, Edlich** F
  Clin Cancer Res 2017, 23(16), 4805-16 ** co-corresponding authors
  
• Alternative splicing of SMPD1 coding for acid sphingomyelinase in major depression.
  Rhein C, Reichel M, Kramer M, Rotter A, Lenz B, Mühle C, Gulbins E, Kornhuber J
  J Affect Disord 2017, 209, 10-5
  
• Central immune tolerance depends on crosstalk between the classical and alternative NF-κB pathways in medullary thymic epithelial cells.
  Riemann M, Andreas N, Fedoseeva M, Meier E, Weih D, Freytag H, Schmidt-Ullrich R, Klein U, Wang ZQ, Weih F
  J Autoimmun 2017, 81, 56-67
  
• MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging.
  Ripa R, Dolfi L, Terrigno M, Pandolfini L, Savino A, Arcucci V, Groth M, Terzibasi Tozzini E, Baumgart M, Cellerino A
  BMC Biol 2017, 15(1), 9
  
• Pomalidomide in myeloproliferative neoplasm-associated myelofibrosis.
  Schlenk RF, Stegelmann F, Reiter A, Jost E, Gattermann N, Hebart H, Waller C, Hochhaus A, Platzbecker U, Schafhausen P, Blau IW, Verbeek W, Heidel FH, Werner M, Kreipe H, Teleanu V, Benner A, Döhner H, Grießhammer M, Döhner K
  Leukemia 2017, 31(4), 889-95
  
• Macrophage's little helper: vitamin A directs alternatively activated monocyte-derived macrophages to tissue-resident macrophages.
  Schlüter D, Heidel FH
  Cell Mol Immunol 2017, 14(10), 805-8
  
• The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase.
  Schneble N, Müller J, Kliche S, Bauer R, Wetzker R, Böhmer FD, Wang ZQ, Müller JP
  Glia 2017, 65(2), 416-28
  
• Phosphoinositide 3-kinase γ ties chemoattractant- and adrenergic control of microglial motility.
  Schneble N, Schmidt C, Bauer R, Müller JP, Monajembashi S, Wetzker R
  Mol Cell Neurosci 2017, 78, 1-8
  
• Cell autonomous expression of CXCL-10 in JAK2V617F-mutated MPN.
  Schnöder TM, Eberhardt J, Koehler M, Bierhoff HB, Weinert S, Pandey AD, Nimmagadda SC, Wolleschak D, Jöhrens K, Fischer T, Heidel FH
  J Cancer Res Clin Oncol 2017, 143(5), 807-20
  
• Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells.
  Schreck C, Istvánffy R, Ziegenhain C, Sippenauer T, Ruf F, Henkel L, Gärtner F, Vieth B, Florian MC, Mende N, Taubenberger A, Prendergast Á, Wagner A, Pagel C, Grziwok S, Götze KS, Guck J, Dean DC, Massberg S, Essers M, Waskow C, Geiger H, Schiemann M, Peschel C, Enard W, Oostendorp RAJ
  J Exp Med 2017, 214(1), 165-81
  
• ViSiBooL - visualization and simulation of Boolean networks with temporal constraints.
  Schwab J, Burkovski A, Siegle L, Müssel** C, Kestler** HA
  Bioinformatics 2017, 33(4), 601-4 ** co-senior authors
  
• Stability of Signaling Pathways during Aging-A Boolean Network Approach.
  Schwab JD, Siegle L, Kühlwein SD, Kühl M, Kestler HA
  Biology (Basel) 2017, 6(4)
  
• An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.
  Scott RA, Scott LJ, Mägi R, Marullo L, Gaulton KJ, Kaakinen M, Pervjakova N, Pers TH, Johnson AD, Eicher JD, Jackson AU, Ferreira T, Lee Y, Ma C, Steinthorsdottir V, Thorleifsson G, Qi L, Van Zuydam NR, Mahajan A, Chen H, Almgren P, Voight BF, Grallert H, Müller-Nurasyid M, Ried JS, Rayner WN, Robertson N, Karssen LC, van Leeuwen EM, Willems SM, Fuchsberger C, Kwan P, Teslovich TM, Chanda P, Li M, Lu Y, Dina C, Thuillier D, Yengo L, Jiang L, Sparso T, Kestler HA, Chheda H, Eisele L, Gustafsson S, Frånberg M, Strawbridge RJ, Benediktsson R, Hreidarsson AB, Kong A, Sigurðsson G, Kerrison ND, Luan J, Liang L, Meitinger T, Roden M, Thorand B, Esko T, Mihailov E, Fox C, Liu CT, Rybin D, Isomaa B, Lyssenko V, Tuomi T, Couper DJ, Pankow JS, Grarup N, Have CT, Jørgensen ME, Jørgensen T, Linneberg A, Cornelis MC, van Dam RM, Hunter DJ, Kraft P, Sun Q, Edkins S, Owen KR, Perry JR, Wood AR, Zeggini E, Tajes-Fernandes J, Abecasis GR, Bonnycastle LL, Chines PS, Stringham HM, Koistinen HA, Kinnunen L, Sennblad B, Mühleisen TW, Nöthen MM, Pechlivanis S, Baldassarre D, Gertow K, Humphries SE, Tremoli E, Klopp N, Meyer J, Steinbach G, Wennauer R, Eriksson JG, Mӓnnistö S, Peltonen L, Tikkanen E, Charpentier G, Eury E, Lobbens S, Gigante B, Leander K, McLeod O, Bottinger EP, Gottesman O, Ruderfer D, Blüher M, Kovacs P, Tonjes A, Maruthur NM, Scapoli C, Erbel R, Jöckel KH, Moebus S, de Faire U, Hamsten A, Stumvoll M, Deloukas P, Donnelly PJ, Frayling TM, Hattersley AT, Ripatti S, Salomaa V, Pedersen NL, Boehm BO, Bergman RN, Collins FS, Mohlke KL, Tuomilehto J, Hansen T, Pedersen O, Barroso I, Lannfelt L, Ingelsson E, Lind L, Lindgren CM, Cauchi S, Froguel P, Loos RJ, Balkau B, Boeing H, Franks PW, Gurrea AB, Palli D, van der Schouw YT, Altshuler D, Groop LC, Langenberg C, Wareham NJ, Sijbrands E, van Duijn CM, Florez JC, Meigs JB, Boerwinkle E, Gieger C, Strauch K, Metspalu A, Morris AD, Palmer CN, Hu FB, Thorsteinsdottir U, Stefansson K, Dupuis J, Morris AP, Boehnke M, McCarthy MI, Prokopenko I, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
  Diabetes 2017, 66(11), 2888-902
  
• Regulation of life span by the gut microbiota in the short-lived African turquoise killifish.
  Smith P, Willemsen D, Popkes M, Metge F, Gandiwa E, Reichard M, Valenzano DR
  Elife 2017, 6
  
• TRE5-A retrotransposition profiling reveals putative RNA polymerase III transcription complex binding sites on the Dictyostelium extrachromosomal rDNA element.
  Spaller T, Groth M, Glöckner G, Winckler T
  PLoS One 2017, 12(4), e0175729
  
• Candidate Brocadiales dominates C, N and S cycling in anoxic groundwater of a pristine limestone-fracture aquifer.
  Starke R, Müller M, Gaspar M, Marz M, Küsel K, Totsche KU, von Bergen M, Jehmlich N
  J PROTEOMICS 2017, 152, 153-60
  
• Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development.
  Stopp S, Gründl M, Fackler M, Malkmus J, Leone M, Naumann R, Frantz S, Wolf E, von Eyss B, Engel FB, Gaubatz S
  Proc Natl Acad Sci U S A 2017, 114(30), 8029-34 published during change of institution
  
• Switch-like behavior enables Wnt11 concentration specific response during dorso-ventral axis formation in Xenopus laevis.
  Sträng JE, Schuler R, Kühl** M, Kestler** HA
  J Theor Biol 2017, 429, 82-94 ** co-senior authors
  
• Cdc45-induced loading of human RPA onto single-stranded DNA.
  Szambowska A, Tessmer I, Prus P, Schlott B, Pospiech H, Grosse F
  Nucleic Acids Res 2017, 45(6), 3217-30
  
• Lysine Acetylation and Deacetylation in Brain Development and Neuropathies.
  Tapias A, Wang ZQ
  Genomics Proteomics Bioinformatics 2017, 15(1), 19-36
  
• Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis.
  Tassone B, Saoncella S, Neri F, Ala U, Brusa D, Magnuson MA, Provero P, Oliviero S, Riganti C, Calautti E
  Cell Death Differ 2017, 24(4), 731-46 published during change of institution
  
• RHEB1 insufficiency in aged male mice is associated with stress-induced seizures.
  Tian Q, Gromov P, Clement JH, Wang Y, Riemann M, Weih F, Sun XX, Dai MS, Fedorov LM
  Geroscience 2017, 39(5-6), 557-70
  
• Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation.
  Tsitsipatis D, Jayavelu AK, Müller JP, Bauer R, Schmidt-Arras D, Mahboobi S, Schnöder TM, Heidel F, Böhmer FD
  Oncotarget 2017, 8(16), 26613-24
  
• Keeping it complicated: Mitochondrial genome plasticity across diplonemids.
  Valach M, Moreira S, Hoffmann S, Stadler PF, Burger G
  Sci Rep 2017, 7(1), 14166
  
• Non-canonical aging model systems and why we need them.
  Valenzano DR, Aboobaker A, Seluanov A, Gorbunova V
  EMBO J 2017, 36(8), 959-63
  
• The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels.
  Valkova C, Liebmann L, Krämer A, Hübner CA, Kaether C
  Sci Rep 2017, 7, 41248
  
• NMR spectroscopic studies of a TAT-derived model peptide in imidazolium-based ILs: influence on chemical shifts and the cis/trans equilibrium state.
  Wiedemann C, Ohlenschläger O, Mrestani-Klaus C, Bordusa F
  Phys Chem Chem Phys 2017, 19(35), 24115-25
  
• Synthesis and Evaluation of Amyloid β Derived and Amyloid β Independent Enhancers of the Peroxidase-like Activity of Heme.
  Wißbrock A, Kühl T, Silbermann K, Becker AJ, Ohlenschläger** O, Imhof** D
  J Med Chem 2017, 60(1), 373-85 ** co-corresponding authors
  
• A Stably Protonated Adenine Nucleotide with a Highly Shifted pKa Value Stabilizes the Tertiary Structure of a GTP-Binding RNA Aptamer.
  Wolter AC, Weickhmann AK, Nasiri AH, Hantke K, Ohlenschläger O, Wunderlich CH, Kreutz C, Duchardt-Ferner E, Wöhnert J
  Angew Chem Int Ed Engl 2017, 56(1), 401-4
  
• Nucleosome Positioning Assay
  Zhao Z, Bierhoff H
  Bio-protocol 2017, 7(10), e2285
  

Publications 2016:

• Differential sensitivity of lipegfilgrastim and pegfilgrastim to neutrophil elastase correlates with differences in clinical pharmacokinetic profile.
  Abdolzade-Bavil A, von Kerczek A, Cooksey BA, Kaufman T, Krasney PA, Pukac L, Görlach M, Lammerich A, Scheckermann C, Allgaier H, Shen WD, Liu PM
  J Clin Pharmacol 2016, 56(2), 186-94
  
• Polymorphism of Amyloid Fibrils In Vivo.
  Annamalai K, Gührs KH, Koehler R, Schmidt M, Michel H, Loos C, Gaffney PM, Sigurdson CJ, Hegenbart U, Schönland S, Fändrich M
  Angew Chem Int Ed Engl 2016, 55(15), 4822-5
  
• Impact of FLT3-ITD location on sensitivity to TKI-therapy in vitro and in vivo.
  Arreba-Tutusaus P, Mack TS, Bullinger L, Schnöder TM, Polanetzki A, Weinert S, Ballaschk A, Wang Z, Deshpande AJ, Armstrong SA, Döhner K, Fischer T, Heidel FH
  Leukemia 2016, 30(5), 1220-5
  
• Multiplex sequencing of bacterial artificial chromosomes for assembling complex plant genomes.
  Beier S, Himmelbach A, Schmutzer T, Felder M, Taudien S, Mayer KFX, Platzer M, Stein N, Scholz U, Mascher M
  Plant Biotechnol J 2016, 14(7), 1511-22
  
• Changes of bivalent chromatin coincide with increased expression of developmental genes in cancer.
  Bernhart SH, Kretzmer H, Holdt LM, Jühling F, Ammerpohl O, Bergmann AK, Northoff BH, Doose G, Siebert R, Stadler PF, Hoffmann S
  Sci Rep 2016, 6, 37393
  
• Blood stem cells: from beginning to end.
  Bigas A, Waskow C
  Development 2016, 143(19), 3429-33
  
• From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology.
  Cellerino A, Valenzano DR, Reichard M
  Biol Rev Camb Philos Soc 2016, 91(2), 511-33
  
• Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing.
  Chandel NS, Jasper H, Ho TT, Passegué E
  Nat Cell Biol 2016, 18(8), 823-32
  
• Discovering miRNA regulatory networks in Holt-Oram Syndrome using a Zebrafish model
  D'Aurizio R, Russo F, Chiavacci E, Baumgart M, Groth M, D'Onofrio M, Arisi I, Rainaldi G, Pitto L, Pellegrini M
  Front. Bioeng. Biotechnol. 2016, 4, Article 60
  
• Boolean modeling identifies greatwall/MASTL as an important regulator in the AURKA network of neuroblastoma.
  Dahlhaus M, Burkovski A, Hertwig F, Mussel C, Volland R, Fischer M, Debatin KM, Kestler** HA, Beltinger** C
  Cancer Lett 2016, 371(1), 79-89 ** co-corresponding authors
  
• The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.
  Dahms SO, Creemers JWM, Schaub Y, Bourenkov GP, Zögg T, Brandstetter H, Than ME
  Sci Rep 2016, 6, 34303.doi:10.1038/srep303
  
• Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
  Dahms* SO, Arciniega* M, Steinmetzer T, Huber** R, Than** ME
  Proc Natl Acad Sci U S A 2016, 113(40), 11196-201 * equal contribution, ** co-corresponding authors
  
• The role of hypothalamic NF-κB signaling in the response of the HPT-axis to acute inflammation in female mice.
  de Vries EM, Nagel S, Haenold R, Sundaram SM, Pfrieger FW, Fliers E, Heuer H, Boelen A
  Endocrinology 2016, 157(7), 2947-56
  
• Analysis of cultivable microbiota and diet intake pattern of the long-lived naked mole-rat.
  Debebe T, Holtze S, Morhart M, Hildebrandt TB, Rodewald S, Huse K, Platzer M, Wyohannes D, Yirga S, Lemma A, Thieme R, König B, Birkenmeier G
  Gut Pathog 2016, 8, 25
  
• Ethyl Pyruvate: An Anti-Microbial Agent that Selectively Targets Pathobionts and Biofilms.
  Debebe T, Krüger M, Huse K, Kacza J, Mühlberg K, König B, Birkenmeier G
  PLoS One 2016, 11(9), e0162919
  
• Sexual Dimorphism: How Female Cells Win the Race.
  Deng H, Jasper H
  Curr Biol 2016, 26(5), R212-5
  
• Reply to Hart et al.: MINCR and MYC: More than expression correlation.
  Doose G, Hoffmann S, Iaccarino I
  Proc Natl Acad Sci U S A 2016, 113(5), E498
  
• What a Difference an OH Makes: Conformational Dynamics as the Basis for the Ligand Specificity of the Neomycin-Sensing Riboswitch.
  Duchardt-Ferner E, Gottstein-Schmidtke SR, Weigand JE, Ohlenschläger O, Wurm JP, Hammann C, Suess B, Wöhnert J
  Angew Chem Int Ed Engl 2016, 55(4), 1527-30
  
• Expression and function of ABC-transporter protein ABCB1 correlates with inhibitory capacity of Ruxolitinib in vitro and in vivo.
  Ebert C, Perner F, Wolleschak D, Schnöder TM, Fischer T, Heidel FH
  Haematologica 2016, 101(3), e81-5
  
• DNA Damage as a Critical Factor of Stem Cell Aging and Organ Homeostasis
  Espada L, Ermolaeva MA
  Curr Stem Cell Rep 2016, 2, 290-8
  
• Multifocal Nerve Lesions and LZTR1 Germline Mutations in Segmental Schwannomatosis.
  Farschtschi S, Mautner VF, Pham M, Nguyen R, Kehrer-Sawatzki H, Hutter S, Friedrich RE, Schulz A, Morrison H, Jones DTW, Bendszus M, Bäumer P
  Ann Neurol 2016, 80(4), 625-8
  
• Automated structure modeling of large protein assemblies using crosslinks as distance restraints.
  Ferber M, Kosinski J, Ori A, Rashid UJ, Moreno-Morcillo M, Simon B, Bouvier G, Batista PR, Müller CW, Beck M, Nilges M
  Nat Methods 2016, 13(6), 515-20 published during change of institution
  
• The tumour suppressor CYLD regulates the p53 DNA damage response.
  Fernández-Majada V, Welz PS, Ermolaeva MA, Schell M, Adam A, Dietlein F, Komander D, Büttner R, Thomas RK, Schumacher B, Pasparakis M
  Nat Commun 2016, 7, 12508 published during change of institution
  
• S100A11 plays a role in homologous recombination and genome maintenance by influencing the persistence of RAD51 in DNA repair foci.
  Foertsch F, Szambowska A, Weise A, Zielinski A, Schlott B, Kraft F, Mrasek K, Borgmann K, Pospiech** H, Grosse F, Melle** C
  Cell Cycle 2016, 15(20), 2766-79 ** co-corresponding authors
  
• Prediction of conserved long-range RNA-RNA interactions in full viral genomes.
  Fricke M, Marz M
  Bioinformatics 2016, 32(19), 2928-35
  
• High Copy Numbers of Beta-Defensin Cluster on 8p23.1 Confer Genetic Susceptibility and Modulate the Physical Course of Hidradenitis Suppurativa/Acne Inversa.
  Giamarellos-Bourboulis* EJ, Platzer* M, Karagiannidis* I, Kanni T, Nikolakis G, Ulrich J, Bellutti M, Gollnick H, Bauer M, Zouboulis CC, Huse K
  J Invest Dermatol 2016, 136(8), 1592-8 * equal contribution
  
• You Are What You Eat: Linking High-Fat Diet to Stem Cell Dysfunction and Tumorigenesis.
  Haller S, Jasper H
  Cell Stem Cell 2016, 18(5), 564-6
  
• DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression.
  Hampp S, Kiessling T, Buechle K, Mansilla SF, Thomale J, Rall M, Ahn J, Pospiech H, Gottifredi V, Wiesmüller L
  Proc Natl Acad Sci U S A 2016, 113(30), E4311-9
  
• Efficient genome engineering approaches for the short-lived African turquoise killifish.
  Harel I, Valenzano DR, Brunet A
  Nat Protoc 2016, 11(10), 2010-28
  
• Gene Dosage Reductions of Trf1 and/or Tin2 Induce Telomere DNA Damage and Lymphoma Formation in Aging Mice.
  Hartmann K, Illing A, Leithäuser F, Baisantry A, Quintanilla-Fend L, Rudolph KL
  Leukemia 2016, 30(3), 749-53
  
• Feedback activation of neurofibromin terminates growth factor-induced Ras activation.
  Hennig A, Markwart R, Wolff K, Schubert K, Cui Y, Prior IA, Esparza-Franco MA, Ladds G, Rubio I
  Cell Commun Signal 2016, 14(1), 5
  
• Age-Dependent Changes of Monocarboxylate Transporter 8 Availability in the Postnatal Murine Retina.
  Henning Y, Szafranski K
  Front Cell Neurosci 2016, 10, 205
  
• Alterations of microRNA and microRNA-regulated messenger RNA expression in germinal center B-cell lymphomas determined by integrative sequencing analysis.
  Hezaveh K, Kloetgen A, Bernhart SH, Mahapatra KD, Lenze D, Richter J, Haake A, Bergmann AK, Brors B, Burkhardt B, Claviez A, Drexler HG, Eils R, Haas S, Hoffmann S, Karsch D, Klapper W, Kleinheinz K, Korbel J, Kretzmer H, Kreuz M, Küppers R, Lawerenz C, Leich E, Loeffler M, Mantovani-Loeffler L, López C, McHardy AC, Möller P, Rohde M, Rosenstiel P, Rosenwald A, Schilhabel M, Schlesner M, Scholz I, Stadler PF, Stilgenbauer S, Sungalee S, Szczepanowski M, Trümper L, Weniger MA, Siebert R, Borkhardt A, Hummel M, Hoell JI, ICGC MMML-Seq Project
  Haematologica 2016, 101(11), 1380-9
  
• Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.
  Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsusui K, Takeda S, Sasanuma H
  Mol Cell 2016, 64(3), 580-92
  
• Whole-Genome Sequence of Chlamydia gallinacea Type Strain 08-1274/3.
  Hölzer M, Laroucau K, Creasy HH, Ott S, Vorimore F, Bavoil PM, Marz M, Sachse K
  Genome Announc 2016, 4(4), pii: e00708-16
  
• Leukemogenic potency of the novel FLT3-N676K mutant.
  Huang K, Yang M, Pan Z, Heidel FH, Scherr M, Eder M, Fischer T, Büsche G, Welte K, von Neuhoff N, Ganser A, Li Z
  Ann Hematol 2016, 95(5), 783-91
  
• Wnt/β-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers.
  Huraskin D, Eiber N, Reichel M, Zidek LM, Kravic B, Bernkopf D, von Maltzahn J, Behrens J, Hashemolhosseini S
  Development 2016, 143(17), 3128-42
  
• Control of apoptosis by Drosophila DCAF12.
  Hwangbo DS, Biteau B, Rath S, Kim J, Jasper H
  Dev Biol 2016, 413(1), 50-9
  
• RNA structure framework: automated transcriptome-wide reconstruction of RNA secondary structures from high-throughput structure probing data.
  Incarnato D, Neri F, Anselmi F, Oliviero S
  Bioinformatics 2016, 32(3), 459-61 published during change of institution
  
• Human DNA polymerase α interacts with mismatch repair proteins MSH2 and MSH6.
  Itkonen HM, Kantelinen J, Vaara M, Parkkinen S, Schlott B, Grosse F, Nyström M, Syväoja JE, Pospiech H
  FEBS Lett 2016, 590(23), 4233-41
  
• Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation.
  Jaenicke* LA, von Eyss* B, Carstensen A, Wolf E, Xu W, Greifenberg AK, Geyer M, Eilers M, Popov N
  Mol Cell 2016, 61(1), 54-67 * equal contribution
  
• NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells.
  Jayavelu AK, Müller JP, Bauer R, Böhmer SA, Lässig J, Cerny-Reiterer S, Sperr WR, Valent P, Maurer B, Moriggl R, Schröder K, Shah AM, Fischer M, Scholl S, Barth J, Oellerich T, Berg T, Serve H, Frey S, Fischer T, Heidel FH, Böhmer FD
  Leukemia 2016, 30(2), 473-83
  
• Characteristics and treatment of polycythemia vera patients in clinical practice: a multicenter chart review on 1476 individuals in Germany.
  Jentsch-Ullrich K, Eberhardt J, Zeremski V, Koehler M, Wolleschak D, Heidel FH
  J Cancer Res Clin Oncol 2016, 142(9), 2041-9
  
• A homolog of Blade-On-Petiole 1 and 2 (BOP1/2) controls internode length and homeotic changes of the barley inflorescence.
  Jost M, Taketa S, Mascher M, Himmelbach A, Yuo T, Shahinnia F, Rutten T, Druka A, Schmutzer T, Steuernagel B, Beier S, Taudien S, Scholz U, Morgante M, Waugh R, Stein N
  Plant Physiol 2016, 171(2), 1113-27
  
• metilene: fast and sensitive calling of differentially methylated regions from bisulfite sequencing data.
  Jühling F, Kretzmer H, Bernhart SH, Otto C, Stadler PF, Hoffmann S
  Genome Res 2016, 26(2), 256-62
  
• PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways.
  Kaistha BP, Lorenz H, Schmidt H, Sipos B, Pawlak M, Gierke B, Kreider R, Lankat-Buttgereit B, Sauer M, Fiedler L, Krattenmacher A, Geisel B, Kraus JM, Frese KK, Kelkenberg S, Giese NA, Kestler HA, Gress TM, Buchholz M
  Cancer Res 2016, 76, 96-107
  
• Molecular specification of germ layers in vertebrate embryos.
  Kiecker C, Bates T, Bell E
  Cell Mol Life Sci 2016, 73(5), 923-47
  
• The short-lived African turquoise killifish: an emerging experimental model for ageing.
  Kim Y, Nam HG, Valenzano DR
  Dis Model Mech 2016, 9(2), 115-29
  
• Structure of the ribosome post-recycling complex probed by chemical cross-linking and mass spectrometry.
  Kiosze-Becker K, Ori A, Gerovac M, Heuer A, Nürenberg-Goloub E, Rashid UJ, Becker T, Beckmann R, Beck M, Tampé R
  Nat Commun 2016, 7, 13248
  
• Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion.
  Kolter J, Feuerstein R, Spoeri E, Gharun K, Elling R, Trieu-Cuot P, Goldmann T, Waskow C, Chen ZJ, Kirschning CJ, Deshmukh SD, Henneke P
  J Immunol 2016, 196(6), 2733-41
  
• Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation.
  Kourtzelis I, Kotlabova K, Lim JH, Mitroulis I, Ferreira A, Chen LS, Gercken B, Steffen A, Kemter E, Klotzsche-von Ameln A, Waskow C, Hosur K, Chatzigeorgiou A, Ludwig B, Wolf E, Hajishengallis G, Chavakis T
  Thromb Haemost 2016, 115(4), 781-8
  
• Phagocytosis of bone marrow derived macrophages is controlled by phosphoinositide 3-kinase γ.
  Kresinsky A, Schneble N, Schmidt C, Frister A, Bauer R, Wetzker R, Müller JP
  Immunol Lett 2016, 180, 9-16
  
• Analysis of an echovirus 18 outbreak in Thuringia, Germany: insights into the molecular epidemiology and evolution of several enterovirus species B members.
  Krumbholz A, Egerer R, Braun H, Schmidtke M, Rimek D, Kroh C, Hennig B, Groth M, Sauerbrei A, Zell R
  Med Microbiol Immunol 2016, 205(5), 471-83
  
• Solvent Removal Induces a Reversible β-to-α Switch in Oligomeric Aβ Peptide.
  Kumar ST, Leppert J, Bellstedt P, Wiedemann C, Fändrich** M, Görlach** M
  J Mol Biol 2016, 428(2 Pt A), 268-73 ** co-corresponding authors
  
• Abolishing Aging? Ethical implications of biological research on aging. Gemeinsames Seminar des Fritz Lipmann Institutes und des Ethikzentrums der Friedrich-Schiller-Universität Jena
  Kunzmann P, Briest W, Ehni HJ
  In: Diskurs Biogerontologie, Fachwissenschaftliche Einführung und Leitfaden für Lehrende (edited by Spindler M, Dietrich J, Ehni HJ) 2016, 285-287, Springer VS, Wiesbaden
  
• Gastrointestinal stem cells in health and disease: from flies to humans.
  Li H, Jasper H
  Dis Model Mech 2016, 9(5), 487-99
  
• Preventing Age-Related Decline of Gut Compartmentalization Limits Microbiota Dysbiosis and Extends Lifespan.
  Li H, Qi Y, Jasper H
  Cell Host Microbe 2016, 19(2), 240-53
  
• DNA Damage Response in Hematopoietic Stem Cell Ageing.
  Li T, Zhou ZW, Ju Z, Wang ZQ
  Genomics Proteomics Bioinformatics 2016, 14(3), 147-54
  
• Telomere shortening leads to earlier age of onset in ALS mice.
  Linkus B, Wiesner D, Meßner M, Karabatsiakis A, Scheffold A, Rudolph KL, Thal DR, Weishaupt JH, Ludolph AC, Danzer KM
  Aging (Albany NY) 2016, 8(2), 382-93
  
• Different promoter affinities account for specificity in MYC-dependent gene regulation.
  Lorenzin F, Benary U, Baluapuri A, Walz S, Jung LA, von Eyss B, Kisker C, Wolf J, Eilers M, Wolf E
  Elife 2016, 5. pii: e15161, doi: 10.7554/eLife.15161.
  
• Transcriptomic profiling of Alexandrium fundyense during physical interaction with or exposure to chemical signals from the parasite Amoebophrya.
  Lu Y, Wohlrab S, Groth M, Glöckner G, Guillou L, John U
  Mol Ecol 2016, 25(6), 1294-307
  
• Intestinal IRE1 Is Required for Increased Triglyceride Metabolism and Longer Lifespan under Dietary Restriction.
  Luis NM, Wang L, Ortega M, Deng H, Katewa SD, Li PWL, Karpac J, Jasper** H, Kapahi** P
  Cell Rep 2016, 17(5), 1207-16 ** co-corresponding authors
  
• The distribution of α-kleisin during meiosis in the holocentromeric plant Luzula elegans.
  Ma W, Schubert V, Martis MM, Hause G, Liu Z, Shen Y, Conrad U, Shi W, Scholz U, Taudien S, Cheng Z, Houben A
  Chromosome Res 2016, 24(3), 393-405
  
• Coronavirus cis-Acting RNA Elements.
  Madhugiri R, Fricke M, Marz M, Ziebuhr J
  In: Advances in Virus Research (edited by John Ziebuhr) 2016, 96, 127-163, Elsevier Inc. Academic
  
• The long intergenic non-coding RNA CCR492 functions as a let-7 competitive endogenous RNA to regulate c-Myc expression.
  Maldotti M, Incarnato D, Neri F, Krepelova A, Rapelli S, Anselmi F, Parlato C, Basile G, Dettori D, Calogero R, Oliviero S
  BBA-GENE REGUL MECH 2016, 1859(10), 1322-32 published during change of institution
  
• Conserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-Seq.
  Marthandan S, Baumgart M, Priebe S, Groth M, Schaer J, Kaether C, Guthke R, Cellerino A, Platzer M, Diekmann S, Hemmerich P
  PLoS One 2016, 11(5), e0154531
  
• Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence.
  Marthandan S, Menzel U, Priebe S, Groth M, Guthke R, Platzer M, Hemmerich P, Kaether C, Diekmann S
  Biol Res 2016, 49(1), 34
  
• Olfactory phenotypic expression unveils human aging.
  Mazzatenta A, Cellerino A, Origlia N, Barloscio D, Sartucci F, Di Giulio C, Domenici L
  Oncotarget 2016, 7(15), 19193-200
  
• Multilineage readout after HSC expansion - erythrocytes matter.
  Mende N, Rahmig S, Waskow C
  Cell Cycle 2016, 15(8), 1032-3
  
• A standardized production pipeline for high profile targets from Mycobacterium tuberculosis.
  Milewski MC, Broger T, Kirkpatrick J, Filomena A, Komadina D, Schneiderhan-Marra N, Wilmanns M, Parret AHA
  Proteom Clin Appl 2016, 10(9-10), 1049-57
  
• BiTrinA - multiscale binarization and trinarization with quality analysis.
  Mϋssel C, Schmid F, Blätte TJ, Hopfensitz M, Lausser** L, Kestler** HA
  Bioinformatics 2016, 32(3), 465-8 ** co-senior authors
  
• Methylation-assisted bisulfite sequencing to simultaneously map 5fC and 5caC on a genome-wide scale for DNA demethylation analysis.
  Neri F, Incarnato D, Krepelova A, Parlato C, Oliviero S
  Nat Protoc 2016, 11(7), 1191-205 published during change of institution
  
• Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients.
  Obermeier K, Sachsenweger J, Friedl TWP, Pospiech H, Winqvist R, Wiesmüller L
  Oncogene 2016, 35(29), 3796-806
  
• Spatiotemporal variation of mammalian protein complex stoichiometries.
  Ori A, Iskar M, Buczak K, Kastritis P, Parca L, Andrés-Pons A, Singer S, Bork P, Beck M
  Genome Biol 2016, 17(1), 47 featured in Research Highlights
  
• Growth factor and co-receptor release by structural regulation of substrate metalloprotease accessibility.
  Parra* LM, Hartmann* M, Schubach S, Ma J, Herrlich** P, Herrlich** A
  Sci Rep 2016, 6, 37464 * equal contribution, ** co-senior authors
  
• Comparative genomics to explore phylogenetic relationship, cryptic sexual potential and host specificity of Rhynchosporium species on grasses.
  Penselin D, Münsterkötter M, Kirsten S, Felder M, Taudien S, Platzer M, Ashelford K, Paskiewicz KH, Harrison RJ, Hughes DJ, Wolf T, Shelest E, Graap J, Hoffmann J, Wenzel C, Wöltje N, King KM, Fitt BDL, Güldener U, Avrova A, Knogge W
  BMC Genomics 2016, 17(1), 953
  
• Immunofluorescence Staining of Wt1 on Sections of Zebrafish Embryos and Larvae.
  Perner B, Englert C
  In: The Wilms' Tumor (WT1) Gene, Methods and Protocols (edited by Nicholas Hastie), Methods in Molecular Biology 2016, 1467, 129-32, Springer New York, New Y
  
• Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function.
  Perner F, Schnöder TM, Ranjan S, Wolleschak D, Ebert C, Pils MC, Frey S, Polanetzki A, Fahldieck C, Schönborn U, Schraven B, Isermann B, Fischer T, Heidel FH
  Leukemia 2016, 30(4), 991-5
  
• Genotyping of herpes simplex virus type 1 by whole-genome sequencing.
  Pfaff F, Groth M, Sauerbrei A, Zell R
  J Gen Virol 2016, 97(10), 2732-41
  
• Nothobranchius furzeri: A Model for Aging Research and More.
  Platzer M, Englert C
  Trends Genet 2016, 32(9), 543-52
  
• The Oncogenic Fusion Proteins SET-Nup214 and Sequestosome-1 (SQSTM1)-Nup214 Form Dynamic Nuclear Bodies and Differentially Affect Nuclear Protein and Poly(A)+ RNA Export.
  Port SA, Mendes A, Valkova C, Spillner C, Fahrenkrog B, Kaether C, Kehlenbach RH
  J Biol Chem 2016, 291(44), 23068-83
  
• Assembly of the Cdc45-Mcm2-7-GINS Complex, the Replication Helicase
  Pospiech H, Szambowska A
  In: The Initiation of DNA Replication in Eukaryotes (edited by Daniel Kaplan) 2016, 393-409, Springer International
  
• Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice.
  Rahmig S, Kronstein-Wiedemann R, Fohgrub J, Kronstein N, Nevmerzhitskaya A, Bornhäuser M, Gassmann M, Platz A, Ordemann R, Tonn T, Waskow C
  Stem Cell Reports 2016, 7(4), 591-601
  
• p21 shapes cancer evolution.
  Romanov VS, Rudolph KL
  Nat Cell Biol 2016, 18(7), 722-4
  
• Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death.
  Salah FS, Ebbinghaus M, Muley VY, Zhou Z, Al-Saadi KRD, Pacyna-Gengelbach M, O'Sullivan GA, Betz H, König R, Wang ZQ, Bräuer R, Petersen I
  Cell Death Dis 2016, 7, e2205
  
• MHC-dependent mate choice is linked to a trace-amine-associated receptor gene in a mammal.
  Santos PSC, Courtiol A, Heidel AJ, Höner OP, Heckmann I, Nagy M, Mayer F, Platzer M, Voigt CC, Sommer S
  Sci Rep 2016, 6, 38490
  
• Cool-temperature-mediated activation of phospholipase C-γ2 in the human hereditary disease PLAID.
  Schade A, Walliser C, Wist M, Haas J, Vatter P, Kraus JM, Filingeri D, Havenith G, Kestler HA, Milner JD, Gierschik P
  Cell Signal 2016, 28(9), 1237-51
  
• Leukemic mastopathy.
  Schalk E, Heidel FH
  Int J Hematol 2016, 103(4), 357-8
  
• The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR.
  Scharaw S, Iskar M, Ori A, Boncompain G, Laketa V, Poser I, Lundberg E, Perez F, Beck M, Bork P, Pepperkok R
  J Cell Biol 2016, 215(4), 543-58 published during change of institution
  
• Anti-amyloid compounds protect from silica nanoparticle-induced neurotoxicity in the nematode C. elegans.
  Scharf A, Gührs KH, von Mikecz A
  Nanotoxicology 2016, 10(4), 426-35
  
• Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model.
  Scheffold A, Holtman IR, Dieni S, Brouwer N, Katz SF, Jebaraj BMC, Kahle PJ, Hengerer B, Lechel A, Stilgenbauer S, Boddeke EWGM, Eggen BJL, Rudolph KL, Biber K
  Acta Neuropathol Commun 2016, 4(1), 87
  
• Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality.
  Scherag A, Schöneweck F, Kesselmeier M, Taudien S, Platzer M, Felder M, Sponholz C, Rautanen A, Hill AVS, Hinds CJ, Hossain H, Suttorp N, Kurzai O, Slevogt H, Giamarellos-Bourboulis EJ, Armaganidis A, Trips E, Scholz M, Brunkhorst FM
  EBioMedicine 2016, 12, 239-46
  
• GiANT: Gene set uncertainty in enrichment analysis.
  Schmid F, Schmid M, Müssel C, Sträng JE, Buske C, Bullinger L, Kraus JM, Kestler HA
  Bioinformatics 2016, 32(12), 1891-4
  
• Phosphoinositide 3-Kinase γ Restrains Neurotoxic Effects of Microglia After Focal Brain Ischemia.
  Schmidt C, Frahm C, Schneble N, Müller JP, Brodhun M, Franco I, Witte OW, Hirsch E, Wetzker R, Bauer R
  Mol Neurobiol 2016, 53(8), 5468-79
  
• Lipedema – lack of evidence for the involvement of tyrosine kinases.
  Schneble N, Wetzker R, Wollina U
  J Biol Regul Homeost Agents 2016, 30(1), 161-3
  
• The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis.
  Schoedel KB, Morcos MNF, Zerjatke T, Roeder I, Grinenko T, Voehringer D, Göthert JR, Waskow C, Roers A, Gerbaulet A
  Blood 2016, 128(19), 2285-96
  
• An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation.
  Schur FKM, Obr M, Hagen WJH, Wan W, Jakobi AJ, Kirkpatrick JM, Sachse C, Kräusslich HG, Briggs JAG
  Science 2016, 353(6298), 506-8 published during change of institution
  
• Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis.
  Seidel P, Remus M, Delacher M, Grigaravicius P, Reuss DE, Frappart L, von Deimling A, Feueuer M, Abdollahi A, Frappart PO
  Oncotarget 2016, 7(17), 23006-18
  
• BCL3 Reduces the Sterile Inflammatory Response in Pancreatic and Biliary Tissues.
  Song L, Wörmann S, Ai J, Neuhöfer P, Lesina M, Diakopoulos KN, Ruess D, Treiber M, Witt H, Bassermann F, Halangk W, Steiner JM, Esposito I, Rosendahl J, Schmid RM, Riemann M, Algül H
  Gastroenterology 2016, 150(2), 499-512
  
• Polymorphisms of cystathionine beta-synthase gene are associated with susceptibility to sepsis.
  Sponholz C, Kramer M, Schöneweck F, Menzel U, Inanloo Rahatloo K, Giamarellos-Bourboulis EJ, Papavassileiou V, Lymberopoulou K, Pavlaki M, Koutelidakis I, Perdios I, Scherag A, Bauer M, Platzer M, Huse K
  Eur J Hum Genet 2016, 24(7), 1041-8
  
• Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive.
  Taudien* S, Lausser* L, Giamarellos-Bourboulis EJ, Sponholz C, Schöneweck F, Felder M, Schirra LR, Schmid F, Gogos C, Groth S, Petersen BS, Franke A, Lieb W, Huse K, Zipfel PF, Kurzai O, Moepps B, Gierschik P, Bauer M, Scherag A, Kestler** HA, Platzer** M
  EBioMedicine 2016, 12, 227-38 * equal contribution, ** co-senior authors
  
• PARP activation promotes nuclear AID accumulation in lymphoma cells.
  Tepper S, Jeschke J, Böttcher K, Schmidt A, Davari K, Müller P, Kremmer E, Hemmerich P, Pfeil I, Jungnickel B
  Oncotarget 2016, 7(11), 13197-208
  
• Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6.
  Uras IZ, Walter GJ, Scheicher R, Bellutti F, Prchal-Murphy M, Tigan AS, Valent P, Heidel FH, Kubicek S, Scholl C, Fröhling S, Sexl V
  Blood 2016, 127(23), 2890-902
  
• Stress promotes Arabidopsis - Piriformospora indica interaction.
  Vahabi K, Dorcheh SK, Monajembashi S, Westermann M, Reichelt M, Falkenberg D, Hemmerich P, Sherameti I, Oelmüller R
  Plant Signal Behav 2016, 11(5), e1136763
  
• NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions.
  Vlantis K, Wullaert A, Polykratis A, Kondylis V, Dannappel M, Schwarzer R, Welz P, Corona T, Walczak H, Weih F, Klein U, Kelliher M, Pasparakis M
  Immunity 2016, 44(3), 553-67
  
• TraqBio - Flexible Progress Tracking for Core Unit Projects.
  Völkel G, Wiese S, Holzmann K, Kraus JM, Schneider F, Görlach M, Kestler HA
  PLoS One 2016, 11(9), e0162857
  
• Characterization of SKAP/Kinastrin isoforms - The N-terminus defines tissue specificity and Pontin binding.
  Vranesic AC, Reiche J, Hoischen C, Wohlmann A, Bratsch J, Friedrich K, Günes B, Cappallo-Obermann H, Kirchhoff C, Diekmann S, Günes C, Huber O
  Hum Mol Genet 2016, 25(13), 2838-52
  
• SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling.
  Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Wu Y, Rudolph KL, Liu G, Li T, Ju Z
  Cell Stem Cell 2016, 18(4), 495-507
  
• A Set of Efficient nD NMR Protocols for Resonance Assignments of Intrinsically Disordered Proteins.
  Wiedemann C, Bellstedt P, Häfner S, Herbst C, Bordusa F, Görlach M, Ohlenschläger O, Ramachandran R
  Chemphyschem 2016, 17(13), 1961-8
  
• Analysis of Large and Complex Data
  Wilhelm AFX, Kestler HA (eds)
  Book series: Studies in Classification, Data Analysis, and Knowledge Organization 2016, Springer International Publishin
  
• Cellular apoptosis susceptibility (CAS) is linked to integrin β1 and required for tumor cell migration and invasion in hepatocellular carcinoma (HCC).
  Winkler J, Roessler S, Sticht C, DiGuilio AL, Drucker E, Holzer K, Eiteneuer E, Herpel E, Breuhahn K, Gretz N, Schirmacher P, Ori A, Singer S
  Oncotarget 2016, 7(16), 22883-92
  
• Finding approximate gene clusters with Gecko 3.
  Winter S, Jahn K, Wehner S, Kuchenbecker L, Marz M, Stoye J, Böcker S
  Nucleic Acids Res 2016, 44(20), 9600-10
  
• Chronic myelogenous leukemia evolving after treatment of multiple myeloma.
  Wolleschak D, Heidel FH
  Blood 2016, 128(1), 146
  
• Attenuated LKB1-SIK1 signaling promotes epithelial-mesenchymal transition and radioresistance of non-small cell lung cancer cells.
  Yao YH, Cui Y, Qiu XN, Zhang LZ, Zhang W, Li H, Yu JM
  Chin J Cancer 2016, 35(1), 50
  
• Inhibition of cargo export at ER-exit sites and the trans-Golgi network by the secretion inhibitor FLI-06.
  Yonemura Y, Li X, Müller K, Krämer A, Atigbire P, Mentrup T, Feuerhake T, Kroll T, Shomron O, Nohl R, Arndt HD, Hoischen C, Hemmerich P, Hirschberg K, Kaether C
  J Cell Sci 2016, 129(20), 3868-77
  
• Age-Dependent Changes of Monocarboxylate Transporter 8 Availability in the Postnatal Murine Retina
  Yoshiyuki H, Szafranski K
  Front Cell Neurosci 2016, http://dx.doi.org/10.3389/fncel.
  
• lncRNA-Induced Nucleosome Repositioning Reinforces Transcriptional Repression of rRNA Genes upon Hypotonic Stress.
  Zhao Z, Dammert MA, Grummt I, Bierhoff H
  Cell Rep 2016, 14(8), 1876-82
  
• Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning.
  Zhao Z, Dammert MA, Hoppe S, Bierhoff H, Grummt I
  Nucleic Acids Res 2016, 44(17), 8144-52
  

Publications 2015:

• Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer.
  Adams* PD, Jasper* H, Rudolph* KL
  Cell Stem Cell 2015, 16(6), 601-12 ** co-corresponding authors
  
• Amyloid domains in the cell nucleus controlled by nucleoskeletal protein lamin B1 reveal a new pathway of mercury neurotoxicity.
  Arnhold F, Gührs KH, von Mikecz A
  PeerJ 2015, 3, e754
  
• Stem Cells and Aging: What’s Next?
  Artandi SE, Blau HM, de Haan G, Geiger H, Goodell MA, Jones L, Levine RL, Munoz-Canoves P, Rodewald HR, Wagers A, Wang ZQ, Yamashita Y
  Cell Stem Cell 2015, 16, 578-81
  
• Haemocytes control stem cell activity in the Drosophila intestine.
  Ayyaz A, Li H, Jasper H
  Nat Cell Biol 2015, 17(6), 736-48
  
• Differential Regulation of MicroRNAs in End-Stage Failing Hearts Is Associated with Left Ventricular Assist Device Unloading.
  Barsanti C, Trivella MG, D'Aurizio R, El Baroudi M, Baumgart M, Groth M, Caruso R, Verde A, Botta L, Cozzi L, Pitto L
  Biomed Res Int 2015, 2015, 592512
  
• Comparison of captive lifespan, age-associated liver neoplasias and age-dependent gene expression between two annual fish species: Nothobranchius furzeri and Nothobranchius korthause.
  Baumgart M, Di Cicco E, Rossi G, Cellerino A, Tozzini ET
  Biogerontology 2015, 16(1), 63-9
  
• Elevated copper ion levels as potential cause of impaired kinesin-dependent transport processes.
  Böhm KJ
  Arch Toxicol 2015, 89(4), 565-72
  
• Aluminium-induced kinesin inactivation as potential molecular cause of impairment of neuronal transport processes.
  Böhm KJ, Shabanpour M, Kalchishkova N
  Chem Res Toxicol 2015, 28(6), 1275-81
  
• A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis.
  Buch S, Stickel F, Trépo E, Way M, Herrmann A, Nischalke HD, Brosch M, Rosendahl J, Berg T, Ridinger M, Rietschel M, McQuillin A, Frank J, Kiefer F, Schreiber S, Lieb W, Soyka M, Semmo N, Aigner E, Datz C, Schmelz R, Brückner S, Zeissig S, Stephan AM, Wodarz N, Devière J, Clumeck N, Sarrazin C, Lammert F, Gustot T, Deltenre P, Völzke H, Lerch MM, Mayerle J, Eyer F, Schafmayer C, Cichon S, Nöthen MM, Nothnagel M, Ellinghaus D, Huse K, Franke A, Zopf S, Hellerbrand C, Moreno C, Franchimont D, Morgan MY, Hampe J
  Nat Genet 2015, 47(12), 1443-8
  
• Phenotypic regulation of the sphingosine 1-phosphate receptor Miles Apart by GRK2.
  Burczyk MS, Burkhalter MD, Blätte T, Matysik S, Caron MG, Barak LS, Philipp M
  Biochemistry 2015, 54(3), 765-75
  
• Genome instability of ageing stem cells-Induction and defence mechanisms.
  Burkhalter MD, Rudolph KL, Sperka T
  Ageing Res Rev 2015, 23(Pt A), 29-36
  
• Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupying an essential rRNA-binding site.
  Calviño FR, Kharde S, Ori A, Hendricks A, Wild K, Kressler D, Bange G, Hurt E, Beck M, Sinning I
  Nat Commun 2015, 6, 6510
  
• Annual fishes of the genus Nothobranchius as an experimental model. p.93-99 in Annual Fishes
  Cellerino A
  In: Annual Fishes, Life History Strategy, Diversity and Evolution. (edited by Beiros N, García G, de Sá R) 2015, 93-99, CRC Press Taylor and Fran
  
• Editorial for "Regulatory RNAs in the nervous system".
  Cellerino A, Bally-Cuif L, Pizzorusso T
  Front Cell Neurosci 2015, 9, 38
  
• MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome.
  Chiavacci E, D'Aurizio R, Guzzolino E, Russo F, Baumgart M, Groth M, Mariani L, D'Onofrio M, Arisi I, Pellegrini M, Cellerino A, Cremisi F, Pitto L
  Sci Rep 2015, 5, 18240
  
• AKI Recovery Induced by Mesenchymal Stromal Cell-Derived Extracellular Vesicles Carrying MicroRNAs.
  Collino F, Bruno S, Incarnato D, Dettori D, Neri F, Provero P, Pomatto M, Oliviero S, Tetta C, Quesenberry PJ, Camussi G
  J Am Soc Nephrol 2015, 26(10), 2349-60
  
• Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes.
  Dahms SO, Mayer MC, Roeser D, Multhaup G, Than ME
  Acta Crystallogr D Biol Crystallogr 2015, 71(Pt 3), 494-504
  
• Signal integration by Ca(2+) regulates intestinal stem-cell activity.
  Deng H, Gerencser AA, Jasper H
  Nature 2015, 528(7581), 212-7
  
• Mutants of Metal Binding Site M1 in APP E2 Show Metal Specific Differences in Binding of Heparin but Not of sorLA.
  Dienemann C, Coburger I, Mehmedbasic A, Andersen OM, Than ME
  Biochemistry 2015, 54(15), 2490-9
  
• MicroRNAs provide the first evidence of genetic link between diapause and aging in vertebrates
  Dolfi* L, Baumgart* M, Groth M, Platzer M, Cellerino A
  bioRxiv 2015, https://doi.org/10.1101/017848 * equal contribution
  
• MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells.
  Doose G, Haake A, Bernhart SH, López C, Duggimpudi S, Wojciech F, Bergmann AK, Borkhardt A, Burkhardt B, Claviez A, Dimitrova L, Haas S, Hoell JI, Hummel M, Karsch D, Klapper W, Kleo K, Kretzmer H, Kreuz M, Küppers R, Lawerenz C, Lenze D, Loeffler M, Mantovani-Löffler L, Möller P, Ott G, Richter J, Rohde M, Rosenstiel P, Rosenwald A, Schilhabel M, Schneider M, Scholz I, Stilgenbauer S, Stunnenberg HG, Szczepanowski M, Trümper L, Weniger MA, ICGC MMML-Seq Consortium, Hoffmann S, Siebert R, Iaccarino I
  Proc Natl Acad Sci U S A 2015, 112(38), E5261-70
  
• Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division.
  Dumont NA, Wang YX, von Maltzahn J, Pasut A, Bentzinger CF, Brun CE, Rudnicki MA
  Nat Med 2015, 21(12), 1455-63
  
• SPLIFF: A Single-Cell Method to Map Protein-Protein Interactions in Time and Space.
  Dünkler A, Rösler R, Kestler HA, Moreno-Andrés D, Johnsson N
  Methods Mol Biol 2015, 1346, 151-68 published during change of institution
  
• The butterfly plant arms-race escalated by gene and genome duplications.
  Edger PP, Heidel-Fischer HM, Bekaert M, Rota J, Glöckner G, Platts AE, Heckel DG, Der JP, Wafula EK, Tang M, Hofberger JA, Smithson A, Hall JC, Blanchette M, Bureau TE, Wright SI, dePamphilis CW, Schranz ME, Barker MS, Conant GC, Wahlberg N, Vogel H, Pires JC, Wheat CW
  Proc Natl Acad Sci U S A 2015, 112(27), 8362-6
  
• Quality control mechanisms in cellular and systemic DNA damage responses.
  Ermolaeva** MA, Dakhovnik A, Schumacher** B
  Ageing Res Rev 2015, 23(Pt A), 3-11 ** co-corresponding authors
  
• Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization.
  Eschbach J, von Einem B, Müller K, Bayer H, Scheffold A, Morrison BE, Rudolph KL, Thal DR, Witting A, Weydt P, Otto M, Fauler M, Liss B, McLean PJ, Spada ARL, Ludolph AC, Weishaupt JH, Danzer KM
  Ann Neurol 2015, 77(1), 15-32
  
• Telomeres and Stem Cell Aging
  Felix DA
  In: Adult Stem Cells in Aging, Diseases and Cancer (edited by Rudolph KL), Else Kröner-Fresenius Symposia 2015, 5, 69-73, Karger Verlag, Basel
  
• Stem Cells in Adult Intestine
  Feng J, Sperka T
  In: Adult Stem Cells in Aging, Diseases and Cancer (edited by Rudolph KL), Else Kröner-Fresenius Symposia 2015, 5, 18-24, Karger Verlag, Basel
  
• Engineering a Constrained Peptidic Scaffold towards Potent and Selective Furin Inhibitors.
  Fittler H, Depp A, Avrutina O, Dahms SO, Than ME, Empting M, Kolmar H
  Chembiochem 2015, 16(17), 2441-4
  
• VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice with Colitis.
  Foersch S, Sperka T, Lindner C, Taut A, Rudolph KL, Breier G, Boxberger F, Rau TT, Hartmann A, Stürzl M, Wittkopf N, Haep L, Wirtz S, Neurath MF, Waldner MJ
  Gastroenterology 2015, 149(1), 177-89
  
• Conserved RNA secondary structures and long-range interactions in hepatitis C viruses.
  Fricke M, Dünnes N, Zayas M, Bartenschlager R, Niepmann M, Marz M
  RNA 2015, 21(7), 1219-32
  
• Extended pairwise local alignment of wild card DNA/RNA sequences using dynamic programming
  Fürstenberg A, Maucher M, Kestler HA
  J Stat Comput Sim 2015, 85(1), 3-13 published during change of institution
  
• Structural basis for assembly and function of the Nup82 complex in the nuclear pore scaffold.
  Gaik M, Flemming D, von Appen A, Kastritis P, Mücke N, Fischer J, Stelter P, Ori A, Bui KH, Baßler J, Barbar E, Beck M, Hurt E
  J Cell Biol 2015, 208(3), 283-97
  
• Snai1 represses Nanog to promote embryonic stem cell differentiation.
  Galvagni F, Neri F
  Genom Data 2015, 4, 82-3
  
• Snai1 promotes ESC exit from the pluripotency by direct repression of self-renewal genes.
  Galvagni* F, Lentucci* C, Neri* F, Dettori D, De Clemente C, Orlandini M, Anselmi F, Rapelli S, Grillo M, Borghi S, Oliviero S
  Stem Cells 2015, 33(3), 742-50 * equal contribution
  
• Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
  Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, William Rayner N, Robertson N, Scott RA, Prokopenko I, Scott LJ, Green T, Sparso T, Thuillier D, Yengo L, Grallert H, Wahl S, Frånberg M, Strawbridge RJ, Kestler H, Chheda H, Eisele L, Gustafsson S, Steinthorsdottir V, Thorleifsson G, Qi L, Karssen LC, van Leeuwen EM, Willems SM, Li M, Chen H, Fuchsberger C, Kwan P, Ma C, Linderman M, Lu Y, Thomsen SK, Rundle JK, Beer NL, van de Bunt M, Chalisey A, Kang HM, Voight BF, Abecasis GR, Almgren P, Baldassarre D, Balkau B, Benediktsson R, Blüher M, Boeing H, Bonnycastle LL, Bottinger EP, Burtt NP, Carey J, Charpentier G, Chines PS, Cornelis MC, Couper DJ, Crenshaw AT, van Dam RM, Doney ASF, Dorkhan M, Edkins S, Eriksson JG, Esko T, Eury E, Fadista J, Flannick J, Fontanillas P, Fox C, Franks PW, Gertow K, Gieger C, Gigante B, Gottesman O, Grant GB, Grarup N, Groves CJ, Hassinen M, Have CT, Herder C, Holmen OL, Hreidarsson AB, Humphries SE, Hunter DJ, Jackson AU, Jonsson A, Jørgensen ME, Jørgensen T, Kao WHL, Kerrison ND, Kinnunen L, Klopp N, Kong A, Kovacs P, Kraft P, Kravic J, Langford C, Leander K, Liang L, Lichtner P, Lindgren CM, Lindholm E, Linneberg A, Liu CT, Lobbens S, Luan J, Lyssenko V, Männistö S, McLeod O, Meyer J, Mihailov E, Mirza G, Mühleisen TW, Müller-Nurasyid M, Navarro C, Nöthen MM, Oskolkov NN, Owen KR, Palli D, Pechlivanis S, Peltonen L, Perry JRB, Platou CGP, Roden M, Ruderfer D, Rybin D, van der Schouw YT, Sennblad B, Sigurðsson G, Stančáková A, Steinbach G, Storm P, Strauch K, Stringham HM, Sun Q, Thorand B, Tikkanen E, Tonjes A, Trakalo J, Tremoli E, Tuomi T, Wennauer R, Wiltshire S, Wood AR, Zeggini E, Dunham I, Birney E, Pasquali L, Ferrer J, Loos RJF, Dupuis J, Florez JC, Boerwinkle E, Pankow JS, van Duijn C, Sijbrands E, Meigs JB, Hu FB, Thorsteinsdottir U, Stefansson K, Lakka TA, Rauramaa R, Stumvoll M, Pedersen NL, Lind L, Keinanen-Kiukaanniemi SM, Korpi-Hyövälti E, Saaristo TE, Saltevo J, Kuusisto J, Laakso M, Metspalu A, Erbel R, Jöcke KH, Moebus S, Ripatti S, Salomaa V, Ingelsson E, Boehm BO, Bergman RN, Collins FS, Mohlke KL, Koistinen H, Tuomilehto J, Hveem K, Njølstad I, Deloukas P, Donnelly PJ, Frayling TM, Hattersley AT, de Faire U, Hamsten A, Illig T, Peters A, Cauchi S, Sladek R, Froguel P, Hansen T, Pedersen O, Morris AD, Palmer CNA, Kathiresan S, Melander O, Nilsson PM, Groop LC, Barroso I, Langenberg C, Wareham NJ, O'Callaghan CA, Gloyn AL, Altshuler D, Boehnke M, Teslovich TM, McCarthy MI, Morris AP, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
  Nat Genet 2015, 47(12), 1415-25
  
• Grundlagen der Durchflusszytometrie
  Gompf A
  In: Zelluläre Diagnostik und Therapie (edited by Sack U) 2015, 1-28, Walter de Gruyter GmbH, Be
  
• Predicting Variabilities in Cardiac Gene Expression with a Boolean Network Incorporating Uncertainty.
  Grieb M, Burkovski A, Sträng JE, Kraus JM, Groß A, Palm G, Kühl M, Kestler HA
  PLoS One 2015, 10(7), e0131832
  
• Novel Furin Inhibitors with Potent Anti-infectious Activity.
  Hardes K, Becker GL, Lu Y, Dahms SO, Köhler S, Beyer W, Sandvig K, Yamamoto H, Lindberg I, Walz L, von Messling V, Than ME, Garten W, Steinmetzer T
  ChemMedChem 2015, 10(7), 1218-31
  
• A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.
  Harel I, Benayoun BA, Machado B, Singh PP, Hu CK, Pech MF, Valenzano DR, Zhang E, Sharp SC, Artandi SE, Brunet A
  Cell 2015, 160(5), 1013-26
  
• Core cross-linked nanogels based on the self-assembly of double hydrophilic poly(2-oxazoline) block copolymers
  Hartlieb M, Pretzel D, Wagner M, Hoeppener S, Bellstedt P, Görlach M, Englert C, Kempe K, Schubert US
  J Mater Chem B 2015, 3, 1748-59
  
• Plasma N-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome.
  Hartmann D, von Figura G, Song Z, Harden S, Scott LC, Evans TJ, Rudolph KL, Bilsland AE, Keith WN
  Future Oncol 2015, 11(2), 193-203
  
• Evolutionarily conserved signaling pathways: acting in the shadows of acute myelogenous leukemia's genetic diversity.
  Heidel FH, Arreba-Tutusaus P, Armstrong SA, Fischer T
  Clin Cancer Res 2015, 21(2), 240-8
  
• Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response.
  Hein K, Mittler G, Cizelsky W, Kühl M, Ferrante F, Liefke R, Berger IM, Just S, Sträng JE, Kestler HA, Oswald F, Borggrefe T
  Sci Signal 2015, 8(369), ra30
  
• A simple data-adaptive probabilistic variant calling model.
  Hoffmann S, Stadler PF, Strimmer K
  Algorithms Mol Biol 2015, 10, 10
  
• High-throughput whole-genome sequencing of E14 mouse embryonic stem cells.
  Incarnato D, Neri F
  Genom Data 2015, 3, 6-7
  
• Exploring the physiology and pathology of aging in the intestine of Drosophila melanogaster.
  Jasper H
  Invertebr Reprod Dev 2015, 59(sup1), 51-8
  
• Proceedings of Reisensburg 2013 (Foreword).
  Kestler HA, Schmid M
  J Stat Comput Sim 2015, 85(1), 1-2
  
• Polyketide synthesis genes associated with toxin production in two species of Gambierdiscus (Dinophyceae).
  Kohli GS, John U, Figueroa RI, Rhodes LL, Harwood DT, Groth M, Bolch CJS, Murray SA
  BMC Genomics 2015, 16, 410
  
• NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis.
  Kondylis V, Polykratis A, Ehlken H, Ochoa-Callejero L, Straub BK, Krishna-Subramanian S, Van TM, Curth HM, Heise N, Weih F, Klein U, Schirmacher P, Kelliher M, Pasparakis M
  Cancer Cell 2015, 28(5), 582-98
  
• Xlink Analyzer: software for analysis and visualization of cross-linking data in the context of three-dimensional structures.
  Kosinski J, von Appen A, Ori A, Karius K, Müller CW, Beck M
  J Struct Biol 2015, 189(3), 177-83
  
• Alternative Splicing of SMPD1 in Human Sepsis.
  Kramer M, Quickert S, Sponholz C, Menzel U, Huse K, Platzer M, Bauer M, Claus RA
  PLoS One 2015, 10(4), e0124503
  
• Exhaustive k-nearest-neighbour subspace clustering
  Krause JM, Lausser L, Kestler HA
  J Stat Comput Sim 2015, 85(1), 30–46 published during change of institution
  
• DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control.
  Kretzmer H, Bernhart SH, Wang W, Haake A, Weniger MA, Bergmann AK, Betts MJ, Carrillo-de-Santa-Pau E, Doose G, Gutwein J, Richter J, Hovestadt V, Huang B, Rico D, Jühling F, Kolarova J, Lu Q, Otto C, Wagener R, Arnolds J, Burkhardt B, Claviez A, Drexler HG, Eberth S, Eils R, Flicek P, Haas S, Humme M, Karsch D, Kerstens HHD, Klapper W, Kreuz M, Lawerenz C, Lenzek D, Loeffler M, López C, MacLeod RAF, Martens JHA, Kulis M, Martín-Subero JI, Möller P, Nage I, Picelli S, Vater I, Rohde M, Rosenstiel P, Rosolowski M, Russell RB, Schilhabel M, Schlesner M, Stadler PF, Szczepanowski M, Trümper L, Stunnenberg HG, Küppers R, Ammerpohl O, Lichter P, Siebert R, Hoffmann S, Radlwimmer B
  Nat Genet 2015, 47(11), 1316-25
  
• Survival of primary, but not of cancer cells after combined Plk1-HDAC inhibition.
  Lange L, Hemmerich P, Spänkuch B
  Oncotarget 2015, 6(28), 25801-14
  
• Defining the transcriptomic landscape of Candida glabrata by RNA-Seq.
  Linde J, Duggan S, Weber M, Horn F, Sieber P, Hellwig D, Riege K, Marz M, Martin R, Guthke R, Kurzai O
  Nucleic Acids Res 2015, 43(3), 1392-406
  
• Genomic and epigenomic co-evolution in follicular lymphomas.
  Loeffler M, Kreuz M, Haake A, Hasenclever D, Trautmann H, Arnold C, Winter K, Koch K, Klapper W, Scholtysik R, Rosolowski M, Hoffmann S, Ammerpohl O, Szczepanowski M, Herrmann D, Küppers R, Pott C, Siebert R, HaematoSys-Project
  Leukemia 2015, 29(2), 456-63
  
• Interventions to Slow Aging in Humans: Are We Ready?
  Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L
  Aging Cell 2015, 14(4), 497-510
  
• Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells.
  Lu Y, Hardes K, Dahms SO, Böttcher-Friebertshäuser E, Steinmetzer T, Than ME, Klenk HD, Garten W
  Antiviral Res 2015, 120, 89-100
  
• Histone Deacetylase Inhibitors (HDACi) Cause the Selective Depletion of Bromodomain Containing Proteins (BCPs).
  Mackmull MT, Iskar M, Parca L, Singer S, Bork P, Ori** A, Beck** M
  Mol Cell Proteomics 2015, 14(5), 1350-60 ** co-corresponding authors
  
• Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.
  Madhusudhan T, Wang H, Dong W, Ghosh S, Bock F, Thangapandi VR, Ranjan S, Wolter J, Kohli S, Shahzad K, Heidel F, Krueger M, Schwenger V, Moeller MJ, Kalinski T, Reiser J, Chavakis T, Isermann B
  Nat Commun 2015, 6, 6496
  
• Effects of ebselen and N-acetyl cysteine on replicative aging of primary human fibroblast strains.
  Marthandan S
  Immun Ageing 2015, 12, 8
  
• Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts.
  Marthandan S, Priebe S, Baumgart M, Groth M, Cellerino A, Guthke R, Hemmerich P, Diekmann S
  Biomed Res Int 2015, 2015, 731938
  
• Hormetic effect of rotenone in primary human fibroblasts.
  Marthandan S, Priebe S, Groth M, Guthke R, Platzer M, Hemmerich P, Diekmann S
  Immun Ageing 2015, 12, 11
  
• MicroRNAs as biomarker of Parkinson disease? Small but mighty.
  Marz M, Ferracin M, Klein C
  Neurology 2015, 84(7), 636-8
  
• Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.
  Matthews LC, Berry AA, Morgan DJ, Poolman TM, Bauer K, Kramer F, Spiller DG, Richardson RV, Chapman KE, Farrow SN, Norman MR, Williamson AJK, Whetton AD, Taylor SS, Tuckermann JP, White MRH, Ray DW
  Proc Natl Acad Sci U S A 2015, 112(17), 5479-84
  
• CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo.
  Mende N, Kuchen EE, Lesche M, Grinenko T, Kokkaliaris KD, Hanenberg H, Lindemann D, Dahl A, Platz A, Höfer T, Calegari F, Waskow C
  J Exp Med 2015, 212(8), 1171-83
  
• Comprehensive insights in the Mycobacterium avium subsp. paratuberculosis genome using new WGS data of sheep strain JIII-386 from Germany.
  Möbius P, Hölzer M, Felder M, Nordsiek G, Groth M, Köhler H, Reichwald K, Platzer M, Marz M
  Genome Biol Evol 2015, 7(9), 2585-601
  
• Mechanism of Functional Alterations in Hematopoietic Stem Cell Aging
  Morita Y
  In: Adult Stem Cells in Aging, Diseases and Cancer (edited by Rudolph KL), Else Kröner-Fresenius Symposia 2015, 5, 40-59, Karger Verlag, Basel
  
• Space constraints govern fate of hematopoietic stem and progenitor cells in vitro.
  Müller E, Grinenko T, Pompe T, Waskow C, Werner C
  Biomaterials 2015, 53, 709-15
  
• The function of embryonic stem cell-expressed Ras (E-Ras), a unique Ras family member, correlates with its additional motifs and its structural properties.
  Nakhaei-Rad S, Nakhaeizadeh H, Kordes C, Cirstea IC, Schmick M, Dvorsky R, Bastiaens PIH, Häussinger D, Ahmadian MR
  J Biol Chem 2015, 290(25), 15892-903
  
• Cooperative development of logical modelling standards and tools with CoLoMoTo.
  Naldi A, Monteiro PT, Müssel C, the Consortium for Logical Models and Tools, Kestler HA, Thieffry D, Xenarios I, Saez-Rodriguez J, Helikar T, Chaouiya C
  Bioinformatics 2015, 31(7), 1154-9
  
• TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway.
  Neri F, Dettori D, Incarnato D, Krepelova A, Rapelli S, Maldotti M, Parlato C, Paliogiannis P, Oliviero S
  Oncogene 2015, 34(32), 4168-76
  
• TET1 is controlled by pluripotency-associated factors in ESCs and downmodulated by PRC2 in differentiated cells and tissues.
  Neri F, Incarnato D, Krepelova A, Dettori D, Rapelli S, Maldotti M, Parlato C, Anselmi F, Galvagni F, Oliviero S
  Nucleic Acids Res 2015, 43(14), 6814-26
  
• DNA methylation and demethylation dynamics.
  Neri F, Incarnato D, Oliviero S
  Oncotarget 2015, 6(33), 34049-50
  
• Murine Embryonic Stem Cells Synthesize Retinoic Acid to Promote their Own Differentiation
  Neri* F, De Clemente* C, Orlandini M, Lentucci C, Anselmi F, Galvagni F
  J Stem Cell Res Ther 2015, 5(7), 293 * equal contribution
  
• Single-Base Resolution Analysis of 5-Formyl and 5-Carboxyl Cytosine Reveals Promoter DNA Methylation Dynamics.
  Neri* F, Incarnato* D, Krepelova A, Rapelli S, Anselmi F, Parlato C, Medana C, Dal Bello F, Oliviero S
  Cell Rep 2015, 10(5), 674–683 * equal contribution
  
• Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging.
  Neves J, Demaria M, Campisi J, Jasper H
  Dev Cell 2015, 32(1), 9-18
  
• Stat5 gene dosage in T cells modulates CD8+ T-cell homeostasis and attenuates contact hypersensitivity response in mice.
  Nivarthi H, Prchal-Murphy M, Swoboda A, Hager M, Schlederer M, Kenner L, Tuckermann J, Sexl V, Moriggl R, Ermakova O
  Allergy 2015, 70(1), 67-79 published during change of institution
  
• Identification of ageing-associated naturally occurring peptides in human urine.
  Nkuipou-Kenfack E, Bhat A, Klein J, Jankowski V, Mullen W, Vlahou A, Dakna M, Koeck T, Schanstra JP, Zürbig P, Rudolph KL, Schumacher B, Pich A, Mischak H
  Oncotarget 2015, 6(33), 34106-17
  
• Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats
  Ori* A, Toyama* BH, Harris MS, Bock T, Iskar M, Bork P, Ingolia NT, Hetzer MW, Beck M
  Cell Syst 2015, 1(3), 224–237 * equal contribution, published during change of institution
  
• High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation.
  Parplys AC, Seelbach JI, Becker S, Behr M, Jend C, Mansour WY, Joosse S, Stuerzbecher HW, Pospiech H, Petersen C, Dikomey E, Borgmann K
  Cell Cycle 2015, 14(19), 3190-202
  
• Distinct Intracellular Domain Substrate Modifications Selectively Regulate Ectodomain Cleavage of NRG1 or CD44
  Parra* LM, Hartmann* M, Schubach S, Li Y, Herrlich P, Herrlich A
  Mol Cell Biol 2015, 35(19), 3381-95 * equal contribution
  
• Deficiency of the protein-tyrosine phosphatase DEP-1/PTPRJ promotes matrix metalloproteinase-9 expression in meningioma cells.
  Petermann A, Stampnik Y, Cui Y, Morrison H, Pachow D, Kliese N, Mawrin C, Böhmer FD
  J Neurooncol 2015, 122(3), 451-9
  
• Characterization and quantification of proteins secreted by single human embryos prior to implantation.
  Poli* M, Ori* A, Child T, Jaroudi S, Spath K, Beck M, Wells D
  EMBO Mol Med 2015, 7(11), 1465-79 * equal contribution, published during change of institution
  
• Glandular ß-glucosidases in juvenile Chrysomelina leaf beetles support the evolution of a host-plant-dependent chemical defense.
  Rahfeld P, Haeger W, Kirsch R, Pauls G, Becker T, Schulze E, Wielsch N, Wang D, Groth M, Brandt W, Boland W, Burse A
  Insect Biochem Mol Biol 2015, 58, 28-38
  
• Turquoise killifish.
  Reichard M, Cellerino A, Valenzano DR
  Curr Biol 2015, 25(17), R741-2
  
• The deubiquitinating enzyme CYLD regulates the differentiation and maturation of thymic medullary epithelial cells.
  Reissig S, Hövelmeyer N, Tang Y, Weih D, Nikolaev A, Riemann M, Weih F, Waisman A
  Immunol Cell Biol 2015, 93(6), 558-66
  
• The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection.
  Roquis D, Lepesant JMJ, Picard MAL, Freitag M, Parrinello H, Groth M, Emans R, Cosseau C, Grunau C
  PLoS Negl Trop Dis 2015, 9(8), e0003853
  
• Adult Stem Cells in Aging, Diseases and Cancer
  Rudolph KL (ed)
  Book series: Else Kröner-Fresenius Symposia 2015, 5, Karger Verlag, Basel, Switzerlan
  
• Loss of ATM accelerates pancreatic cancer formation and epithelial-mesenchymal transition.
  Russell R, Perkhofer L, Liebau S, Lin Q, Lechel A, Feld FM, Hessmann E, Gaedcke J, Güthle M, Zenke M, Hartmann D, von Figura G, Weissinger SE, Rudolph KL, Möller P, Lennerz JK, Seufferlein T, Wagner M, Kleger A
  Nat Commun 2015, 6, 7677
  
• Towards a comprehensive picture of alloacceptor tRNA remolding in metazoan mitochondrial genomes.
  Sahyoun AH, Hölzer M, Jühling F, Höner zu Siederdissen C, Al-Arab M, Tout K, Marz M, Middendorf M, Stadler PF, Bernt M
  Nucleic Acids Res 2015, 43(16), 8044-56
  
• Central Venous Catheter-Related Bloodstream Infections in Obese Hematologic Patients.
  Schalk E, Färber J, Fischer T, Heidel FH
  Infect Control Hosp Epidemiol 2015, 36(8), 995-6
  
• Prediction of central venous catheter-related bloodstream infections (CRBSIs) in patients with haematologic malignancies using a modified Infection Probability Score (mIPS).
  Schalk E, Hanus L, Färber J, Fischer T, Heidel FH
  Ann Hematol 2015, 94(9), 1451-6
  
• On the validity of time-dependent AUC estimators.
  Schmid M, Kestler HA, Potapov S
  Brief Bioinform 2015, 16(1), 153-68 published during change of institution
  
• Epo-induced erythroid maturation is dependent on Plcγ1 signaling.
  Schnöder TM, Arreba-Tutusaus P, Griehl I, Bullinger L, Buschbeck M, Lane SW, Döhner K, Plass C, Lipka DB, Heidel FH, Fischer T
  Cell Death Differ 2015, 22(6), 974-85
  
• Mast cell promotion of T cell-driven antigen-induced arthritis despite being dispensable for antibody-induced arthritis in which T cells are bypassed.
  Schubert N, Dudeck J, Liu P, Karutz A, Speier S, Maurer M, Tuckermann J, Dudeck A
  Arthritis Rheumatol 2015, 67(4), 903-13 published during change of institution
  
• High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation.
  Sokka M, Rilla K, Miinalainen I, Pospiech H, Syväoja JE
  Nucleic Acids Res 2015, 43(10), 4975-89
  
• It's a bit over, is that ok? The subtle surplus from tandem alternative splicing.
  Szafranski K, Kramer M
  RNA BIOL 2015, 12(2), 115-22
  
• Sestrins in Aging and Metabolism
  Tang D, Tao S
  In: Adult Stem Cells in Aging, Diseases and Cancer (edited by Rudolph KL), Else Kröner-Fresenius Symposia 2015, 5, 60-65, Karger Verlag, Basel
  
• Internalization of near-infrared fluorescently labeled activatable cell-penetrating peptide and of proteins into human fibrosarcoma cell line HT-1080.
  Tansi F, Kallweit E, Kaether C, Kappe K, Schumann C, Hilger I, Reissmann S
  J Cell Biochem 2015, 116(7), 1222-31
  
• Left-right asymmetry in the light of TOR: An update on what we know so far.
  Tena TC, Burkhalter** MD, Philipp** M
  Biol Cell 2015, 107(9), 306-18 ** co-corresponding authors
  
• A Branch-and-Bound Approach for Tautomer Enumeration
  Thalheim T, Wagner B, Kühne R, Middendorf M, Schüürmann G
  Mol Inform 2015, 34, 263–75
  
• Analysis of Alpha-2 Macroglobulin from the Long-Lived and Cancer-Resistant Naked Mole-Rat and Human Plasma.
  Thieme R, Kurz S, Kolb M, Debebe T, Holtze S, Morhart M, Huse K, Szafranski K, Platzer M, Hildebrandt TB, Birkenmeier G
  PLoS One 2015, 10(6), e0130470
  
• The African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan.
  Valenzano DR, Benayoun BA, Singh PP, Zhang E, Etter PD, Hu CK, Clément-Ziza M, Willemsen D, Cui R, Harel I, Machado BE, Yee MC, Sharp SC, Bustamante CD, Beyer A, Johnson EA, Brunet A
  Cell 2015, 163(6), 1539-54
  
• A pooled analysis of overall survival in COMFORT-I and COMFORT-II, 2 randomized phase III trials of ruxolitinib for the treatment of myelofibrosis.
  Vannucchi AM, Kantarjian HM, Kiladjian JJ, Gotlib J, Cervantes F, Mesa RA, Sarlis NJ, Peng W, Sandor V, Gopalakrishna P, Hmissi A, Stalbovskaya V, Gupta V, Harrison C, Verstovsek S, COMFORT Investigators
  Haematologica 2015, 100(9), 1139-45
  
• Sputnik: Ad hoc distributed computation.
  Völkel G, Lausser L, Schmid F, Kraus JM, Kestler HA
  Bioinformatics 2015, 31(8), 1298-301
  
• In situ structural analysis of the human nuclear pore complex.
  von Appen A, Kosinski J, Sparks L, Ori A, DiGuilio AL, Vollmer B, Mackmull MT, Banterle N, Parca L, Kastritis P, Buczak K, Mosalaganti S, Hagen W, Andres-Pons A, Lemke EA, Bork P, Antonin W, Glavy JS, Bui KH, Beck M
  Nature 2015, 526(7571), 140-3 published during change of institution
  
• A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer.
  von Eyss B, Jaenicke LA, Kortlever RM, Royla N, Wiese KE, Letschert S, McDuffus LA, Sauer M, Rosenwald A, Evan GI, Kempa S, Eilers M
  Cancer Cell 2015, 28(6), 743-57
  
• The PCBP1 gene encoding poly(rC) binding protein I is recurrently mutated in Burkitt lymphoma.
  Wagener R, Aukema SM, Schlesner M, Haake A, Burkhardt B, Claviez A, Drexler HG, Hummel M, Kreuz M, Loeffler M, Rosolowski M, López C, Möller P, Richter J, Rohde M, Betts MJ, Russell RB, Bernhart SH, Hoffmann S, Rosenstiel P, Schilhabel M, Szczepanowski M, Trümper L, Klapper W, Siebert R, ICGC MMML-Seq-Project, "Molecular Mechanisms in Malignant Lymphomas" Network Project of the Deutsche Krebshilfe
  Genes Chromosomes Cancer 2015, 54(9), 555-64
  
• Sumoylation of HDAC2 promotes NF-κB-dependent gene expression.
  Wagner T, Kiweler N, Wolff K, Knauer SK, Brandl A, Hemmerich P, Dannenberg JH, Heinzel T, Schneider G, Krämer OH
  Oncotarget 2015, 6(9), 7123-35
  
• PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress.
  Wang L, Ryoo HD, Qi Y, Jasper H
  PLoS Genet 2015, 11(5), e1005220
  
• Structure and regulatory role of the C-terminal winged helix domain of the archaeal minichromosome maintenance complex.
  Wiedemann C, Szambowska A, Häfner S, Ohlenschläger O, Gührs KH, Görlach M
  Nucleic Acids Res 2015, 43(5), 2958-67
  
• Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells.
  Wiese* KE, Haikala* HM, von Eyss* B, Wolf E, Esnault C, Rosenwald A, Treisman R, Klefström J, Eilers M
  EMBO J 2015, 34(11), 1554-71 * equal contribution
  
• Generation of Aorta Transcript Atlases of Wild-Type and Apolipoprotein E-null Mice by Laser Capture Microdissection-Based mRNA Expression Microarrays.
  Yin C, Mohanta S, Ma Z, Weber C, Hu D, Weih F, Habenicht A
  Methods Mol Biol 2015, 1339, 297-308
  
• Inhibition of Wild-type p53-induced phosphatase 1 promotes liver regeneration in mice by direct activation of mTOR.
  Zhang L, Liu L, He Z, Li G, Liu J, Song Z, Jin H, Rudolph KL, Yang H, Mao Y, Zhang L, Zhang H, Xiao Z, Ju Z
  Hepatology 2015, 61(6), 2030-41
  
• Merlin's wizardry guides cohesive migration.
  Zoch A, Morrison H
  Nat Cell Biol 2015, 17(3), 212-3
  

Publications 2014:

• A sequence-ready physical map of barley anchored genetically by two million single-nucleotide polymorphisms.
  Ariyadasa R, Mascher M, Nussbaumer T, Schulte D, Frenkel Z, Poursarebani N, Zhou R, Steuernagel B, Gundlach H, Taudien S, Felder M, Platzer M, Himmelbach A, Schmutzer T, Hedley P, Muehlbauer G, Scholz U, Korol A, Mayer K, Waugh R, Langridge P, Graner A, Stein N
  Plant Physiol 2014, 164(1), 412-23
  
• HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization.
  Azoitei N, Diepold K, Brunner C, Rouhi A, Genze F, Becher A, Kestler H, van Lint J, Chiosis G, Koren J, Fröhling S, Scholl C, Seufferlein T
  Cancer Res 2014, 74(23), 7125-36 published during change of institution
  
• Transcriptomic immune response of the cotton stainer Dysdercus fasciatus to experimental elimination of vitamin-supplementing intestinal symbionts.
  Bauer E, Salem H, Marz M, Vogel H, Kaltenpoth M
  PLoS One 2014, 9(12), e114865
  
• RNA-seq of the aging brain in the short-lived fish N. furzeri - conserved pathways and novel genes associated with neurogenesis.
  Baumgart* M, Groth* M, Priebe* S, Savino A, Testa G, Dix A, Ripa R, Spallotta F, Gaetano C, Ori M, Terzibasi Tozzini E, Guthke R, Platzer M, Cellerino A
  Aging Cell 2014, 13(6), 965-74 * equal contribution
  
• Explorative Analysis of Heterogeneous, Unstructured, and Uncertain Data: A Computer Science Perspective on Biodiversity Research
  Beckstein C, Böcker S, Bogdan M, Bücker HM.Bruelheide H, Denzler J, Dittrich P, Grosse I, Hinneburg A, König-Ries B, Löffler F, Marz M, Müller-Hannemann M, Winter M, Zimmermann W
  In: Proceedings of 3rd International Conference on Data Management Technologies and Applications (DATA-2014) 2014, 251-257, Science and Technology
  
• Impact of genomic damage and ageing on stem cell function.
  Behrens A, van Deursen JM, Rudolph* KL, Schumacher B
  Nat Cell Biol 2014, 16(3), 201-7 * corresponding author, based on the Else Kröner-Fresenius-Symposium in Molecular Medicine
  
• Analysis of disorder in tricalcium silicate by 29Si NMR spectroscopy and additional methods
  Bellmann F, Leppert J, Görlach M, Krbetschek M, Damidot D, Ludwig HM
  Cement Concrete Res 2014, 57, 105-16
  
• Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength.
  Bentzinger* CF, von Maltzahn* J, Dumont NA, Stark DA, Wang YX, Nhan K, Frenette J, Cornelison DDW, Rudnicki MA
  J Cell Biol 2014, 205(1), 97-111 * equal contribution, published during change of institution
  
• Slit/Robo signaling regulates cell fate decisions in the intestinal stem cell lineage of Drosophila.
  Biteau B, Jasper H
  Cell Rep 2014, 7(6), 1867-75
  
• Chlamydia psittaci inclusion membrane protein IncB associates with host protein Snapin.
  Böcker S, Heurich A, Franke C, Monajembashi S, Sachse K, Saluz HP, Hänel F
  Int J Med Microbiol 2014, 304(5-6), 542-53
  
• Kinesin-dependent motility generation as target mechanism of cadmium intoxication.
  Böhm KJ
  Toxicol Lett 2014, 224(3), 356-61
  
• Novel Insights into Structure and Function of Factor XIIIa-Inhibitor Tridegin.
  Böhm M, Bäuml CA, Hardes K, Steinmetzer T, Roeser D, Schaub Y, Than ME, Biswas A, Imhof D
  J Med Chem 2014, 57(24), 10355-65
  
• The Wilms' tumor suppressor WT1 enhances CD95L expression and promotes activation-induced cell death in leukemic T cells.
  Bourkoula K, Englert C, Giaisi M, Koehler R, Krammer PH, Li-Weber M
  Int J Cancer 2014, 134(2), 291-300
  
• A 'telomere-associated secretory phenotype' cooperates with BCR-ABL to drive malignant proliferation of leukemic cells.
  Braig M, Pällmann N, Preukschas M, Steinemann D, Hofmann W, Gompf A, Streichert T, Braunschweig T, Copland M, Rudolph KL, Bokemeyer C, Koschmieder S, Schuppert A, Balabanov S, Brümmendorf TH
  Leukemia 2014, 28(10), 2028-39
  
• Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.
  Bruedigam C, Bagger FO, Heidel FH, Paine Kuhn C, Guignes S, Song A, Austin R, Vu T, Lee E, Riyat S, Moore AS, Lock RB, Bullinger L, Hill GR, Armstrong SA, Williams DA, Lane SW
  Cell Stem Cell 2014, 15(6), 775-90
  
• Lin28a - boost your energy for youthful regeneration.
  Burkhalter MD, Morita Y, Rudolph KL
  EMBO J 2014, 33(1), 5–6
  
• Control of metabolic adaptation to fasting by dILP6-induced insulin signaling in Drosophila oenocytes.
  Chatterjee D, Katewa SD, Qi Y, Jackson SA, Kapahi P, Jasper H
  Proc Natl Acad Sci U S A 2014, 111(50), 17959-64
  
• Gadd45a Regulates Hematopoietic Stem Cell Stress Responses in Mice.
  Chen Y, Ma X, Zhang M, Wang X, Wang C, Wang H, Guo P, Yuan W, Rudolph KL, Zhan Q, Ju Z
  Blood 2014, 123(6), 851-62
  
• Gender identity rather than sexual orientation impacts on facial preferences.
  Ciocca G, Limoncin E, Cellerino A, Fisher AD, Gravina GL, Carosa E, Mollaioli D, Valenzano DR, Mennucci A, Bandini E, Di Stasi SM, Maggi M, Lenzi A, Jannini EA
  J Sex Med 2014, 11(10), 2500-7
  
• Kit regulates HSC engraftment across the human-mouse species barrier.
  Cosgun KN, Rahmig S, Mende N, Reinke S, Hauber I, Schäfer C, Petzold A, Weisbach H, Heidkamp G, Purbojo A, Cesnjevar R, Platz A, Bornhäuser M, Schmitz M, Dudziak D, Hauber J, Kirberg J, Waskow C
  Cell Stem Cell 2014, 15(2), 227-38
  
• Nerve growth factor in the adult brain of a teleostean model for aging research: Nothobranchius furzeri.
  D'Angelo L, Castaldo L, Cellerino A, de Girolamo P, Lucini C
  Ann Anat 2014, 196(4), 183-91
  
• Brain derived neurotrophic factor: mRNA expression and protein distribution in the brain of the teleost Nothobranchius furzeri.
  D'Angelo L, de Girolamo P, Lucini C, Terzibasi ET, Baumgart M, Castaldo L, Cellerino A
  J Comp Neurol 2014, 522(5), 1004-30
  
• X-ray structures of human furin in complex with competitive inhibitors.
  Dahms SO, Hardes K, Becker GL, Steinmetzer T, Brandstetter H, Than ME
  ACS Chem Biol 2014, 9(5), 1113-18
  
• FACS-FRET: Reply to comments on "Biomolecular dynamics and binding studies in the living cell".
  Diekmann S, Hoischen C
  Phys Life Rev 2014, 11(1), 38
  
• Biomolecular dynamics and binding studies in the living cell.
  Diekmann S, Hoischen C
  Phys Life Rev 2014, 11(1), 1-30
  
• Transition to annual life history coincides with reduction in cell cycle speed during early cleavage in three independent clades of annual killifish.
  Dolfi L, Ripa R, Cellerino A
  Evodevo 2014, 5, 32
  
• Expression of the lymphoid enhancer factor 1 is required for normal hematopoietic stem and progenitor cell function.
  Edmaier KE, Stahnke K, Vegi N, Mulaw M, Ihme S, Scheffold A, Rudolph KL, Buske C
  Leukemia 2014, 28(1), 227-30 published during change of institution
  
• The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells.
  Eguether T, Ermolaeva MA, Zhao Y, Bonnet MC, Jain A, Pasparakis M, Courtois G, Tassin AM
  Nat Commun 2014, 5, 4585
  
• Systemic DNA damage responses: organismal adaptations to genome instability.
  Ermolaeva MA, Schumacher B
  Trends Genet 2014, 30(3), 95-102
  
• Insights from the worm: the C. elegans model for innate immunity.
  Ermolaeva MA, Schumacher B
  Semin Immunol 2014, 26(4), 303-9
  
• Functional Mutation Analysis Provides Evidence for a Role of REEP1 in Lipid Droplet Biology.
  Falk J, Rohde M, Bekhite MM, Sophie Neugebauer, Hemmerich P, Kiehntopf M, Deufel T, Hübner CA, Beetz C
  Hum Mutat 2014, 35(4), 497-504
  
• Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2α and ETS1.
  Fiorito V, Neri F, Pala V, Silengo L, Oliviero S, Altruda F, Tolosano E
  Biochim Biophys Acta 2014, 1839(4), 259-64
  
• Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis.
  Flex E, Jaiswal M, Pantaleoni F, Martinelli S, Strullu M, Fansa EK, Caye A, De Luca A, Lepri F, Dvorsky R, Pannone L, Paolacci S, Zhang SC, Fodale V, Bocchinfuso G, Rossi C, Burkitt-Wright EMM, Farrotti A, Stellacci E, Cecchetti S, Ferese R, Bottero L, Castro S, Fenneteau O, Brethon B, Sanchez M, Roberts AE, Yntema HG, Van Der Burgt I, Cianci P, Bondeson ML, Cristina Digilio M, Zampino G, Kerr B, Aoki Y, Loh ML, Palleschi A, Di Schiavi E, Carè A, Selicorni A, Dallapiccola B, Cirstea IC, Stella L, Zenker M, Gelb BD, Cavé H, Ahmadian MR, Tartaglia M
  Hum Mol Genet 2014, 23(16), 4315-27
  
• Brain derived neurotrophic factor in the retina of the teleost N. furzeri.
  Gatta C, Castaldo L, Cellerino A, de Girolamo P, Lucini C, D'Angelo L
  Ann Anat 2014, 196(4), 192-6
  
• The Genome of the Foraminiferan Reticulomyxa filosa.
  Glöckner G, Hülsmann N, Schleicher M, Noegel AA, Eichinger L, Gallinger C, Pawlowski J, Sierra R, Euteneuer U, Pillet L, Moustafa A, Platzer M, Groth M, Szafranski K, Schliwa M
  Curr Biol 2014, 24, 11-8
  
• Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cells.
  Grinenko T, Arndt K, Portz M, Mende N, Günther M, Cosgun KN, Alexopoulou D, Lakshmanaperumal N, Henry I, Dahl A, Waskow C
  J Exp Med 2014, 211(2), 209-15
  
• The genome of an influenza virus from a pilot whale: Relation to influenza viruses of gulls and marine mammals.
  Groth M, Lange J, Kanrai P, Pleschka S, Scholtissek C, Krumbholz A, Platzer M, Sauerbrei A, Zell R
  Infect Genet Evol 2014, 24, 183-6
  
• Transkriptom-Sequenzierung in der Alternsforschung
  Groth M, Reichwald K, Szafranski K, Taudien S, Platzer M
  BIOspektrum 2014, 20(2), 163-6
  
• PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan.
  Guo L, Karpac J, Tran SL, Jasper H
  Cell 2014, 156(1-2), 109-22
  
• Manganese-Enhanced MRI: In Vivo Imaging of CNS Anatomy, Fiber Connectivity and Functional Activity
  Haenold R
  In: In Vivo Imaging: New Research (edited by Rick Hough and Jared Camarillo), Biotechnology in Agriculture, Industry and Medicine 2014, 49-86, Nova Science Publishers
  
• Studying aging in Drosophila.
  He Y, Jasper H
  Methods 2014, 68(1), 129-33
  
• A multi-split mapping algorithm for circular RNA, splicing, trans-splicing and fusion detection.
  Hoffmann S, Otto C, Doose G, Tanzer A, Langenberger D, Christ S, Kunz M, Holdt LM, Teupser D, Hackermüller J, Stadler PF
  Genome Biol 2014, 15(2), R34
  
• AgeFactDB – The JenAge Ageing Factor Database – Towards data integration in ageing research
  Huehne R, Thalheim T, Suehnel J
  Nucleic Acids Res 2014, 42(1), D892-6
  
• Telomerase exerts physiological and tumor promoting functions by stimulating ribosomal biogenesis
  Iben S, Günes C
  Telomere and Telomerases 2014, 1, e433
  
• Mutation in ST6GALNAC5 identified in family with coronary artery disease.
  Inanloorahatloo K, Parsa AFZ, Huse K, Rasooli P, Davaran S, Platzer M, Kramer M, Fan JB, Turk C, Amini S, Steemers F, Gunderson K, Ronaghi M, Elahi E
  Sci Rep 2014, 4, 3595
  
• High-throughput single nucleotide variant discovery in E14 mouse embryonic stem cells provides a new reference genome assembly.
  Incarnato D, Krepelova A, Neri F
  Genomics 2014, 104(2), 121-7
  
• Genome-wide profiling of mouse RNA secondary structures reveals key features of the mammalian transcriptome.
  Incarnato D, Neri F, Anselmi F, Oliviero S
  Genome Biol 2014, 15(10), 491
  
• Functional crosstalk between Ras and Rho pathways: p120RasGAP competitively inhibits the RhoGAP activity of Deleted in Liver Cancer (DLC) tumor suppressors by masking its catalytic arginine finger.
  Jaiswal M, Dvorsky R, Amin E, Risse SL, Fansa EK, Zhang SC, Taha MS, Gauhar AR, Nakhaei-Rad S, Kordes C, Koessmeier KT, Cirstea IC, Olayioye MA, Haeussinger D, Ahmadian MR
  J Biol Chem 2014, 289(10), 6839-49
  
• Mitochondrial proteostasis in the control of aging and longevity.
  Jensen MB, Jasper H
  Cell Metab 2014, 20(2), 214-25
  
• Telomere shortening in leukocyte subpopulations in depression.
  Karabatsiakis A, Kolassa IT, Kolassa S, Rudolph KL, Dietrich DE
  BMC Psychiatry 2014, 14, 192
  
• Transduction of proteins into leishmania tarentolae by formation of non-covalent complexes with cell-penetrating peptides.
  Keller AA, Breitling R, Hemmerich P, Kappe K, Braun M, Wittig B, Schaefer B, Lorkowski S, Reissmann S
  J Cell Biochem 2014, 115(2), 243-52
  
• Sensory neuropathy with bone destruction due to a mutation in the membrane-shaping atlastin GTPase 3.
  Kornak U, Mademan I, Schinke M, Voigt M, Krawitz P, Hecht J, Barvencik F, Schinke T, Gießelmann S, Beil FT, Pou-Serradell A, Vílchez JJ, Beetz C, Deconinck T, Timmerman V, Kaether C, De Jonghe P, Hübner CA, Gal A, Amling M, Mundlos S, Baets J, Kurth I
  Brain 2014, 137(Pt 3), 683-92
  
• Myc and max genome-wide binding sites analysis links the Myc regulatory network with the polycomb and the core pluripotency networks in mouse embryonic stem cells.
  Krepelova* A, Neri* F, Maldotti M, Rapelli S, Oliviero S
  PLoS One 2014, 9(2), e88933 * equal contribution
  
• The origin of the European avian-like swine influenza viruses.
  Krumbholz A, Lange J, Sauerbrei A, Groth M, Platzer M, Kanrai P, Pleschka S, Scholtissek C, Büttner M, Dürrwald R, Zell R
  J Gen Virol 2014, 95(Pt11), 2372-6
  
• Virus isolate from carp: genetic characterisation reveals a novel picornavirus with two aphthovirus 2A-like sequences.
  Lange J, Groth M, Fichtner D, Granzow H, Keller B, Walther M, Platzer M, Sauerbrei A, Zell R
  J Gen Virol 2014, 95, 80-90
  
• Circulation of classical swine influenza virus in Europe between the wars?
  Lange J, Groth M, Kanrai P, Pleschka S, Scholtissek C, Dürrwald R, Platzer M, Sauerbrei A, Zell R
  Arch Virol 2014, 159(6), 1467-73
  
• Unlabeling data can improve classification accuracy
  Lausser L, Schmid F, Schmid M, Kestler HA
  Pattern Recogn Lett 2014, 37, 15–23
  
• Enhanced Telomere Rejuvenation in Pluripotent Cells Reprogrammed via Nuclear Transfer Relative to Induced Pluripotent Stem Cells.
  Le R, Kou Z, Jiang Y, Li M, Huang B, Liu W, Li H, Kou X, He W, Rudolph KL, Ju Z, Gao S
  Cell Stem Cell 2014, 14(1), 27-39
  
• Genomewide comparison and novel ncRNAs of Aquificales.
  Lechner M, Nickel AI, Wehner S, Riege K, Wieseke N, Beckmann BM, Hartmann** RK, Marz** M
  BMC Genomics 2014, 15, 522 ** co-corresponding authors
  
• Suppression of the DHX9 helicase induces premature senescence in human diploid fibroblasts in a p53-dependent manner.
  Lee T, Di Paola D, Malina A, Mills JR, Kreps A, Grosse F, Tang H, Zannis-Hadjopoulos M, Larsson O, Pelletier J
  J Biol Chem 2014, 289(33), 22798-814
  
• Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features.
  Lessel D, Vaz B, Halder S, Lockhart PJ, Marinovic-Terzic I, Lopez-Mosqueda J, Philipp M, Sim JCH, Smith KR, Oehler J, Cabrera E, Freire R, Pope K, Nahid A, Norris F, Leventer RJ, Delatycki MB, Barbi G, von Ameln S, Högel J, Degoricija M, Fertig R, Burkhalter MD, Hofmann K, Thiele H, Altmüller J, Nürnberg G, Nürnberg P, Bahlo M, Martin GM, Aalfs CM, Oshima J, Terzic J, Amor DJ, Dikic I, Ramadan K, Kubisch C
  Nat Genet 2014, 11, 1239-44
  
• RNA structure analysis of alphacoronavirus terminal genome regions.
  Madhugiri R, Fricke M, Marz M, Ziebuhr J
  Virus Res 2014, 194, 76-89
  
• p21 promotes sustained liver regeneration and hepatocarcinogenesis in chronic cholestatic liver injury.
  Marhenke S, Buitrago-Molina LE, Endig J, Orlik J, Schweitzer N, Klett S, Longerich T, Geffers R, Sánchez Muñoz A, Dorrell C, Katz SF, Lechel A, Weng H, Krech T, Lehmann U, Dooley S, Rudolph KL, Manns MP, Vogel A
  Gut 2014, 63(9), 1501-12
  
• SENIEUR status of the originating cell donor negates certain 'anti-immunosenescence' effects of ebselen and N-acetyl cysteine in human T cell clone cultures.
  Marthandan S, Freeburn R, Steinbrecht S, Pawelec G, Barnett Y
  Immun Ageing 2014, 11(1), 17
  
• Challenges in RNA virus bioinformatics.
  Marz M, Beerenwinkel N, Drosten C, Fricke M, Frishman D, Hofacker IL, Hoffmann D, Middendorf M, Rattei T, Stadler PF, Töpfer A
  Bioinformatics 2014, 30(13), 1793-9
  
• Novel Zinc-binding Site in the E2 Domain Regulates Amyloid Precursor-like Protein 1 (APLP1) Oligomerization.
  Mayer MC, Kaden D, Schauenburg L, Hancock MA, Voigt P, Roeser D, Barucker C, Than ME, Schaefer M, Multhaup G
  J Biol Chem 2014, 289(27), 19019-30
  
• Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice.
  Missios P, Zhou Y, Guachalla LM, von Figura G, Wegner A, Chakkarappan SR, Binz T, Gompf A, Hartleben G, Burkhalter MD, Wulff V, Günes C, Sattler RW, Song Z, Illig T, Klaus S, Böhm BO, Wenz T, Hiller K, Rudolph KL
  Nat Commun 2014, 5, 4924
  
• Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures.
  Movérare-Skrtic S, Henning P, Liu X, Nagano K, Saito H, Börjesson AE, Sjögren K, Windahl SH, Farman H, Kindlund B, Engdahl C, Koskela A, Zhang FP, Eriksson EE, Zaman F, Hammarstedt A, Isaksson H, Bally M, Kassem A, Lindholm C, Sandberg O, Aspenberg P, Sävendahl L, Feng JQ, Tuckermann J, Tuukkanen J, Poutanen M, Baron R, Lerner UH, Gori F, Ohlsson C
  Nat Med 2014, 20(11), 1279-88 published during change of institution
  
• DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage.
  Mueller MM, Castells-Roca L, Babu V, Ermolaeva MA, Müller RU, Frommolt P, Williams AB, Greiss S, Schneider JI, Benzing T, Schermer B, Schumacher B
  Nat Cell Biol 2014, 16(12), 1168-79
  
• Expression pattern of thyroid hormone transporters in the postnatal mouse brain.
  Müller J, Heuer H
  Front Endocrinol (Lausanne) 2014, 5, 92
  
• Atypical RNAs in the coelacanth transcriptome.
  Nitsche A, Doose G, Tafer H, Robinson M, Saha NR, Gerdol M, Canapa A, Hoffmann S, Amemiya CT, Stadler PF
  J Exp Zool B Mol Dev Evol 2014, 322(6), 342-51
  
• Measuring telomere length and telomere dynamics in evolutionary biology and ecology
  Nussey DH, Baird D, Barrett E, Boner W, Fairlie J, Gemmell N, Hartmann N, Horn T, Haussmann M, Olsson M, Turbill C, Verhulst S, Zahn S, Monaghan P
  Methods Ecol Evol 2014, 5(4), 299–310
  
• Substantial telomere shortening in the substantia nigra of telomerase-deficient mice does not increase susceptibility to MPTP-induced dopamine depletion.
  Oeckl P, Scheffold A, Lechel A, Rudolph KL, Ferger B
  Neuroreport 2014, 25(5), 335-9 published during change of institution
  
• Häm und seine Abbauprodukte
  Ohlenschläger O, Schiller A, Jahns F, Heinemann SH
  Nachr Chem 2014, 62(2), 119-24
  
• The use of targeted proteomics to determine the stoichiometry of large macromolecular assemblies.
  Ori* A, Andrés-Pons* A, Beck M
  Methods Cell Biol 2014, 122, 117-46 * equal contribution
  
• Lacking alignments? The next-generation sequencing mapper segemehl revisited.
  Otto C, Stadler PF, Hoffmann S
  Bioinformatics 2014, 30(13), 1837-43
  
• Association of condensin with chromosomes depends on DNA binding by its HEAT-repeat subunits.
  Piazza I, Rutkowska A, Ori A, Walczak M, Metz J, Pelechano V, Beck M, Haering CH
  Nat Struct Mol Biol 2014, 21(6), 560-8
  
• Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.
  Placke T, Faber K, Nonami A, Putwain SL, Salih HR, Heidel FH, Krämer A, Root DE, Barbie DA, Krivtsov AV, Armstrong SA, Hahn WC, Huntly BJ, Sykes SM, Milsom MD, Scholl C, Fröhling S
  Blood 2014, 124(1), 13-23
  
• Inhibition of JAK-STAT signaling stimulates adult satellite cell function.
  Price* FD, von Maltzahn* J, Bentzinger CF, Dumont NA, Yin H, Chang NC, Wilson DH, Frenette J, Rudnicki MA
  Nat Med 2014, 10, 1174-81 * equal contribution, published during change of institution
  
• The Ca2+ sensor protein swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons.
  Purohit P, Perez-Branguli F, Prots I, Borger E, Gunn-Moore F, Welzel O, Loy K, Wenzel EM, Grömer TW, Brachs S, Holzer M, Buslei R, Fritsch K, Regensburger M, Böhm KJ, Winner B, Mielenz D
  PLoS One 2014, 9(8), e103976
  
• Graph-distance distribution of the Boltzmann ensemble of RNA secondary structures.
  Qin J, Fricke M, Marz M, Stadler PF, Backofen R
  Algorithms Mol Biol 2014, 9, 19
  
• Independently recruited oxidases from the glucose-methanol-choline oxidoreductase family enabled chemical defences in leaf beetle larvae (subtribe Chrysomelina) to evolve.
  Rahfeld P, Kirsch R, Kugel S, Wielsch N, Stock M, Groth M, Boland W, Burse A
  Proc Biol Sci 2014, 281(1788), 20140842
  
• The Comet-Fish technique, a tool for detection of specific DNA damage and repair
  Rapp A, Hausmann M, Greulich KO
  In: Molecular Toxicology Protocols, Methods in Molecular Biology (edited by Phouthone K, Stephen GG) 2014, 107-19, Humana Press Inc., Totow
  
• A first glimpse at the genome of the Baikalian amphipod Eulimnogammarus verrucosus.
  Rivarola-Duarte L, Otto C, Jühling F, Schreiber S, Bedulina D, Jakob L, Gurkov A, Axenov-Gribanov D, Sahyoun AH, Lucassen M, Hackermüller J, Hoffmann S, Sartoris F, Pörtner HO, Timofeyev M, Luckenbach T, Stadler PF
  J Exp Zool B Mol Dev Evol 2014, 322(3), 177-89
  
• Novel mechanism of JNK pathway activation by adenoviral E1A.
  Romanov* VS, Brichkina* AI, Morrison H, Pospelova TV, Pospelov VA, Herrlich P
  Oncotarget 2014, 5(8), 2176-86 * equal contribution
  
• Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans.
  Sabala I, Jagielska E, Bardelang PT, Czapinska H, Dahms SO, Sharpe JA, James R, Than ME, Thomas NR, Bochtler M
  FEBS J 2014, 281(18), 4112-22
  
• Evidence for the existence of two new members of the family Chlamydiaceae and proposal of Chlamydia avium sp. nov. and Chlamydia gallinacea sp. nov.
  Sachse K, Laroucau K, Riege K, Wehner S, Dilcher M, Creasy HH, Weidmann M, Myers G, Vorimore F, Vicari N, Magnino S, Liebler-Tenorio E, Ruettger A, Bavoil PM, Hufert FT, Rosselló-Móra R, Marz M
  Syst Appl Microbiol 2014, 37(2), 79-88
  
• Vitamin supplementation by gut symbionts ensures metabolic homeostasis in an insect host.
  Salem H, Bauer E, Strauss AS, Vogel H, Marz M, Kaltenpoth M
  Proc Biol Sci 2014, 281(1796), 20141838
  
• Miz1 deficiency in the mammary gland causes a lactation defect by attenuated Stat5 expression and phosphorylation.
  Sanz-Moreno A, Fuhrmann D, Wolf E, von Eyss B, Eilers M, Elsässer HP
  PLoS One 2014, 9(2), e89187
  
• Germ and hematology: underlying disease influences diversity of germ spectra and antibiotic therapy.
  Schalk E, Tammer I, Heidel FH
  Infect Control Hosp Epidemiol 2014, 35(2), 208-10
  
• Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum.
  Scherer O, Steinmetz H, Kaether C, Weinigel C, Barz D, Kleinert H, Menche D, Müller R, Pergola C, Werz O
  Biochem Pharmacol 2014, 91(4), 490-500
  
• Exon 11 skipping of SCN10A coding for voltage-gated sodium channels in dorsal root ganglia.
  Schirmeyer J, Szafranski K, Leipold E, Mawrin C, Platzer M, Heinemann SH
  Channels 2014, 8(3), 210 -15
  
• Linear Contrast Classifiers in High-Dimensional Spaces
  Schmid F, Lausser L, Kestler HA
  In: Lecture Notes in Computer Science (edited by El G, Neamat, Schwenker, Friedhelm, Suen, Ching Y), Artificial Neural Networks in Pattern Recognition 2014, 8774, 141-52, Springer International P published during change of institution
  
• Biosimilar G-CSF Based Mobilization of Peripheral Blood Hematopoietic Stem Cells for Autologous and Allogeneic Stem Cell Transplantation.
  Schmitt M, Publicover A, Orchard KH, Görlach M, Wang L, Schmitt A, Mani J, Tsirigotis P, Kuriakose R, Nagler A
  Theranostics 2014, 4(3), 280-9
  
• Gene expansion shapes genome architecture in the human pathogen Lichtheimia corymbifera: an evolutionary genomics analysis in the ancient terrestrial mucorales (Mucoromycotina).
  Schwartze VU, Winter S, Shelest E, Marcet-Houben M, Horn F, Wehner S, Linde J, Valiante V, Sammeth M, Riege K, Nowrousian M, Kaerger K, Jacobsen ID, Marz M, Brakhage AA, Gabaldón T, Böcker S, Voigt K
  PLoS Genet 2014, 10(8), e1004496
  
• Epithelial regeneration and cancer: news from the Src front.
  Sousa-Victor P, Jasper H
  EMBO J 2014, 33(13), 1423-4
  
• Integrin αvβ3 and thyroid hormones promote expansion of progenitors in embryonic neocortex.
  Stenzel D, Wilsch-Bräuninger M, Wong FK, Heuer H, Huttner WB
  Development 2014, 141(4), 795-806
  
• Tissue-Specific Transcript Profiling for ABC Transporters in the Sequestering Larvae of the Phytophagous Leaf Beetle Chrysomela populi.
  Strauss AS, Wang D, Stock M, Gretscher RR, Groth M, Boland W, Burse A
  PLoS One 2014, 9(6), e98637
  
• Physiological state co-regulates thousands of mammalian mRNA splicing events at tandem splice sites and alternative exons.
  Szafranski K, Fritsch C, Schumann F, Siebel L, Sinha R, Hampe J, Hiller M, Englert C, Huse K, Platzer M
  Nucleic Acids Res 2014, 42(14), 8895-904
  
• DNA binding properties of human Cdc45 suggest a function as molecular wedge for DNA unwinding.
  Szambowska A, Tessmer I, Kursula P, Usskilat C, Prus P, Pospiech H, Grosse F
  Nucleic Acids Res 2014, 42(4), 2308-19
  
• RelB-induced expression of Cot, a MAP3K, rescues RANKL-induced osteoclastogenesis in alymphoplasia mice by promoting NF-κB2 processing by IKKα
  Taniguchi R, Fukushima H, Osawa K, Maruyama T, Yasuda H, Weih F, Doi T, Maki K, Jimi E
  J Biol Chem 2014, 289(11), 7349-61
  
• Narrowing down the distal border of the copy number variable beta-defensin gene cluster on human 8p23.
  Taudien S, Huse K, Groth M, Platzer M
  BMC Res Notes 2014, 7(1), 93
  
• Regulation of microRNA expression in the neuronal stem cell niches during aging of the short-lived annual fish Nothobranchius furzeri.
  Terzibasi Tozzini E, Savino A, Ripa R, Battistoni G, Baumgart M, Cellerino A
  Front Cell Neurosci 2014, 8, 51
  
• Comparative analysis of mitochondrial genomes from closely related Rhynchosporium species reveals extensive intron invasion.
  Torriani SFF, Penselin D, Knogge W, Felder M, Taudien S, Platzer M, McDonald BA, Brunner PC
  Fungal Genet Biol 2014, 62, 34-42
  
• Aging stem cells: transcriptome meets epigenome meets methylome.
  Tümpel S, Rudolph KL
  Cell Stem Cell 2014, 14(5), 551-2
  
• Characterisation of the interaction of neuropilin-1 with heparin and a heparan sulfate mimetic library of heparin-derived sugars.
  Uniewicz KA, Ori A, Ahmed YA, Yates EA, Fernig DG
  PeerJ 2014, 2, e461
  
• Gap-directed translesion DNA synthesis of an abasic site on circular DNA templates by a human replication complex.
  Villani G, Shevelev I, Orlando E, Pospiech H, Syvaoja JE, Markkanen E, Hubscher U, Le Gac NT
  PLoS One 2014, 9(4), e93908
  
• Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles.
  Walz S, Lorenzin F, Morton J, Wiese KE, von Eyss B, Herold S, Rycak L, Dumay-Odelot H, Karim S, Bartkuhn M, Roels F, Wüstefeld T, Fischer M, Teichmann M, Zender L, Wei CL, Sansom O, Wolf E, Eilers M
  Nature 2014, 511(7510), 483-7
  
• Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres.
  Wang J, Lu X, Sakk V, Klein CA, Rudolph KL
  Blood 2014, 124(22), 3237-40
  
• Promoting longevity by maintaining metabolic and proliferative homeostasis.
  Wang L, Karpac J, Jasper H
  J Exp Biol 2014, 217(Pt 1), 109-18
  
• Integration of UPRER and oxidative stress signaling in the control of intestinal stem cell proliferation.
  Wang L, Zeng X, Ryoo HD, Jasper H
  PLoS Genet 2014, 10(8), e1004568
  
• A coimmunization vaccine of Aβ42 ameliorates cognitive deficits without brain inflammation in an Alzheimer's disease model.
  Wang S, Yu Y, Geng S, Wang D, Zhang L, Xie X, Wu B, Li C, Xu H, Li X, Hu Y, Zhang L, Kaether C, Wang B
  Alzheimers Res Ther 2014, 6(3), 26
  
• The fidelity of the ligation step determines how ends are resolved during nonhomologous end joining.
  Waters CA, Strande NT, Pryor JM, Strom CN, Mieczkowski P, Burkhalter MD, Oh S, Qaqish BF, Moore DT, Hendrickson EA, Ramsden DA
  Nat Commun 2014, 5, 4286
  
• Dissemination of 6S RNA among bacteria.
  Wehner S, Damm K, Hartmann RK, Marz M
  RNA Biol 2014, 11(11), 1467-78
  
• pRNA: NoRC-associated RNA of rRNA operons.
  Wehner S, Dörrich AK, Ciba P, Wilde A, Marz M
  RNA Biol 2014, 11(1), 3-9
  
• Detection of very long antisense transcripts by whole transcriptome RNA-Seq analysis of Listeria monocytogenes by semiconductor sequencing technology.
  Wehner S, Mannala GK, Qing X, Madhugiri R, Chakraborty T, Mraheil MA, Hain** T, Marz** M
  PLoS One 2014, 9(10), e108639 ** co-corresponding authors
  
• D-Glucosamine supplementation extends life span of nematodes and of ageing mice.
  Weimer S, Priebs J, Kuhlow D, Groth M, Priebe S, Mansfeld J, Merry TL, Dubuis S, Laube B, Pfeiffer AF, Schulz TJ, Guthke R, Platzer M, Zamboni N, Zarse K, Ristow M
  Nat Commun 2014, 5, 3563
  
• CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies.
  Widemann BC, Acosta MT, Ammoun S, Belzberg AJ, Bernards A, Blakeley J, Bretscher A, Cichowski K, Clapp DW, Dombi E, Evans GD, Ferner R, Fernandez-Valle C, Fisher MJ, Giovannini M, Gutmann DH, Hanemann CO, Hennigan R, Huson S, Ingram D, Kissil J, Korf BR, Legius E, Packer RJ, McClatchey AI, McCormick F, North K, Pehrsson M, Plotkin SR, Ramesh V, Ratner N, Schirmer S, Sherman L, Schorry E, Stevenson D, Stewart DR, Ullrich N, Bakker AC, Morrison H
  Am J Med Genet A 2014, 164A(3), 563-78
  
• Prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer.
  Winkler J, Ori A, Holzer K, Sticht C, Dauch D, Eiteneuer EM, Pinna F, Geffers R, Ehemann V, Andres-Pons A, Breuhahn K, Longerich T, Bermejo JL, Gretz N, Zender L, Schirmacher P, Beck M, Singer S
  Hepatology 2014, 60(3), 884-95
  
• A rare cause of lower back pain.
  Wolleschak D, Heidel FH
  Blood 2014, 124(2), 165
  
• Clinically relevant doses of FLT3-kinase inhibitors quizartinib and midostaurin do not impair T-cell reactivity and function.
  Wolleschak D, Mack TS, Perner F, Frey S, Schnöder TM, Wagner MC, Höding C, Pils MC, Parkner A, Kliche S, Schraven B, Hebel K, Brunner-Weinzierl M, Ranjan S, Isermann B, Lipka DB, Fischer T, Heidel FH
  Haematologica 2014, 99(6), e90-3
  
• Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutants.
  Wolters S, Ermolaeva MA, Bickel JS, Fingerhut JM, Khanikar J, Chan RC, Schumacher B
  Genetics 2014, 196(4), 985-99
  
• Quantitative Dissection and Modeling of the NF-κB p100-p105 Module Reveals Interdependent Precursor Proteolysis.
  Yılmaz ZB, Kofahl B, Beaudette P, Baum K, Ipenberg I, Weih F, Wolf J, Dittmar G, Scheidereit C
  Cell Rep 2014, 9(5), 1756-69
  
• Exonuclease 1 is essential for maintaining genomic stability and the proliferative capacity of neural but not hematopoietic stem cells.
  Zhang J, Yang R, Zhou D, Rudolph KL, Meng A, Ju Z
  Stem Cell Res 2014, 12(1), 250-9
  
• Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1.
  Zhang SC, Gremer L, Heise H, Janning P, Shymanets A, Cirstea IC, Krause E, Nürnberg B, Ahmadian MR
  PLoS One 2014, 9(7), e102425
  
• 8p23 beta-defensin copy number determination by single-locus pseudogene-based paralog ratio tests risk bias due to low-frequency sequence variations.
  Zhang X, Müller S, Möller M, Huse K, Taudien S, Book M, Stuber F, Platzer M, Groth M
  BMC Genomics 2014, 15(1), 64
  

Publications 2013:

• The African coelacanth genome provides insights into tetrapod evolution.
  Amemiya CT, Alföldi J, Lee AP, Fan S, Philippe H, Maccallum I, Braasch I, Manousaki T, Schneider I, Rohner N, Organ C, Chalopin D, Smith JJ, Robinson M, Dorrington RA, Gerdol M, Aken B, Biscotti MA, Barucca M, Baurain D, Berlin AM, Blatch GL, Buonocore F, Burmester T, Campbell MS, Canapa A, Cannon JP, Christoffels A, De Moro G, Edkins AL, Fan L, Fausto AM, Feiner N, Forconi M, Gamieldien J, Gnerre S, Gnirke A, Goldstone JV, Haerty W, Hahn ME, Hesse U, Hoffmann S, Johnson J, Karchner SI, Kuraku S, Lara M, Levin JZ, Litman GW, Mauceli E, Miyake T, Mueller MG, Nelson DR, Nitsche A, Olmo E, Ota T, Pallavicini A, Panji S, Picone B, Ponting CP, Prohaska SJ, Przybylski D, Saha NR, Ravi V, Ribeiro FJ, Sauka-Spengler T, Scapigliati G, Searle SMJ, Sharpe T, Simakov O, Stadler PF, Stegeman JJ, Sumiyama K, Tabbaa D, Tafer H, Turner-Maier J, van Heusden P, White S, Williams L, Yandell M, Brinkmann H, Volff JN, Tabin CJ, Shubin N, Schartl M, Jaffe DB, Postlethwait JH, Venkatesh B, Di Palma F, Lander ES, Meyer A, Lindblad-Toh K
  Nature 2013, 496(7445), 311-6
  
• CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells.
  Arndt K, Grinenko T, Mende N, Reichert D, Portz M, Ripich T, Carmeliet P, Corbeil D, Waskow C
  Proc Natl Acad Sci U S A 2013, 110(14), 5582-7
  
• Intestinal inflammation and stem cell homeostasis in aging Drosophila melanogaster.
  Ayyaz A, Jasper H
  Front Cell Infect Microbiol 2013, 3, 98
  
• Strong population genetic structuring in an annual fish, Nothobranchius furzeri, suggests multiple savannah refugia in southern Mozambique.
  Bartáková V, Reichard M, Janko K, Polačik M, Blažek R, Reichwald K, Cellerino A, Bryja J
  BMC Evol Biol 2013, 13(1), 196
  
• Molecular determinants of glucocorticoid actions in inflammatory joint diseases.
  Baschant U, Culemann S, Tuckermann J
  Mol Cell Endocrinol 2013, 380(1-2), 108-18
  
• The emerging biology of muscle stem cells: implications for cell-based therapies.
  Bentzinger CF, Wang YX, von Maltzahn J, Rudnicki MA
  Bioessays 2013, 35(3), 231-41
  
• Fibronectin regulates Wnt7a signaling and satellite cell expansion.
  Bentzinger CF, Wang YX, von Maltzahn J, Soleimani VD, Yin H, Rudnicki MA
  Cell Stem Cell 2013, 12(1), 75-87
  
• The positional identity of mouse ES cell-generated neurons is affected by BMP signaling.
  Bertacchi M, Pandolfini L, Murenu E, Viegi A, Capsoni S, Cellerino A, Messina A, Casarosa S, Cremisi F
  Cell Mol Life Sci 2013, 70(6), 1095-111
  
• Quantitative proteomic profiling of tumor cell response to telomere dysfunction using isotope-coded protein labeling (ICPL) reveals interaction network of candidate senescence markers.
  Biniossek ML, Lechel A, Rudolph KL, Martens UM, Zimmermann S
  J Proteomics 2013, 91, 515-35 published during change of institution
  
• Integrated structural analysis of the human nuclear pore complex scaffold.
  Bui KH, von Appen A, DiGuilio AL, Ori A, Sparks L, Mackmull MT, Bock T, Hagen W, Andrés-Pons A, Glavy JS, Beck M
  Cell 2013, 155(6), 1233-43
  
• LMX1B is essential for the maintenance of differentiated podocytes in adult kidneys.
  Burghardt T, Kastner J, Suleiman H, Rivera-Milla E, Stepanova N, Lottaz C, Kubitza M, Böger CA, Schmidt S, Gorski M, de Vries U, Schmidt H, Hertting I, Kopp J, Rascle A, Moser M, Heid IM, Warth R, Spang R, Wegener J, Mierke CT, Englert C, Witzgall R
  J Am Soc Nephrol 2013, 24(11), 1830-48
  
• Grk5l Controls Heart Development by Limiting mTOR Signaling during Symmetry Breaking.
  Burkhalter MD, Fralish GB, Premont RT, Caron MG, Philipp M
  Cell Rep 2013, 4(4), 625-32
  
• Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and cardio-facio-cutaneous syndromes.
  Cirstea IC, Gremer L, Dvorsky R, Zhang SC, Piekorz RP, Zenker M, Ahmadian MR
  Hum Mol Genet 2013, 22(2), 262-70
  
• Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways.
  Dang M, Armbruster N, Miller MA, Cermeno E, Hartmann M, Bell GW, Root DE, Lauffenburger DA, Lodish HF, Herrlich A
  Proc Natl Acad Sci U S A 2013, 110(24), 9776-81 Editors' Choice
  
• Mapping the RNA-Seq trash bin: unusual transcripts in prokaryotic transcriptome sequencing data.
  Doose G, Alexis M, Kirsch R, Findeiß S, Langenberger D, Machné R, Mörl M, Hoffmann S, Stadler PF
  RNA Biol 2013, 10(7), 1204-10
  
• Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.
  Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KHA, Copenhaver GP, Deluca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LET, Karpen G, Kops GJPL, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O'Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K, Cleveland DW
  Chromosome Res 2013, 21(2), 101-6
  
• Novel CIC point mutations and an exon-spanning, homozygous deletion identified in oligodendroglial tumors by a comprehensive genomic approach including transcriptome sequencing.
  Eisenreich S, Abou-El-Ardat K, Szafranski K, Campos Valenzuela JA, Rump A, Nigro JM, Bjerkvig R, Gerlach EM, Hackmann K, Schröck E, Krex D, Kaderali L, Schackert G, Platzer M, Klink B
  PLoS One 2013, 8(9), e76623
  
• The innate immune system as mediator of systemic DNA damage responses.
  Ermolaeva M, Schumacher B
  Commun Integr Biol 2013, 6(6), e26926
  
• DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance.
  Ermolaeva MA, Segref A, Dakhovnik A, Ou HL, Schneider JI, Utermöhlen O, Hoppe T, Schumacher B
  Nature 2013, 501(7467), 416-20
  
• FOSL1 controls the assembly of endothelial cells into capillary tubes by direct repression of αv and β3 integrin transcription.
  Evellin S, Galvagni F, Zippo A, Neri F, Orlandini M, Incarnato D, Dettori D, Neubauer S, Kessler H, Wagner EF, Oliviero S
  Mol Cell Biol 2013, 33(6), 1198-209
  
• Are aging biomarkers clinically relevant in oncogeriatrics?
  Falandry C, Gilson E, Rudolph KL
  Crit Rev Oncol Hematol 2013, 85(3), 257-65 published during change of institution
  
• Characterization of a novel picornavirus isolate from a diseased European eel (Anguilla anguilla).
  Fichtner D, Philipps A, Groth M, Schmidt-Posthaus H, Granzow H, Dauber M, Platzer M, Bergmann SM, Schrudde D, Sauerbrei A, Zell R
  J Virol 2013, 87(19), 10895-99
  
• In silico approaches and the role of ontologies in aging research.
  Fuellen G, Boerries M, Busch H, de Grey A, Hahn U, Hiller T, Hoeflich A, Jansen L, Janssens GE, Kaleta C, Meinema AC, Schäuble S, Simm A, Schofield PN, Smith B, Sühnel J, Vera J, Wagner W, Wönne EC, Wuttke D
  Rejuvenation Res 2013, 16(6), 540-6
  
• Haplotypes of IL-12Rβ1 impact on the clinical phenotype of hidradenitis suppurativa.
  Giatrakos S, Huse K, Kanni T, Tzanetakou V, Kramer M, Grech I, Papadavid E, Katoulis A, Stavrianeas N, Nothnagel M, Platzer M, Bauer M, Giamarellos-Bourboulis EJ
  Cytokine 2013, 62(2), 297-301
  
• The mitochondrial genome of Arctica islandica; Phylogeny and variation.
  Glöckner G, Heinze I, Platzer M, Held C, Abele D
  PLoS One 2013, 8(12), e82857
  
• Absence of replicative senescence in cultured cells from the short-lived killifish Nothobranchius furzeri.
  Graf* M, Hartmann* N, Reichwald K, Englert C
  Exp Gerontol 2013, 48(1), 17-28 * equal contribution
  
• What is a particle? A lesson from the photon
  Greulich KO
  In: The Nature of Light: What are Photons? V 2013, 8832, 431-7, SPIE Press, Bellingham, W
  
• The role of telomeres in stem cells and cancer.
  Günes C, Rudolph KL
  Cell 2013, 152(3), 390-3
  
• Role of NF-κB in Neurodegenerative Diseases
  Haenold R, Kretz A, Weih F
  In: Forum on Immunopathological Diseases and Therapeutics (edited by Benjamin B, Zouhair Atassi M) 2013, 4(2), 161-79, Begell House, Inc., Redd
  
• Ein kurzlebiger Fisch als Modell für die Alternsforschung
  Hartmann N, Reichwald K, Platzer M, Englert C
  Biol Unserer Zeit 2013, 43, 87-95
  
• The holocentric species Luzula elegans shows interplay between centromere and large-scale genome organization.
  Heckmann S, Macas J, Kumke K, Fuchs J, Schubert V, Ma L, Novák P, Neumann P, Taudien S, Platzer M, Houben A
  Plant J 2013, 73(4), 555-65
  
• The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML.
  Heidel FH, Bullinger L, Arreba-Tutusaus P, Wang Z, Gaebel J, Hirt C, Niederwieser D, Lane SW, Döhner K, Vasioukhin V, Fischer T, Armstrong SA
  J Exp Med 2013, 210(1), 15-22
  
• Defining the subcellular interface of nanoparticles by live-cell imaging.
  Hemmerich PH, von Mikecz AH
  PLoS One 2013, 8(4), e62018
  
• The responsibility of the scientist. What can history teach us about how scientists should handle research that has the potential to create harm?
  Herrlich P
  EMBO Rep 2013, 14(9), 759-64
  
• The pathophysiological consequences of thyroid hormone transporter deficiencies: Insights from mouse models.
  Heuer H, Visser TJ
  Bba-Gen Subjects 2013, 1830(7), 3974-8
  
• Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks.
  Holdt LM, Hoffmann S, Sass K, Langenberger D, Scholz M, Krohn K, Finstermeier K, Stahringer A, Wilfert W, Beutner F, Gielen S, Schuler G, Gäbel G, Bergert H, Bechmann I, Stadler PF, Thiery J, Teupser D
  PLoS Genet 2013, 9(7), e1003588
  
• The duck genome and transcriptome provide insight into an avian influenza virus reservoir species.
  Huang Y, Li Y, Burt DW, Chen H, Zhang Y, Qian W, Kim H, Gan S, Zhao Y, Li J, Yi K, Feng H, Zhu P, Li B, Liu Q, Fairley S, Magor KE, Du Z, Hu X, Goodman L, Tafer H, Vignal A, Lee T, Kim KW, Sheng Z, An Y, Searle S, Herrero J, Groenen MAM, Crooijmans RPMA, Faraut T, Cai Q, Webster RG, Aldridge JR, Warren WC, Bartschat S, Kehr S, Marz M, Stadler PF, Smith J, Kraus RHS, Zhao Y, Ren L, Fei J, Morisson M, Kaiser P, Griffin DK, Rao M, Pitel F, Wang J, Li N
  Nat Genet 2013, 45(7), 776-83
  
• JenAge Ageing Factor Database - AgeFactDB
  Hühne R, Thalheim T, Sühnel J
  JenAge 2013, JenAge, version 1, URL http://ag
  
• Mutation in CYP27A1 identified in family with coronary artery disease.
  Inanloorahatloo K, Zand Parsa AF, Huse K, Rasooli P, Davaran S, Platzer M, Fan JB, Amini S, Steemers F, Elahi E
  Eur J Med Genet 2013, 56(12), 655-60
  
• MREdictor: a two-step dynamic interaction model that accounts for mRNA accessibility and Pumilio binding accurately predicts microRNA targets.
  Incarnato D, Neri F, Diamanti D, Oliviero S
  Nucleic Acids Res 2013, 41(18), 8421-33
  
• GABAB receptor antibodies in paraneoplastic cerebellar ataxia.
  Jarius S, Steinmeyer F, Knobel A, Streitberger K, Hotter B, Horn S, Heuer H, Schreiber SJ, Wilhelm T, Trefzer U, Wildemann B, Ruprecht K
  J Neuroimmunol 2013, 256(1-2), 94-6
  
• Sirtuins: Longevity focuses on NAD+.
  Jasper H
  Nat Chem Biol 2013, 9(11), 666-7
  
• Misregulation of an adaptive metabolic response contributes to the age-related disruption of lipid homeostasis in Drosophila.
  Karpac J, Biteau B, Jasper H
  Cell Rep 2013, 4(6), 1250-61
  
• Aging: seeking mitonuclear balance.
  Karpac J, Jasper H
  Cell 2013, 154(2), 271-3
  
• Relationships between Cargo, Cell Penetrating Peptides and Cell Type for Uptake of Non-Covalent Complexes into Live Cells.
  Keller AA, Mussbach F, Breitling R, Hemmerich P, Schaefer B, Lorkowski S, Reissmann S
  Pharmaceuticals 2013, 6(2), 184-203
  
• Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding.
  Koeberle A, Shindou H, Koeberle SC, Laufer SA, Shimizu T, Werz O
  Proc Natl Acad Sci U S A 2013, 110(7), 2546-51
  
• Alternative 5' Untranslated Regions Are Involved in Expression Regulation of Human Heme Oxygenase-1.
  Kramer M, Sponholz C, Slaba M, Wissuwa B, Claus RA, Menzel U, Huse K, Platzer M, Bauer M
  PLoS One 2013, 8(10), e77224
  
• CEBP factors regulate telomerase reverse transcriptase promoter activity in whey acidic protein-T mice during mammary carcinogenesis.
  Kumar M, Witt B, Knippschild U, Koch S, Meena JK, Heinlein C, Weise JM, Krepulat F, Kuchenbauer F, Iben S, Rudolph KL, Deppert W, Günes C
  Int J Cancer 2013, 132(9), 2032-43 published during change of institution
  
• Reassortants of the pandemic (H1N1) 2009 virus and establishment of a novel porcine H1N2 influenza virus, lineage in Germany.
  Lange J, Groth M, Schlegel M, Krumbholz A, Wieczorek K, Ulrich R, Köppen S, Schulz K, Appl D, Selbitz HJ, Sauerbrei A, Platzer M, Zell R, Dürrwald R
  Vet Microbiol 2013, 167(3-4), 345-56
  
• Dicer-processed small RNAs: rules and exceptions.
  Langenberger D, Çakir MV, Hoffmann S, Stadler PF
  J Exp Zool B Mol Dev Evol 2013, 320(1), 35-46
  
• The correlation of genome size and DNA methylation rate in metazoans.
  Lechner M, Marz M, Ihling C, Sinz A, Stadler PF, Krauss V
  Theor Biosci 2013, 132(1), 47-60
  
• Characterization of a new class of androgen receptor antagonists with potential therapeutic application in advanced prostate cancer.
  Li H, Hassona MD, Lack NA, Axerio-Cilies P, Leblanc E, Kanaan N, Frewin K, Singh K, Adomat H, Böhm KJ, Prinz H, Guns ET, Rennie PS, Cherkasov A
  Mol Cancer Ther 2013, 12(11), 2425-35
  
• Dpp signaling determines regional stem cell identity in the regenerating adult Drosophila gastrointestinal tract.
  Li H, Qi Y, Jasper H
  Cell Rep 2013, 4(1), 10-8
  
• Identification of purple sea urchin telomerase RNA using a next-generation sequencing based approach.
  Li* Y, Podlevsky* JD, Marz* M, Qi X, Hoffmann S, Stadler PF, Chen JJL
  RNA 2013, 19(6), 852-60 * equal contribution
  
• BSTA: a targeted approach combines bulked segregant analysis with next- generation sequencing and de novo transcriptome assembly for SNP discovery in sunflower.
  Livaja M, Wang Y, Wieckhorst S, Haseneyer G, Seidel M, Hahn V, Knapp SJ, Taudien S, Schön CC, Bauer E
  BMC Genomics 2013, 14, 628
  
• Genomics-based high-resolution mapping of the BaMMV/BaYMV resistance gene rym11 in barley (Hordeum vulgare L.).
  Lüpken T, Stein N, Perovic D, Habekuß A, Krämer I, Hähnel U, Steuernagel B, Scholz U, Zhou R, Ariyadasa R, Taudien S, Platzer M, Martis M, Mayer K, Friedt W, Ordon F
  Theor Appl Genet 2013, 126(5), 1201-12
  
• An investigation of the effects of the antioxidants, ebselen or N-acetyl cysteine on human peripheral blood mononuclear cells and T cells.
  Marthandan S, Hyland P, Pawelec G, Barnett Y
  Immun Ageing 2013, 10(1), 7
  
• RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model.
  Mills JR, Malina A, Lee T, Di Paola D, Larsson O, Miething C, Grosse F, Tang H, Zannis-Hadjopoulos M, Lowe SW, Pelletier J
  Blood 2013, 121(17), 3402-12
  
• Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera.
  Mullally A, Bruedigam C, Poveromo L, Heidel FH, Purdon A, Vu T, Austin R, Heckl D, Breyfogle LJ, Kuhn CP, Kalaitzidis D, Armstrong SA, Williams DA, Hill GR, Ebert BL, Lane SW
  Blood 2013, 121(18), 3692-702
  
• Distribution, functional impact, and origin mechanisms of copy number variation in the barley genome.
  Muñoz-Amatriaín M, Eichten SR, Wicker T, Richmond TA, Mascher M, Steuernagel B, Scholz U, Ariyadasa R, Spannagl M, Nussbaumer T, Mayer KF, Taudien S, Platzer M, Jeddeloh JA, Springer NM, Muehlbauer GJ, Stein N
  Genome Biol 2013, 14(6), R58
  
• Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells.
  Neri F, Incarnato D, Krepelova A, Rapelli S, Pagnani A, Zecchina R, Parlato C, Oliviero S
  Genome Biol 2013, 14(8), R91
  
• Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs.
  Neri* F, Krepelova* A, Incarnato D, Maldotti M, Parlato C, Galvagni F, Matarese F, Stunnenberg HG, Oliviero S
  Cell 2013, 155(1), 121-34 * equal contribution
  
• Heterozygous mutations in PALB2 cause DNA replication and damage response defects.
  Nikkilä J, Parplys AC, Pylkäs K, Bose M, Huo Y, Borgmann K, Rapakko K, Nieminen P, Xia B, Pospiech* H, Winqvist* R
  Nat Commun 2013, 4, 2578 * equal contribution
  
• Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines.
  Ori A, Banterle N, Iskar M, Andrés-Pons A, Escher C, Bui KH, Sparks L, Solis-Mezarino V, Rinner O, Bork P, Lemke EA, Beck M
  Mol Syst Biol 2013, 9, 648
  
• Swimming behavior of the monotrichous bacterium Pseudomonas fluorescens SBW25.
  Ping L, Birkenbeil J, Monajembashi S
  FEMS Microbiol Ecol 2013, 86(1), 36-44
  
• Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments.
  Prewitz MC, Seib FP, von Bonin M, Friedrichs J, Stißel A, Niehage C, Müller K, Anastassiadis K, Waskow C, Hoflack B, Bornhäuser M, Werner C
  Nat Methods 2013, 10(8), 788-94
  
• Extension of Life Span by Impaired Glucose Metabolism in Caenorhabditis elegans Is Accompanied by Structural Rearrangements of the Transcriptomic Network.
  Priebe S, Menzel U, Zarse K, Groth M, Platzer M, Ristow M, Guthke R
  PLoS One 2013, 8(10), e77776
  
• α-Synuclein Oligomers Impair Neuronal Microtubule-Kinesin Interplay.
  Prots I, Veber V, Brey S, Campioni S, Buder K, Riek R, Böhm KJ, Winner B
  J Biol Chem 2013, 288(30), 21742-54
  
• The common ancestral core of vertebrate and fungal telomerase RNAs.
  Qi X, Li Y, Honda S, Hoffmann S, Marz M, Mosig A, Podlevsky JD, Stadler PF, Selker EU, Chen JJL
  Nucleic Acids Res 2013, 41(1), 450-62
  
• Why soft UV-A damages DNA: An optical micromanipulation study
  Rapp A, Greulich KO
  In: Optical Trapping and Optical Micromanipulation X (edited by Dholakia K, Spalding GC), Proceedings of SPIEE 2013, 8810, 511-7, SPIE Press, Bellingham, W
  
• Pan genome of the phytoplankton Emiliania underpins its global distribution.
  Read BA, Kegel J, Klute MJ, Kuo A, Lefebvre SC, Maumus F, Mayer C, Miller J, Monier A, Salamov A, Young J, Aguilar M, Claverie JM, Frickenhaus S, Gonzalez K, Herman EK, Lin YC, Napier J, Ogata H, Sarno AF, Shmutz J, Schroeder D, de Vargas C, Verret F, von Dassow P, Valentin K, Van de Peer Y, Wheeler G, Emiliania huxleyi Annotation Consortium, Dacks JB, Delwiche CF, Dyhrman ST, Glöckner G, John U, Richards T, Worden AZ, Zhang X, Grigoriev IV
  Nature 2013, 499(7457), 209-13
  
• Identification of prolyl oligopeptidase as a cyclosporine-sensitive protease by screening of mouse liver extracts.
  Rentzsch A, Kahlert V, Jahreis G, Schlott B, Schutkowski M, Malešević M, Fischer G
  Biol Chem 2013, 394(8), 1057-67
  
• Histone acetyltransferase cofactor trrap maintains self-renewal and restricts differentiation of embryonic stem cells.
  Sawan C, Hernandez-Vargas H, Murr R, Lopez F, Vaissière T, Ghantous AY, Cuenin C, Imbert J, Wang ZQ, Ren B, Herceg Z
  Stem Cells 2013, 31(5), 979-91
  
• Conserved gene regulatory function of the carboxy-terminal domain of dictyostelid C-module-binding factor.
  Schmith A, Groth M, Ratka J, Gatz S, Spaller T, Siol O, Glöckner G, Winckler T
  Eukaryot Cell 2013, 12(3), 460-8
  
• Structural RNA alignment by multi-objective optimization.
  Schnattinger T, Schöning U, Kestler HA
  Bioinformatics 2013, 29(13), 1607-13
  
• PPARβ/δ governs Wnt signaling and bone turnover.
  Scholtysek C, Katzenbeisser J, Fu H, Uderhardt S, Ipseiz N, Stoll C, Zaiss MM, Stock M, Donhauser L, Böhm C, Kleyer A, Hess A, Engelke K, David JP, Djouad F, Tuckermann JP, Desvergne B, Schett G, Krönke G
  Nat Med 2013, 19(5), 608-13
  
• Ciliated sensory hair cell formation and function require the F-BAR protein syndapin I and the WH2 domain-based actin nucleator Cobl.
  Schüler S, Hauptmann J, Perner B, Kessels** MM, Englert** C, Qualmann** B
  J Cell Sci 2013, 126(Pt 1), 196-208 ** co-corresponding authors
  
• Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors.
  Schwitalla S, Ziegler PK, Horst D, Becker V, Kerle I, Begus-Nahrmann Y, Lechel A, Rudolph KL, Langer R, Slotta-Huspenina J, Bader FG, Prazeres da Costa O, Neurath MF, Meining A, Kirchner T, Greten FR
  Cancer Cell 2013, 23(1), 93-106 published during change of institution
  
• Inflammatory monocytes and Fcγ receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice.
  Seeling M, Hillenhoff U, David JP, Schett G, Tuckermann J, Lux A, Nimmerjahn F
  Proc Natl Acad Sci U S A 2013, 110(26), 10729-34 published during change of institution
  
• Putative Sugar Transporters of the Mustard Leaf Beetle Phaedon cochleariae: Their Phylogeny and Role for Nutrient Supply in Larval Defensive Glands.
  Stock M, Gretscher RR, Groth M, Eiserloh S, Boland W, Burse A
  PLoS One 2013, 8(12), e84461
  
• Rule-based modeling and simulations of the inner kinetochore structure.
  Tschernyschkow S, Herda S, Gruenert G, Döring V, Görlich D, Hofmeister A, Hoischen C, Dittrich P, Diekmann S, Ibrahim B
  Prog Biophys Mol Biol 2013, 113(1), 33-45
  
• Monocarboxylate transporter 8 modulates the viability and invasive capacity of human placental cells and fetoplacental growth in mice.
  Vasilopoulou E, Loubière LS, Heuer H, Trajkovic-Arsic M, Darras VM, Visser TJ, Lash GE, Whitley GS, McCabe CJ, Franklyn JA, Kilby MD, Chan SY
  PLoS One 2013, 8(6), e65402
  
• Systematic analysis and evolution of 5S ribosomal DNA in metazoans.
  Vierna J, Wehner S, Höner zu Siederdissen C, Martínez-Lage A, Marz M
  Heredity 2013, 111(5), 410-21
  
• Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locus.
  von Kampen O, Buch S, Nothnagel M, Azocar L, Molina H, Brosch M, Erhart W, von Schönfels W, Egberts J, Seeger M, Arlt A, Balschun T, Franke A, Lerch MM, Mayerle J, Kratzer W, Boehm BO, Huse K, Schniewind B, Tiemann K, Jiang ZY, Han TQ, Mittal B, Srivastava A, Fenger M, Jørgensen T, Schirin-Sokhan R, Tönjes A, Wittenburg H, Stumvoll M, Kalthoff H, Lammert F, Tepel J, Puschel K, Becker T, Schreiber S, Platzer M, Völzke H, Krawczak M, Miquel JF, Schafmayer C, Hampe J
  Hepatology 2013, 57(6), 2407-17
  
• Pax7 is critical for the normal function of satellite cells in adult skeletal muscle.
  von Maltzahn J, Jones AE, Parks RJ, Rudnicki MA
  Proc Natl Acad Sci U S A 2013, 110(41), 16474-9
  
• A truncated Wnt7a retains full biological activity in skeletal muscle.
  von Maltzahn J, Zinoviev R, Chang NC, Bentzinger CF, Rudnicki MA
  Nat Commun 2013, 4, 2869 research results from former institution
  
• Nilotinib shows prolonged intracellular accumulation upon pulse-exposure: a novel mechanism for induction of apoptosis in CML cells.
  Wagner MC, Dziadosz M, Melo JV, Heidel F, Fischer T, Lipka DB
  Leukemia 2013, 27(7), 1567-70
  
• The role of MIZ-1 in MYC-dependent tumorigenesis.
  Wiese KE, Walz S, von Eyss B, Wolf E, Athineos D, Sansom O, Eilers M
  Cold Spring Harb Perspect Med 2013, 3(12), a014290
  
• Miz1 is required to maintain autophagic flux.
  Wolf E, Gebhardt A, Kawauchi D, Walz S, von Eyss B, Wagner N, Renninger C, Krohne G, Asan E, Roussel MF, Eilers M
  Nat Commun 2013, 4, 2535
  
• Rapid induction of complete molecular remission by sequential therapy with LDAC and sorafenib in FLT3-ITD-positive patients unfit for intensive treatment: two cases and review of the literature.
  Wolleschak D, Schalk E, Krogel C, Schnoeder TM, Luehr H, Jentsch-Ullrich K, Fischer T, Heidel FH
  J Hematol Oncol 2013, 6, 39
  
• Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.
  Yamamoto* R, Morita* Y, Ooehara J, Hamanaka S, Onodera M, Rudolph KL, Ema H, Nakauchi H
  Cell 2013, 154(5), 1112-26 * equal contribution
  
• PARP-1 Controls Immunosuppressive Function of Regulatory T Cells by Destabilizing Foxp3.
  Zhang P, Maruyama T, Konkel JE, Abbatiello B, Zamarron B, Wang ZQ, Chen W
  PLoS One 2013, 8(8), e71590
  
• PARP-1 regulates expression of TGF-β receptors in T cells.
  Zhang P, Nakatsukasa H, Tu E, Kasagi S, Cui K, Ishikawa M, Konkel JE, Maruyama T, Wei G, Abbatiello B, Wang ZQ, Zhao K, Chen W
  Blood 2013, 122(13), 2224-32
  

Publications 2012:

• Comparative evaluation of the gut microbiota associated with the below- and above-ground life stages (larvae and beetles) of the forest cockchafer, Melolontha hippocastani.
  Arias-Cordero E, Ping L, Reichwald K, Delb H, Platzer M, Boland W
  PLoS One 2012, 7(12), e51557
  
• Developmental gene regulation by an ancient intercellular communication system in social amoebae.
  Asghar A, Groth M, Siol O, Gaube F, Enzensperger C, Glöckner G, Winckler T
  Protist 2012, 163(1), 25-37
  
• The multiple facets of glucocorticoid action in rheumatoid arthritis.
  Baschant U, Lane NE, Tuckermann J
  Nat Rev Rheumatol 2012, 8(11), 645-55
  
• Age-dependent regulation of tumor-related microRNAs in the brain of the annual fish Nothobranchius furzeri.
  Baumgart M, Groth M, Priebe S, Appelt J, Guthke R, Platzer M, Cellerino A
  Mech Ageing Dev 2012, 133(5), 226-33
  
• A pRNA-induced structural rearrangement triggers 6S-1 RNA release from RNA polymerase in Bacillus subtilis.
  Beckmann BM, Hoch PG, Marz M, Willkomm DK, Salas M, Hartmann RK
  EMBO J 2012, 31(7), 1727-38
  
• Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis.
  Begus-Nahrmann Y, Hartmann D, Kraus J, Eshraghi P, Scheffold A, Grieb M, Rasche V, Schirmacher P, Lee HW, Kestler HA, Lechel A, Rudolph KL
  J Clin Invest 2012, 122(6), 2283-8 published during change of institution
  
• Fungal-Induced Cell Cycle Impairment, Chromosome Instability and Apoptosis via Differential Activation of NF-κB.
  Ben-Abdallah M, Sturny-Leclère A, Avé P, Louise A, Moyrand F, Weih F, Janbon G, Mémet S
  PLoS Pathog 2012, 8(3), e1002555
  
• Precise RNAi-mediated silencing of metabolically active proteins in the defence secretions of juvenile leaf beetles.
  Bodemann RR, Rahfeld P, Stock M, Kunert M, Wielsch N, Groth M, Frick S, Boland W, Burse A
  Proc Biol Sci 2012, 279(1745), 4126-34
  
• RSK2 protects mice against TNF-induced bone loss.
  Böhm C, Derer A, Axmann R, Hillienhoff U, Zaiss MM, Luther J, Zech C, Stock M, Scholtysek C, Engelke K, Hess A, Tuckermann JP, Schett G, David JP
  J Cell Sci 2012, 125(Pt 9), 2160-71
  
• Synthesis and functional characterization of tridegin and its analogues: inhibitors and substrates of factor XIIIa.
  Böhm M, Kühl T, Hardes K, Coch R, Arkona C, Schlott B, Steinmetzer T, Imhof D
  ChemMedChem 2012, 7(2), 326-33
  
• Cell-cycle-dependent structural transitions in the human CENP-A nucleosome in vivo.
  Bui M, Dimitriadis EK, Hoischen C, An E, Quénet D, Giebe S, Nita-Lazar A, Diekmann S, Dalal Y
  Cell 2012, 150(2), 317-26
  
• Unusual combinatorial involvement of poly-A/T tracts in organizing genes and chromatin in Dictyostelium.
  Chang GS, Noegel AA, Mavrich TN, Müller R, Tomsho L, Ward E, Felder M, Jiang C, Eichinger L, Glöckner G, Schuster SC, Pugh BF
  Genome Res 2012, 22(6), 1098-106
  
• Genome dynamics explain the evolution of flowering time CCT domain gene families in the Poaceae.
  Cockram J, Thiel T, Steuernagel B, Stein N, Taudien S, Bailey PC, O'Sullivan DM
  PLoS One 2012, 7(9), e45307
  
• Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity.
  Creemers JWM, Choquet H, Stijnen P, Vatin V, Pigeyre M, Beckers S, Meulemans S, Than ME, Yengo L, Tauber M, Balkau B, Elliott P, Jarvelin MR, Van Hul W, Van Gaal L, Horber F, Pattou F, Froguel P, Meyre D
  Diabetes 2012, 61(2), 383-90
  
• Immunolocalization of S100-like protein in the brain of an emerging model organism: Nothobranchius furzeri.
  D'Angelo L, De Girolamo P, Cellerino A, Terzibasi Tozzini E, Varricchio E, Castaldo L, Lucini C
  Microsc Res Tech 2012, 75(4), 441-47
  
• Neurotrophin Trk receptors in the brain of a teleost fish, Nothobranchius furzeri.
  D'Angelo L, de Girolamo P, Cellerino A, Tozzini ET, Castaldo L, Lucini C
  Microsc Res Tech 2012, 75(1), 81-8
  
• CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin.
  Dambacher S, Deng W, Hahn M, Sadic D, Fröhlich J, Nuber A, Hoischen C, Diekmann S, Leonhardt H, Schotta G
  Nucleus 2012, 3(1), 101-10
  
• ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis.
  Dellago H, Khan A, Nussbacher M, Gstraunthaler A, Lämmermann I, Schosserer M, Mück C, Anrather D, Scheffold A, Ammerer G, Jansen-Dürr P, Rudolph KL, Voglauer-Grillari R, Grillari J
  Aging (Albany NY) 2012, 4(4), 290-304 published during change of institution
  
• Transcriptional Repression of ATF4 Gene by CCAAT/Enhancer-binding Protein β (C/EBPβ) Differentially Regulates Integrated Stress Response.
  Dey S, Savant S, Teske BF, Hatzoglou M, Calkhoven CF, Wek RC
  J Biol Chem 2012, 287(26), 21936-49
  
• Genome-wide search for novel human uORFs and N-terminal protein extensions using ribosomal footprinting.
  Fritsch C, Herrmann A, Nothnagel M, Szafranski K, Huse K, Schumann F, Schreiber S, Platzer M, Krawczak M, Hampe J, Brosch M
  Genome Res 2012, 22(11), 2208-18
  
• Systems biology and bioinformatics in aging research: a workshop report.
  Fuellen G, Dengjel J, Hoeflich A, Hoeijemakers J, Kestler HA, Kowald A, Priebe S, Rebholz-Schuhmann D, Schmeck B, Schmitz U, Stolzing A, Sühnel J, Wuttke D, Vera J
  Rejuvenation Res 2012, 15(6), 631-41
  
• A novel role of human holiday junction resolvase GEN1 in the maintenance of centrosome integrity.
  Gao M, Rendtlew Danielsen J, Wei LZ, Zhou DP, Xu Q, Li MM, Wang ZQ, Tong WM, Yang YG
  PLoS One 2012, 7(11), e49687
  
• Contribution of the C-terminal regions of promyelocytic leukemia protein (PML) isoforms II and V to PML nuclear body formation.
  Geng Y, Monajembashi S, Shao A, Cui D, He W, Chen Z, Hemmerich** P, Tang** J
  J Biol Chem 2012, 287(36), 30729-42 ** co-senior authors
  
• Autophagy researchers
  González-Estévez C
  Autophagy 2012, 8(10), 1411-14
  
• Decreased neoblast progeny and increased cell death during starvation-induced planarian degrowth.
  González-Estévez C, Felix DA, Rodríguez-Esteban G, Aboobaker AA
  Int J Dev Biol 2012, 56(1-3), 83-91
  
• SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians.
  González-Estévez C, Felix DA, Smith MD, Paps J, Morley SJ, James V, Sharp TV, Aboobaker AA
  PLoS Genet 2012, 8(3), e1002619
  
• UVA-induced DNA double-strand breaks result from the repair of clustered oxidative DNA damages.
  Greinert R, Volkmer B, Henning S, Breitbart EW, Greulich KO, Cardoso MC, Rapp A
  Nucleic Acids Res 2012, 40(20), 10263-73
  
• Single DNA Molecule Typing, Heart Beating, DNA Repair and Ageing: The Contribution of Fluorescence Techniques
  Greulich KO, Grigaravicius P, Monajembashi S
  In: Reviews in Fluorescence 2012, Volume 2010, 199-222, Springer, Heidelberg
  
• Colony-stimulating factor-1 mediates macrophage-related neural damage in a model for Charcot-Marie-Tooth disease type 1X.
  Groh J, Weis J, Zieger H, Stanley ER, Heuer H, Martini R
  Brain 2012, 135(1), 88-104
  
• Telomere dysfunction puts the brakes on oncogene-induced cancers.
  Günes C, Rudolph KL
  EMBO J 2012, 31(13), 2833-4
  
• The actin nucleator Cobl is crucial for Purkinje cell development and works in close conjunction with the F-actin binding protein Abp1.
  Haag N, Schwintzer L, Ahuja R, Koch N, Grimm J, Heuer H, Qualmann B, Kessels MM
  J Neurosci 2012, 32(49), 17842-56
  
• Trafficking and proteolytic processing of APP.
  Haass C, Kaether C, Thinakaran G, Sisodia S
  Cold Spring Harb Perspect Med 2012, 2(5), a006270
  
• Magnetic resonance imaging of the mouse visual pathway for in vivo studies of degeneration and regeneration in the CNS.
  Haenold R, Herrmann KH, Schmidt S, Reichenbach JR, Schmidt KF, Löwel S, Witte OW, Weih F, Kretz A
  Neuroimage 2012, 59(1), 363-76
  
• Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.
  Hamidi T, Algül H, Cano CE, Sandi MJ, Molejon MI, Riemann M, Calvo EL, Lomberk G, Dagorn JC, Weih F, Urrutia R, Schmid RM, Iovanna JL
  J Clin Invest 2012, 122(6), 2092-103
  
• A microinjection protocol for the generation of transgenic killifish (Species: Nothobranchius furzeri).
  Hartmann N, Englert C
  Dev Dyn 2012, 241(6), 1133-41
  
• Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia stem cells in CML.
  Heidel FH, Bullinger L, Feng Z, Wang Z, Neff TA, Stein L, Kalaitzidis D, Lane SW, Armstrong SA
  Cell Stem Cell 2012, 10(4), 412-24
  
• Possibilities and limitations for high resolution small animal MRI on a clinical whole-body 3T scanner.
  Herrmann KH, Schmidt S, Kretz A, Haenold R, Krumbein I, Metzler M, Gaser C, Witte OW, Reichenbach JR
  MAGMA 2012, 25(3), 233-44
  
• Niche science: the aging stem cell.
  Jasper H, Kennedy BK
  Cell Cycle 2012, 11(16), 2959-60
  
• Neurofibromatosis 2011: a report of the Children's Tumor Foundation Annual Meeting.
  Kalamarides M, Acosta MT, Babovic-Vuksanovic D, Carpen O, Cichowski K, Gareth Evans D, Giancotti F, Oliver Hanemann C, Ingram D, Lloyd AC, Mayes DA, Messiaen L, Morrison H, North K, Packer R, Pan D, Stemmer-Rachamimov A, Upadhyaya M, Viskochil D, Wallace MR, Hunter-Schaedle K, Ratner N
  Acta Neuropathol (Berl) 2012, 123(3), 369-80
  
• Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage.
  Kapuria S, Karpac J, Biteau B, Hwangbo D, Jasper H
  PLoS Genet 2012, 8(11), e1003045
  
• Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation.
  Katz SF, Lechel A, Obenauf AC, Begus-Nahrmann Y, Kraus JM, Hoffmann EM, Duda J, Eshraghi P, Hartmann D, Liss B, Schirmacher P, Kestler HA, Speicher MR, Rudolph KL
  Gastroenterology 2012, 142(5), 1229-1239.e3 published during change of institution
  
• Functionality, growth and accelerated aging of tissue engineered living autologous vascular grafts.
  Kelm JM, Emmert MY, Zürcher A, Schmidt D, Begus Nahrmann Y, Rudolph KL, Weber B, Brokopp CE, Frauenfelder T, Leschka S, Odermatt B, Jenni R, Falk V, Zünd G, Hoerstrup SP
  Biomaterials 2012, 33(33), 8277-85 published during change of institution
  
• Schnurri regulates hemocyte function to promote tissue recovery after DNA damage.
  Kelsey EM, Luo X, Brückner K, Jasper H
  J Cell Sci 2012, 125(Pt 6), 1393-400
  
• Malfunctioning DNA Damage Response (DDR) Leads to the Degeneration of Nigro-Striatal Pathway in Mouse Brain.
  Kirshner M, Galron R, Frenkel D, Mandelbaum G, Shiloh Y, Wang ZQ, Barzilai A
  J Mol Neurosci 2012, 46(3), 554-68
  
• Increased reprogramming capacity of mouse liver progenitor cells, compared with differentiated liver cells, requires the BAF complex.
  Kleger A, Mahaddalkar PU, Katz SF, Lechel A, Joo JY, Loya K, Lin Q, Hartmann D, Liebau S, Kraus JM, Cantz T, Kestler HA, Zaehres H, Schöler H, Rudolph KL
  Gastroenterology 2012, 142(4), 907-17 published during change of institution
  
• Liver X receptors orchestrate osteoblast/osteoclast crosstalk and counteract pathologic bone loss.
  Kleyer A, Scholtysek C, Bottesch E, Hillienhof U, Beyer C, Distler JH, Tuckermann JP, Schett G, Krönke G
  J Bone Miner Res 2012, 27(12), 2442-51
  
• Guidelines for the use and interpretation of assays for monitoring autophagy.
  Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NYO, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ETW, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LAM, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RCC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SSL, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CHK, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AMK, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RSB, Clarke PGH, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CAM, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LMD, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S
  Autophagy 2012, 8(4), 445-544
  
• Guidelines for the use and interpretation of assays for monitoring autophagy.
  Klionsky DJ, Abdalla FC, other participants, González-Estévez C, other participants, Zuckerbraun B
  Autophagy 2012, 8(4), 445-544
  
• Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
  Koeberle SC, Romir J, Fischer S, Koeberle A, Schattel V, Albrecht W, Grütter C, Werz O, Rauh D, Stehle T, Laufer SA
  Nat Chem Biol 2012, 8(2), 141-3
  
• Proteomic identification of PSF and p54(nrb) as TopBP1-interacting proteins.
  Kuhnert A, Schmidt U, Monajembashi S, Franke C, Schlott B, Grosse F, Greulich KO, Saluz HP, Hänel F
  J Cell Biochem 2012, 113(5), 1744-53
  
• deepBlockAlign: a tool for aligning RNA-seq profiles of read block patterns.
  Langenberger D, Pundhir S, Ekstrøm CT, Stadler PF, Hoffmann S, Gorodkin J
  Bioinformatics 2012, 28(1), 17-24
  
• Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo.
  Lee MK, Teoh WW, Phang BH, Tong WM, Wang ZQ, Sabapathy K
  Cancer Cell 2012, 22(6), 751-64
  
• A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons.
  Li R, Yang YG, Gao Y, Wang ZQ, Tong WM
  Cell Res 2012, 22(5), 859-72
  
• Molecular, phylogenetic and comparative genomic analysis of the cytokinin oxidase/dehydrogenase gene family in the Poaceae.
  Mameaux S, Cockram J, Thiel T, Steuernagel B, Stein N, Taudien S, Jack P, Werner P, Gray JC, Greenland AJ, Powell W
  Plant Biotechnol J 2012, 10(1), 67-82
  
• Telomere length, telomerase activity and osteogenic differentiation are maintained in adipose-derived stromal cells from senile osteoporotic SAMP6 mice.
  Mirsaidi A, Kleinhans KN, Rimann M, Tiaden AN, Stauber M, Rudolph KL, Richards PJ
  J Tissue Eng Regen M 2012, 6(5), 378-90 published during change of institution
  
• Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development.
  Mueller KM, Themanns M, Friedbichler K, Kornfeld JW, Esterbauer H, Tuckermann JP, Moriggl R
  Mol Cell Endocrinol 2012, 361(1-2), 1-11
  
• Multi-Objective Parameter Selection for Classifiers
  Müssel C, Lausser L, Maucher M, Kestler HA
  J Stat Softw 2012, 46(5), 1–27
  
• Myc regulates the transcription of the PRC2 gene to control the expression of developmental genes in embryonic stem cells.
  Neri F, Zippo A, Krepelova A, Cherubini A, Rocchigiani M, Oliviero S
  Mol Cell Biol 2012, 32(4), 840-51
  
• Visual acuity is reduced in alpha 7 nicotinic receptor knockout mice.
  Origlia N, Valenzano DR, Moretti M, Gotti C, Domenici L
  Invest Ophthalmol Vis Sci 2012, 53(3), 1211-8
  
• Fast and sensitive mapping of bisulfite-treated sequencing data.
  Otto C, Stadler PF, Hoffmann S
  Bioinformatics 2012, 28(13), 1698-704
  
• Isolation and molecular characterization of a second serotype of the encephalomyocarditis virus.
  Philipps A, Dauber M, Groth M, Schirrmeier H, Platzer M, Krumbholz A, Wutzler P, Zell R
  Vet Microbiol 2012, 161(1-2), 49-57
  
• Coevolution of aah: a dps-like gene with the host bacterium revealed by comparative genomic analysis.
  Ping L, Platzer M, Wen G, Delaroque N
  SCI WORLD J 2012, 2012, 504905
  
• The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing.
  Rashmi RN, Eckes B, Glöckner G, Groth M, Neumann S, Gloy J, Sellin L, Walz G, Schneider M, Karakesisoglou I, Eichinger L, Noegel AA
  Nucleus 2012, 3(2), 172-86
  
• Glucocorticoids Enhance Intestinal Glucose Uptake Via the Dimerized Glucocorticoid Receptor in Enterocytes.
  Reichardt SD, Föller M, Rexhepaj R, Pathare G, Minnich K, Tuckermann JP, Lang F, Reichardt HM
  Endocrinology 2012, 153(4), 1783-94
  
• Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing.
  Richter J, Schlesner M, Hoffmann S, Kreuz M, Leich E, Burkhardt B, Rosolowski M, Ammerpohl O, Wagener R, Bernhart SH, Lenze D, Szczepanowski M, Paulsen M, Lipinski S, Russell RB, Adam-Klages S, Apic G, Claviez A, Hasenclever D, Hovestadt V, Hornig N, Korbel JO, Kube D, Langenberger D, Lawerenz C, Lisfeld J, Meyer K, Picelli S, Pischimarov J, Radlwimmer B, Rausch T, Rohde M, Schilhabel M, Scholtysik R, Spang R, Trautmann H, Zenz T, Borkhardt A, Drexler HG, Möller P, MacLeod RAF, Pott C, Schreiber S, Trümper L, Loeffler M, Stadler PF, Lichter P, Eils R, Küppers R, Hummel M, Klapper W, Rosenstiel P, Rosenwald A, Brors B, Siebert R, ICGC MMML-Seq Project
  Nat Genet 2012, 44(12), 1316-20
  
• Advances in Stem Cell Aging
  Rudolph KL (ed)
  Book series: lse Kröner-Fresenius Symposia 2012, 3, Karger Verlag, Basel, Switzerlan
  
• Connexin45 is expressed in vascular smooth muscle but its function remains elusive.
  Schmidt VJ, Jobs A, von Maltzahn J, Wörsdörfer P, Willecke K, de Wit C
  PLoS One 2012, 7(7), e42287
  
• Genome-wide transcriptome analysis of the plant pathogen Xanthomonas identifies sRNAs with putative virulence functions.
  Schmidtke C, Findeiss S, Sharma CM, Kuhfuss J, Hoffmann S, Vogel J, Stadler PF, Bonas U
  Nucleic Acids Res 2012, 40(5), 2020-31
  
• Pharmacological estrogen administration causes a FSH-independent osteo-anabolic effect requiring ER alpha in osteoblasts.
  Seitz S, Keller J, Schilling AF, Jeschke A, Marshall RP, Stride BD, Wintermantel T, Beil FT, Amling M, Schütz G, Tuckermann** J, Schinke** T
  PLoS One 2012, 7(11), e50301 ** co-corresponding authors
  
• Accumulation of p100, a Precursor of NF-κB2, Enhances Osteoblastic Differentiation in Vitro and Bone Formation in Vivo in aly/aly Mice.
  Seo Y, Fukushima H, Maruyama T, Kuroishi KN, Osawa K, Nagano K, Aoki K, Weih F, Doi T, Zhang M, Ohya K, Katagiri T, Hosokawa R, Jimi E
  Mol Endocrinol 2012, 26(3), 414-22
  
• Telomere dysfunctional environment induces loss of quiescence and inherent impairments of hematopoietic stem cell function.
  Song Z, Zhang J, Ju Z, Rudolph KL
  Aging Cell 2012, 11(3), 449-55 published during change of institution
  
• DNA damage checkpoints in stem cells, ageing and cancer.
  Sperka T, Wang J, Rudolph KL
  Nat Rev Mol Cell Biol 2012, 13(9), 579-90 published during change of institution
  
• Gene polymorphisms in the heme degradation pathway and outcome of severe human sepsis.
  Sponholz C, Huse K, Kramer M, Giamarellos-Bourboulis EJ, Claus RA, Kern A, Engel C, Kuhnt E, Kiehntopf M, Routsi C, Mylona V, Tsangaris I, Heinemann SH, Reinhart K, Platzer M, Bauer M
  Shock 2012, 38(5), 459-65
  
• Two novel germline KRAS mutations: expanding the molecular and clinical phenotype.
  Stark Z, Gillessen-Kaesbach G, Ryan MM, Cirstea IC, Gremer L, Ahmadian MR, Savarirayan R, Zenker M
  Clin Genet 2012, 81(6), 590-4
  
• Disrupted-in-Schizophrenia 1 (DISC1) is necessary for the correct migration of cortical interneurons.
  Steinecke A, Gampe C, Valkova C, Kaether C, Bolz J
  J Neurosci 2012, 32(2), 738-45
  
• Kcnh1 voltage-gated potassium channels are essential for early zebrafish development.
  Stengel* R, Rivera-Milla* E, Sahoo N, Ebert C, Bollig F, Heinemann SH, Schönherr R, Englert C
  J Biol Chem 2012, 287(42), 35565-75 * equal contribution
  
• Association studies of the copy-number variable ß-defensin cluster on 8p23.1 in adenocarcinoma and chronic pancreatitis.
  Taudien* S, Gäbel* G, Kuss* O, Groth M, Grützmann R, Huse K, Kluttig A, Wolf A, Nothnagel M, Rosenstiel P, Greiser KH, Werdan K, Krawczak M, Pilarsky C, Platzer M
  BMC Res Notes 2012, 5, 629 * equal contribution
  
• A physical, genetic and functional sequence assembly of the barley genome.
  The International Barley Genome Sequencing Consortium, Principal investigators, Mayer KFX, Waugh R, Langridge P, Close TJ, Wise RP, Graner A, Matsumoto T, Sato K, Schulman A, Muehlbauer GJ, Stein N, Physical map construction and direct anchoring, Ariyadasa R, Schulte D, Poursarebani N, Zhou R, Steuernagel B, Mascher M, Scholz U, Shi B, Langridge P, Madishetty K, Svensson JT, Bhat P, Moscou M, Resnik J, Close TJ, Muehlbauer GJ, Hedley P, Liu H, Morris J, Waugh R, Frenkel Z, Korol A, Bergès H, Graner A, Stein N, Genomic sequencing and assembly, Steuernagel B, Scholz U, Taudien S, Felder M, Groth M, Platzer M, Stein N, BAC sequencing and assembly, Steuernagel B, Scholz U, Himmelbach A, Taudien S, Felder M, Platzer M, Lonardi S, Duma D, Alpert M, Cordero F, Beccuti M, Ciardo G, Ma Y, Wanamaker S, Close TJ, Stein N, BAC-end sequencing, Cattonaro F, Vendramin V, Scalabrin S, Radovic S, Wing R, Schulte D, Steuernagel B, Morgante M, Stein N, Waugh R, Integration of physical/genetic map and sequence resources, Nussbaumer T, Gundlach H, Martis M, Ariyadasa R, Poursarebani N, Steuernagel B, Scholz U, Wise RP, Poland J, Stein N, Mayer KFX, Gene annotation, Spannagl M, Pfeifer M, Gundlach H, Mayer KFX, Repetitive DNA analysis, Gundlach H, Moisy C, Tanskanen J, Scalabrin S, Zuccolo A, Vendramin V, Morgante M, Mayer KFX, Schulman A, Transcriptome sequencing and analysis, Pfeifer M, Spannagl M, Hedley P, Morris J, Russell J, Druka A, Marshall D, Bayer M, Swarbreck D, Sampath D, Ayling S, Febrer M, Caccamo M, Matsumoto T, Tanaka T, Sato K, Wise RP, Close TJ, Wannamaker S, Muehlbauer GJ, Stein N, Mayer KFX, Waugh R, Re-sequencing and diversity analysis, Steuernagel B, Schmutzer T, Mascher M, Scholz U, Taudien S, Platzer M, Sato K, Marshall D, Bayer M, Waugh R, Stein N, Writing and editing of the manuscript, Mayer KFX, Waugh R, Brown JWS, Schulman A, Langridge P, Platzer M, Fincher GB, Muehlbauer GJ, Sato K, Close TJ, Wise RP, Stein N
  Nature 2012, 491(7426), 711-16
  
• Selective glucocorticoid receptor modulation maintains bone mineral density in mice.
  Thiele S, Ziegler N, Tsourdi E, De Bosscher K, Tuckermann JP, Hofbauer LC, Rauner M
  J Bone Miner Res 2012, 27(11), 2242-50
  
• VEGFR-3 is expressed on megakaryocyte precursors in the murine bone marrow and plays a regulatory role in megakaryopoiesis.
  Thiele W, Krishnan J, Rothley M, Weih D, Plaumann D, Kuch V, Quagliata L, Weich HA, Sleeman JP
  Blood 2012, 120(9), 1899-907
  
• Adult neurogenesis in the short-lived teleost Nothobranchius furzeri: localization of neurogenic niches, molecular characterization and effects of aging.
  Tozzini ET, Baumgart M, Battistoni G, Cellerino A
  Aging Cell 2012, 11(2), 241-51 evaluated by "Faculty of 1000"
  
• The role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems.
  Tümpel S, Rudolph KL
  Ann N Y Acad Sci 2012, 1266, 28-39 published during change of institution
  
• Telomere shortening is associated with reduced duodenal HCOFormula secretory but normal gastric acid secretory capacity in aging mice.
  Tuo B, Ju Z, Riederer B, Engelhardt R, Manns MP, Rudolph KL, Seidler U
  Am J Physiol Gastrointest Liver Physiol 2012, 303(12), G1312-21 published during change of institution
  
• Following protein-glycosaminoglycan polysaccharide interactions with differential scanning fluorimetry.
  Uniewicz KA, Ori A, Rudd TR, Guerrini M, Wilkinson MC, Fernig DG, Yates EA
  Methods Mol Biol 2012, 836, 171-82
  
• Segregation of replicative DNA polymerases during S phase: DNA polymerase ε, but not DNA polymerases α/δ, are associated with lamins throughout S phase in human cells.
  Vaara M, Itkonen H, Hillukkala T, Liu Z, Nasheuer HP, Schaarschmidt D, Pospiech H, Syväoja JE
  J Biol Chem 2012, 287(40), 33327-38
  
• Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation.
  Vandevyver S, Dejager L, Van Bogaert T, Kleyman A, Liu Y, Tuckermann J, Libert C
  J Clin Invest 2012, 122(6), 2130-40 published during change of institution
  
• The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation.
  von Eyss B, Maaskola J, Memczak S, Möllmann K, Schuetz A, Loddenkemper C, Tanh MD, Otto A, Muegge K, Heinemann U, Rajewsky N, Ziebold U
  EMBO J 2012, 31(4), 972-85
  
• Wnt7a-Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle.
  von Maltzahn J, Bentzinger CF, Rudnicki MA
  Nat Cell Biol 2012, 14(2), 186-91
  
• Wnt signaling in myogenesis.
  von Maltzahn J, Chang NC, Bentzinger CF, Rudnicki MA
  Trends Cell Biol 2012, 22(11), 602-9
  
• Wnt7a treatment ameliorates muscular dystrophy.
  von Maltzahn J, Renaud JM, Parise G, Rudnicki MA
  Proc Natl Acad Sci U S A 2012, 109(50), 20614-9
  
• A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage.
  Wang J, Sun Q, Morita Y, Jiang H, Gross A, Lechel A, Hildner K, Guachalla LM, Gompf A, Hartmann D, Schambach A, Wuestefeld T, Dauch D, Schrezenmeier H, Hofmann WK, Nakauchi H, Ju Z, Kestler HA, Zender L, Rudolph KL
  Cell 2012, 148(5), 1001-14 published during change of institution
  
• Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease.
  Watabe-Rudolph M, Song Z, Lausser L, Schnack C, Begus-Nahrmann Y, Scheithauer MO, Rettinger G, Otto M, Tumani H, Thal DR, Attems J, Jellinger KA, Kestler HA, von Arnim CAF, Rudolph KL
  Neurology 2012, 78(8), 569-77 published during change of institution
  
• A cell autonomous role for the glucocorticoid receptor in skeletal muscle atrophy induced by systemic glucocorticoid exposure.
  Watson ML, Baehr LM, Reichardt HM, Tuckermann JP, Bodine SC, Furlow JD
  Am J Physiol Endocrinol Metab 2012, 302(10), E1210-20
  
• Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia.
  Weber M, Lambeck S, Ding N, Henken S, Kohl M, Deigner HP, Enot DP, Igwe EI, Frappart L, Kiehntopf M, Claus RA, Kamradt T, Weih D, Vodovotz Y, Briles DE, Ogunniyi AD, Paton JC, Maus UA, Bauer M
  FASEB J 2012, 26(6), 2424-36
  
• CD44 Promotes Intoxication by the Clostridial Iota-Family Toxins.
  Wigelsworth DJ, Ruthel G, Schnell L, Herrlich P, Blonder J, Veenstra TD, Carman RJ, Wilkins TD, Van Nhieu GT, Pauillac S, Gibert M, Sauvonnet N, Stiles BG, Popoff MR, Barth H
  PLoS One 2012, 7(12), e51356
  
• Comparative evaluation of establishing a human gut microbial community within rodent models.
  Wos-Oxley M, Bleich A, Oxley APA, Kahl S, Janus L, Smoczek A, Nahrstedt H, Pils M, Taudien S, Platzer M, Hedrich HJ, Medina E, Pieper D
  Gut Microbes 2012, 3(3), 234-49
  
• Diversification of the structural determinants of fibroblast growth factor-heparin interactions: implications for binding specificity.
  Xu R, Ori A, Rudd TR, Uniewicz KA, Ahmed YA, Guimond SE, Skidmore MA, Siligardi G, Yates EA, Fernig DG
  J Biol Chem 2012, 287(47), 40061-73
  
• Sequencing of 21 varicella-zoster virus genomes reveals two novel genotypes and evidence of recombination.
  Zell R, Taudien S, Pfaff F, Wutzler P, Platzer M, Sauerbrei A
  J Virol 2012, 86(3), 1608-22
  

Publications 2011:

• Laser microbeam - kinetic studies combined with molecule - structures reveal mechanisms of DNA repair
  Altenberg B, Greulich KO
  In: Optical Trapping and Optical Micromanipulation VIII, From Bio-Molecules to Tissue Studies (edited by Dholakia K, Spalding GC), Proceedings of SPIEE 2011, 8097, 80970D, SPIE Press, Bellingham,
  
• Steady state migratory RelB+ langerin+ dermal dendritic cells mediate peripheral induction of antigen-specific CD4+ CD25+ Foxp3+ regulatory T cells.
  Azukizawa H, Döhler A, Kanazawa N, Nayak A, Lipp M, Malissen B, Autenrieth I, Katayama I, Riemann M, Weih F, Berberich-Siebelt F, Lutz MB
  Eur J Immunol 2011, 41(5), 1420-34
  
• The quantitative proteome of a human cell line.
  Beck M, Schmidt A, Malmstroem J, Claassen M, Ori A, Szymborska A, Herzog F, Rinner O, Ellenberg J, Aebersold R
  Mol Syst Biol 2011, 7, 549
  
• NF-kappaB signaling and lymphoid tissue organogenesis.
  Benezech C, Mader E, Weih F, Caamano J
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• Maintaining tissue homeostasis: dynamic control of somatic stem cell activity.
  Biteau B, Hochmuth CE, Jasper H
  Cell Stem Cell 2011, 9(5), 402-11
  
• EGF signaling regulates the proliferation of intestinal stem cells in Drosophila.
  Biteau B, Jasper H
  Development 2011, 138(6), 1045-55
  
• Regulation of Drosophila lifespan by JNK signaling.
  Biteau B, Karpac J, Hwangbo D, Jasper H
  Exp Gerontol 2011, 46(5), 349-54
  
• The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation.
  Bonnet MC, Preukschat D, Welz PS, van Loo G, Ermolaeva MA, Bloch W, Haase I, Pasparakis M
  Immunity 2011, 35(4), 572-82
  
• Influence of the HLA-DRB1 genotype on antibody development to interferon beta in multiple sclerosis.
  Buck D, Cepok S, Hoffmann S, Grummel V, Jochim A, Berthele A, Hartung HP, Wassmuth R, Hemmer B
  Arch Neurol 2011, 68(4), 480-7
  
• Structure-function relationship in an archaebacterial methionine sulphoxide reductase B.
  Carella M, Becher J, Ohlenschläger O, Ramachandran R, Gührs KH, Wellenreuther G, Meyer-Klaucke W, Heinemann SH, Görlach M
  Mol Microbiol 2011, 79(2), 342-58
  
• Retinoids Stimulate Periosteal Bone Resorption by Enhancing the Protein RANKL, a Response Inhibited by Monomeric Glucocorticoid Receptor.
  Conaway HH, Pirhayati A, Persson E, Pettersson U, Svensson O, Lindholm C, Henning P, Tuckermann J, Lerner UH
  J Biol Chem 2011, 286(36), 31425-36
  
• Investigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum.
  Dar I, Yosha G, Elfassy R, Galron R, Wang ZQ, Shiloh Y, Barzilai A
  J Biol Chem 2011, 286(17), 15361-76
  
• Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion.
  DeGennaro M, Hurd TR, Siekhaus DE, Biteau B, Jasper H, Lehmann R
  Dev Cell 2011, 20(2), 233-43
  
• The short-lived annual fish Nothobranchius furzeri shows a typical teleost aging process reinforced by high incidence of age-dependent neoplasias.
  Di Cicco E, Tozzini Terzibasi E, Rossi G, Cellerino A
  Exp Gerontol 2011, 46(4), 249-56
  
• Microscopic Techniques.
  Diekmann S
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• Identification of adult nephron progenitors capable of kidney regeneration in zebrafish.
  Diep CQ, Ma D, Deo RC, Holm TM, Naylor RW, Arora N, Wingert RA, Bollig F, Djordjevic G, Lichman B, Zhu H, Ikenaga T, Ono F, Englert C, Cowan CA, Hukriede NA, Handin RI, Davidson AJ
  Nature 2011, 470(7332), 95-100
  
• Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33.
  Dislich B, Than ME, Lichtenthaler SF
  Biochem J 2011, 433(1), 75-83
  
• Molecular and biochemical properties of the S-layer protein from the wine bacterium Lactobacillus hilgardii B706.
  Dohm N, Petri A, Schlander M, Schlott B, König H, Claus H
  Arch Microbiol 2011, 193(4), 251-61
  
• Lineage-specific pleiotropy in immune aging.
  Eshraghi P, Rudolph KL
  Blood 2011, 117(12), 3250-1
  
• DARIO: a ncRNA detection and analysis tool for next-generation sequencing experiments.
  Fasold M, Langenberger D, Binder H, Stadler PF, Hoffmann S
  Nucleic Acids Res 2011, 39(Web Server issue), W112-7
  
• Traces of post-transcriptional RNA modifications in deep sequencing data.
  Findeiss S, Langenberger D, Stadler PF, Hoffmann S
  Biol Chem 2011, 392(4), 305-13
  
• Bioinformatics in aging research: a workshop report.
  Fuellen G, Adjaye J, de Grey A, Lepperdinger G, de Magalhães JP, Sühnel J, Wipat A
  Rejuvenation Res 2011, 13(6), 763-7
  
• Requirement for DNA ligase IV during embryonic neuronal development.
  Gatz SA, Ju L, Gruber R, Hoffmann E, Carr AM, Wang ZQ, Liu C, Jeggo PA
  J Neurosci 2011, 31(27), 10088-100
  
• Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.
  Gremer* L, Merbitz-Zahradnik* T, Dvorsky* R, Cirstea* IC, Kratz CP, Zenker M, Wittinghofer A, Ahmadian MR
  Hum Mutat 2011, 32(1), 33-43 * equal contribution
  
• Understanding the masses of elementary particles: a step towards understanding the massless photon?
  Greulich KO
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• Why does the wave particle dualism appear to become evident particularly at optical wavelengths
  Greulich KO
  In: The Nature of Light: What are Photons? IV, Superposition and Interaction Process Models I (edited by Roychoudhuri C, Kracklauer AF, Khrennikov Andrei Yu), Proceedings of SPIEE 2011, 8121, 812116, SPIE Press, Bellingham,
  
• The birth of a photon
  Greulich KO
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• Photons bring light into DNA repair: the comet assay and laser microbeams for studying photogenotoxicity of drugs and ageing.
  Greulich KO
  J Biophotonics 2011, 4(3), 165-71
  
• The GAPs between hepatocellular carcinoma and RAS.
  Guachalla LM, Rudolph KL
  J Hepatol 2011, 54(2), 191-2
  
• Telomerase gene mutations are associated with cirrhosis formation.
  Hartmann D, Srivastava U, Thaler M, Kleinhans KN, N'kontchou G, Scheffold A, Bauer K, Kratzer RF, Kloos N, Katz SF, Song Z, Begus-Nahrmann Y, Kleger A, von Figura G, Strnad P, Lechel A, Günes C, Potthoff A, Deterding K, Wedemeyer H, Ju Z, Song G, Xiao F, Gillen S, Schrezenmeier H, Mertens T, Ziol M, Friess H, Jarek M, Manns MP, Beaugrand M, Rudolph KL
  Hepatology 2011, 53(5), 1608-17
  
• From RNA-seq to large-scale genotyping - genomics resources for rye (Secale cereale L.).
  Haseneyer G, Schmutzer T, Seidel M, Zhou R, Mascher M, Schön CC, Taudien S, Scholz U, Stein N, Mayer KF, Bauer E
  BMC Plant Biol 2011, 11, 131
  
• Cellular distribution of metastasis suppressor 1 and the shape of cell bodies are temporarily altered in Engrailed-2 overexpressing cerebellar Purkinje cells.
  Hayn-Leichsenring G, Liebig C, Miething A, Schulz A, Kumar S, Schwalbe M, Eiberger B, Baader SL
  Neuroscience 2011, 189, 68-78
  
• Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication.
  Heidel AJ, Lawal HM, Felder M, Schilde C, Helps NR, Tunggal B, Rivero F, John U, Schleicher M, Eichinger L, Platzer M, Noegel AA, Schaap P, Glöckner G
  Genome Res 2011, 21(11), 1882-91
  
• KAP1: a new link between the DNA damage response and PML nuclear bodies.
  Hemmerich P
  Cell Cycle 2011, 10(4), 576-7
  
• Dynamic as well as stable protein interactions contribute to genome function and maintenance.
  Hemmerich P, Schmiedeberg L, Diekmann S
  Chromosome Res 2011, 19(1), 131-51
  
• Chemical shift correlation at high MAS frequencies employing low-power symmetry-based mixing schemes.
  Herbst C, Herbst J, Leppert J, Ohlenschläger O, Görlach M, Ramachandran R
  J Biomol NMR 2011, 50(3), 277-84
  
• Pipeline for large-scale microdroplet bisulfite PCR-based sequencing allows the tracking of hepitype evolution in tumors.
  Herrmann A, Haake A, Ammerpohl O, Martin-Guerrero I, Szafranski K, Stemshorn K, Nothnagel M, Kotsopoulos SK, Richter J, Warner J, Olson J, Link DR, Schreiber S, Krawczak M, Platzer M, Nürnberg P, Siebert R, Hampe J
  PLoS One 2011, 6(7), e21332
  
• Hear, hear! Thyroid hormone transporters in cochlear development.
  Heuer H
  Endocrinology 2011, 152(12), 4478-80
  
• Subcellular distribution of connexin45 in OFF bipolar cells of the mouse retina.
  Hilgen G, von Maltzahn J, Willecke K, Weiler R, Dedek K
  J Comp Neurol 2011, 519(3), 433-50
  
• Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila.
  Hochmuth CE, Biteau B, Bohmann D, Jasper H
  Cell Stem Cell 2011, 8(2), 188-99
  
• Computational analysis of high throughput sequencing data.
  Hoffmann S
  Methods Mol Biol 2011, 719, 199-217
  
• Progress in the function and regulation of ADP-Ribosylation.
  Hottiger MO, Boothby* M, Koch-Nolte* F, Lüscher* B, Martin* NMB, Plummer* R, Wang* ZQ, Ziegler* M
  Sci Signal 2011, 4(174), mr5 * equal contribution
  
• The ITS1-5.8S-ITS2 sequence region in the Musaceae: structure, diversity and use in molecular phylogeny.
  Hřibová E, Čížková J, Christelová P, Taudien S, de Langhe E, Doležel J
  PLoS One 2011, 6(3), e17863
  
• JenAge Information Centre
  Hühne R, Thalheim T, Wagner K, Schleicher J, Sühnel J
  2011, URL http://info-centre.jenage.de
  
• Creation and Comparison of Different Chip Definition Files for Affymetrix Microarrays.
  Hummert C, Mech F, Horn F, Weber M, Dryndab S, Gausmann U, Guthke R
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• Polymorphisms in the 3'-untranslated region of the CDH1 gene are a risk factor for primary gastric diffuse large B-cell lymphoma.
  Jacobs G, Hellmig S, Huse K, Titz A, Franke A, Kwiatkowski R, Ott S, Kosmahl M, Fischbach W, Lucius R, Klapper W, Fölsch UR, Hampe J, Schreiber S, Rosenstiel P
  Haematologica 2011, 96(7), 987-95
  
• Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).
  Jaiswal M, Gremer L, Dvorsky R, Haeusler LC, Cirstea IC, Uhlenbrock K, Ahmadian MR
  J Biol Chem 2011, 286(20), 18202-12
  
• Metabolic homeostasis: HDACs take center stage.
  Karpac J, Jasper H
  Cell 2011, 145(4), 497-9
  
• Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage.
  Karpac J, Younger A, Jasper H
  Dev Cell 2011, 20(6), 841-54
  
• TNF gene cluster deletion abolishes lipopolysaccharide-mediated sensitization of the neonatal brain to hypoxic ischemic insult.
  Kendall GS, Hirstova M, Horn S, Dafou D, Acosta-Saltos A, Almolda B, Zbarsky V, Rumajogee P, Heuer H, Castellano B, Pfeffer K, Nedospasov SA, Peebles DM, Raivich G
  Lab Invest 2011, 91(3), 328-41
  
• Host plant shifts affect a major defense enzyme in Chrysomela lapponica.
  Kirsch R, Vogel H, Muck A, Reichwald K, Pasteels JM, Boland W
  Proc Natl Acad Sci U S A 2011, 108(12), 4897-901
  
• Protein kinase D2 is an essential regulator of murine myoblast differentiation.
  Kleger A, Loebnitz C, Pusapati GV, Armacki M, Müller M, Tümpel S, Illing A, Hartmann D, Brunner C, Liebau S, Rudolph KL, Adler G, Seufferlein T
  PLoS One 2011, 6(1), e14599
  
• Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice.
  Kraft M, Cirstea IC, Voss AK, Thomas T, Goehring I, Sheikh BN, Gordon L, Scott H, Smyth GK, Ahmadian MR, Trautmann U, Zenker M, Tartaglia M, Ekici A, Reis A, Dörr HG, Rauch A, Thiel CT
  J Clin Invest 2011, 121(9), 3479-91
  
• Determination of hemin-binding characteristics of proteins by a combinatorial peptide library approach.
  Kühl T, Sahoo N, Nikolajski M, Schlott B, Heinemann SH, Imhof D
  Chembiochem 2011, 12(18), 2846-55
  
• Artificial linear episome-based protein expression system for protozoon Leishmania tarentolae.
  Kushnir S, Cirstea IC, Basiliya L, Lupilova N, Breitling R, Alexandrov K
  Mol Biochem Parasitol 2011, 176(2), 69-79
  
• A microRNA contribution to aberrant Ras activation in gastric cancer.
  Lam EK, Wang X, Shin VY, Zhang S, Morrison H, Sun J, Ng EK, Yu J, Jin H
  Am J Transl Res 2011, 3(2), 209-18
  
• Serine 312 phosphorylation is dispensable for wild-type p53 functions in vivo.
  Lee MK, Tong WM, Wang ZQ, Sabapathy K
  Cell Death Differ 2011, 18(2), 214-21
  
• Point mutation at the Nbs1 Threonine 278 site does not affect mouse development, but compromises the Chk2 and Smc1 phosphorylation after DNA damage.
  Li T, Wang ZQ
  Mech Ageing Dev 2011, 132(8-9), 382-8
  
• Highly parallel gene-to-BAC addressing using microarrays.
  Liu H, McNicol J, Bayer M, Morris JA, Cardle L, Marshall DF, Schulte D, Stein N, Shi BJ, Taudien S, Waugh R, Hedley PE
  Biotechniques 2011, 50(3), 165-74
  
• Cancer, senescence, and aging: translation from basic research to clinics.
  Lleonart ME, Carnero A, Paciucci R, Wang ZQ, Shomron N
  J Aging Res 2011, 2011, 1-2
  
• Elevated Fra-1 expression causes severe lipodystrophy.
  Luther J, Driessler F, Megges M, Hess A, Herbort B, Mandic V, Zaiss MM, Reichardt A, Zech C, Tuckermann JP, Calkhoven CF, Wagner EF, Schett G, David JP
  J Cell Sci 2011, 124(Pt 9), 1465-76
  
• An investigation of the effects of MitoQ on human peripheral mononuclear cells.
  Marthandan S, Murphy MP, Billett E, Barnett Y
  Free Radic Res 2011, 45(3), 351-8
  
• Inferring Boolean network structure via correlation.
  Maucher M, Kracher B, Kühl M, Kestler HA
  Bioinformatics 2011, 27(11), 1529-36
  
• A radiation-induced gene expression signature as a tool to predict acute radiotherapy-induced adverse side effects.
  Mayer C, Popanda O, Greve B, Fritz E, Illig T, Eckardt-Schupp F, Gomolka M, Benner A, Schmezer P
  Cancer Lett 2011, 302(1), 20-8
  
• Unlocking the barley genome by chromosomal and comparative genomics.
  Mayer KFX, Martis M, Hedley PE, Simková H, Liu H, Morris JA, Steuernagel B, Taudien S, Roessner S, Gundlach H, Kubaláková M, Suchánková P, Murat F, Felder M, Nussbaumer T, Graner A, Salse J, Endo T, Sakai H, Tanaka T, Itoh T, Sato K, Platzer M, Matsumoto T, Scholz U, Dolezel J, Waugh R, Stein N
  Plant Cell 2011, 23(4), 1249-63
  
• Early relapse in ALL is identified by time to leukemia in NOD/SCID mice and is characterized by a gene signature involving survival pathways.
  Meyer LH, Eckhoff SM, Queudeville M, Kraus JM, Giordan M, Stursberg J, Zangrando A, Vendramini E, Möricke A, Zimmermann M, Schrauder A, Lahr G, Holzmann K, Schrappe M, Basso G, Stahnke K, Kestler HA, Te Kronnie G, Debatin KM
  Cancer Cell 2011, 19(2), 206-17
  
• Poly(ADP-ribose) metabolism is essential for proper nucleoprotein exchange during mouse spermiogenesis.
  Meyer-Ficca ML, Ihara M, Lonchar JD, Meistrich ML, Austin CA, Min W, Wang ZQ, Meyer RG
  Biol Reprod 2011, 84(2), 218-28
  
• Eukaryotic initiation factor 2{alpha} phosphorylation is required for B-cell maturation and function in mice.
  Mielke N, Schwarzer R, Calkhoven CF, Kaufman R, Dorken B, Leutz A, Jundt F
  Haematologica 2011, 96(9), 1261-8
  
• Technology-specific error signatures in the 1000 Genomes Project data.
  Nothnagel M, Herrmann A, Wolf A, Schreiber S, Platzer M, Siebert R, Krawczak M, Hampe J
  Hum Genet 2011, 130(4), 505-16
  
• Statistical inference of allelic imbalance from transcriptome data.
  Nothnagel M, Wolf A, Herrmann A, Szafranski K, Vater I, Brosch M, Huse K, Siebert R, Platzer M, Hampe J, Krawczak M
  Hum Mutat 2011, 32(1), 98-106
  
• Endosymbiotic gene transfer and transcriptional regulation of transferred genes in Paulinella chromatophora.
  Nowack ECM, Vogel H, Groth M, Grossman AR, Melkonian** M, Glöckner** G
  Mol Biol Evol 2011, 28(1), 407-22 ** co-senior authors
  
• A systems biology approach for the investigation of the heparin/heparan sulfate interactome.
  Ori A, Wilkinson MC, Fernig DG
  J Biol Chem 2011, 286(22), 19892-904
  
• Fast local fragment chaining using sum-of-pair gap costs.
  Otto C, Hoffmann S, Gorodkin J, Stadler PF
  Algorithms Mol Biol 2011, 6, 4
  
• A major invasion of transposable elements accounts for the large size of the Blumeria graminis f.sp. tritici genome.
  Parlange F, Oberhaensli S, Breen J, Platzer M, Taudien S, Simková H, Wicker T, Doležel J, Keller B
  Funct Integr Genomics 2011, 11(4), 671-7
  
• Loss of the Protein-Tyrosine Phosphatase DEP-1/PTPRJ Drives Meningioma Cell Motility.
  Petermann A, Haase D, Wetzel A, Balavenkatraman KK, Tenev T, Gührs KH, Friedrich S, Nakamura M, Mawrin C, Böhmer FD
  Brain Pathol 2011, 21(4), 405-18
  
• Der annuelle Türkise Prachtgrundkärpfling Nothobranchius furzeri als neues Modell für die Alternsforschung
  Platzer M, Reichwald K, Hartmann N, Cellerino A, Englert C
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• N-Benzoylated Phenoxazines and Phenothiazines: Synthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization.
  Prinz H, Chamasmani B, Vogel K, Bohm KJ, Aicher B, Gerlach M, Gunther EG, Amon P, Ivanov I, Muller K
  J Med Chem 2011, 54(12), 4247-63
  
• Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.
  Prinz H, Schmidt P, Böhm KJ, Baasner S, Müller K, Gerlach M, Günther EG, Unger E
  Bioorg Med Chem 2011, 19(14), 4183-91
  
• Dissociation of osteogenic and immunological effects by the selective glucocorticoid receptor agonist, compound A, in human bone marrow stromal cells.
  Rauner M, Goettsch C, Stein N, Thiele S, Bornhaeuser M, De Bosscher K, Haegeman G, Tuckermann J, Hofbauer LC
  Endocrinology 2011, 152(1), 103-12
  
• To be or not to be the odd one out--allele-specific transcription in pentaploid dogroses (Rosa L. sect. Caninae (DC.) Ser).
  Ritz CM, Köhnen I, Groth M, Theissen G, Wissemann V
  BMC Plant Biol 2011, 11, 37
  
• Telomere shortening reduces Alzheimer's disease amyloid pathology in mice.
  Rolyan H, Scheffold A, Heinrich A, Begus-Nahrmann Y, Langkopf BH, Hölter SM, Vogt-Weisenhorn DM, Liss B, Wurst W, Lie DC, Thal DR, Biber K, Rudolph KL
  Brain 2011, 134(Pt 7), 2044-56
  
• Molecular control of systemic bile Acid homeostasis by the liver glucocorticoid receptor.
  Rose AJ, Díaz MB, Reimann A, Klement J, Walcher T, Krones-Herzig A, Strobel O, Werner J, Peters A, Kleyman A, Tuckermann JP, Vegiopoulos A, Herzig S
  Cell Metab 2011, 14(1), 123-30
  
• Synergistic activation by p38MAPK and glucocorticoid signaling mediates induction of M2-like tumor-associated macrophages expressing the novel CD20 homolog MS4A8A.
  Schmieder A, Schledzewski K, Michel J, Tuckermann JP, Tome L, Sticht C, Gkaniatsou C, Nicolay JP, Demory A, Faulhaber J, Kzhyshkowska J, Géraud C, Goerdt S
  Int J Cancer 2011, 129(1), 122-32
  
• Liposomal Encapsulation of Glucocorticoids Alters Their Mode of Action in the Treatment of Experimental Autoimmune Encephalomyelitis.
  Schweingruber N, Haine A, Tiede K, Karabinskaya A, van den Brandt J, Wüst S, Metselaar JM, Gold R, Tuckermann JP, Reichardt HM, Lühder F
  J Immunol 2011, 187(8), 4310-8
  
• Association of TLR7 variants with AIDS-like disease and AIDS vaccine efficacy in rhesus macaques.
  Siddiqui RA, Krawczak M, Platzer M, Sauermann U
  PLoS One 2011, 6(10), e25474
  
• New furin inhibitors based on weakly basic amidinohydrazones.
  Sielaff F, Than ME, Bevec D, Lindberg I, Steinmetzer T
  Bioorg Med Chem Lett 2011, 21(2), 836-40
  
• The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation.
  Sirma H, Kumar M, Meena JK, Witt B, Weise JM, Lechel A, Ande S, Sakk V, Guguen-Guillouzo C, Zender L, Rudolph KL, Günes C
  Gastroenterology 2011, 141(1), 326-37, 337.e1-3
  
• Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction.
  Sperka T, Song Z, Morita Y, Nalapareddy K, Guachalla LM, Lechel A, Begus-Nahrmann Y, Burkhalter MD, Mach M, Schlaudraff F, Liss B, Ju Z, Speicher MR, Rudolph KL
  Nat Cell Biol 2011, 14(1), 73-9 published during change of institution
  
• p38α mitogen-activated protein kinase inhibitors, a patent review (2005 – 2011)
  Stefan F, Solveigh C K, Stefan A L
  Expert Opin Ther Pat 2011, 21(12), 1843-66
  
• Revealing the position of the substrate in nickel superoxide dismutase: a model study.
  Tietze D, Voigt S, Mollenhauer D, Tischler M, Imhof D, Gutmann T, González L, Ohlenschläger O, Breitzke H, Görlach M, Buntkowsky G
  Angew Chem Int Ed Engl 2011, 50(13), 2946-50
  
• Transposon-Mediated Transgenesis in the Short-Lived African Killifish Nothobranchius furzeri, a Vertebrate Model for Aging.
  Valenzano DR, Sharp S, Brunet A
  G3 (Bethesda) 2011, 1(7), 531-8
  
• Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled alpha-subunits.
  Valkova* C, Albrizio* M, Röder IV, Schwake M, Betto R, Rudolf** R, Kaether** C
  Proc Natl Acad Sci U S A 2011, 108(2), 621-5 * equal contribution, ** co-corresponding authors
  
• Tumor necrosis factor inhibits glucocorticoid receptor function in mice: a strong signal toward lethal shock.
  Van Bogaert T, Vandevyver S, Dejager L, Van Hauwermeiren F, Pinheiro I, Petta I, Engblom D, Kleyman A, Schütz G, Tuckermann J, Libert C
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• In vitro gap-directed translesion DNA synthesis of an abasic site involving human DNA polymerases epsilon, lambda, and beta.
  Villani G, Hubscher U, Gironis N, Parkkinen S, Pospiech H, Shevelev I, di Cicco G, Markkanen E, Syväoja JE, Tanguy Le Gac N
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• Addicted to Myc--but why?
  von Eyss B, Eilers M
  Genes Dev 2011, 25(9), 895-7
  
• Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice.
  von Figura G, Wagner M, Nalapareddy K, Hartmann D, Kleger A, Guachalla LM, Rolyan H, Adler G, Rudolph KL
  PLoS One 2011, 6(2), e17122
  
• Connexin39 deficient mice display accelerated myogenesis and regeneration of skeletal muscle.
  von Maltzahn J, Wulf V, Matern G, Willecke K
  Exp Cell Res 2011, 317(8), 1169-78
  
• Immunoaging induced by hematopoietic stem cell aging.
  Wang J, Geiger H, Rudolph KL
  Curr Opin Immunol 2011, 23(4), 532-6
  
• Telomere shortening impairs regeneration of the olfactory epithelium in response to injury but not under homeostatic conditions.
  Watabe-Rudolph M, Begus-Nahrmann Y, Lechel A, Rolyan H, Scheithauer MO, Rettinger G, Thal DR, Rudolph KL
  PLoS One 2011, 6(11), e27801
  
• FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.
  Welz PS, Wullaert A, Vlantis K, Kondylis V, Fernández-Majada V, Ermolaeva M, Kirsch P, Sterner-Kock A, van Loo G, Pasparakis M
  Nature 2011, 477(7364), 330-4
  
• Frequent gene movement and pseudogene evolution is common to the large and complex genomes of wheat, barley, and their relatives.
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  Plant Cell 2011, 23(5), 1706-18
  
• Origin of land plants: do conjugating green algae hold the key?
  Wodniok S, Brinkmann H, Glöckner G, Heidel AJ, Philippe H, Melkonian M, Becker B
  BMC Evol Biol 2011, 11, 104
  
• Segrosome assembly at the pliable parH centromere.
  Wu M, Zampini M, Bussiek M, Hoischen C, Diekmann S, Hayes F
  Nucleic Acids Res 2011, 39(12), 5082-97
  
• Telomere dysfunction-related serological markers are associated with type 2 diabetes.
  Xiao F, Zheng X, Cui M, Shi G, Chen X, Li R, Song Z, Rudolph KL, Chen B, Ju Z
  Diabetes Care 2011, 34(10), 2273-8
  
• The first Sino-German Symposium on DNA Repair and Human Diseases.
  Xu* X, Eilers* M, Xiao* W, Du* LL, Bürkle* A, Wiesmüller* L, Wang* ZQ
  DNA Repair 2011, 10(3), 349-54 * equal contribution
  
• RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice.
  Yu C, Li Y, Holmes A, Szafranski K, Faulkes CG, Coen CW, Buffenstein R, Platzer M, de Magalhães JP, Church GM
  PLoS One 2011, 6(11), e26729
  

Publications 2010:

• The small RNA expression profile of the developing murine urinary and reproductive systems.
  Aguilar ALG, Piskol R, Beitzinger M, Zhu JY, Kruspe D, Aszodi A, Moser M, Englert C, Meister G
  FEBS Lett 2010, 584(21), 4426-34
  
• Cofilin-1 inactivation leads to proteinuria--studies in zebrafish, mice and humans.
  Ashworth S, Teng B, Kaufeld J, Miller E, Tossidou I, Englert C, Bollig F, Staggs L, Roberts ISD, Park JK, Haller H, Schiffer M
  PLoS One 2010, 5(9), e12626
  
• Rigid assembly and Monte Carlo models of stable and unstable chromatin structures: the effect of nucleosomal spacing.
  Aumann* F, Sühnel* J, Langowski J, Diekmann S
  Theor Chem Acc 2010, 125, 217-31 * equal contribution
  
• Transcriptomic changes arising during light-induced sporulation in Physarum polycephalum.
  Barrantes I, Glockner G, Meyer S, Marwan W
  BMC Genomics 2010, 11, 115
  
• Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.
  Becker GL, Sielaff F, Than ME, Lindberg I, Routhier S, Day R, Lu Y, Garten W, Steinmetzer T
  J Med Chem 2010, 53(3), 1067-75
  
• Extrinsic regulation of satellite cell specification.
  Bentzinger CF, von Maltzahn J, Rudnicki MA
  Stem Cell Res Ther 2010, 1(3), 27
  
• Bioelectromagnetic field effects on cancer cells and mice tumors.
  Berg H, Günther B, Hilger I, Radeva M, Traitcheva N, Wollweber L
  Electromagn Biol Med 2010, 29(4), 132-43
  
• Posttranslational modification of human glyoxalase 1 indicates redox-dependent regulation.
  Birkenmeier G, Stegemann C, Hoffmann R, Günther R, Huse K, Birkemeyer C
  PLoS One 2010, 5(4), e10399
  
• Lifespan extension by preserving proliferative homeostasis in Drosophila.
  Biteau B, Karpac J, Supoyo S, Degennaro M, Lehmann R, Jasper H
  PLoS Genet 2010, 6(10), e1001159
  
• Impact papers on aging in 2009.
  Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J
  Aging (Albany NY) 2010, 2(3), 111-21
  
• Radiation Induced Cytoplasmic Signaling
  Böhmer FD, Weiss C, Herrlich P
  In: Handbook of Cell Signaling (edited by Ralph A. Bradshaw and Edward A. Dennis) 2010, Volume 3(Chapter 267), 2225-30, Elsevier Inc. Academic
  
• Assembly dynamics of PML nuclear bodies in living cells.
  Brand P, Lenser T, Hemmerich P
  PMC Biophys 2010, 3(1), 3
  
• 1H, 13C and 15N resonance assignment of a zinc-binding methionine sulfoxide reductase type-B from the thermophilic archeabacterium Methanothermobacter thermoautotrophicus.
  Carella M, Ohlenschläger O, Ramachandran R, Görlach M
  Biomol NMR Assign 2010, 4(1), 93-5
  
• Thymus-derived glucocorticoids mediate androgen effects on thymocyte homeostasis.
  Chen Y, Qiao S, Tuckermann J, Okret S, Jondal M
  FASEB J 2010, 24(12), 5043-51
  
• Containment of extended length polymorphisms in silk proteins.
  Chinali A, Vater W, Rudakoff B, Sponner A, Unger E, Grosse F, Guehrs KH, Weisshart K
  J Mol Evol 2010, 70(4), 325-38
  
• A restricted spectrum of NRAS mutations causes Noonan syndrome.
  Cirstea IC, Kutsche K, Dvorsky R, Gremer L, Carta C, Horn D, Roberts AE, Lepri F, Merbitz-Zahradnik T, König R, Kratz CP, Pantaleoni F, Dentici ML, Joshi VA, Kucherlapati RS, Mazzanti L, Mundlos S, Patton MA, Silengo MC, Rossi C, Zampino G, Digilio C, Stuppia L, Seemanova E, Pennacchio LA, Gelb BD, Dallapiccola B, Wittinghofer A, Ahmadian MR, Tartaglia M, Zenker M
  Nat Genet 2010, 42(1), 27-9
  
• Multi-platform next-generation sequencing of the domestic turkey (Meleagris gallopavo): genome assembly and analysis.
  Dalloul RA, Long JA, Zimin AV, Aslam L, Beal K, Blomberg LA, Bouffard P, Burt DW, Crasta O, Crooijmans RPMA, Cooper K, Coulombe RA, De S, Delany ME, Dodgson JB, Dong JJ, Evans C, Frederickson KM, Flicek P, Florea L, Folkerts O, Groenen MAM, Harkins TT, Herrero J, Hoffmann S, Megens HJ, Jiang A, de Jong P, Kaiser P, Kim H, Kim KW, Kim S, Langenberger D, Lee MK, Lee T, Mane S, Marcais G, Marz M, McElroy AP, Modise T, Nefedov M, Notredame C, Paton IR, Payne WS, Pertea G, Prickett D, Puiu D, Qioa D, Raineri E, Ruffier M, Salzberg SL, Schatz MC, Scheuring C, Schmidt CJ, Schroeder S, Searle SMJ, Smith EJ, Smith J, Sonstegard TS, Stadler PF, Tafer H, Tu ZJ, Van Tassell CP, Vilella AJ, Williams KP, Yorke JA, Zhang L, Zhang HB, Zhang X, Zhang Y, Reed KM
  PLoS Biol 2010, 8(9)
  
• The nuclear isoform of the LIM domain protein Trip6 integrates activating and repressing signals at the promoter-bound glucocorticoid receptor.
  Diefenbacher ME, Litfin M, Herrlich P, Kassel O
  Mol Cell Endocrinol 2010, 320(1-2), 58-66
  
• Systems biology to battle vascular disease.
  Dominiczak AF, Herget-Rosenthal S, Delles C, Fliser D, Fournier I, Graber A, Girolami M, Holmes E, Lang F, Molina F, Nicholson J, Remuzzi G, Rossing P, Rudolph KL, Wolkenhauer O, Xenarios I, Zubarev R, Zubov D, Vlahou A, Schanstra JP
  Nephrol Dial Transplant 2010, 25(4), 1019-22
  
• ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.
  Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IRA, Capell A, Schmid B, Neumann M, Haass C
  EMBO J 2010, 29(16), 2841-57
  
• Recovery of tubulin functions after freeze-drying in the presence of trehalose.
  Dráberová E, Sulimenko V, Sulimenko T, Böhm KJ, Dráber P
  Anal Biochem 2010, 397(1), 67-72
  
• Highly modular structure and ligand binding by conformational capture in a minimalistic riboswitch.
  Duchardt-Ferner E, Weigand JE, Ohlenschläger O, Schmidtke SR, Suess B, Wöhnert J
  Angew Chem Int Ed Engl 2010, 49(35), 6216-9
  
• Brain ischemic preconditioning does not require PARP-1.
  Faraco G, Blasi F, Min W, Wang ZQ, Moroni F, Chiarugi A
  Stroke 2010, 41(1), 181-3
  
• Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor.
  Frijters R, Fleuren W, Toonen EJM, Tuckermann JP, Reichardt HM, van der Maaden H, van Elsas A, van Lierop MJ, Dokter W, de Vlieg J, Alkema W
  BMC Genomics 2010, 11, 359
  
• Endothelial cell adhesion to the extracellular matrix induces c-Src-dependent VEGFR-3 phosphorylation without the activation of the receptor intrinsic kinase activity.
  Galvagni F, Pennacchini S, Salameh A, Rocchigiani M, Neri F, Orlandini M, Petraglia F, Gotta S, Sardone GL, Matteucci G, Terstappen GC, Oliviero S
  Circ Res 2010, 106(12), 1839-48
  
• Purification and crystallization of human Cu/Zn superoxide dismutase recombinantly produced in the protozoan Leishmania tarentolae.
  Gazdag EM, Cirstea IC, Breitling R, Lukes J, Blankenfeldt W, Alexandrov K
  Acta Crystallogr Sect F Struct Biol Cryst Commun 2010, 66(Pt 8), 871-7
  
• Impaired endothelial repair capacity of early endothelial progenitor cells in prehypertension: relation to endothelial dysfunction.
  Giannotti G, Doerries C, Mocharla PS, Mueller MF, Bahlmann FH, Horvàth T, Jiang H, Sorrentino SA, Steenken N, Manes C, Marzilli M, Rudolph KL, Lüscher TF, Drexler H, Landmesser U
  Hypertension 2010, 55(6), 1389-97
  
• Autophagy and apoptosis in planarians.
  González-Estévez C, Saló E
  Apoptosis 2010, 15(3), 279-92
  
• Calculation of the Masses of All Fundamental Elementary Particles with an Accuracy of Approx. 1%.
  Greulich KO
  J Mod Phys 2010, 1(5), 300-2
  
• Single molecule experiments challenge the strict wave-particle dualism of light.
  Greulich KO
  Int J Mol Sci 2010, 11(1), 304-11
  
• Optical Tweezers.
  Greulich KO
  In: eLS 2010, published online, John Wiley and
  
• Single-Molecule Light Microscopy.
  Greulich KO, Uhl V
  In: eLS 2010, published online, John Wiley and
  
• A dexter exo within p53.
  Grosse F
  Cell Cycle 2010, 9(6), 1025-30
  
• ROS induced DNA damage and checkpoint responses: influences on aging?
  Guachalla LM, Rudolph KL
  Cell Cycle 2010, 9(20), 4058-60
  
• Telomere length of patients with major depression is shortened but independent from therapy and severity of the disease.
  Hartmann N, Boehner M, Groenen F, Kalb R
  Depress Anxiety 2010, 27(12), 1111-6
  
• Linking chemical and microbial diversity in marine sponges: possible role for poribacteria as producers of methyl-branched fatty acids.
  Hochmuth T, Niederkrüger H, Gernert C, Siegl A, Taudien S, Platzer M, Crews P, Hentschel U, Piel J
  Chembiochem 2010, 11(18), 2572-8
  
• Activation and deactivation of periventricular white matter phagocytes during postnatal mouse development.
  Hristova M, Cuthill D, Zbarsky V, Acosta-Saltos A, Wallace A, Blight K, Buckley SMK, Peebles D, Heuer H, Waddington SN, Raivich G
  Glia 2010, 58(1), 11-28
  
• The JenAge Information Centre, an information hub for ageing research and systems biology
  Hühne R, Thalheim T, Schleicher J, Wagner K, Sühnel J
  2010, URL http://info-centre.jenage.de
  
• Metabolic regulation of stem cell behavior and implications for aging.
  Jasper H, Jones DL
  Cell Metab 2010, 12(6), 561-5
  
• Genomic characterisation of the ichthyotoxic prymnesiophyte Chrysochromulina polylepis, and the expression of polyketide synthase genes in synchronized cultures.
  John U, Beszteri S, Glöckner G, Singh R, Medlin L, Cembella AD
  Eur J Phycol 2010, 45(3), 215-29 published during change of institution
  
• A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway.
  Kim MS, Yoon SK, Bollig F, Kitagaki J, Hur W, Whye NJ, Wu YP, Rivera MN, Park JY, Kim HS, Malik K, Bell DW, Englert C, Perantoni AO, Lee SB
  J Biol Chem 2010, 285(19), 14585-93
  
• What's new in neurofibromatosis? Proceedings from the 2009 NF Conference: new frontiers.
  Kissil JL, Blakeley JO, Ferner RE, Huson SM, Kalamarides M, Mautner VF, McCormick F, Morrison H, Packer R, Ramesh V, Ratner N, Rauen KA, Stevenson DA, Hunter-Schaedle K, North K
  Am J Med Genet A 2010, 152A(2), 269-83
  
• A highly efficient multi-core algorithm for clustering extremely large datasets.
  Kraus JM, Kestler HA
  BMC Bioinformatics 2010, 11, 169
  
• Telomerase deficiency impairs glucose metabolism and insulin secretion.
  Kuhlow D, Florian S, von Figura G, Weimer S, Schulz N, Petzke KJ, Zarse K, Pfeiffer AFH, Rudolph KL, Ristow M
  Aging (Albany NY) 2010, 2(10), 650-8
  
• Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development.
  Landgraf K, Bollig F, Trowe MO, Besenbeck B, Ebert C, Kruspe D, Kispert A, Hänel F, Englert C
  Mol Cell Biol 2010, 30(24), 5764-75
  
• Identification and classification of small RNAs in transcriptome sequence data.
  Langenberger D, Bermudez-Santana CI, Stadler PF, Hoffmann S
  Pac Symp Biocomput 2010, 80-7
  
• Alpha2-macroglobulin inhibits the malignant properties of astrocytoma cells by impeding beta-catenin signaling.
  Lindner I, Hemdan NYA, Buchold M, Huse K, Bigl M, Oerlecke I, Ricken A, Gaunitz F, Sack U, Naumann A, Hollborn M, Thal D, Gebhardt R, Birkenmeier G
  Cancer Res 2010, 70(1), 277-87
  
• Effect of 8-oxoguanine and abasic site DNA lesions on in vitro elongation by human DNA polymerase in the presence of replication protein A and proliferating-cell nuclear antigen.
  Locatelli GA, Pospiech H, Tanguy Le Gac N, van Loon B, Hubscher U, Parkkinen S, Syväoja JE, Villani G
  Biochem J 2010, 429(3), 573-82
  
• Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizer-like cells on combined tumor necrosis factor receptor-1/lymphotoxin beta-receptor NF-kappaB signaling.
  Lötzer* K, Döpping* S, Connert* S, Gräbner R, Spanbroek R, Lemser B, Beer M, Hildner M, Hehlgans T, van der Wall M, Mebius RE, Lovas A, Randolph GJ, Weih* F, Habenicht* AJR
  Arterioscler Thromb Vasc Biol 2010, 30(3), 395-402 * equal contribution
  
• The origins of eukaryotic-like proteins in Legionella pneumophila.
  Lurie-Weinberger MN, Gomez-Valero L, Merault N, Glöckner G, Buchrieser C, Gophna U
  Int J Med Microbiol 2010, 300(7), 470-81
  
• Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones.
  Maes C, Goossens S, Bartunkova S, Drogat B, Coenegrachts L, Stockmans I, Moermans K, Nyabi O, Haigh K, Naessens M, Haenebalcke L, Tuckermann JP, Tjwa M, Carmeliet P, Mandic V, David JP, Behrens A, Nagy A, Carmeliet G, Haigh JJ
  EMBO J 2010, 29(2), 424-41
  
• Processing of the NF-kappa B2 precursor p100 to p52 is critical for RANKL-induced osteoclast differentiation.
  Maruyama T, Fukushima H, Nakao K, Shin M, Yasuda H, Weih F, Doi T, Aoki K, Alles N, Ohya K, Hosokawa R, Jimi E
  J Bone Miner Res 2010, 25(5), 1058-67
  
• An unusual peptide from Conus villepinii: synthesis, solution structure, and cardioactivity.
  Miloslavina A, Ebert C, Tietze D, Ohlenschläger O, Englert C, Görlach M, Imhof D
  Peptides 2010, 31(7), 1292-300
  
• Deletion of the nuclear isoform of poly(ADP-ribose) glycohydrolase (PARG) reveals its function in DNA repair, genomic stability and tumorigenesis.
  Min W, Cortes U, Herceg Z, Tong WM, Wang ZQ
  Carcinogenesis 2010, 31(12), 2058-65
  
• C/EBPalpha enters the nucleolus.
  Müller C, Calkhoven CF
  Cell Cycle 2010, 9(7), 1229-30
  
• CHK2-independent induction of telomere dysfunction checkpoints in stem and progenitor cells.
  Nalapareddy K, Choudhury AR, Gompf A, Ju Z, Ravipati S, Leucht T, Lechel A, Rudolph KL
  EMBO Rep 2010, 11(8), 619-25
  
• Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.
  Nickel HC, Schmidt P, Böhm KJ, Baasner S, Müller K, Gerlach M, Unger E, Günther EG, Prinz H
  Eur J Med Chem 2010, 45(8), 3420-38
  
• Wt1 and retinoic acid signaling in the subcoelomic mesenchyme control the development of the pleuropericardial membranes and the sinus horns.
  Norden J, Grieskamp T, Lausch E, van Wijk B, van den Hoff MJB, Englert C, Petry M, Mommersteeg MTM, Christoffels VM, Niederreither K, Kispert A
  Circ Res 2010, 106(7), 1212-20
  
• Feedback between p21 and reactive oxygen production is necessary for cell senescence.
  Passos JF, Nelson G, Wang C, Richter T, Simillion C, Proctor CJ, Miwa S, Olijslagers S, Hallinan J, Wipat A, Saretzki G, Rudolph KL, Kirkwood TBL, von Zglinicki T
  Mol Syst Biol 2010, 6, 347
  
• The Initiation Step of Eukaryotic DNA Replication.
  Pospiech H, Grosse F, Pisani FM
  In: Genome Stability and Human Diseases, Subcellular Biochemistry 2010, 50, 79-104, Springer Netherlands, Do
  
• Synthesis of 2,6-aceanthrylenedione, a cyclic vinylog of anthraquinone.
  Prinz H, Böhm KJ, Müller K
  J Org Chem 2010, 75(11), 3867-70
  
• The unique complexity of the CYP3A4 upstream region suggests a nongenetic explanation of its expression variability.
  Qiu H, Mathäs M, Nestler S, Bengel C, Nem D, Gödtel-Armbrust U, Lang T, Taudien S, Burk O, Wojnowski L
  Pharmacogenet Genomics 2010, 20(3), 167-78
  
• Potential negative impacts and low effectiveness in the use of African annual killifish in the biocontrol of aquatic mosquito larvae in temporary water bodies.
  Reichard M, Watters BR, Wildekamp RH, Sonnenberg R, Nagy B, Polacik M, Valdesalici S, Cellerino A, Cooper BJ, Hengstler H, Rosenstock J, Sainthouse I
  Parasit Vectors 2010, 3, 89
  
• Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships.
  Rudd TR, Uniewicz KA, Ori A, Guimond SE, Skidmore MA, Gaudesi D, Xu R, Turnbull JE, Guerrini M, Torri G, Siligardi G, Wilkinson MC, Fernig DG, Yates EA
  Org Biomol Chem 2010, 8(23), 5390-7
  
• Molecular Mechanisms of Adult Stem Cell Aging
  Rudolph KL (ed)
  Book series: Else Kröner-Fresenius-Symposia 2010, 1, Karger Verlag, Basel, Switzerlan
  
• Molecular analysis of cataract families in India: new mutations in the CRYBB2 and GJA3 genes and rare polymorphisms.
  Santhiya ST, Kumar GS, Sudhakar P, Gupta N, Klopp N, Illig T, Söker T, Groth M, Platzer M, Gopinath PM, Graw J
  Mol Vis 2010, 16, 1837-47
  
• A subtle alternative splicing event of the Na(V)1.8 voltage-gated sodium channel is conserved in human, rat, and mouse.
  Schirmeyer J, Szafranski K, Leipold E, Mawrin C, Platzer M, Heinemann SH
  J Mol Neurosci 2010, 41(2), 310-4
  
• The centrosome and mitotic spindle apparatus in cancer and senescence.
  Schmidt S, Essmann F, Cirstea IC, Kuck F, Thakur HC, Singh M, Kletke A, Jänicke RU, Wiek C, Hanenberg H, Ahmadian MR, Schulze-Osthoff K, Nürnberg B, Piekorz RP
  Cell Cycle 2010, 9(22), 4469-73
  
• The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program.
  Schmidt S, Schneider L, Essmann F, Cirstea IC, Kuck F, Kletke A, Jänicke RU, Wiek C, Hanenberg H, Ahmadian MR, Schulze-Osthoff K, Nürnberg B, Piekorz RP
  Oncogene 2010, 29(46), 6184-92
  
• Characterisation of prostate cancer lesions in heterozygous Men1 mutant mice.
  Seigne C, Fontanière S, Carreira C, Lu J, Tong WM, Fontanière B, Wang ZQ, Zhang CX, Frappart L
  BMC Cancer 2010, 10, 395
  
• Commensal microflora and interferon-gamma promote steady-state interleukin-7 production in vivo.
  Shalapour S, Deiser K, Sercan O, Tuckermann J, Minnich K, Willimsky G, Blankenstein T, Hämmerling GJ, Arnold B, Schüler T
  Eur J Immunol 2010, 40(9), 2391-400
  
• The primary transcriptome of the major human pathogen Helicobacter pylori.
  Sharma CM, Hoffmann S, Darfeuille F, Reignier J, Findeiss S, Sittka A, Chabas S, Reiche K, Hackermüller J, Reinhardt R, Stadler PF, Vogel J
  Nature 2010, 464(7286), 250-5
  
• A cytohesin homolog in Dictyostelium amoebae.
  Shina MC, Müller R, Blau-Wasser R, Glöckner G, Schleicher M, Eichinger L, Noegel AA, Kolanus W
  PLoS One 2010, 5(2), e9378
  
• Identification and characterization of NAGNAG alternative splicing in the moss Physcomitrella patens.
  Sinha R, Zimmer AD, Bolte K, Lang D, Reski R, Platzer M, Rensing SA, Backofen R
  BMC Plant Biol 2010, 10, 76
  
• Function of TopBP1 in genome stability.
  Sokka M, Parkkinen S, Pospiech H, Syväoja JE
  In: Genome Stability and Human Diseases, Subcellular Biochemistry 2010, 50, 119-141, Springer Netherlands, D
  
• Lifestyle impacts on the aging-associated expression of biomarkers of DNA damage and telomere dysfunction in human blood.
  Song Z, von Figura G, Liu Y, Kraus JM, Torrice C, Dillon P, Rudolph-Watabe M, Ju Z, Kestler HA, Sanoff H, Lenhard Rudolph K
  Aging Cell 2010, 9(4), 607-15
  
• Alterations of the systemic environment are the primary cause of impaired B and T lymphopoiesis in telomere-dysfunctional mice.
  Song Z, Wang J, Guachalla LM, Terszowski G, Rodewald HR, Ju Z, Rudolph KL
  Blood 2010, 115(8), 1481-9
  
• The pivotal role of the alternative NF-kappaB pathway in maintenance of basal bone homeostasis and osteoclastogenesis.
  Soysa NS, Alles N, Weih D, Lovas A, Mian AH, Shimokawa H, Yasuda H, Weih F, Jimi E, Ohya K, Aoki K
  J Bone Miner Res 2010, 25(4), 809-18 excellent by "Faculty of 1000"
  
• Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives.
  Surkau G, Böhm KJ, Müller K, Prinz H
  Eur J Med Chem 2010, 45(8), 3354-64
  
• Assisted reproductive technologies do not enhance the variability of DNA methylation imprints in human.
  Tierling S, Souren NY, Gries J, Loporto C, Groth M, Lutsik P, Neitzel H, Utz-Billing I, Gillessen-Kaesbach G, Kentenich H, Griesinger G, Sperling K, Schwinger E, Walter J
  J Med Genet 2010, 47(6), 371-6
  
• Development of a functional cis-prolyl bond biomimetic and mechanistic implications for nickel superoxide dismutase.
  Tietze D, Tischler M, Voigt S, Imhof D, Ohlenschläger O, Görlach M, Buntkowsky G
  Chemistry 2010, 16(25), 7572-8
  
• Meeting report: nuclear receptors: transcription factors and drug targets connecting basic research with translational medicine.
  Tuckermann J, Bourguet W, Mandrup S
  Mol Endocrinol 2010, 24(7), 1311-21
  
• Differential scanning fluorimetry measurement of protein stability changes upon binding to glycosaminoglycans: a screening test for binding specificity.
  Uniewicz KA, Ori A, Xu R, Ahmed Y, Wilkinson MC, Fernig DG, Yates EA
  Anal Chem 2010, 82(9), 3796-802
  
• Transcriptome analysis of the sex pheromone gland of the noctuid moth Heliothis virescens.
  Vogel H, Heidel AJ, Heckel DG, Groot AT
  BMC Genomics 2010, 11, 29
  
• C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated translational control in mammals.
  Wethmar K, Bégay V, Smink JJ, Zaragoza K, Wiesenthal V, Dörken B, Calkhoven CF, Leutz A
  Genes Dev 2010, 24(1), 15-20
  
• A poke into the diversity and associations within human anterior nare microbial communities.
  Wos-Oxley ML, Plumeier I, von Eiff C, Taudien S, Platzer M, Vilchez-Vargas R, Becker K, Pieper DH
  ISME J 2010, 4(7), 839-51
  
• Comparative gene expression in toxic versus non-toxic strains of the marine dinoflagellate Alexandrium minutum.
  Yang I, John U, Beszteri S, Glöckner G, Krock B, Goesmann A, Cembella AD
  BMC Genomics 2010, 11, 248
  
• Molecular characterization of nuclear DNA helicase II (RNA helicase A).
  Zhang S, Grosse F
  Methods Mol Biol 2010, 587, 291-302
  
• Genomic analysis of the 55 kDa subunit of DNA polymerase epsilon in human intracranial neoplasms.
  Zhou Q, Lehtonen T, Lehtonen J, Laakso S, Szymas J, Pospiech H, Huoponen K, Syväoja J, Collan Y
  Cancer Genomics Proteomics 2010, 7(3), 143-6
  
• Characterization of mesonephric development and regeneration using transgenic zebrafish.
  Zhou W, Boucher RC, Bollig F, Englert C, Hildebrandt F
  AM J PHYSIOL-RENAL 2010, 299(5), F1040-7