Francesco Annunziata

Italy
LGSA Member

Analysis of intestinal stem cell competition in calorie restriction and aging

Friedrich Schiller University Jena (FSU): Faculty of Biological Sciences
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI): Neri Research Group

First Supervisor:

Francesco Neri (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Co – Supervisor(s):

Zhao-Qi Wang (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Doctoral Disputation:

2021

Publications 2022:

  • Paneth cells drive intestinal stem cell competition and clonality in aging and calorie restriction
    Annunziata F, Rasa SMM, Krepelova A, Lu J, Minetti A, Omrani O, Nunna S, Adam L, Käppel S, Neri F
    Eur J Cell Biol 2022, 101(4), 151282
  • Establishment and evaluation of module-based immune-associated gene signature to predict overall survival in patients of colon adenocarcinoma.
    Lu J, Annunziata F, Sirvinskas D, Omrani O, Li H, Rasa SMM, Krepelova A, Adam L, Neri F
    J Biomed Sci 2022, 29(1), 81
  • Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction.
    Rasa* SMM, Annunziata* F, Krepelova A, Nunna S, Omrani O, Gebert N, Adam L, Käppel S, Höhn S, Donati G, Jurkowski TP, Rudolph KL, Ori A, Neri F
    Cell Rep 2022, 39(13), 111017 * equal contribution

Publications 2021:

  • Analysis of intestinal stem cell competition in calorie restriction and aging
    Annunziata F
    Dissertation 2021, Jena
  • Establishment of a fluorescent reporter of RNA-polymerase II activity to identify dormant cells
    Freter R, Falletta P, Omrani O, Rasa M, Herbert K, Annunziata F, Minetti A, Krepelova A, Adam L, Käppel S, Rüdiger T, Wang ZQ, Goding** CR, Neri** F
    Nat Commun 2021, 12(1), 3318 ** co-corresponding authors
  • Characterization of an in vitro 3D intestinal organoid model by using massive RNAseq-based transcriptome profiling.
    Lu J, Krepelova A, Rasa SMM, Annunziata F, Husak O, Adam L, Nunna S, Neri F
    Sci Rep 2021, 11(1), 16668
  • DNA methylation modulates allograft survival and acute rejection after renal transplantation by regulating the mTOR pathway
    Zhu C, Xiang W, Li B, Wang Y, Feng S, Wang C, Chen Y, Xie W, Qu L, Huang H, Annunziata F, Nunna S, Krepelova A, Rasa SMM, Neri F, Chen J, Jiang H
    Am J Transplant 2021, 21(2), 567-81

Publications 2020:

  • Intestinal stem cells heterogeneity and clonal dominance during aging: two faces of the same coin?
    Sirvinskas* D, Annunziata* F, Neri F
    Mech Ageing Dev 2020, 189, 111247 * equal contribution