The Sammons lab is interested in how cells and organisms respond to changes in homeostasis, and how these processes are regulated during normal human lifespan and how they contribute to human disease. In this talk, Dr. Sammons will discuss the lab’s work on two transcription factors (p53 and ATF4) that control independent, evolutionarily conserved stress response pathways: the DNA Damage Response and the Integrated Stress Response.
Their data suggests that these two transcription factors use both distinct and shared regulatory mechanisms to respond to and mitigate stress. These observations have direct implications for the design and use of targeted, combinatorial therapeutic strategies across numerous human diseases.
Morgan Sammons is an, and member of the , at the University at Albany, State University of New York.
His lab’s work is sponsored by the National Institutes of Health and the State of New York, USA.
|Talk:||Common gene regulatory strategies in the DNA Damage and Integrated Stress Response Pathways|
|When:||Thursday, July 13, 2023, 2:30 pm|
|Where:||Seminar room “Nucleus”, main building (FLI 1), Beutenbergstraße 11, Jena|
|Hosts:||Martin Fischer and Steve Hoffmann (Group leader: Computational Biology)|
The seminar will take place as an in-person event.