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Amit Kumar Sahu

India
Phone: +49 3641 656856
Email: amit-kumar.sahu@leibniz-fli.de

Comprehensive Landscape of Age-induced alterations in Protein Ubiquitination and Deubiquitination

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI): Ori Research Group

First Supervisor:

Alessandro Ori (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Co – Supervisor(s):

Lars-Oliver Klotz (Friedrich Schiller University of Jena (FSU))

Publications 2025:

  • Altered translation elongation contributes to key hallmarks of aging in the killifish brain.
    Di Fraia* D, Marino* A, Lee* JH, Kelmer Sacramento E, Baumgart M, Bagnoli S, Balla T, Schalk F, Kamrad S, Guan R, Caterino C, Giannuzzi C, Tomaz da Silva P, Sahu AK, Gut H, Siano G, Tiessen M, Terzibasi-Tozzini E, Fornasiero EF, Gagneur J, Englert C, Patil KR, Correia-Melo C, Nedialkova DD, Frydman** J, Cellerino** A, Ori** A
    Science 2025, 389(6759), eadk3079 * equal contribution, ** co-senior authors
  • Aging and diet alter the protein ubiquitylation landscape in the mouse brain.
    Marino* A, Di Fraia* D, Panfilova D, Sahu AK, Minetti A, Omrani O, Cirri E, Ori A
    Nat Commun 2025, 16(1), 5266 * equal contribution

Publications 2023:

  • Impaired biogenesis of basic proteins impacts multiple hallmarks of the aging brain
    Di Fraia* D, Marino* A, Ho Lee* J, Kelmer Sacramento E, Baumgart M, Bagnoli S, Tomaz da Silva P, Kumar Sahu A, Siano G, Tiessen M, Terzibasi-Tozzini E, Gagneur J, Frydman** J, Cellerino** A, Ori** A
    bioRxiv 2023, 10.1101/2023.07.20.549210 * equal contribution, ** co-corresponding authors
  • Remodeling of the protein ubiquitylation landscape in the aging vertebrate brain
    Marino* A, Di Fraia* D, Panfilova D, Kumar Sahu A, Ori A
    bioRxiv 2023, 10.1101/2023.12.02.569713 * equal contribution