LGSA - Research Statement

Aging is a complex stochastic process based on genetic composition as well as environmental influences. The process is still not well understood. The Leibniz Graduate School on Aging and Age Related Diseases (LGSA) in Jena will strengthen research on the mechanisms of decisive processes, in particular pathological processes which lead to consequences for general health and healthy ageing.

Our biomedical research projects are embedded in the research concept of the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) with the two program areas:

• Stem cell aging and organ maintenance
• Accumulation of molecular damages and (epi)genetics of aging

Our aim is to understand the cellular and organismic senescence and aging as well as to find the mechanisms leading to specific age-associated diseases such as Alzheimer's disease, kidney failure, immunosenescence or cancer.

The experimental methodology includes genomic approaches, proteomics, cell culture and animal models of disease.