Dr. Leidecker's group is interested in two key cellular processes that often become deregulated during aging and in cancer: genome stability maintenance and trafficking through the nuclear pore complex (NPC). They explore critical questions related to how individual NPC components contribute to DNA repair and how posttranslational modifications regulate NPC functions, both within and outside the NPC. A major focus of the group's research is on ADP-ribosylation, catalyzed by two biomedically important enzymes: PARP11, which modulates the innate immune response and serves as a novel immuno-oncology target and PARP1, an early stress responder to DNA damage.
Information about Dr. Orsolya Leidecker:
- CECAD Aging Research, FMNS Institute for Genetics (UoC), Cologne
| Title of Talk: | Signalling at the nuclear pore complex |
| When: | Monday, September 23, 2024, 3:00 p.m. |
| Where: | Seminar room “Nucleus”, main building (FLI 1), Beutenbergstraße 11, Jena |
| Host: | Dario Riccardo Valenzano |
The seminar will be a hybrid event. Details for accessing the session will be provided before the colloquium takes place. For external guests: Please contact Nicole.Wolf@leibniz-fli.de for details.
