Zhiang Chen

LGSA Member

Cohesin deficiency enhances hematopoietic stem cell self-renewal in the context of aging and inflammation by imparing NF-kappaB induced differentiation

Friedrich Schiller University Jena (FSU) - Faculty of Biology and Pharmacy
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI): Rudolph Research Group

First Supervisor:

Karl Lenhard Rudolph (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Doctoral Disputation:


Publications 2016:

  • Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging.
    Tang D, Tao S, Chen Z, Koliesnik IO, Calmes PG, Hoerr V, Han B, Gebert N, Zörnig M, Löffler B, Morita** Y, Rudolph** KL
    J Exp Med 2016, 213(4), 535-53 ** co-corresponding authors
  • Publications 2015:

    • Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways.
      Chen Z, Yi W, Morita Y, Wang H, Cong Y, Liu JP, Xiao Z, Rudolph KL, Cheng T, Ju Z
      Nat Commun 2015, 6, 6808
    • Phosphatase Wip1 controls antigen-independent B cell development in a p53-dependent manner.
      Yi* W, Hu* X, Chen* Z, Liu L, Tian Y, Chen H, Cong YS, Yang F, Zhang L, Rudolph KL, Zhang Z, Zhao Y, Ju Z
      Blood 2015, 126(5), 620-8 * equal contribution