Oleksandr Dakhovnik

Ukraine
Email: oleksandr.dakhovnik@leibniz-fli.de

Metformin supplementation starting from old age C. elegans exhibits high toxicity and median lifespan reduction

Friedrich Schiller University Jena (FSU): Faculty of Biological Sciences
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI): Ermolaeva Research Group

First Supervisor:

Maria Ermolaeva (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Co – Supervisor(s):

Zhao-Qi Wang (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI))

Publications 2019:

  • Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism
    Espada* L, Dakhovnik* A, Chaudhari* P, Martirosyan A, Miek L, Poliezhaieva T, Schaub Y, Nair A, Döring N, Rahnis N, Werz O, Koeberle A, Kirkpatrick J, Ori A, Ermolaeva MA
    bioRxiv 2019, https://doi.org/10.1101/863357 * equal contribution
  • Publications 2018:

    • Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging.
      Heinze* I, Bens* M, Calzia* E, Holtze S, Dakhovnik O, Sahm A, Kirkpatrick JM, Szafranski K, Romanov N, Sama SN, Holzer K, Singer S, Ermolaeva M, Platzer** M, Hildebrandt** T, Ori** A
      BMC Biol 2018, 16(1), 82 * equal contribution, ** co-senior authors
    • DNA-Damage-Induced Hormetic Responses
      Mägdefrau AS, Ludwig K, Weigel C, Köse N, Guerra GM, Dakhovnik A, Kosan C
      In: The Science of Hormesis in Health and Longevity, Chapter 13 (edited by Suresh ISR, Marios K) 2018, 149-159, Academic Press, London